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Preliminary Investigation of Association between Methylphenidate and Serum Growth Markers in Children with Attention-Deficit/Hyperactivity Disorder: A Cross-Sectional Case-Control Study

  • Kim, Woo Jin;Bang, Young Rong;Kang, Je-Wook;Yoo, Jae Ho;Kim, Seong Hwan;Park, Jae Hong
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.31 no.3
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    • pp.154-160
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    • 2020
  • Objectives: It remains unclear whether methylphenidate (MPH) has yadverse effects on growth in children. This study aimed to investigate the association of MPH with serum biological markers of growth in children with attention-deficit/hyperactivity disorder (ADHD). Methods: The present study included 103 children with ADHD (64 drug-naive children, 39 MPH-treated children) and 112 control subjects. Children with ADHD were diagnosed on the basis of a semi-structured interview. Levels of biochemical markers of growth, including insulin-like growth factor-I, thyroid stimulating hormone (TSH), free T4, calcium, phosphorus, alkaline phosphatase, vitamin D, hemoglobin, total protein, albumin, total cholesterol, and hematocrit were measured in these individuals. Results: Except in case of TSH, no intergroup differences were found in the levels of the growth markers. The levels of TSH were found to be lower in the MPH-treated boys with ADHD than in the drug-naive and control groups (p<0.05), although the levels of TSH in all the groups were within normal limits. Conclusion: In this cross-sectional study, no significant association was found between MPH and growth markers. This calls for the need to carry out prospective longitudinal research studies in the future that investigate the effect of MPH on the growth trajectory in children.

Minimum Number of Input Ground-motions to Assess Seismic Performance of Nuclear Facilities (원전시설의 내진성능평가를 위한 입력지반운동의 최소개수)

  • Hong, Kee-Jeung;Choi, Ji-Hae;Kim, Hyun-Uk;Joo, Kwang-Ho
    • Journal of the Earthquake Engineering Society of Korea
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    • v.20 no.5
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    • pp.341-349
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    • 2016
  • Currently, researches are being actively conducted in assessing seismic performance of nuclear facilities in USA and Europe. In particular, applying this technique of assessing seismic performance to design of isolation systems in nuclear power plants is being performed and then ASCE 4 Draft (2013) is being revised accordingly in the United States. In order to satisfy the probabilistic performance objectives described by seismic responses with certain confidence levels (ASCE 43, 2005), the probability distributions of these responses have to be defined. What is the minimum number of input ground-motions to obtain the probability distribution precise enough to represent the unknown actual distribution? Theoretical basis, for how to determine the minimum number of input ground-motions for given a logarithmic standard deviation to approximate the unknown actual median of the log-normal distribution within a range of error at a certain level of confidence, is introduced by Huang et al. (2008). However, the relationship between the level of confidence and the range of error is not stated in the previous study. In this paper, based on careful reviews on the previous work, the relationship between the level of confidence and the range of error is logically and explicitly stated. Furthermore, this relationship is also applied to derive the minimum number of input ground-motions in order to approximate the unknown actual logarithmic standard deviation. Several recommendations are made for determining the minimum number of input ground-motions in probabilistic assessment on seismic performance of facilities in nuclear power plants.

The Effect of Salt in Medicine for Salt Pharmacopuncture (염약침(鹽藥鍼)을 위한 소금의 의학적 효용)

  • Kim, Kee Hyun;Kim, Jee Hwa;Song, Ho Sueb
    • Journal of Acupuncture Research
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    • v.32 no.2
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    • pp.131-145
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    • 2015
  • Objectives : The purpose of this study was to demonstrate the effectiveness and availability of salt pharmacopuncture of Korean sun-dried salt and processing salt on the basis of bibliographical review. Methods : This study was done through a narrative review of related bibliography including medical books, journals, general bibliography, and web sites. Results : 1. Korean sun-dried salt is produced in the ground with soil, tiles, and pottery. Sun-dried, traditional, granulated, bamboo, and grilled salts are all appropriate for medical use. They are composed of a lower level of NaCl and unnecessary substances, and have a higher water and mineral content. 2. The 9~30 g of NaCl included in the physiological saline matches the ratio of a normal human body. However, if the saline is used for water supply, it should be improved because the recommended amount is much lower. 3. Medicine that includes NaCl is applied for lessening the congestion of the nasal cavity, alleviating cornea swelling, or for a lack of water. NaCl can also be used for washing contact lenses as well as cleaning the mucous membrane of the eyes and nose. 4. Salt relieves anger, detoxifies, induces vomiting, builds strong muscles and bones, gives energy, slows aging, and ultimately improves health. 5. Salt treats many diseases including: cardiovascular, hematosis, respirometer, obstetric, musculoskeletal, mineral supplement, eye, teeth and skin issues, etc.. However, salt is not used for treating asthma, cough, or other ailments mainly affecting the vascular system. 6. While NaCl in salt absorbs water and the vascular constriction results in higher blood pressure, the pressure induced from salt is actually a physiologically temporary rise. Rather, salt helps remove oil from the body and its potassium lowers blood pressure. Conclusions : It was suggested that salt pharmacopuncture of Korean sun-dried salt and processing salt should be made available for adjusting the physiological salt concentration and control of the Na side effects, therefore it would be useful in the treatment of diseases.

AN EXPERIMENTAL STUDY ON TISSUE RESPONSE FOLLOWING IMPLANTATION OF THE FREEZE - DRIED AND RADIATION - STERILIZED ALLOGENEIC BONE IN RECTUS ABDOMINICUS MUSCLE (백서 복근에 매식된 동결 건조 및 방사선 멸균처리된 동종골의 조직 반응에 관한 실험적 연구)

  • Lee, Chang-Woo;Yim, Chang-Joon;Lee, Dong-Kuen;Kim, Soo-Nam
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.13 no.3
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    • pp.265-277
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    • 1991
  • In this study, the healing changes of the implanted bone and its surrounding tissues were examined on the histopathologic basis following implantation of the freeze - dried and radiation - sterilized allogeneic bone in Rectus abdominicus of the rat. This study was performed to see the tissue recations after implantation of the freeze - dried and radiation - sterilized allogeneic bone and whether osteogenesis or osteo - induction or osteo - conduction is happened. And the results were as follows : 1. The shape of the implanted allogeneic bone of the 1, 2 - week group specimen was similar to that of normal bone in light - microscopic finding and the atrophy of cellular organells was found in trans - mission electron - microscopic finding. 2. The implanted allogeneic bone was surrounded with the dense fibroconnective tissues, and infiltration of the chronic inflammatory cells gradually became increased. 3. Hyaline degeneration was observed in the surrounding tissue at the 3, 4, 6 - week group specimen. 4. Light - microscopically the resorption of implanted bone became prominent after 4 - week group and the necrosis of allogeneic bone implant became severe with loss of cell components in lacuna. 5. Electron - microscopically, the osteoclast - like cells ere fond after, 2 - week group. It is summarized that the osteo - conduction potential of the bone is remained just after implanting the freeze - dried and radiation - sterilized allogeneic bone on Rectus abdominicus of the rat, but gradually it disappeared with the gradual increse of chronic inflammatory reaction and osteoclastic activity. So it is suggested that the antigenicity of the freeze - dried and radiation - sterilized bone is remained and it has little osteo - conductive activity when it is implanted in the muscle.

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Factors related to Drinking Problems among the Homeless in Homeless Facilities in Incheon (노숙인 시설 입소 대상자의 음주실태와 음주문제 관련요인: 인천광역시 노숙관련 시설을 중심으로)

  • Kim, Hee Kyung;Lee, Mihyoung;Han, Jin Sook;Lee, Sang Hee
    • Korean Journal of Health Education and Promotion
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    • v.31 no.2
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    • pp.15-26
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    • 2014
  • Objectives: This study investigates the drinking state of the homeless, including the factors that influence this state, and the related services that the homeless require. Methods: A total of 163 adults residing in homeless shelters in Incheon, were recruited from November 15 to December 28, 2013. The Korean version of the Alcohol Use Disorders Identification Test was used. The data collected were analyzed using descriptive statistics, ANOVA, chi-square, and logistic regression. All analyses were conducted using SPSS 18. Results: Among the respondents, 59.5% engaged in normal drinking, 17.2% engaged in problem drinking and 23.3% suffered from high risk drinking. Alcohol Problems of homeless were found to increase along with total drinking periods. And high risk drinker were more likely to have 3.2 times of loneliness, 6.5 times of insomnia, and the reason for homeless is alcohol problem 14.0 times higher. Conclusions: Alcohol problems among the homeless are chronic and difficult to solve through temporary measures and short-term interventions. Therefore, the development of appropriate services and policies for the homeless is important. The results of the study can be used as a basis for the development of management measures tailored to the distinctive needs of the homeless.

A Study on the early modernist woman architect, Margarete Schutte-Lihotzky - A Revolution of woman's space or an assignment to the new industrialization? - (초창기 모더니즘 여성 건축가 마가레테 쉬테-리호츠키에 관한 연구 - 여성 공간의 혁명인가 아니면 새로운 기계화로의 편입인가? -)

  • Lee Ran-Pyo
    • Korean Institute of Interior Design Journal
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    • v.14 no.3 s.50
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    • pp.20-27
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    • 2005
  • The built-in kitchen that is seen in every household is one of the achievements of the modernism architecture in early 20th century. Developed on the basis of two axis, one of which is the high industrialization and the other the sceptical assessment on the traditional value-system, the 20th century was launched in the form of the twofold entanglement, through the unfolding of which the cultural code of the modernism could be operated. The Quantification of the psychic that was attempted by H. v. Helmholtz and E. Mach in the pursuit of the reunification of sensation to the normal science was the first thread of that, while the second the break-down of the authoritative ideology and the emancipation of woman labour, which were initiated by the leftist movements. In this situation Margarete Schutte-Lihotzky was the woman architect who has tried to overcome the patriarchism in the household through architectural work by dwelling on that the emancipation of the housewives from the inefficient household labour is directly connected with the accomplishment of human freedom. She applied the modernist functionalism to the designing the kitchen for that purpose and outlined the effective range and operational realm of the rationalization. After all this the future preoccupying endeavor became the decisive moment that gave birth to a aesthetically and functionally good deliberated design of the kitchen in the present. This study is purposed to actualize the architectural ideas of Lihotzky into the present context through the consideration on the Frankfurt Kitchen of her and to grope for the relationship between architecture and feminism on the common horizon of the functionalist architecture and the women's liberation.

Operational modal analysis of Canton Tower by a fast frequency domain Bayesian method

  • Zhang, Feng-Liang;Ni, Yi-Qing;Ni, Yan-Chun;Wang, You-Wu
    • Smart Structures and Systems
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    • v.17 no.2
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    • pp.209-230
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    • 2016
  • The Canton Tower is a high-rise slender structure with a height of 610 m. A structural health monitoring system has been instrumented on the structure, by which data is continuously monitored. This paper presents an investigation on the identified modal properties of the Canton Tower using ambient vibration data collected during a whole day (24 hours). A recently developed Fast Bayesian FFT method is utilized for operational modal analysis on the basis of the measured acceleration data. The approach views modal identification as an inference problem where probability is used as a measure for the relative plausibility of outcomes given a model of the structure and measured data. Focusing on the first several modes, the modal properties of this supertall slender structure are identified on non-overlapping time windows during the whole day under normal wind speed. With the identified modal parameters and the associated posterior uncertainty, the distribution of the modal parameters in the future is predicted and assessed. By defining the modal root-mean-square value in terms of the power spectral density of modal force identified, the identified natural frequencies and damping ratios versus the vibration amplitude are investigated with the associated posterior uncertainty considered. Meanwhile, the correlations between modal parameters and temperature, modal parameters and wind speed are studied. For comparison purpose, the frequency domain decomposition (FDD) method is also utilized to identify the modal parameters. The identified results obtained by the Bayesian method, the FDD method and a finite element model are compared and discussed.

Statistical analysis and probabilistic modeling of WIM monitoring data of an instrumented arch bridge

  • Ye, X.W.;Su, Y.H.;Xi, P.S.;Chen, B.;Han, J.P.
    • Smart Structures and Systems
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    • v.17 no.6
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    • pp.1087-1105
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    • 2016
  • Traffic load and volume is one of the most important physical quantities for bridge safety evaluation and maintenance strategies formulation. This paper aims to conduct the statistical analysis of traffic volume information and the multimodal modeling of gross vehicle weight (GVW) based on the monitoring data obtained from the weigh-in-motion (WIM) system instrumented on the arch Jiubao Bridge located in Hangzhou, China. A genetic algorithm (GA)-based mixture parameter estimation approach is developed for derivation of the unknown mixture parameters in mixed distribution models. The statistical analysis of one-year WIM data is firstly performed according to the vehicle type, single axle weight, and GVW. The probability density function (PDF) and cumulative distribution function (CDF) of the GVW data of selected vehicle types are then formulated by use of three kinds of finite mixed distributions (normal, lognormal and Weibull). The mixture parameters are determined by use of the proposed GA-based method. The results indicate that the stochastic properties of the GVW data acquired from the field-instrumented WIM sensors are effectively characterized by the method of finite mixture distributions in conjunction with the proposed GA-based mixture parameter identification algorithm. Moreover, it is revealed that the Weibull mixture distribution is relatively superior in modeling of the WIM data on the basis of the calculated Akaike's information criterion (AIC) values.

Performance evaluation of LTE/LTE-A closed subscriber group femto-cell discovery (LTE/LTE-A 배타적 접속 펨토셀에 대한 검출 성능 평가)

  • Joo, Yang-Ick
    • Journal of Advanced Marine Engineering and Technology
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    • v.38 no.4
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    • pp.451-455
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    • 2014
  • In LTE (Long Term Evolution)/LTE-A (Long Term Evolution-Advanced) networks, hierarchical macro/femto-cell structure is adopted to enhance system capacity. Such a femto-cell is deployed as a Closed Subscriber Group (CSG) eNB. However, the inbound handover to CSG cell experiences longer delay than normal handover because it spends more time detecting the associated CSG cells due to its sparse deployment. Most of all the legacy UEs (User Equipments) have been implemented without considering the inbound CSG handover. Accordingly, they may not meet the performance requirements on the cell discovery described in the LTE/LTE-A standards. Therefore, in this paper, the performance of the CSG femto-cell detection is evaluated using computer simulation. The evaluation results will provide a basis to tackle the latency problem of inbound CSG handover.

A study on the Effects and Improvements of a Train Drivers' Licensing System (철도기관사 면허제 시행효과 및 개선방안에 관한 연구)

  • Lee, Chan-Bong;Park, Jin-Pyo
    • Journal of the Korean Society for Railway
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    • v.18 no.1
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    • pp.71-80
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    • 2015
  • During normal subway rush hours, a train-driver is in charge of more than 3,000 people on a daily basis. When an emergency event occurs, millions of people and their property come to depend only on the train-driver's ability. After the Daegu subway fire disaster in February 2003, the Railway Safety Act was enacted in October 2004 and the 'Train Drivers' Licensing System' was introduced by the National Railroad Administration in July 2006 to secure and improve protection. This study was conducted to investigate and evaluate the effects of the Train Drivers' Licensing System since the Licensing System was first introduced eight years ago. In addition, the analysis will suggest better policies for the effectiveness of the 'Train Drivers' Licensing System'.