• Journal of the Korean Society for Aviation and Aeronautics
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• v.30 no.3
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• pp.109-116
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• 2022

A modular platform development technique was proposed to minimize development cost and development period by utilizing the already developed unmanned Aerial target AVT, which has been operated and verified for many years. New Mission Profile was designed and structural analysis was performed through finite element analysis (FEA) by analyzing mission requirements for visual short-range, non-visible mid-range, and long-range targets. The targets are used for guided missile anti-aircraft training. In addition, avionics systems including flight control computers for autonomous flights were developed to verify their conformance by performing launcher take-off tests with rapid acceleration changes and autonomous flight tests at a maximum speed of 300km per hour.

• 제어로봇시스템학회:학술대회논문집
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• 1994.10a
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• pp.622-627
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• 1994

In this paper, we discuss an application of LTR techniques to integral controller design for discrete-time non-minimum phase plant models. It is shown that the feedback property obtained by enforcing the conventional LTR procedure can be achieved by the partial LTR technique. In addition, we point out that the partial LTR technique provides more design freedom in shaping a target feedback property.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.239.1-239.1
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• 2003

The vanilloid receptor VR has attracted great interest as a sensory transducer for capsaicin. protons, and heat. and as a therapeutic target. On the basis of the previous studies on vanilloid agonists and antagonists. we have looked for non-vanilloid VR antagonists by developing ideal vanilloid equivalents, which might provide the perfect analgesic effects without the side effects caused by vanilloid receptor agonists. (omitted)

• Korean Journal of Remote Sensing
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• v.33 no.5_1
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• pp.547-557
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• 2017

In this paper, a new spectral unmixing based target detection algorithm is proposed which adopted Iterative Error Analysis as a tool for extraction of background endmembers by using the target spectrum to be detected as initial endmember. In the presented method, the number of background endmembers is automatically decided during the IEA by stopping the iteration when the maximum change in abundance of the target is less than a given threshold value. The proposed algorithm does not have the dependence on the selection of image endmembers in the model-based approaches such as Orthogonal Subspace Projection and the target influence on the background statistics in the stochastic approaches such as Matched Filter. The experimental result with hyperspectral image data where various real and simulated targets are implanted shows that the proposed method is very effective for the detection of both rare and non-rare targets. It is expected that the proposed method can be effectively used for mineral detection and mapping as well as target object detection.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.39 no.4
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• pp.370-380
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• 2002

This paper proposes an ATR (Automatic Target Recognition) algorithm for identifying non-occluded and occluded military vehicles in natural FLIR (Forward Looking InfraRed) images. After segmenting a target, a radial function is defined from the target boundary to extract global shape features. Also, to extract local shape features of upper region of a target, a distance function is defined from boundary points and a line between two extreme points. From two functions and target contour, four global and four local shape features are proposed. They are much more invariant to translation, rotation and scale transform than traditional feature sets. In the experiments, we show that the proposed feature set is superior to the traditional feature sets with respect to the similarity-transform invariance and recognition performance.

• Development and Reproduction
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• v.18 no.1
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• pp.1-11
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• 2014

Early growth response 1 (Egr1) is a zinc-finger transcription factor to direct second-wave gene expression leading to cell growth, differentiation and/or apoptosis. While it is well-known that Egr1 controls transcription of an array of targets in various cell types, downstream target gene(s) whose transcription is regulated by Egr1 in the uterus has not been identified yet. Thus, we have tried to identify a list of potential target genes of Egr1 in the uterus by performing multi-step in silico promoter analyses. Analyses of mRNA microarray data provided a cohort of genes (102 genes) which were differentially expressed (DEGs) in the uterus between Egr1(+/+) and Egr1(-/-) mice. In mice, the frequency of putative EGR1 binding sites (EBS) in the promoter of DEGs is significantly higher than that of randomly selected non-DEGs, although it is not correlated with expression levels of DEGs. Furthermore, EBS are considerably enriched within -500 bp of DEG's promoters. Comparative analyses for EBS of DEGs with the promoters of other species provided power to distinguish DEGs with higher probability as EGR1 direct target genes. Eleven EBS in the promoters of 9 genes among analyzed DEGs are conserved between various species including human. In conclusion, this study provides evidence that analyses of mRNA expression profiles followed by two-step in silico analyses could provide a list of putative Egr1 direct target genes in the uterus where any known direct target genes are yet reported for further functional studies.

• Clinical and Experimental Reproductive Medicine
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• v.47 no.1
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• pp.42-53
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• 2020

Objective: Recently, microRNA (miRNA) has been identified both as a powerful regulator involved in various biological processes through the regulation of numerous genes and as an effective biomarker for the prediction and diagnosis of various disease states. The objective of this study was to identify and validate miRNAs and their target genes involved in inflammation in placental tissue. Methods: Microarrays were utilized to obtain miRNA and gene expression profiles from placentas with or without inflammation obtained from nine normal pregnant women and 10 preterm labor patients. Quantitative real-time polymerase chain reaction and Western blots were performed to validate the miRNAs and differentially-expressed genes in the placentas with inflammation. Correlations between miRNA and target gene expression were confirmed by luciferase assays in HTR-8/SVneo cells. Results: We identified and validated miRNAs and their target genes that were differentially expressed in placentas with inflammation. We also demonstrated that several miRNAs (miR-371a-5p, miR-3065-3p, miR-519b-3p, and miR-373-3p) directly targeted their target genes (LEF1, LOX, ITGB4, and CD44). However, some miRNAs and their direct target genes showed no correlation in tissue samples. Interestingly, miR-373-3p and miR-3065-3p were markedly regulated by lipopolysaccharide (LPS) treatment, although the expression of their direct targets CD44 and LOX was not altered by LPS treatment. Conclusion: These results provide candidate miRNAs and their target genes that could be used as placental biomarkers of inflammation. These candidates may be useful for further miRNA-based biomarker development.

• Korean journal of applied entomology
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• v.56 no.4
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• pp.331-338
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• 2017

In the present study, we investigated the effects of two herbicide-resistant genetically modified rice (GM rice) varieties, Milyang 204 and Iksan 483, recently developed in Korea on non-target insects and a spider. No difference in host preferences of the English grain aphid Sitobion avenae and the brown planthopper Nilaparvata lugens were observed between GM rice and non-GM rice. Wolf spider Pirata subpiraticus, feeding on N. lugens reared on GM rice or non-GM rice, revealed no significant difference in body weight. P. subpiraticus, fed with N. lugens reared on Milyang 204, showed survival rates similar to that in P. subpiraticus fed with N. lugens reared on non-GM rice. However, P. subpiraticus feeding on N. lugens reared on Iksan 483 demonstrated significantly lower survival rates than that in P. subpiraticus feeding on N. lugens reared on Milyang 204 or non-GM rice. In addition, when larvae of the western honeybee Apis mellifera were supplied with Iksan 483 pollen, a significantly longer pupal period occurred, as compared with that of A. mellifera supplied with pollen of Milyang 204 or non-GM rice. As GM rice has negative effects on P. subpiraticus, which is an important predator in agricultural ecosystems, and on A. mellifera, which plays important roles in pollination and honey production, additional studies on risk assessment of GM rice should be conducted before releasing newly developed herbicide-resistant GM rice to the agricultural environment.

• Journal of Korean Society of Environmental Engineers
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• v.37 no.8
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• pp.480-491
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• 2015

In this study, methods using LDC (Load Duration Curve) and watershed model were suggested to develope management targets and evaluate target achievement for non-point source pollution management considering watershed and runoff characteristics and possibility for achievement of target. These methods were applied for Saemangeum watershed which was designated as nonpoint source pollution management area recently. Flow duration interval of 5 to 40% was selected as flow range for management considering runoff characteristics and TP was selected as indicator for management. Management targets were developed based on scenarios for non-point source pollutant reduction of management priority areas using LDC method and HSPF model which was calibrated using 4 years data (2009~2012). In the scenario of LID, road sweeping and 50% reduction in CSOs and untreated sewage at Jeonju A20 and 30% reduction in fertilizer and 50% in livestock NPS at Mankyung C03, Dongjin A14 and KobuA14, management targets for Mangyung bridge, Dongjin bridge, Jeonju stream and Gunpo bridge were developed as TP 0.38, 0.18, 0.64 and 0.16 mg/L respectively. When TP loads at the target stations were assumed to have been reduced by a certain percentage (10%), management targets for those target stations were developed as TP 0.35, 0.17, 0.60 and 0.15 mg/L respectively. The result of this study is expected to be used as reference material for management master plan, implementation plan and implementation assessment for non-point source management area.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.49 no.2
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• pp.35-44
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• 2012

Most recent infrared (IR) sensors have a focal-plane array (FPA) structure. Spatial non-uniformity of a FPA structure, however, introduces unwanted fixed pattern noise (FPN) to images. This non-uniformity correction (NUC) of a FPA can be categorized into target-based and scene-based approaches. In a target-based approach, FPN can be separated by using a uniform target such as a black body. Since the detector response randomly drifts along the time axis, however, several scene-based algorithms on the basis of a video sequence have been proposed. Among those algorithms, the state-of-the-art one based on Kalman filter uses one-directional warping for motion compensation and only compensates for offset non-uniformity of IR camera detectors. The system model using one-directional warping cannot correct the boundary region where a new scene is being introduced in the next video frame. Furthermore, offset-only correction approaches may not completely remove the FPN in images if it is considerably affected by gain non-uniformity. Therefore, for FPN reduction in IR videos, we propose a joint correction algorithm of gain and offset based on bi-directional warping. Experiment results using simulated and real IR videos show that the proposed scheme can provide better performance compared with the state-of-the art in FPN reduction.