• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.834-837
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• 2005

In this paper, we describe the method of non-invasive blood pressure measurement using pulse wave transit time(PWTT). PWTT is a new parameter involved with a vascular that can indicate the change of BP. PWTT is measured by continuous monitoring of ECG and pulse wave. No additional sensors or modules are required. In many cases, the change of PWTT correlates with the change of BP. We measure pulse wave using the photo plethysmograph(PPG) sensor in an earlobe and we measure ECG using the ECG monitoring device our made in the chest. The measurement device for detecting pulse wave consists of infrared LED for transmitted light illumination, pin photodiode as light detector, amplifier and filter. We composed 0.5Hz high pass, 60Hz notch and 10Hz low pass filter. ECG measurement device consists of multiplexer, amplifier, filter, micro-controller and RF module. After amplification and filtering, ECG signal and pulse wave is fed through micro-controller. We performed the initial work towards the development of ambulatory BP monitoring system using PWTT. An earlobe is suitable place to measure PPG signal without the restraint in daily work. From the results, we can know that the dependence of PWTT on BP is almost linear and it is possible to monitoring an individual BP continuously after the individual calibration.

• Earthquakes and Structures
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• v.4 no.5
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• pp.471-487
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• 2013

Performance of a prototype base isolated building located at Indian Institute of Technology, Guwahati (IITG) has been studied here. Two numbers of three storeyed single bay RCC framed prototype buildings were constructed for experimental purpose at IITG, one supported on conventional isolated footings and the other on a seismic isolation system, consisting of lead plug bearings. Force balance accelerometers and a 12 channel strong motion recorder have been used for recording building response during seismic events. Floor responses from these buildings show amplification for the conventional building while 60 to 70% reduction has been observed for the isolated building. Numerical models of both the buildings have been created in SAP2000 Nonlinear. Infill walls have been modeled as compression struts and have been incorporated into the 3D models using Gap elements. System identification of the recorded data has been carried out using Parametric State Space Modeling (N4SID) and the numerical models have been updated accordingly. The study demonstrates the effectiveness of base isolation systems in controlling seismic response of isolated buildings thereby leading to increased levels of seismic protection. The numerical models calibrated by relatively low level of earthquake shaking provides the starting point for modeling the non-linear response of the building when subjected to strong shaking.

• Journal of Microbiology
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• v.40 no.4
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• pp.274-281
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• 2002

The competitive quantitative PCR method targeting pcbC gene was developed for monitoring 4-chlorobiphenyl(4CB)-degrading bacteria, Pseudomonas sp. strain DJ-12, in soil microcosms. The method involves extraction of DNA from soil contaminated with 4CB, PCR amplification of a pcbC gene fragment from the introduced strain with a set of strain-specific primers, and quantification of the elec-trophoresed PCR product by densitometry. To test the adequacy of the method, Pseudomonas sp. strain DJ-12 was introduced into both contaminated and non-contaminated soil microcosms amended with 4CB. Pseudomonas sp. strain DJ-12 was monitored and quantified by a competitive quantitative PCR in comparison with 4CB degradation and the result was compared to those obtained by using the conventional cultivation method. We successfully detected and monitored 4CB-degrading bacteria in each microcosm and found a significant linear relationship between the number of 4CB-degrading bacteria and the capacity for 4CB biodegradation. The results of DNA spiking and cell-spreading experiments suggest that this competitive quantitative PCR method targeting the pcbC gene for monitoring 4CB- degrading bacteria appears to be rapid, sensitive and more suitable than the microbiological approach in estimating the capacity of 4CB biodegradation in environmental samples.

• Proceedings of the Korean Geotechical Society Conference
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• 2009.09a
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• pp.905-912
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• 2009

1-g shaking table test is conducted to evaluate the dynamic behavior of a soil-structure system under seismic loading condition. A consistent similitude law between the model and prototype is needed to predict the behavior of the prototype structure, quantitatively. The natural frequency of geomaterial decreases with the increase of shaking intensity because of the non-linear property of the geomaterial. This phenomenon affects the applicability of similitude laws in 1-g shaking table tests. In this study, a simple method is suggested to determine the frequency of the input motions in 1-g tests in order to enhance the applicability of similitude laws. Modified input frequency is calculated using the frequency ratio with consideration of the variation of the natural frequency according to the intensity of input ground acceleration. To verify the applicability of the suggested method, a series of 1-g shaking table tests were performed for three different sizes of model piles having an overburden mass on their heads by varying the acceleration and the frequency of input motion. The acceleration amplification ratio on the overburden mass, the lateral displacement at the pile head and the maximum bending moment along the pile depth were measured. The projected behaviors of the virtual prototype based on the measured values of the model tests, where the input frequencies were calculated by the new method, showed good consistency, verifying the applicability of the suggested method.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.2A
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• pp.171-178
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• 2008

The object of this study is to propose a rate of vibration increase in the analysis of temporary rail non-fixed in the vertical direction and characterize the nonlinear dynamic behavior of temporary rail while considering longitudinal and latitudinal load, vibration and lifting. The rate of vibration increase is proposed through measurement of an actual structure that is largely affected by loading and vibration of the superstructure. Dynamic behavior was additionally characterized by the dynamic response resulting from nonlinear dynamic finite element analysis with vehicle loading, including the rate of vibration increase. As a result, the rate of vibration increase by the vibration of an Auto Bar Machine is determined as 7% and the maximum stress in the analysis of the nonlinear rail is increased 14.5% over that of linear rail, and temporary rail is shown to be very sensitive to the velocity of the superstructure.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.17
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• pp.7169-7174
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• 2014

Background: NPAS2 is a product of the circadian clock gene. It acts as a putative tumor suppressor by playing an important role in DNA damage responses, cell cycle control and apoptosis. Chronic lymphocytic leukemia (CLL) appears to be an apoptosis related disorder and alteration in the NPAS2 gene might therefore be directly involved in the etiology of CLL. Here, the Ala394Thr polymorphism (rs2305160:G>A) in the NPAS2 gene was genotyped and melatonin concentrations were measured in a total of seventy-four individuals, including thirty-seven CLL cases and an equal number of age- and sex-matched healthy controls in order to examine the effect of NPAS2 polymorphism and melatonin concentrations on CLL risk in a Pakistani population. Materials and Methods: Genotyping of rs2305160:G>A polymorphism at NPAS2 locus was carried out by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Melatonin concentrations were determined by enzyme linked immunosorbent assay (ELISA). Statistical analysis was performed using Statistical Package for Social Sciences software. Results: Our results demonstrated no association of the variant Thr genotypes (Ala/Thr and Thr/Thr) with risk of CLL. Similarly, no association of rs2305160 with CLL was observed in either females or males after stratification of study population on a gender basis. Moreover, when the subjects with CLL were further stratified into shift-workers and non-shift-workers, no association of rs2305160 with CLL was seen in either case. However, significantly low serum melatonin levels were observed in CLL patients as compared to healthy subjects (p<0.05). Also, lower melatonin levels were seen in shift-workers as compared to non-shift-workers (p<0.05). There was no significant difference (p>0.05) in the melatonin levels across NPAS2 genotypes in all subjects, subjects with CLL who were either shift workers or non-shift-workers. General Linear Model (GLM) univariate analysis revealed no significant association (p>0.05) of the rs2305160 polymorphism of the NPAS2 gene with melatonin levels in any of the groups. Conclusions: While low melatonin levels and shift-work can be considered as one of the risk factors for CLL, the NPAS2 rs2305160 polymorphism does not appear to have any association with risk of CLL in our Pakistani population.