• International Journal of Aeronautical and Space Sciences
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• 제5권2호
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• pp.1-8
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• 2004

Real-Time Kinematic GPS positioning is widely used for many applications.Resolving ambiguities is the key to precise positioning. Integer ambiguity resolution isthe process of resolving the unknown cycle ambiguities of double difference carrierphase data as integers. Two important issues of resolving are efficiency andreliability. In the conventional search techniques, we generally used chi-squarerandom variables for decision variables. Mathematically, a chi-square random variableis the sum of mutually independent, squared zero-mean unit-variance normal(Gaussian) random variables. With this base knowledge, we can separate decisionvariables to several normal random variables. We showed it with related equationsand conceptual diagrams. With this separation, we can improve the computationalefficiency of the process without losing the needed performance. If we averageseparated normal random variables sequentially, averaged values are also normalrandom variables. So we can use them as decision variables, which prevent from asudden increase of some decision variable. With the method using averaged decisionvalues, we can get the solution more quicklv and more reliably.To verify the performance of our proposed algorithm, we conducted simulations.We used some visual diagrams that are useful for intuitional approach. We analyzedthe performance of the proposed algorithm and compared it to the conventionalmethods.

• 한국유체기계학회 논문집
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• 제7권1호
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• pp.51-57
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• 2004

The waterhammer has recently become more important because the pumping stations were big and the systems conveying the fluid through the large and long transmission pipelines were complex. When the pumps are started or stopped for the operation or tripped due to the power failure, the hydraulic transients occur as a result of the sudden change in velocity As the pressure waves are propagating between the pumping station and the distributing reservoir, the pressure inside the pipe drops to the liquid vapor pressure with the pipeline profile, at which time a vapor cavity forms, and finally the column separation occurs. If the pressure in the pipe is less than the atmospheric pressure, the pipe can be collapsed and destroyed after the water columns separated by the vapor cavity rejoin. During the reverse flow, the pressure is so abnormally increased at the pumping station that the accident of flooding may happen due to the failure of system. In this paper, the field tests on the waterhammer by the startup, stoppage, and power failure of a centrifugal pump were carried out for Yongma transmission pumping station in Seoul. The experimental results were compared with that of the numerical calculations, in which results the procedure of controlled pump normal shut-down and the two-step closing mode of controlling the ball valve for pump emergency stop are proposed to reduce the pressure surge.

• Computers and Concrete
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• 제20권6호
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• pp.655-661
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• 2017

Fiber reinforced concretes exhibit higher tensile strength depending on the percent and type of the fiber used. These concretes are used to reduce cracks and improve concrete behavior. The use of these fibers increases the production costs and reduces the compressive strength to a certain extent. Therefore, the use of fiber reinforced concrete in regions where higher tensile strength is required can cut costs and improve the overall structural strength. The behavior of fiber reinforced concrete and normal concrete adjacent to each other was investigated in the present study. The concrete used was self-compacting and did not require vibration. The samples had 0, 1, 2 and 4 wt% polypropylene fibers. 15 cm sample cubes were subjected to uniaxial loads to investigate their compressive strength. Fiber Self-Compacting Concrete was poured in the mold up to 0, 30, 50, 70 and 100 percent of the mold height, and then Self-Compacting Concrete without fiber was added to the empty section of that mold. In order to investigate concrete behavior under bending moment, concrete beam samples with similar conditions were prepared and subjected to the three-point bending flexural test. The results revealed that normal Self-Compacting Concrete and Fiber Self-Compacting Concrete may be used in adjacent to each other in structures and structural members. Moreover, no separation was observed at the interface of Fiber Self-Compacting Concrete and Self-Compacting Concrete, either in the cubic samples under compression or in the concrete beams under bending moment.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제25권4호
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• pp.81-91
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• 2019

Purpose: Since infectious disease hospitals are premised on emergency operations, the operational efficiency of secured personnel, equipment, facilities, etc. is relatively low. In order to increase such normal operational efficiency, it is necessary to flexibly operate facilities and operations during normal and emergency times. The purpose of this study is to suggest the architectural planning method focusing on the space composition and circulation of the regional infectious disease hospital which can increase the operational efficiency in the private hospitals. Methods: Through literature review, functional requirements of infectious disease hospitals were identified, and related personnels inter-views and field surveys were conducted to understand the spatial composition and circulation requirements of infectious disease hospitals. Results: Through the complete separation between the negative pressure zone and the general zone, even when the negative pressure zone is completely closed, the general zone should be operated separately to achieve operational efficiency. In addition, the separation of the negative pressure zone and the general zone should simultaneously consider the optimal space configuration and movement for each function while the zone settings match in the floor plan of each department and the overall cross-sectional configuration of the hospital. Implications: Infectious disease hospitals intended to be installed in private hospitals should not apply excessive space just for safety reasons and should plan to ensure their operational efficiency.

• KSBB Journal
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• 제15권5호
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• pp.537-540
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• 2000

일반적으로 paclitaxel과 유사한 구조를 가진 복잡한 유도체의 분리나 최종 제품에서의 엄격한 규정 등으로 인하여 한 단계의 HPLC system으로 정 제하는 것은 상당히 어렵다. 이러한 이유로 두 단계 HPLC system으로 식물세포 배양액으로 부터 paclitaxel의 대량 정제를 수행하였다. 즉, 첫번째 단계에 서 reverse-phase HPLC column, 두번째 단계에서 normal­p phase HPLC column을 사용하여 최종 제품을 얻었다. 또한 최종 정 제 된 paclitaxel 내 에 포함되어 있는 불순물 profile 확 언, 함량 분석, 그리고 이들 물질들에 대한 분리, 정제 및 동 정을 실시하였다 이들 불순물들 중에서 0.1% 이상되는 것은 모두 6종 (side chain derivative, baccatin III, 10-deacetyltaxol, cephalomannine, taxane derivative, 7-epitaxol)이며 NMR과 MS를 사용하여 화학구조를 분석한 결과 이미 알려진 pacli­t taxel 유도체 또는 전구체와 동일한 물칠로 밝혀 졌다. 본 연구 결과는 결국 paclitaxel 생산을 위한 품질관리 (quality con­t tr이)와 허가를 위한 자료로 유용하게 사용되어 진다.

• Radiation Oncology Journal
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• 제30권3호
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• pp.146-151
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• 2012

Purpose: This treatment planning study was undertaken to evaluate the impact of beam angle configuration of intensity-modulated radiotherapy (IMRT) on the dose of the normal liver in hepatocellular carcinoma (HCC). Materials and Methods: The computed tomography datasets of 25 patients treated with IMRT for HCC were selected. Two IMRT plans using five beams were made in each patient; beams with equidistance of $72^{\circ}$ (Plan I), and beams with a $30^{\circ}$ angle of separation entering the body near the tumor (Plan II). Both plans were generated using the same constraints in each patient. Conformity index (CI), homogeneity index (HI), gamma index, mean dose of the normal liver (Dmean_NL), Dmean_NL difference between the two plans, and percentage normal liver volumes receiving at least 10, 20, and 30 Gy (V10, V20, and V30) were evaluated and compared. Results: Dmean_NL, V10, and V20 were significantly better for Plan II. The Dmean_NL was significantly lower for peripheral (p = 0.001) and central tumors (p = 0.034). Dmean_NL differences between the two plans increased in proportion to gross tumor volume to normal liver volume ratios (p = 0.002). CI, HI, and gamma indices were not significantly different for the two plans. Conclusion: The IMRT plan based on beams with narrow separations reduced the irradiated dose of the normal liver, which would allow radiation dose escalation for HCC.

• 대한기계학회논문집B
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• 제28권10호
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• pp.1210-1218
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• 2004

Experimental study was performed to investigate the flow behavior in boundary layer on the blade suction surface of a multi-stage axial flow compressor, which was focused on the third stage of the 4-stage Low Speed Research Compressor. Flow measurements in the boundary layer were obtained using a boundary layer hot wire probe, which was traversed normal to the blade suction surface at small increments by the probe traverse specially designed. Detailed boundary layer flow measurements covering most of the stator suction surface were taken and are described using time mean and ensemble averaged velocity profiles. Amplitude of the velocity fluctuation and turbulence intensity in the boundary layer flow are also discussed. At midspan, narrow but strong wake zone due to passing wake disturbances is generated in the boundary layer near the blade leading edge for the rotor blade passing period. Corner separation is observed at the tip region near the trailing edge, which causes to increase steeply the boundary layer thickness.

• 대한기계학회논문집A
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• 제30권7호
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• pp.833-840
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• 2006

The paper presents a numerical solution to the problem of a hot rigid indenter sliding over a thermoelastic Winkler foundation with a thermal contact resistance at constant speed. It is shown analytically that no steady-state solution can exist for sufficiently high temperature or sufficiently small normal load or speed, regardless of the thermal contact resistance. However the steady state solution may exist in the same situation if the thermal contact resistance is considered. This means that the effect of the large values of temperature difference and small value of force or velocity which occur at no steady state can be lessened due to the thermal contact resistance. When there is no steady state, the predicted transient behavior involves regions of transient stationary contact interspersed with regions of separation regardless of the thermal contact resistance. Initially, the system typically exhibits a small number of relatively large contact and separation regions, but after the initial transient, the trailing edge of the contact area is only established and the leading edge loses contact, reducing the total extent of contact considerably. As time progresses, larger and larger numbers of small contact areas are established, unlit eventually the accuracy of the algorithm is limited by the discretization used.

• 한국해양공학회지
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• 제17권5호
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• pp.1-10
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• 2003

When a body with slant angle behind its shoulder is moving at a high speed, the turbulent motion around the afterbody is generally associated with the flow separation, and determines the normal component of the drag. By changing the slant angle of the afterbody, the drag coefficients can be changed, drastically. Understanding and controlling the turbulent separated flows has significant importance for the design of optimal configuration of the moving bodies. In this paper, a new Large Eddy Simulation technique has been developed to investigate turbulent vortical motions around the afterbodies, using slant angle. By understanding the structure of the turbulent flow around the body, the new configuration of afterbodies is designed to reduce the drag of body, and the nonlinear effects, due to the interaction between the body configuration and the turbulent separated flows, are investigated by use of the developed LES technique.

• Applied Microscopy
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• 제20권1호
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• pp.65-76
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• 1990

The effect of calcium-free reperfusion for 5, 10, and 15 minutes, respectively, followed by continuous reperfusion with normal Tyrode solution containing 1.0mM calcium chloride, after global ischemia in the isolated perfused guinea pig heart by Langendorff techniques was examined with transmission electron microscope. Compared to the nomal Tyrode solution-perfused control hearts, the 5 minute calcium-free-reperfused hearts showed loss or thickening of Z lines, focal sarcolemmal disruption, mitochondrial swelling, clumping of chroma-tin, intracellular fluid accumulation, and some separation of cell junctions, especially the fasciae adherentes. These changes became more severe in the hearts of 10 minute calcium-free reperfusion. Subsarcolemmal larger bleb and near complete separation of cell junctions were noticed. In the 15 minute calcium-free-reperfused hearts, irreversible ultrastructural changes including contraction bands, biazrre mitochondria, and sarcolemmal destruction were widely distributed. The severity of myocardial changes were in accordance with the duration of calcium-free reperfusion. These changes indicate that calcium-free reperfusion regardless of its duration could not salvage the post-ischemic myocardium probably due to development of calcium paradox.