• Journal of Animal Science and Technology
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• v.61 no.4
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• pp.185-191
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• 2019

The aim of this study was to evaluate different herbicides for optimum growth, yield and nutritive value of corn-soybean mixed forage under randomized complete block design. The experimental site was selected and divided equally into 3 blocks. Each block was further divided into 5 plots that each plot had 15 square meter space ($3{\times}5$). Five herbicidal treatments were randomly applied over 5 plots and herbicides were used under 5 herbicidal treatments, viz. 1) No herbicide (control); 2) Pendimethalin; 3) Linuron; 4) S-metolachlor and 5) Ethalfluralin. The collected data were analyzed using ANOVA through SAS 9.1.3 software. The results indicated that growth characteristics were not influenced (p > 0.05) by any herbicide. However, arithmetically corn stalk height was highest in the field of Pendimethalin treatment, whereas highest soybean height was found in the field of S-metolachlor. Arithmetically dry matter (DM) yield was increased with herbicidal treatments as compared to that of control treatment. Relatively highest DM yield (130%) was recorded in the treatment of Ethalfluralin followed by Pendimethalin (126%), S-metolachlor (126%) and Linuron (108%) as compared to that of control treatment. The weed emergence was significantly reduced in all herbicidal treatments as compared to that of control (p > 0.05), but the difference among herbicidal treatments was non-significant. It was concluded that weed emergence can be effectively controlled by use of any tested herbicide. However, optimum DM yield can be achieved through using herbicides; Ethalfluralin, Pendimethalin and S-metolachlor.

• Journal of Digital Convergence
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• v.17 no.8
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• pp.95-104
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• 2019

Recently, software education has been emphasized as a key element of the fourth industrial revolution. Many universities are strengthening the software education for all students according to the needs of the times. The use of online content is an effective way to introduce SW education for all students. However, the provision of uniform online contents has limitations in that it does not consider individual characteristics(major, sw interest, comprehension, interests, etc.) of students. In this study, we propose a recommendation method that utilizes the directional similarity between contents in the boolean view history data environment. We propose a new item-based recommendation formula that uses the confidence value of association rule analysis as the similarity level and apply it to the data of domestic paid contents site. Experimental results show that the recommendation accuracy is improved than when using the traditional collaborative recommendation using cosine or jaccard for similarity measurements.

• Journal of Sasang Constitutional Medicine
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• v.32 no.4
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• pp.11-28
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• 2020

Objectives The purpose of this study was to evaluate quality of reporting of intervention studies on Sasang Constitutional diet (SCD) based on the Consolidated Standards for Reporting of Trials (CONSORT) and Transparent Reporting of Evaluations with Nonrandomized Designs (TREND) statements. Methods We searched for Randomized controlled trials (RCT) and Non randomized studies for intervention (NRSI) on SCD in 4 databases and other sources, selected them by the inclusion criteria, and then evaluated quality of reporting of them. Results 1. A total of 10 studies (1 RCT and 9 NRSI) from 1999 to 2006 were selected and evaluated. The detailed items of up to 78%, at least 40%, and median value of 59% in the CONSORT and TREND statements were not reported. 2. One RCT was reporting 4 (11%) sufficiently, and 4 (11%) insufficiently among the 37 detailed items in the CONSORT statement while it was not reporting 29 (78%) items. 3. Nine NRSI were reporting 7 (12%) items sufficiently, and 2 (3%) items insufficiently among the 58 detailed items in the TREND statement while they were not reporting 15 (26%) items. Twenty (34%) items in the TREND statement were reported in some papers but not in more than half. Conclusions The quality of reporting of intervention studies on SCD has been assessed to be generally low. Subsequent researchers are recommended to select an appropriate statement for research design, and use it as a checklist from the time of designing the study to the time of reporting.

• Journal of the Economic Geographical Society of Korea
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• v.25 no.1
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• pp.183-201
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• 2022

Estimating the implicit value of housing assets is a very important task for participants in the housing market. Until now, such estimations were usually carried out using multiple regression analysis based on the inherent characteristics of the estate. However, in this paper, we examine the estimation capabilities of the Artificial Neural Network(ANN) and its 'Deep Learning' faculty. To make use of the strength of the neural network model, which allows the recognition of patterns in data by modeling non-linear and complex relationships between variables, this study utilizes geographic coordinates (i.e. longitudinal/latitudinal points) as the locational factor of housing prices. Specifically, we built a dataset including structural and spatiotemporal factors based on the hedonic price model and compared the estimation performance of the models with and without geographic coordinate variables. The results show that high estimation performance can be achieved in ANN by explaining the spatial effect on housing prices through the geographic location.

• Molecules and Cells
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• v.45 no.7
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• pp.479-494
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• 2022

Human mesenchymal stem cells (MSCs) are multipotent stem cells that have been intensively studied as therapeutic tools for a variety of disorders. To enhance the efficacy of MSCs, therapeutic genes are introduced using retroviral and lentiviral vectors. However, serious adverse events (SAEs) such as tumorigenesis can be induced by insertional mutagenesis. We generated lentiviral vectors encoding the wild-type herpes simplex virus thymidine kinase (HSV-TK) gene and a gene containing a point mutation that results in an alanine to histidine substitution at residue 168 (TK(A168H)) and transduced expression in MSCs (MSC-TK and MSC-TK(A168H)). Transduction of lentiviral vectors encoding the TK(A168H) mutant did not alter the proliferation capacity, mesodermal differentiation potential, or surface antigenicity of MSCs. The MSC-TK(A168H) cells were genetically stable, as shown by karyotyping. MSC-TK(A168H) responded to ganciclovir (GCV) with an half maximal inhibitory concentration (IC₅₀) value 10-fold less than that of MSC-TK. Because MSC-TK(A168H) cells were found to be non-tumorigenic, a U87-TK(A168H) subcutaneous tumor was used as a SAE-like condition and we evaluated the effect of valganciclovir (vGCV), an oral prodrug for GCV. U87-TK(A168H) tumors were more efficiently ablated by 200 mg/kg vGCV than U87-TK tumors. These results indicate that MSC-TK(A168H) cells appear to be pre-clinically safe for therapeutic use. We propose that genetic modification with HSV-TK(A168H) makes allogeneic MSC-based ex vivo therapy safer by eliminating transplanted cells during SAEs such as uncontrolled cell proliferation.

• Journal of Dental Anesthesia and Pain Medicine
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• v.22 no.4
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• pp.295-304
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• 2022

Background: The first dental experience is vital in molding a child's attitude towards dentistry and dental outcomes. The cooperation of a child during dental treatment is essential to render successful and high-quality treatment. Dental anxiety is common in children undergoing dental treatment. The success of pediatric dental treatments and patient comfort depends on controlling the levels of patient anxiety in clinical settings. This study aimed to compare the effectiveness of the recorded maternal voice and virtual cognitive tool (Roogies application) in the management of pediatric dental patients. Methods: The study was carried out with children aged of 4-7 years [n = 80, (40 male and 40 female)], without any past dental history, and were randomly allocated into two groups. After informed consent was obtained, the entire procedure was explained to the parents. Anxiety was assessed pre-, during, and post-treatment by measuring pulse rate, and recording Venham Picture Test (VPT) scores. Group A [n = 40; 20 boys and 20 girls)] was provided with a headphone that played a recorded maternal voice. Group B [n = 40; 20 boys and 20 girls)] was administered the virtual cognitive tool. After conditioning the children, oral prophylaxis was performed for both groups. A comparative evaluation was conducted for each treatment session. Results: The intra-group comparison of VPT scores and heart rate for patients assigned to the recorded maternal voice showed a statistically significant difference in dental anxiety (P-value ≤0.001). Conclusion: This study demonstrated that a reduction in dental anxiety with the help of recorded maternal voice forms an important component of non-pharmacological behavior management. Alternatively, the use of a virtual cognitive tool as an anxiety-reducing technique can also be advocated.

• Journal of Veterinary Science
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• v.21 no.3
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• pp.35.1-35.11
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• 2020

Background: Despite common use of tylosin in turkeys, the pharmacokinetic (PK) data for this drug in turkeys is limited. Within a few months of growth, PK of drugs in turkeys undergoes changes that may decrease their efficacy due to variable internal exposure. Objectives: The objective of this study was to investigate the influence of age on the PK of a single intravenous (i.v.) and oral administration of tylosin to turkeys at a dose of 10 and 50 mg/kg, respectively. Methods: Plasma drug concentrations were measured using high-performance liquid chromatography with UV detection. The PK parameters were assessed by means of non-compartmental approach and were subjected to allometric analysis. Results: During a 2.5-month-long period of growth from 1.4 to 14.7 kg, the median value for area under the concentration-time curve after i.v. administration increased from 2.61 to 7.15 mg × h/L and the body clearance decreased from a median of 3.81 to 1.42 L/h/kg. Over the same time, the median elimination half-life increased from 1.03 to 2.96 h. For the oral administration a similar trend was noted but the differences were less pronounced. Bioavailability was variable (5.76%-21.59%) and age-independent. For both routes, the plasma concentration of the major tylosin metabolite, tylosin D, was minimal. Protein binding was age-independent and did not exceed 50%. Allometric analysis indicated a relatively poor predictivity of clearance, volume of distribution and elimination half-life for tylosin in turkeys. Conclusions: Age has a significant impact on tylosin PK in turkeys and dosage adjustment may be needed, particularly in young individuals.

• The Korean Journal of Food And Nutrition
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• v.35 no.6
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• pp.426-434
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• 2022

In this study, the effect of osmotic drying conditions of mangoes on hot air drying was investigated. Four different osmotic agents of 60 Brix, such as S60, SM10, HF80, and SG25, were prepared. Mango slabs were osmotically dried with the agents at a ratio of 1:4 (w/w) for up to 8 hours. SG25 showed the lowest weight reduction and moisture loss during the process. As a result of hot-air drying, all samples showed a high correlation with the Page model (0.9761~0.9997), and the required drying time of all samples that were osmotically dried was reduced compared to the non-osmotically dried group. After hot-air drying, the pH value increased according to the drying temperature. The L, a, and b values and the total polyphenol content also decreased. Through this study, the possibility of osmotic drying was confirmed to increase the efficiency of hot air drying of mangoes, which is expected to contribute to the industrial use of domestic mangoes.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.27 no.1
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• pp.47-53
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• 2023

Devices such as X-Ray, CT, MRI, scanners, etc. can generate S&P noise from several sources during the image acquisition process. Since S&P noise appearing in the image degrades the image quality, it is essential to use noise reduction technology in the image processing process. Various methods have already been proposed in research on S&P noise removal, but all of them have a problem of generating residual noise in an environment with high noise density. Therefore, this paper proposes a filtering algorithm based on a three-dimensional plane equation by setting the grayscale value of the image as a new axis. The proposed algorithm subdivides the local mask to design the three closest non-noisy pixels as effective pixels, and applies cosine similarity to a region with a plurality of pixels. In addition, even when the input pixel cannot form a plane, it is classified as an exception pixel to achieve excellent restoration without residual noise.

• Journal of the Korean earth science society
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• v.44 no.4
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• pp.331-341
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• 2023

The goal of this study was to examine the PCK required for science teachers and PCK required for university teacher educators in terms of school science knowledge, science teaching and learning, and the role of science educators, which are the main axes of science education in future schools, and to explore the relationship between them. This study is a follow-up to a previous stage of research that explored the prospects for changes in schools in the future (2040-2050) in terms of school knowledge, educational methods, and teacher roles. Based on in-depth interviews, qualitative and semantic network analyses were conducted to derive and compare the characteristics of PCK and PCK. As for the main research results, science teacher PCK in future schools should include expertise in organizing science classes centered on convergence topics, expertise in digital platforms and ICT use, and expertise in building a network of learning communities and resources, as part of the expertise of human teachers differentiated from AI. Teacher educators' PCK includes expertise in the research and development of T-L methods using AI, expertise in the knowledge construction process and practice, and expertise in developing preservice teachers' research competencies. Discussed in the conclusion is the change in teacher PCK and teacher educator PCK with changes in science knowledge, such as convergence-type knowledge and cognition-value integrated knowledge; and the need to emphasize values, attitudes, and ethical judgments for the coexistence of humans and non-humans as school science knowledge in the post-humanism future society.