• Journal of Korean Medical Science
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• v.33 no.53
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• pp.322.1-322.14
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• 2018

Background: Osteoprotegerin (OPG) plays protective roles against the development of vascular calcification (VC) which greatly contributes to the increased cardiovascular events in patients with chronic kidney disease (CKD). The present study aimed to find the non-traditional, kidney-related cardiovascular risk factors correlated to serum OPG and the effect of serum OPG on the arterial stiffness measured by brachial ankle pulse wave velocity (baPWV) in patients with the pre-dialysis CKD. Methods: We cross-sectionally analyzed the data from the patients in whom baPWV and the serum OPG were measured at the time of enrollment in a prospective pre-dialysis CKD cohort study in Korea. Results: Along with traditional cardiovascular risk factors such as age, diabetes mellitus, pulse pressure, and baPWV, non-traditional, kidney-related factors such as albuminuria, plasma level of hemoglobin, total $CO_2$ content, alkaline phosphatase, and corrected calcium were independent variables for serum OPG in multivariate linear regression. Reciprocally, the serum OPG was positively associated with baPWV in multivariate linear regression. The baPWV in the 3rd and 4th quartile groups of serum OPG were higher than that in the 1st quartile group after adjustments by age, sex and other significant factors for baPWV in linear mixed model. Conclusion: Non-traditional, kidney-related cardiovascular risk factors in addition to traditional cardiovascular risk factors were related to serum level of OPG in CKD. Serum OPG level was significantly related to baPWV. Our study suggests that kidney-related factors involved in CKD-specific pathways for VC play a role in the increased secretion of OPG into circulation in patients with CKD.

• The Bulletin of The Korean Astronomical Society
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• v.41 no.1
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• pp.38.2-38.2
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• 2016

The mapping of dark matter clustering from real to redshift spaces introduces the anisotropic property to the measured density power spectrum in redshift space, known as the Redshift Space Distortion (hereafter RSD) effect. The mapping formula is intrinsically non-linear, which is complicated by the higher order polynomials due to the indefinite cross correlations between the density and velocity fields, and the Finger-of-God (hereafter FoG) effect due to the randomness of the peculiar velocity field. Furthermore, the rigorous test of this mapping formula is contaminated by the unknown non-linearity of the density and velocity fields, including their auto- and cross-correlations, for calculating which our theoretical calculation breaks down beyond some scales. Whilst the full higher order polynomials remains unknown, the other systematics can be controlled consistently within the same order truncation in the expansion of the mapping formula, as shown in this paper. The systematic due to the unknown non-linear density and velocity fields is removed by separately measuring all terms in the expansion using simulations. The uncertainty caused by the velocity randomness is controlled by splitting the FoG term into two pieces, 1) the non-local FoG term being independent of the separation vector between two different points, and 2) the local FoG term appearing as an indefinite polynomials which is expanded in the same order as all other perturbative polynomials. Using 100 realizations of simulations, we find that the best fitted non-local FoG function is Gaussian, with only one scale-independent free parameter, and that our new mapping formulation accurately reproduces the observed power spectrum in redshift space at the smallest scales by far, up to k ~ 0.3 h/Mpc, considering the resolution of future experiments.

• Journal of Mechanical Science and Technology
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• v.15 no.3
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• pp.309-319
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• 2001

This paper demonstrates the development of optical temperature sensor based on the etched silica-based planar waveguide Bragg grating. Topics include design and fabrication of the etched planar waveguide Bragg grating optical temperature sensor. The typical bandwidth and reflectivity of the surface etched grating has been ∼0.2nm and ∼9%, respectively, at a wavelength of ∼1552nm. The temperature-induced wavelength change is found to be slightly non-linear over ∼200$^{\circ}C$ temperature range. Typically, the temperature-induced fractional Bragg wavelength shift measured in this experiment is 0.0132nm/$^{\circ}C$ with linear curve fit. Theoretical models with nonlinear temperature effect for the grating response based on waveguide and plate deformation theories agree with experiments to within acceptable tolerance.

• Steel and Composite Structures
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• v.8 no.4
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• pp.265-280
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• 2008

An investigation on the combined effect of foundation type, foundation flexibility, axial load and PR (semi-rigid) connections on the natural frequencies of steel frames is presented. These effects were investigated using a suitable modified FE program for cases where the foundation flexibility, foundation connectivity, and semi-rigid connections could be treated as equivalent linear springs. The effect of axial load on the natural frequency of a structure was found to be significant for slender structures subjected to high axial loads. In general, if columns of medium slenderness are designed without consideration of axial load effects, the frequency of the structure will be overestimated. Studies on the 3-story Los Angeles PR SAC frame indicate that the assumption of rigid connections at beam-column and column-base interfaces, as well as the assumption of a rigid foundation, can lead to significant errors if simplified design procedures are used. These errors in an equivalent static analysis are expected to lead to even more serious problems when considering the effect of higher modes under a non-linear dynamic analysis.

• Korea-Australia Rheology Journal
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• v.20 no.4
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• pp.189-196
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• 2008

The pulsatile flow of blood through a stenosed artery under the influence of external periodic body acceleration is studied. The effect of non-Newtonian nature of blood in small blood vessels has been taken into account by modeling blood as a Casson fluid. The non-linear coupled equations governing the flow are solved using perturbation analysis assuming that the Womersley frequency parameter is small which is valid for physiological situations in small blood vessels. The effect of pulsatility, stenosis, body acceleration, yield stress of the fluid and pressure gradient on the yield plane locations, velocity distribution, flow rate, shear stress and frictional resistance are investigated. It is noticed that the effect of yield stress and stenosis is to reduce flow rate and increase flow resistance. The impact of body acceleration is to enhance the flow rate and reduces resistance to flow.

• Structural Engineering and Mechanics
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• v.23 no.4
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• pp.431-447
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• 2006

A new incremental finite element model is developed to simulate the frictional contact of elastic bodies. The incremental convex programming method is exploited, in the framework of finite element approach, to recast the variational inequality principle of contact problem in a discretized form. The non-classical friction model of Oden and Pires is adopted, however, the friction effect is represented by an equivalent non-linear stiffness rather than additional constraints. Different parametric studies are worked out to address the versatility of the proposed model.

• Bulletin of the Korean Chemical Society
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• v.18 no.9
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• pp.1006-1010
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• 1997

The nature and analysis methods of complicated decay profiles found in forced Rayleigh scattering (FRS) have been investigated for the probe diffusion of methyl yellow in 2-propanol. The complementary shifted and ground state grating effect, which is known to be the origin of non-single exponential decays, was analyzed by non-linear regression fitting to a double exponential model function. We confirmed that the parameters were highly correlated so that it was difficult to extract a unique set of parameters in the presence of experimental noise. Nevertheless, a reasonable range of decay time constants could be estimated from the grating spacing dependence.

• Structural Engineering and Mechanics
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• v.59 no.5
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• pp.841-852
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• 2016

The present paper is concerned with the investigation of propagation of thermoelastic media, the finite difference technique is used to obtain the solution for the uncoupled dynamic thermoelastic stress problem in a non-homogeneous orthrotropc thick cylindrical shell. In implementing the method, the linear dynamic thermoelasticity equations are used with the appropriate boundary and initial conditions. Thermal shock stress becomes of significant magnitude due to stress wave propagation which is initiated at the boundaries by sudden thermal loading. Numerical results have been given and illustrated graphically in each case considered. The presented results indicate that the effect of inhomogeneity is very pronounced.

• Proceedings of the KSME Conference
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• 2001.11b
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• pp.118-123
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• 2001

The linear compressor have been widely used for pressure wave generation in the Stirling cryocooler and Stirling type pulse tube cryocooler for tactical purpose. The linear compressor has small and compact structure, and long life due to having non-contact sealing mechanism. and the pressure drop through regenerator was ver important role in the motion of displacer in the expander of the Stirling cryocooler. In this study, the characteristic of the linear compressor and the pressure drop through regenerator in the expander was experimentally investigated. The results show the resonance of the compressor is very important to get maximum performance. and the gas spring force in the compression space of the compressor has effect on the characteristic of reonance. and the results show the pressure drop through regenerator is very small than operating pressure change.

• Journal of the Korean Society for Precision Engineering
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• v.20 no.2
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• pp.58-65
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• 2003

The conventional forming process such as squeeze casting or die casting for fabricating metal matrix composites products have a disadvantage such as non homogenous distribution of reinforcement, weak bonding between matrix and reinforcement and cost increase in parts fabrication. Thixoforming process has been accepted as a new method for fabricating the net shaped metal matrix composites with lightweight and wear resistance. In this paper, the effect of volume fraction and reinforcement sizes on mechanical properties in cylinder liner part of metal matrix composites has been investigated with processes parameters such as pressure and velocity. Moreover, the methods to obtain the thixoforged composites cylinder liner with high quality has been proposed. To evaluate the composites cylinder linear fabricated at the conditions proposed in this study, mechanical properties of fabricated composites cylinder linear were compared with those of commercial composites cylinder linear.