• Title/Summary/Keyword: Noracronycine

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Thio and Nitrogen Analogues of Acronycine

  • Geewananda, Y.A.;Gunawardana, P.;Cordell, Geoffrey A.
    • Archives of Pharmacal Research
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    • v.18 no.3
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    • pp.195-202
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    • 1995

  • The thio, thio acetyl, oxime, and several hydrazone and azine derivatives of the antitumor alkaloid acronycine (1) were prepared. NMR spectroscopy was used to study the configurations around the C=N double bond in these acronycine derivatives. In the hydrazones and azines of acronycine the N-N bond assumes a syn configuration to the $C_6-OCH_3$ group, while the NO bond in the oxime and the N-N bond in noracronycine hydrazone and azines assumes an anti configuration.

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