• Structural Engineering and Mechanics
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• v.65 no.5
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• pp.621-631
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• 2018

In this paper, an exact analytical solution is developed for the analysis of the post-buckling non-linear response of simply supported deformable symmetric composite beams. For this, a new theory of higher order shear deformation is used for the analysis of composite beams in post-buckling. Unlike any other shear deformation beam theories, the number of functions unknown in the present theory is only two as the Euler-Bernoulli beam theory, while three unknowns are needed in the case of the other beam theories. The theory presents a parabolic distribution of transverse shear stresses, which satisfies the nullity conditions on both sides of the beam without a shear correction factor. The shear effect has a significant contribution to buckling and post-buckling behaviour. The results of this analysis show that classical and first-order theories underestimate the amplitude of the buckling whereas all the theories considered in this study give results very close to the static response of post-buckling. The numerical results obtained with the novel theory are not only much more accurate than those obtained using the Euler-Bernoulli theory but are almost comparable to those obtained using higher order theories, Accuracy and effectiveness of the current theory.

• Structural Engineering and Mechanics
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• v.74 no.6
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• pp.789-807
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• 2020

Multiple earthquakes that occur during short seismic intervals affect the inelastic behavior of the structures. Sequential ground motions against the single earthquake event cause the building structure to face loss in stiffness and its strength. Although, numerous research studies had been conducted in this research area but still significant limitations exist such as: 1) use of traditional design procedure which usually considers single seismic excitation; 2) selecting a seismic excitation data based on earthquake events occurred at another place and time. Therefore, it is important to study the effects of successive ground motions on the framed structures. The objective of this study is to overcome the aforementioned limitations through testing a two storey RC building structural model scaled down to 1/10 ratio through a similitude relation. The scaled model is examined using a shaking table. Thereafter, the experimental model results are validated with simulated results using ETABS software. The test framed specimen is subjected to sequential five artificial and four real-time earthquake motions. Dynamic response history analysis has been conducted to investigate the i) observed response and crack pattern; ii) maximum displacement; iii) residual displacement; iv) Interstorey drift ratio and damage limitation. The results of the study conclude that the low-rise building model has ability to resist successive artificial ground motion from its strength. Sequential artificial ground motions cause the framed structure to displace each storey twice in correlation with vary first artificial seismic vibration. The displacement parameters showed that real-time successive ground motions have a limited impact on the low-rise reinforced concrete model. The finding shows that traditional seismic design EC8 requires to reconsider the traditional design procedure.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.13 no.2
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• pp.253-265
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• 1993

This paper presents a numerical method for implementing a nonlinear constitutive material model developed by Lade, into a finite element computer program. The techniques used are based on the displacement method for the solution of axial symmetric and plane strain nonlinear boundary value problems. Laboratory behaviour of Baekma river sand(#40-60) is used to illustrate the determination of the parameters and verification of the model. Computer procedure is developed to determine the material parameters for the nonlinear model from the raw laboratory test data. The model is verified by comparing its predictions with observed data used for the determination of the parameters and then with observed data not used for the determination. Three categories of tests are carried out in the back-prediction exercise; (1) A hydrostatic test including loading and unloading response, (2) Conventional triaxial drained compression tests at three different confining pressure and (3) A model strip footing test not including in the evaluation of material parameters. Pertinent observations are discussed based on the comparison of predicted response and experimental data.

• Journal of the Earthquake Engineering Society of Korea
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• v.5 no.5
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• pp.47-56
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• 2001

In order to assure the safety of NPP structures, margin of safety or conservatism is incorporated in each design step. Seismic risk evaluation of NPP structures is performed based on the realistic capacity and response of structure eliminated the safety margin and conservatism. In this study, the comparative study on the various evaluation methods of the inelastic energy absorption capacity was performed. The inelastic energy absorption capacity due to the nonlinear behavior of structures has significant effect on the results of seismic probabilistic risk assessment. And the comparison study of the HCLPF(high confidence of low probability of failure) values according to the inelastic energy absorption factors was performed. As a conclusion, the inelastic energy absorption factor of NPP containment structure is estimated about 1.5~1.75. It is essential to estimate the nonlinear behavior of structure and its ductility factor correctly for the seismic risk assessment.

• Korean journal of food and cookery science
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• v.30 no.4
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• pp.454-462
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• 2014

This study aimed at the optimization and development of rice snack by response surface methodology (RSM). The effect of rice soaking time and additional ratio of soybean milk on physicochemical properties and sensory evaluation of dried rice flour for non-fried snack was studied. After soaking for 0 to 12 days, Baekjinju rice was milled and then air-dried. A quadratic model was selected for weight, volume, hardness, taste and appearance. Two-factor interaction model was selected for expansibility, color and overall preference. A linear model was selected for yellowness and flavor. Weight, hardness and appearance were increased and decreased thereafter as rice soaking time increased, but the volume was reversed. Expansibility, color, taste and flavor were decreased as rice soaking time increased, but yellowness was reversed. Weight and overall preference decreased as additional ratio of soybean milk increased, but volume, expansibility and yellowness were reversed. Hardness, taste and appearance were increased after initial decrease as additional ratio of soybean milk increased, color and flavor were not changed by additional ratio of soybean milk. The optimum conditions of each factor were set to where the rice soaking time and additional ratio of soybean milk were at their minimum. Weight, volume, expansibility, yellowness, hardness, color, taste, flavor, appearance and overall preference were established at maximum level where the objective of the optimum was in level. Our data indicated the statistically predicted values of the highest desirability was 1.24 day of rice soaking time and 15.80% of additional ratio of soybean milk.

• Structural Engineering and Mechanics
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• v.60 no.4
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• pp.633-653
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• 2016

One of the major threats to the stability of classical columns and colonnades are earthquakes. The behavior of columns under high seismic excitation loads is non-linear and complex since rocking, wobbling and sliding failure modes can occur. Therefore, three dimensional simulation approaches are essential to investigate the in-plane and out-of-plane response of such structures during harmonic and seismic loading excitations. Using a software based on the Distinct Element Method (DEM) of analysis, a three dimensional numerical study has been performed to investigate the parameters affecting the seismic behaviour of colonnades' structural systems. A typical section of the two-storey colonnade of the Forum in Pompeii has been modelled and studied parametrically, in order to identify the main factors affecting the stability and to improve our understanding of the earthquake behaviour of such structures. The model is then used to compare the results between 2D and 3D simulations emphasizing the different response for the selected earthquake records. From the results analysis, it was found that the high-frequency motion requires large base acceleration amplitude to lead to the collapse of the colonnade in a shear-slip mode between the drums. However, low-frequency harmonic excitations are more prominent to cause structural collapse of the two-storey colonnade than the high-frequency ones with predominant rocking failure mode. Finally, the 2D analysis found to be unconservative since underestimates the displacement demands of the colonnade system when compared with the 3D analysis.

• Journal of Microbiology and Biotechnology
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• v.30 no.5
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• pp.662-667
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• 2020

Epidermal growth factor receptor (EGFR) mutations are not only genetic markers for diagnosis but also biomarkers of clinical-response against tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC). Among the EGFR mutations, the in-frame deletion mutation in EGFR exon 19 kinase domain (EGFR exon 19-del) is the most frequent mutation, accounting for about 45% of EGFR mutations in NSCLCs. Development of sensitive method for detecting the EGFR mutation is highly required to make a better screening for drug-response in the treatment of NSCLC patients. Here, we developed a fluorometric tandem gene amplification assay for sensitive detection of low-abundance EGFR exon 19-del mutant genomic DNA. The method consists of pre-amplification with PCR, thermal cycling of ligation by Taq ligase, and subsequent rolling circle amplification (RCA). PCR-amplified DNA from genomic DNA samples was used as splint DNA to conjugate both ends of linear padlock DNA, generating circular padlock DNA template for RCA. Long stretches of ssDNA harboring multiple copies of G-quadruplex structure was generated in RCA and detected by thioflavin T (ThT) fluorescence, which is specifically intercalated into the G-quadruplex, emitting strong fluorescence. Sensitivity of tandem gene amplification assay for detection of the EGFR exon 19-del from gDNA was as low as 3.6 pg, and mutant gDNA present in the pooled normal plasma was readily detected as low as 1% fraction. Hence, fluorometric detection of low-abundance EGFR exon 19 deletion mutation using tandem gene amplification may be applicable to clinical diagnosis of NSCLC patients with appropriate TKI treatment.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.22 no.11
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• pp.1042-1048
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• 2012

A 2-axis gimbal system is one of main disturbance sources affecting image jitter response of a satellite. The gimbal system comprises azimuth stage and elevation stage, and these pointing mechanism can be rotated by stepping motors about its azimuth and elevation axes simultaneously. Because of the complex and coupled dynamic motion of the gimbal system, its moment of inertia and structural modes can be changed according to the system configuration, and thus the gimbal system generates complicated and non-linear disturbance characteristics. In order to improve the jitter response of a spacecraft, it is an indispensable process to reduce the micro-vibration disturbance level of the antenna system. In the present research, a 2-axis gimbal system was manufactured and then its micro-vibration test was performed in terms of two types of stepping motors(2-phase and 5-phase). The test results show that the disturbance level of the gimbal system can be reduced by replacing the 2-phase stepping motor with the 5-phase one, and the average disturbance attenuation ratio is 56 % in peak level and 48 % in standard deviation level. The experimental results confirm that it is an efficient jitter reduction method to adopt a high-phase stepping motor.

• Molecular & Cellular Toxicology
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• v.4 no.4
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• pp.331-337
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• 2008

This study was conducted to quantitatively evaluate the recovery effects of herbal medicines on acetaminophen-induced hepatotoxicity. In the present study, the recovery effects of 251 herbal medicines on THLE-2 cells that had been damaged by acetaminophen were evaluated using an MTS assay. THLE-2 cells were cultured in 96-well plates and then pretreated with or without 60 ${\mu}M$ acetaminophen (${IC}_{50}$ value: 35.84) for 1 hr. Next, different herbal medicines were added to the wells, after which the cells were reincubated at $37^{\circ}C$ for 24 hr. After first round of screening, the candidate herbal medicines were selected based on a recovery rate of greater than 40% and their efficacy were then determined by dose response kinetic analysis. Among these extracts, 8 herbal medicines (Terminalia chebula, Pueraria lobata, Acronychia laurifolia, Lopatherum gracile, Oroxylum indicum, Cynanchum atratum, Senecio scandens, and Sophora flavescens) had a strong recovery effect on acetaminophen-induced damage in THLE-2 cells. Dose response non-linear regression analysis demonstrated that Senecio scandens showed the best recovery rate (98%), and that its ${EC}_{50}$ was 19.54 ng/mL. Additional studies of these herbal medicines should be conducted to determine if they possess novel therapeutic agents for the prevention or treatment of liver disorders.

• Steel and Composite Structures
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• v.19 no.6
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• pp.1549-1560
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• 2015

This paper presents the characterization of fatigue crack in the A283 Grade C steel using the MMM method by identifying the effects of magnetic flux leakage towards the crack growth rate, da/dN, and crack length. The previous and current research on the relation between MMM parameters and fatigue crack effect is still unclear and requires specific analysis to validate that. This method is considered to be a passive magnetic method among other Non-Destructive Testing (NDT) methods. The tension-tension fatigue test was conducted with a testing frequency of 10 Hz with 4 kN loaded, meanwhile the MMM response signals were captured using a MMM instrument. A correlation between the crack growth rate and magnetic flux leakage produces a sigmoid shape curve with a constant values which present the gradient, m value is in the ranges of 1.4357 to 4.0506, and the y-intercept, log C in the ranges of $4{\times}10^{-7}$ to 0.0303. Moreover, a linear relation was obtained between the crack length and magnetic flux leakage which present the R-Squared values is at 0.830 to 0.978. Therefore, MMM method has their own capability to investigate and characterize the fatigue crack effects as a main source of fracture mechanism for ferrous-based materials.