• Clinics in Shoulder and Elbow
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• 제10권2호
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• pp.175-182
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• 2007

목적: 스포츠 손상과 비스포츠 손상에 의한 상부 관절와 순 전후방 병변을 형태학적으로 분류하고 동반 손상의 빈도와 임상적 결과를 분석하고자 하였다. 대상 및 방법: 1996년 5월부터 2005년 11월까지 상부 관절와 순 전후방 병변으로 견관절경 수술을 받은 환자 중 추시가 가능하였던 54예를 대상으로, 평균 연령은 39세($18{\sim}67$세), 평균 추시 기간은 28개월(13개월$\sim$9년 5개월) 이었다. 상부 관절와 순 전후방 병변의 형태학적 분류는 Snyder 분류 및 Morgan분류를 이용하였다. 손상기전에 따라 스포츠 손상군과 비스포츠 손상군으로 분류한 다음, 동반 손상 병변의 빈도를 비교하였으며, 견관절의 기능 평가는 최종 추시 시 UCLA score, Rowe score 그리고 ASES score를 이용하였다. 결과: 상부 관절와 순 전후방 병변의 형태학적 분류는 스포츠 손상군과 비스포츠 손상군 모두에서 제 2형 이 가장 많았다. 손상 기전에 따라 스포츠 손상군은 반복 손상형이, 비스포츠 손상군은 압박 손상형이 가장 많았으며, 동반 손상 병변으로는 스포츠 손상군은 견관절 불안정성이, 비스포츠 손상군은 회전근 개 파열이 가장 많은 발생 빈도를 보였다. 수술 전과 수술 후 시행한 견관절 기능평가에서 스포츠 손상군과 비스포츠 손상군에서 모두 향상되었으나 통계학적인 유의성은 없었다 (P>0.05). 결론: 상부 관절와 순 전후방 병변은 다른 질환의 동반 가능성이 많으므로 술 전 동반 손상 병변을 정확히 파악하는 것이 치료의 결과에 중요할 것으로 판단된다.

• Advances in nano research
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• 제13권1호
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• pp.87-96
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• 2022

Drug self-delivery systems can easily realize combination drug therapy and avoid carrier-induced toxicity and immunogenicity because they do not need non-therapeutic carrier materials. So, designing appropriate drug self-delivery systems for specific diseases can settle most of the problems existing in traditional drug delivery systems. Retinal pigment epithelium is very important for the homeostasis of retina. However, it is vulnerable to oxidative damage and difficult to repair. Worse still, the antioxidants can hardly reach the retina by non-invasive administration routes due to the ocular barriers. Herein, the targeted group (folic acid) and antioxidant (melatonin) have been grafted on the surface of ZnO quantum dots to fabricate a new kind of drug self-delivery systems as a protectant via eyedrops. In this study, the negative nanoparticles with size ranging in 4~6 nm were successfully synthesized. They could easily and precisely deliver drugs to retinal pigment epithelium via eyedrops. And they realized acid degradation to controlled release of melatonin and zinc in retinal pigment epithelium cells. Consequently, the structure of retinal pigment epithelium cells were stabilized according to the expression of ZO-1 and β-catenin. Moreover, the antioxidant capacity of retinal pigment epithelium were enhanced both in health mice and photic injury mice. Therefore, such new drug self-delivery systems have great potential both in prevention and treatment of oxidative damage induced retinal diseases.

• Korean Journal of Acupuncture
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• 제30권4호
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• pp.220-229
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• 2013

Objectives : Electroacupuncture(EA) has been used effectively in producing analgesia on ankle sprain pain of humans and animals. Currently to examine the underlying mechanisms of the EA-induced analgesia, the effects of EA on weight-bearing forces(WBR) were examined at ankle sprain classified as grade 3 in rats. Methods : The severe ankle sprain classified as grade 3 was induced surgically by ankle ligament injury in the Sprague-Dawley rats. WBR of the affected foot were examined to evaluate effects and mechanism of EA(2 Hz, 1 ms pulse width, 2 mA intensity, for 15 min) which was applied to either SI6, GB34, or GB39 acupoints. The rats were pretreated with naltrexone(10 mg/kg, i.p.) as an opioid receptor antagonist or phentolamine(5 mg/kg, i.p) as an ${\alpha}$-adrenoceptor antagonist at 30 min before EA. Results : The daily repeat EA at either SI6, GB34, or GB39 showed significant analgesic effects on the severe ankle sprain. Particularly, daily EA at GB34 showed more potent analgesic effect than the others. In addition, the naltrexone pretreatment completely blocked the analgesic effect of EA at GB34, indicating the involvement of the endogenous opioid system in mediating the effect of EA at GB34. However, the phentolamine pretreament blocked analgesic effects of EA at either SI6 or GB39, indicating the involvement of ${\alpha}$-adrenoceptors in mediating the effect of EA at either SI6 or GB39. Conclusions : These data suggest that EA-induced analgesia on ankle sprain pain is mediated through either endogenous opioids or ${\alpha}$-adrenoceptors dependant on acupoint specific pattern.