• Journal of Biomedical Engineering Research
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• v.29 no.5
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• pp.371-375
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• 2008

In blood pressure measurement, the oscillometric method detects and analyzes the pulse pressure oscillation while deflating the cuff around the arm. For its principle, one has to inflate cuff pressure above the subject's systolic pressure and deflate below the diastolic pressure. Most of the commercialized devices inflate until the fixed target pressure and deflate until the fixed completion pressure because there is no way to know the systolic and diastolic pressure before measurement. Too high target pressure makes stress to the subject and too low target pressure makes big error or long measurement time because of re-inflation. There are similar problems for inadequate completion pressure. In this study, we suggest new algorithm to set proper target and completion pressure for each subject by analyzing pressure waveform while inflating period. We compared our proposed method and auscultation method to see the errors of estimation. The differences between the two measurements were -4.02$\pm$4.80mmHg, -10.50$\pm$10.57mmHg and -0.78$\pm$5.l7mmHg for mean arterial pressure, systolic pressure and diastolic pressure respectively. Consequently, we could set the target pressure by 30 mmHg higher than our estimation and we could stop at 20mmHg lower than our estimated diastolic pressure. Using this method, we could reduce the measurement time.

• Journal of Korean Society of Water and Wastewater
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• v.29 no.5
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• pp.551-557
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• 2015

The TMDL (Total Maximum Daily Load) has been used to determine the water quality target. LDC (Load Duration Curve) based on hydrology has been used to support water quality assessments and development of TMDL. Also FDC (Flow Duration Curve) analysis can be used as a general indicator of hydrologic condition. The LDC is developed by multiplying FDC with the numeric water quality target of the factor for the pollutant of concern. Therefore, this study was to create LDC using the stream flow data and numeric water quality target of BOD and T-P in order to evaluate the pollutant load characterization by flow conditions in Heukcheon stream. When it is to be a high-flows condition, BOD and T-P are necessary to manage. BOD and T-P did not satisfy the numeric water quality target for both seasons (spring and summer). In order to meet the numeric water quality target in Heukcheon stream, management of non point source pollutant is much more important than that of point source pollutant control.

• Journal of Broadcast Engineering
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• v.19 no.3
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• pp.329-341
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• 2014

Kernel-based mean-shift object tracking has gained more interests nowadays, with the aid of its feasibility of reliable real-time implementation of object tracking. This algorithm calculates the best mean-shift vector based on the color histogram similarity between target model and target candidate models, where the color histograms are usually produced after uniform color-space quantization for the implementation of real-time tracker. However, when the image of target model has a reduced contrast, such uniform quantization produces the histogram model having large values only for a few histogram bins, resulting in a reduced accuracy of similarity comparison. To solve this problem, a non-uniform quantization algorithm has been proposed, but it is hard to apply to real-time tracking applications due to its high complexity. Therefore, this paper proposes a fast non-uniform color-space quantization method using the histogram equalization, providing an adjusted histogram distribution such that the bins of target model histogram have as many meaningful values as possible. Using the proposed method, the number of bins involved in similarity comparison has been increased, resulting in an enhanced accuracy of the proposed mean-shift tracker. Simulations with various test videos demonstrate the proposed algorithm provides similar or better tracking results to the previous non-uniform quantization scheme with significantly reduced computation complexity.

• The Korean Journal of Pesticide Science
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• v.11 no.1
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• pp.32-37
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• 2007

The study was carried out to establish buffer zone for the protection of the non-target organisms by aerial pesticide application. The two pesticide combination of 3-way tank-mixing of three pesticides for aerial application, ferimzone tricyclazole SC + BPMC EC + validamycin-A SL and hexaconzole EC + isoprothiolane EC+phenthoate EC were selected for the simultaneous control of key pests on paddy rice as blast, sheath blight, brown planthopper and moth. Aquatic organisms including killifish and loach in the paddy field and nearby water reservoirs were not affected by aerial application of the pesticides. However, all the water flea were killed, when they were exposed 10 m from the aerially sprayed site, while the water flea exposed in 30 m away from the site were not affected. Honeybees within 50 m in the wind direction and 20 m in the opposite wind direction showed a mortality of $7{\sim}100%$. Residues concentration of the pesticides in paddy water were not detectable level after six days from aerial application. Drifting distance of aerially sprayed droplet from the target area was within 30 m in the wind direction and 20 m in the opposite direction. Consequently, it was the buffer zones in the aerial pesticides application for the protection of the non-target organisms should be at least 50 m for aquatic organisms and 100 m for honeybees.

• IMMUNE NETWORK
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• v.1 no.2
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• pp.162-169
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• 2001

Background: Nitric oxide (NO), a cytotoxic molecule is produced in various tissues including tumor cells during interleukin-2 (IL-2) therapy . Lymphokine-activated killer (LAK) cells are induced during IL-2 therapy, and have cytotoxic activity against tumor cells. The current study investigated the effects of NO synthesized in target cells or exposure of target cells to NO on the sensitivity of target cells to LAK cell cytotoxicity. Methods: Cytotoxicity was measured using 4 h chromium release assays. LAK cells which were induced by a 4 day incubation of BALB/c mouse splenocytes with IL-2 (6,000 IU/mL) were employed as effector cells. RD-995 skin tumor cells originated from a C3H/HeN mouse were employed as target cells. NO synthesis in target cells was induced by a 24 h incubation of RD-995 cells with $IFN{\gamma}$ (25 U/mL), TNF (50 U/mL) and IL-1 (20 U/mL). S-nitrosyl acetylpenicillamine (SNAP), an NO donor, was used to expose target cells to NO. $N^G$-monomethyl-L-arginine (MLA) and carboxy-PTIO were added during cytotoxicity assays to inhibit NO synthesis, and to scavenge NO produced by target cells, respectively. Results: Sensitivity of NO-producing RD-995 cells to LAK cell cytotoxicity was decreased by addition of MLA and carboxy-PTIO during cytotoxicity assays. However, the two reagents had no effect on the sensitivity of non-NO-producing RD-995 cells. Pretreatment of RD-995 target cells with SNAP increased the sensitivity in comparison with untreated cells. Conclusions: Sensitivity of target cells to LAK cell cytotoxicity is increased by target cell NO synthesis or exposure to NO. Further studies are needed to evaluate whether these in vitro results have relevance to in vivo phenomena.

• Journal of the Korean Society of Food Culture
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• v.35 no.4
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• pp.351-362
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• 2020

This study investigated the possibility of reducing sodium and sugar intake in the Bulgogi bowl and yogurt, respectively, by utilizing food and non-food factors. Sodium and sugar replacers were the target food factors, and eating environment was the target non-food factor. The sodium content of Bulgogi bowls was reduced by 40%, and a flavor enhancer was applied to compensate for the reduced saltiness. Low calorie sweeteners, such as sucralose and stevia, were used to lower the sugar content of yogurt by 30%. Consumers were asked to evaluate the samples in one of the three eating environments: private booth evaluation, BOOTH; watching video clips during evaluation, VIDEO; conversation with friends during evaluation, FRIEND. The results showed that applying sodium or sugar replacers were effective in lowering sodium or sugar intake, respectively, without compromising the acceptance level of samples. Significant influences of the eating environment were observed on liking and perception of samples, but the influence patterns were not consistent between Bulgogi bowl and yogurt.

• Journal of the Korea Society of Computer and Information
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• v.22 no.2
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• pp.29-35
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• 2017

In this paper, we present a 5W1H programming model for IT non-experienced people who are not familiar with computer programming and those who need programming education. Based on this model, we can design a development tool that can be easily programmed by beginners. This development tool is a programming method applying the 5W1H concept and constructs a sentence to satisfy the control condition of 'Who, When, Where, What, and How', which is the sentence element of 5W1H. Therefore, the user can easily develop the target system as if constructing the sentence without learning the programming language of the target system. In this paper, to verify the effectiveness of the 5W1H programming model proposed in this paper, we applied the concept of 5W1H programming to Arduino and developed the development tool and performed the first verification and applied the second verification to the speech recognition smart home development platform.

• Radiation Oncology Journal
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• v.35 no.2
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• pp.180-184
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• 2017

Patients with locally advanced lung cancer and very limited pulmonary function (forced expiratory volume in 1 second $[FEV1]{\leq}1L$) have dismal prognosis and undergo palliative treatment or best supportive care. We describe two cases of locally advanced node-positive non-small cell lung cancer (NSCLC) patients with very limited lung function treated with induction chemotherapy and moderate hypofractionated image-guided radiotherapy (Hypo-IGRT). Hypo-IGRT was delivered to a total dose of 45 Gy to the primary tumor and involved lymph nodes. Planning was based on positron emission tomography-computed tomography (PET/CT) and four-dimensional computed tomography (4D-CT). Internal target volume (ITV) was defined as the overlap of gross tumor volume delineated on 10 phases of 4D-CT. ITV to planning target volume margin was 5 mm in all directions. Both patients showed good clinical and radiological response. No relevant toxicity was documented. Hypo-IGRT is feasible treatment option in locally advanced node-positive NSCLC patients with very limited lung function ($FEV1{\leq}1L$).

• BMB Reports
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• v.50 no.4
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• pp.226-231
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• 2017

At the post-transcriptional and translational levels, microRNA (miRNA) represses protein-coding genes via seed pairing to the 3' untranslated regions (UTRs) of mRNA. Although working models of miRNA-mediated gene silencing are successfully established using miRNA transfections and knockouts, the regulatory interaction between miRNA and long non-coding RNA (lncRNA) remain unknown. In particular, how the mRNA-resembling lncRNAs with 5' cap, 3' poly(A)-tail, or coding features, are regulated by miRNA is yet to be examined. We therefore investigated the functional interaction between miRNAs and lncRNAs with/without those features, in miRNA-transfected early zebrafish embryos. We observed that the greatest determinants of the miRNA-mediated silencing of lncRNAs were the 5' cap and 3' poly(A)-tails in lncRNAs, at both the post-transcriptional and translational levels. The lncRNAs confirmed to contain 5' cap, 3' poly(A)-tail, and the canonical miRNA target sites, were observed to be repressed in the level of both RNA and ribosome-protected fragment, while those with the miRNA target sites and without 5' cap and 3' poly(A)-tail, were not robustly repressed by miRNA introduction, thus suggesting a role as a miRNA-decoy.

• Journal of Astronomy and Space Sciences
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• v.29 no.4
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• pp.363-374
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• 2012

This paper studies the problem of tracking a re-entry vehicle (RV) in order to predict its impact point on the ground. Re-entry target dynamics combined with super-high speed has a complex non-linearity due to ballistic coefficient variations. However, it is difficult to construct a database for the ballistic coefficient of a unknown vehicle for a wide range of variations, thus the reliability of target tracking performance cannot be guaranteed if accurate ballistic coefficient estimation is not achieved. Various techniques for ballistic coefficient estimation have been previously proposed, but limitations exist for the estimation of non-linear parts accurately without obtaining prior information. In this paper we propose the ballistic coefficient ${\beta}$ model-based interacting multiple model-extended Kalman filter (${\beta}$-IMM-EKF) for precise tracking of an RV. To evaluate the performance, other ballistic coefficient model based filters, which are gamma augmented filter, gamma bootstrapped filter were compared and assessed with the proposed ${\beta}$-IMM-EKF for precise tracking of an RV.