• 제목/요약/키워드: Non-linear relationship

검색결과 496건 처리시간 0.023초

식이 요인이 SCE 빈도수로 본 흡연노인 임파구 DNA손상에 미치는 영향 (Effects of Dietary Factors on Lymphocyte DNA Damage in Smoking Elderly People in Korea)

  • 강명희;이정희
    • 한국식품영양과학회지
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    • 제33권3호
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    • pp.523-532
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    • 2004
  • 영양소의 섭취를 포함한 여러 식이성요인에 따라 일부 지역 남자 노인의 인체 임파구 SCE 빈도수가 어떤 영향을 받는지를 조사해 보고자하여 60세 이상의 노인 45명을 대상으로 설문조사를 실시한 후 채혈하여 임파구 SCE 시험을 실시하였다. 조사 대상자의 식이성 요인이 SCE 빈도수에 미치는 영향에 대해 분석한 결과는 다음과 같다. 1. 채혈 대상자를 흡연여부에 따라 흡연군(n=14), 담배를 피우다가 현재는 끊은 금연군(n=16), 비흡연군(n=15)으로 나눈 후 SCE 빈도수를 비교한 결과 흡연군의 SCE빈도수가 비흡연군에 비해 유의적으로 높았으며 노인의 나이가 많을수록 DNA 손상정도가 증가하였다. 대상 노인의 인구학적 요인 중 신장, 혹은 체중이 전 대상자군에서 SCE 빈도수와 각각 역의 상관관계를 보였으며 흡연군에서는 신장과 SCE빈도수가 역의 상관관계, 그리고 pack years로 본 흡연력과 SCE 빈도수가 정의 상관관계 를 보였다. 2. 전 대상자군에서는 24시간 회상법으로부터 구한 영양소의 섭취와 SCE빈도수 간에 상관관계가 없었으나 흡연군의 경우는 식이섬유질 섭취량, 금연군의 경우는 비타민 C 섭취량과 SCE 빈도수가 각각 정의 상관관계를 보였다. 그러나 비 흡연군에서는 지방, 인 혹은 비타민 A 섭취량과 SCE빈도수 간에 역의 상관관계를 보였다. 3. 흡연군에서 육어류 섭취빈도와 SCE빈도수 간에 정의 상관관계를 보였고, 비 흡연군에서 식 사균형도가 SCE 빈도수와 역의 상관관계를 보였다. 세 군을 모두 합한 전대상자군의 경우, 혈당수준과 SCE 빈도수 사이에 정의 상관관계가 나타났다. 금연군에서 감미료를 섭취하는 군의 SCE 빈도수가 섭취하지 않는 군보다 유의적으로 높았다. 나머지 식이성 요인들은 SCE 빈도수와 상관성을 보이지 않았다. 본 연구 결과는 앞으로 DNA손상도가 높은 노인 대상으로 이의 회복을 위하여 식이성 요인을 이용한 영양중재실험을 계획할 때, 혹은 노인 대상의 영양교육 시에 중요한 기초자료로 활용될 수 있을 것이다.

지역 박탈수준과 중고령층의 활동제한의 연관성 (Relationship between local authority deprivation and activity limitation in adults aged 50 or over)

  • 윤태호;김수영;윤미숙;문경주
    • 보건교육건강증진학회지
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    • 제32권2호
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    • pp.27-37
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    • 2015
  • Objectives: As the increasing of the length of the lifespan, more recent policy interest are concerned with how many years of life are lived without functional disability or activity limitation. We investigated the relationship between deprivation and activity limitation at the 251 local authority level. Methods: The data were derived from the 2010 Census 10% sample data. Crude and age-standardized activity limitation rates by gender at the ages of 50 or over and deprivation index were calculated. Mapping and multiple linear regression analysis were applied to explore relationship between area activity limitation and area deprivation. Results: There were considerable differences in activity limitation rate across the 251 local authorities. Age-standardized activity limitation rate in both male and female were strongly associated with the level of area deprivation. Especially, low social class, male unemployment, or non-apartment residents at the local level were strong positive association with local authorities' age-standardized activity limitation. Conclusion: More policy attention is needed for tackling regional inequality in activity limitation among older adults.

RELATIONSHIP BETWEEN RADIATION INDUCTED YIELD STRENGTH INCREMENT AND CHARPY TRANSITION TEMPERATURE SHIFT IN REACTOR PRESSURE VESSEL STEELS OF KOREAN NUCLEAR POWER PLANTS

  • Lee, Gyeong-Geun;Lee, Yong-Bok;Kwon, Jun-Hyun
    • Nuclear Engineering and Technology
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    • 제44권5호
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    • pp.543-550
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    • 2012
  • The decrease in the fracture toughness of ferritic steels in a reactor pressure vessel is an important factor in determining the lifetime of a nuclear power plant. A surveillance program has been in place in Korea since 1979 to assess the structural integrity of RPV steels. In this work, the surveillance data were collected and analyzed statistically in order to derive the empirical relationship between the embrittlement and strengthening of irradiated reactor pressure vessel steels. There was a linear relationship between the yield strength change and the transition temperature shift change at 41 J due to irradiation. The proportional coefficient was about $0.5^{\circ}C$/MPa in the base metals (plate/forgings). The upper shelf energy decrease ratio was non-linearly proportional to the yield strength change, and most of the data lay along the trend curve of the US results. The transition regime temperature interval, ${\Delta}T_T$, was less than the US data. The overall change from irradiation was very similar to the US results. It is expected that the results of this study will be applied to basic research on the multiscale modeling of the irradiation embrittlement of RPV materials in Korea.

Erythrocyte Sedimentation Rate: Its Determinants and Relationship with Risk Factors Involved in Ischemic Stroke

  • Kaur, Kirandeep;Kaur, Amandeep;Kaur, Anupam
    • 대한임상검사과학회지
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    • 제54권1호
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    • pp.1-8
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    • 2022
  • Erythrocyte sedimentation rate (ESR) evaluation is a useful tool for monitoring disease activity in various inflammatory and non-inflammatory conditions. ESR is known to be influenced by a multitude of confounding factors. The present study aimed to assess the possible determinants of the ESR and its relationship with various risk factors involved in ischemic stroke. ESR and other hematological and biochemical parameters were investigated in 163 ischemic stroke patients (107 males and 56 females) selected based on imaging techniques including magnetic resonance imaging (MRI) or computed tomography (CT) scans. Statistical analysis was performed using the SPSS 16.0 software. Linear regression analysis showed a significant inverse relationship of hemoglobin (Hb) and hematocrit or packed cell volume (PCV) (P<0.001 for females; P<0.01 for males) with the ESR. It was observed that the red blood cell (RBC) count was not strongly correlated with the ESR (P<0.05 for both males and females). It was also observed that sex significantly affected the variables determining the ESR levels, whereas age had no effect. Gender differences were also observed with respect to Hb, RBC, PCV, mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and ESR. The possible determinants of higher ESR levels in ischemic stroke may be sex, Hb, hematocrit, and RBC count, but the role of other clinical and laboratory parameters cannot be underestimated.

Epidemiological application of the cycle threshold value of RT-PCR for estimating infection period in cases of SARS-CoV-2

  • Soonjong Bae;Jong-Myon Bae
    • Journal of Medicine and Life Science
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    • 제20권3호
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    • pp.107-114
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    • 2023
  • Epidemiological control of coronavirus disease 2019 (COVID-19) is needed to estimate the infection period of confirmed cases and identify potential cases. The present study, targeting confirmed cases for which the time of COVID-19 symptom onset was disclosed, aimed to investigate the relationship between intervals (day) from symptom onset to testing the cycle threshold (CT) values of real-time reverse transcription-polymerase chain reaction. Of the COVID-19 confirmed cases, those for which the date of suspected symptom onset in the epidemiological investigation was specifically disclosed were included in this study. Interval was defined as the number of days from symptom onset (as disclosed by the patient) to specimen collection for testing. A locally weighted regression smoothing (LOWESS) curve was applied, with intervals as explanatory variables and CT values (CTR for RdRp gene and CTE for E gene) as outcome variables. After finding its non-linear relationship, a polynomial regression model was applied to estimate the 95% confidence interval values of CTR and CTE by interval. The application of LOWESS in 331 patients identified a U-shaped curve relationship between the CTR and CTE values according to the number of interval days, and both CTR and CTE satisfied the quadratic model for interval days. Active application of these results to epidemiological investigations would minimize the chance of failing to identify individuals who are in contact with COVID-19 confirmed cases, thereby reducing the potential transmission of the virus to local communities.

다이옥신의 환원적 탈염화 분해 경로와 독성 변화예측을 위한 LFER 모델 (Prediction of Pathway and Toxicity on Dechlorination of PCDDs by Linear Free Energy Relationship)

  • 김지훈;장윤석
    • 대한환경공학회지
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    • 제31권2호
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    • pp.125-131
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    • 2009
  • 영가철과 혐기성 미생물을 이용한 환원적 탈염화반응을 통한 다이옥신 처리 능력을 평가하기 위해, 자유에너지 선형관계(linear free energy relationship)를 이용하여 다이옥신의 탈염화에 의한 농도 및 독성변화 예측 모델을 최초로 정립하였다. 수용액상에 존재하는 다이옥신류의 깁스자유에너지는 기존 문헌의 열역학적 계산결과를 범밀도함수이론(density functional theory)을 이용한 계산 수준으로 보정하였으며, 보정된 깁스자유에너지와 실험을 통해 얻은 탈염화 반응속도 상수와의 선형관계를 통해 다이옥신의 탈염화 반응 256개에 대한 반응속도상수를 예측하였다. 본 모델을 통해 탈염화에 의해 변화하는 다이옥신 류 76종에 대한 시간 별 농도를 계산할 수 있다. 8염화다이옥신(Octachlorinated dibenzo-p-dioxin, OCDD)이 완전히탈염화되어 dibenzo-p-dioxin (DD)로 탈염화되기까지는 100년 이상의 반응시간이 필요하였으며, 독성등가값(toxic equivalent quantity, TEQ)의 경우 탈염화가 진행되면서 초기농도의 10배 이상까지 증가하는 것으로 밝혀졌다. 이를 통해, 다이옥신의 처리를 위해서는 좀 더 빠른 탈염화 반응속도를 갖는 다른 전자공여 시스템을 사용하거나, 환원적 탈염화-라디칼 산화와 같은 복합 연계처리가 필요함을 알 수 있다. 본 논문을 통해 제시된 예측 기법은 다이옥신뿐 아니라 다른 할로겐화 화합물의 탈염화 예측과 여러 전자공여 시스템에 대한 평가에 적용이 가능하다.

Wave load resistance of high strength concrete slender column subjected to eccentric compression

  • Jayakumar, M.;Rangan, B.V.
    • Structural Engineering and Mechanics
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    • 제50권3호
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    • pp.287-304
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    • 2014
  • A computer based iterative numerical procedure has been developed to analyse reinforced high strength concrete columns subjected to horizontal wave loads and eccentric vertical load by taking the material, geometrical and wave load non-linearity into account. The behaviour of the column has been assumed, to be represented by Moment-Thrust-Curvature relationship of the column cross-section. The formulated computer program predicts horizontal load versus deflection behaviour of a column up to failure. The developed numerical model has been applied to analyse several column specimens of various slenderness, structural properties and axial load ratios, tested by other researchers. The predicted values are having a better agreement with experimental results. A simplified user friendly hydrodynamic load model has been developed based on Morison equation supplemented with a wave slap term to predict the high frequency non-linear impulsive hydrodynamic loads arising from steep waves, known as ringing loads. A computer program has been formulated based on the model to obtain the wave loads and non-dimensional wave load coefficients for all discretised nodes, along the length of column from instantaneous free water surface to bottom of the column at mud level. The columns of same size and material properties but having different slenderness ratio are analysed by the developed numerical procedure for the simulated wave loads under various vertical thrust. This paper discusses the results obtained in detail and effect of slenderness in resisting wave loads under various vertical thrust.

Spatiotemporal Gait Parameters That Predict the Tinetti Performance-Oriented Mobility Assessment in People With Stroke

  • Jeong, Yeon-gyu;Kim, Jeong-soo
    • 한국전문물리치료학회지
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    • 제22권4호
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    • pp.27-33
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    • 2015
  • The purpose of this study was to find which spatiotemporal gait parameters gained from stroke patients could be predictive factors for the gait part of Tinetti Performance-Oriented Mobility Assessment (POMA-G). Two hundred forty-six stroke patients were recruited for this study. They participated in two assessments, the POMA-G and computerized spatiotemporal gait analysis. To analyze the relationship between the POMA-G and spatiotemporal parameters, we used Pearson's correlation coefficients. In addition, multiple linear regression analyses (stepwise method) were used to predict the spatiotemporal gait parameters that correlated most with the POMA-G. The results show that the gait velocity (r=.67, p<.01), cadence (r=.66, p<.01), step length of the affected side (r=.49, p<.01), step length of the non-affected side (r=.53, p<.01), swing percentage of the non-affected side (r=.47, p<.01), and single support percentage of the affected side (r=.53, p<.01) as well as the double support percentage of the non-affected side (r=-.42, p<.01) and the step-length asymmetry (r=-.64, p<.01) correlated with POMA-G. The gait velocity, step-length asymmetry, cadence, and single support percentage of the affected side explained 67%, 2%, 2%, and 1% of the variance in the POMA-G, respectively. In conclusion, gait velocity would be the most predictive factor for the POMA-G.

유동 가스 온도 변화에 따른 삼각 분리 막대형 차압 유량계 유량 특성에 관한 연구 (A Study on Flow Rate Characteristics of a Triangular Separate Bar Differential Pressure Flow Meter according to the Variation of Gas Flow Temperature)

  • 김광일;유원열;이충훈
    • 한국공작기계학회논문집
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    • 제17권4호
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    • pp.89-94
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    • 2008
  • Differential pressure flow meters which have a shape of triangular separate bar(TSB) were tested for investigating the flow rate characteristics of the flow meters with varying the temperature of the gas flow. Three kinds of the triangular separate bar flow meters whose aerodynamic angles are different one another are used. The mass flow rate of the flow meters are evaluated using a non-dimensional parameter which includes the gas temperature, exhaust gas pressure and differential pressure at the flow meters, and atmospheric pressure. A burner system which is similar to gas turbine was used for raising the gas flow temperature. The burner system was operated with varying the air/fuel ratio by controlling both the fuel injection rate from the fuel nozzle and air flow rate from a blower. An empirical correlation between the mass flow rate at the TSB flow meter and the non-dimensional parameter was obtained. The empirical correlation showed linear relationship between the mass flow rate and the non-dimensional parameter H. Also, the mass flow rate characteristics at the TSB flow meter was affected by the gas temperature.

Research on Security Threats for SMEs by Workplace in the COVID-19 Environment

  • Kim, Woo-Su;Lim, Heon-Wook
    • International Journal of Advanced Culture Technology
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    • 제10권2호
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    • pp.307-313
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    • 2022
  • Although telecommuting of SMEs has been activated due to the COVID-19 phenomenon, the security model for this is insufficient. Accordingly, the study was divided into threats centered on smartphones and threats centered on smartphone users. As a result of the study, one-third of SMEs are working from home. At this company with 100 employees, more than 50% of them work from home.and In the metal, machinery and chemical industries with factories, 20% of them work from home. As a result of analyzing the correlation between telecommuting according to the presence or absence of a factory, the correlation coefficient (r=-.385) has a clear linear relationship. And, as a result of the regression analysis, the R-squared value was 0.148, so companies with factories are highly related to telecommuting. In other words, we found that SMEs with factories do not want to work from home. In addition, as a result of analyzing the level of security threats, there were great concerns about theft, hacking, and phone taking during remote work. As limitations of the study, there were difficulties in selecting SMEs from the population in a non-face-to-face work environment, and there were limitations in the questionnaire items for deriving a non-face-to-face work environment.