• Food Science and Biotechnology
• /
• v.17 no.6
• /
• pp.1165-1170
• /
• 2008

The deposition of the amyloid $\beta}$ ($A{\beta}$)-peptide following proteolytic processing of amyloid precursor protein (APP) by $\beta$-secretase (BACE1) and $\gamma$-secretase is critical feature in the progress of Alzheimer's disease (AD). Consequently, BACE1, a key enzyme in the production of $A{\beta}$, is a prime target for therapeutic intervention in AD. In the course of searching for BACE1 inhibitors from natural sources, the ethyl acetate fraction of Petasites japonicus showed potent inhibitory activity. Two BACE1 inhibitors quercetin (QC) and kaempferol 3-O-(6"-acetyl)-$\beta$-glucopyranoside (KAG) were isolated from P. japonicus by activity-guided purification. QC, in particular, non-competitively attenuated BACE1 activity with $IC_{50}$ value of $2.1{\times}10^{-6}\;M$ and $K_i$ value of $3.7{\times}10^{-6}\;M$. Both compounds exhibited less inhibition of $\alpha$-secreatase (TACE) and other serine proteases including chymotrypsin, trypsin, and elastase, suggesting that they ere relatively specific and selective inhibitors to BACE1. Furthermore, both compounds significantly reduced the extracellular $A{\beta}$ secretion in $APP_{695}$-transfected B103 cells.

• Food Science of Animal Resources
• /
• v.32 no.4
• /
• pp.458-466
• /
• 2012

In this study, consumer preferences toward traditional cheeses were investigated with Tulum cheese sample which is one of the traditional cheeses of Turkey. Type of milk used for Tulum cheese making was identified as the most important factor, followed by Tulum cheese's texture, price, salinity, fat content, origin and flavour. The ideal Tulum cheese profile for the overall consumers was made with cow milk, a hard texture, a price of 20 TL per kg, a low salt cheese, a full fat cheese, the regional cheese which belongs to Izmir region and a mild-flavoured cheese.A cluster analysis revealed there were two clusters with different ideal product profiles. Cluster 1's ideal Tulum cheese comprised a soft texture, a mild-flavoured cheese, a cheese made with cow milk, a full fat cheese, a low salt cheese, the regional cheese which belongs to Izmir region and a price of 10 TL per kg. Cluster 2 differed from cluster 1 in that its ideal Tulum cheese was a hard textured cheese and priced at 20 TL per kg. The consumers in cluster 2 were less price sensitive than those in cluster 1. In addition to, the consumers in both segments are ready to pay extra money for regional Tulum cheese versus non-regional Tulum cheese. We found that the older ones were more willing to pay as compared to younger individuals. Young people are critical target consumers for Tulum cheese marketers. The findings on cluster 1's ideal Tulum cheese of this study could therefore provide guidance to marketing managers.

• Journal of the Korean Institute of Intelligent Systems
• /
• v.20 no.3
• /
• pp.318-325
• /
• 2010

In this study, the wrapper database description language and model is suggested to collect product reviews from Korean shopping malls with multi-layer structures and are built in a variety of web languages. Above all, the wrapper based web crawlers have the website structure information to bring the exact desired data. The previously suggested wrapper based web crawler can collect HTML documents and the hierarchical structure of the target documents were only 2-3 layers. However, the Korean shopping malls in the study consist of not only HTML documents but also of various web language (JavaScript, Flash, and AJAX), and have a 5-layer hierarchical structure. A web crawler should have information about the review pages in order to visit the pages without visiting any non-review pages. The proposed wrapper contains the location information of review pages. We also propose a language grammar used in describing the location information.

• Journal of Oral Medicine and Pain
• /
• v.25 no.2
• /
• pp.159-165
• /
• 2000

Subsequent to an allogenic stem cell transplantation(ASCT) on patients with hematologic malignancy(AML, ALL, CML, multiple myeloma, lymphoma etc.), chronic GVHD(graft versus host disease), which is an immunological reaction, occurs. With treatment results from patients who were diagnosed with ALL(acute lymphocytic leukemia), undergone BMT(bone marrow transplantation) and showed oral and skin lesions due to GVHD, treatment of oral manifestations of leukemia and its general management were studied. 90% of patients with chronic GVHD show change in the oral mucosa causing oral manifestations such as leukoplakia, lichenoid change of the oral mucosa, mucosal atrophy, erythema, ulceration and xerostomia. In treating GVHD, extensive systemic immunosuppression cause bacterial, viral, fungal infection that are fatal, and even if the treatment is successful, the patient is already in a severe immunosuppressed state. Therefore, localized target therapy is preferred. In another words, topical application(rinse, cream, ointment etc.) of cyclosporin and steroid in treating oral chronic GVHD is highly recommended, and the use of PUVA(Psoralen Ultraviolet A) and thalidomide is reported to be effective. In treating such diseases, dental treatment to control pain and prevent secondary infection of oral manifestations is very important. To those patients with systemic diseases who show limited effect by general dental treatment, non-invasive treatment such as the dental laser, in addition to the use of drugs, may be necessary to actively treat pain and help the healing process. For greater results, new effective methods are to be developed for treatment.

• Corrosion Science and Technology
• /
• v.18 no.5
• /
• pp.206-211
• /
• 2019

Silicon carbide (SiC) thin films become superhard when they have microstructures of nanocolumnar crystalline grains (NCCG) with an intergranular amorphous SiC matrix. We investigated the role of ion bombardment and deposition temperature in forming the NCCG in SiC thin films. A direct-current (DC) unbalanced magnetron sputtering method was used with pure Ar as sputtering gas to deposit the SiC thin films at fixed target power of 200 W and chamber pressure of 0.4 Pa. The Ar ion bombardment of the deposited films was conducted by applying a negative DC bias voltage 0-100 V to the substrate during deposition. The deposition temperature was varied between room temperature and $450^{\circ}C$. Above a critical bias voltage of -80 V, the NCCG formed, whereas, below it, the SiC films were amorphous. Additionally, a minimum thermal energy (corresponding to a deposition temperature of $450^{\circ}C$ in this study) was required for the NCCG formation. Transmission electron microscopy, Raman spectroscopy, and glancing angle X-ray diffraction analysis (GAXRD) were conducted to probe the samples' structural characteristics. Of those methods, Raman spectroscopy was a particularly efficient non-destructive tool to analyze the formation of the SiC NCCG in the film, whereas GAXRD was insufficiently sensitive.

• STI Policy Review
• /
• v.8 no.2
• /
• pp.75-93
• /
• 2017

Recently, global competition in the manufacturing sector is driving firms in the manufacturing sector to conduct product innovation projects to maintain their competitive edge. The key points of product innovation projects are 1) what the purpose of the project is and 2) what expected results in the target market can be achieved by implementing the innovation. Therefore, this study focuses on the performance of innovation projects with a business viewpoint. In this respect, this study proposes the "achievement rate" of product innovation projects as a measurement of project performance. Then, this study finds the best strategies from various innovation activities to optimize the achievement rate of product innovation projects. There are three major innovation activities for the projects, including three types of R&D activities: Internal, joint and external R&D, and five types of non-R&D activities - acquisition of machines, equipment and software, purchasing external knowledge, job education and training, market research and design. This study applies decision tree modeling, a kind of data-mining methodology, to explore effective innovation activities. This study employs the data from the 'Korean Innovation Survey (KIS) 2014: Manufacturing Sector.' The KIS 2014 gathered information about innovation activities in the manufacturing sector over three years (2011-2013). This study gives some practical implication for managing the activities. First, innovation activities that increased the achievement rate of product diversification projects included a combination of market research, new product design, and job training. Second, our results show that a combination of internal R&D, job training and training, and market research increases the project achievement most for the replacement of outdated products. Third, new market creation or extension of market share indicates that launching replacement products and continuously upgrading products are most important.

• Nuclear Engineering and Technology
• /
• v.49 no.5
• /
• pp.989-995
• /
• 2017

Distributed Control System (DCS) communication networks, which use Fast Ethernet with redundant networks for the transmission of information, have been installed in digitalized nuclear power plants. Normally, failover tests are performed to verify the reliability of redundant networks during design and manufacturing phases; however, systematic integrity tests of DCS networks cannot be fully performed during these phases because all relevant equipment is not installed completely during these two phases. In additions, practical verification tests are insufficient, and there is a need to test the actual failover function of DCS redundant networks in the target environment. The purpose of this study is to verify that the failover functions works correctly in certain abnormal conditions during installation and commissioning phase and identify the influence of network failover on the entire DCS. To quantify the effects of network failover in the DCS, the packets (Protocol Data Units) must be collected and resource usage of the system has to be monitored and analyzed. This study introduces the use of a new methodology for verification of DCS network failover during the installation and commissioning phases. This study is expected to provide insight into verification methodology and the failover effects from DCS redundant networks. It also provides test results of network performance from DCS network failover in digitalized domestic nuclear power plants (NPPs).

• Nuclear Engineering and Technology
• /
• v.52 no.5
• /
• pp.1013-1021
• /
• 2020

A combination of simultaneous thermal analysis, evolved gas analysis and non-ambient XRD techniques was used to characterise and investigate the conversion reactions of ammonium uranates into uranium oxides. Two solid phases of the ternary system NH₃ - UO₃ - H₂O were synthesised under specified conditions. Microspheres prepared by the sol-gel method via internal gelation were identified as 3UO₃·2NH₃·4H₂O, whereas the product of a typical ammonium diuranate precipitation reaction was associated to the composition 3UO₃·NH₃·5H₂O. The thermal decomposition profile of both compounds in air feature distinct reaction steps towards the conversion to U₃O₈, owing to the successive release of water and ammonia molecules. Both compounds are converted into α-U₃O₈ above 550 ℃, but the crystallographic transition occurs differently. In compound 3UO₃·NH₃·5H₂O (ADU) the transformation occurs via the crystalline β-UO₃ phase, whereas in compound 3UO₃·2NH₃·4H₂O (microspheres) an amorphous UO₃ intermediate was observed. The new insights obtained on these uranate systems improve the information base for designing and synthesising minor actinide-containing target materials in future applications.

• Journal of Soil and Groundwater Environment
• /
• v.13 no.3
• /
• pp.59-66
• /
• 2008

A biological study was conducted to evaluate the enhancement of landfarming of soil contaminated with petroleum hydrocarbon (TPH) applying organic composite nutrients and a chemical oxidation during bioremediation. The target value of soil TPH after treatment was 500 mg/kg TPH. Addition of an organic compost and liquid swine manure for the removal of soil THP showed higher efficiency as 84.4% and 92.2% respectively than inorganic nutrients of 80.2%. In addition to the removal of non-biodegradable portion of residual hydrocarbons in soil, a chemical oxidation was applied during tailing period of the biological remediation, which showed high remediation efficiency as 98.1% compared with single bioremediation efficiency of 84.7%.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.41 no.5
• /
• pp.493-504
• /
• 2021

The target site, Goejeongcheon flows through downtown of Saha-gu, Busan and it connects to the Nakdong-gang estuary. But non-point pollutants and sewage sludge are partially flowing into the stream and deposited. As a result, dissolved oxygen concentrations of the stream were observed close to the anaerobic condition. Multistage Vortex Aerator was applied for restoring this urban stream. It dissolves oxygen by repeatedly causing collisions between water and oxygen by vortex flow. The changes in water quality and odor were monitored for 2 months while circulating 1 m³/min of water with 22 ppm dissolved oxygen. As a result of the operation, the dissolved oxygen was improved from slightly Bad (4)~Bad (5) to Good (1b)~Normal (3) grade, and the total phosphorus concentration was decreased by 76 % on average. In the case of complex odor, a maximum reduction of 84.5 % was observed on the day the entire river was anaerobic. Through this study, we evaluated the feasibility of applying pure oxygen and Vortex Aerator for the the stream restoration. It is expected that the results of this study can be used for full-scale design.