• Korean Journal of Medicinal Crop Science
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• v.26 no.1
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• pp.26-31
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• 2018

Background: Angelica gigas, A. sinensis, and A. acutiloba are commercially important in the herbal medicine market, and among them, A. gigas has the highest economic value and price. However, their similar morphological traits are often used for fraud. Despite their importance in herbal medicine, recognition of the differences between Angelica species is currently inadequate. Methods and Results: A multiplex polymerase chain reaction (PCR) method was developed for direct detection and identification of A. gigas, A. sinensis, and A. acutiloba. The gene for the distinction of species was targeted at ITS in the nucleus and trnC-petN gene in chloroplasts. The optimized multiplex PCR in the present study utilized each Angelica species-specific primer pairs. Each primer pair yielded products of 229 base pairs (bp) for A. gigas, 53 bp for A. sinensis, 170 bp for A. acutiloba. Additionally non-specific PCR products were not detected in similar species by species-specific primers. Conclusions: In the present study, a multiplex-PCR assay, successfully assessed the authenticity of Angelica species (A. gigas, A. sinensis, and A. acutiloba). and whole genome amplification (WGA) was performed after DNA extraction to identify, the species in the product. The detection method of raw materials developed in the present study could be applied to herbal medicine and health functional food management.

• Restorative Dentistry and Endodontics
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• v.21 no.1
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• pp.366-374
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• 1996

The purpose of this study was to investigate whether D-myo-inositol-l,2,6-trisphosphate (PP56) can effectively antagonize vasoconstriction caused by neuropeptide Y in the dental pulp, and to understand involvement of neuropeptide Y in the regulation of microcirculation in the dental pulp with the aim of elucidating neurogenic inflammation. Experiments were performed on 7 cats anesthetised with sodium pentobarbital, and neuropeptide Y and a neuropeptide Y antagonist PP56 were injected close intra-arterially into the dental pulp. The probe of laser Doppler flowmeter was placed on the buccal surface of ipsilateral canine teeth to the drug administration and pulpal blood flow was measured. Intra-arterial injection of neuropeptide Y (1.3-$2.0\;{\mu}g$/kg) resulted in pulpal blood flow decrease of $37.73{\pm}5.73%$(mean${\pm}$SEM) (n=9). Intra-arterial injection of PP56(0.3 mg/kg) alone changed pulpal blood flow little by 1.03 % reduction. The effect of neuropeptide Y in the presence of PP56 resulted in significantly less decreases in pulpal blood flow ranging from $27.17{\pm}5.37$ to $16.63{\pm}3.48%$ from control as compared with neuropeptide Y alone(n = 13). In effect, PP56 attenuated pulpal blood flow caused by neuropeptide Y. Results of the present study have provided evidences that a non-peptide PP56 is capable of antagonizing vasoconstriction caused by neuropeptide Y in the feline dental pulp. In addition, they show functional evidences that neuropeptide Y plays an active role in modulating the microcirculation of the dental pulp.

• Genomics & Informatics
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• v.8 no.1
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• pp.28-33
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• 2010

Increased exposure of human to RF fields has raised concerns for its potential adverse effects on our health. To address the biological effects of RF radiation, we used genome wide gene expression as the indicator. We exposed normal WI-38 human fibroblast cells to 1763 MHz mobile phone RF radiation at a specific absorption rate (SAR) of 60 W/kg with an operating cooling system for 24 h. There were no alterations in cell numbers or morphology after RF exposure. Through microarray analysis, we identified no differentially expressed genes (DEGs) at the 0.05 significance level after controlling for multiple testing errors with the Benjaminiochberg false discovery rate (BH FDR) method. Meanwhile, 82 genes were differentially expressed between RF-exposed cells and controls when the significance level was set at 0.01 without correction for multiple comparisons. We found that 24 genes (0.08% of the total genes examined) were changed by more than 1.5-fold on RF exposure. However, significant enrichment of any gene set or pathway was not observed from the functional annotation analysis. From these results, we did not find any evidence that non-thermal RF radiation at a 60-W/kg SAR significantly affects cell proliferation or gene expression in WI-38 cells.

• Journal of the Korea Safety Management & Science
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• v.16 no.2
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• pp.43-52
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• 2014

In weapon systems development, live fire tests have been frequently adopted to evaluate the performance of the systems under development. Therefore, it is necessary to ensure safety in the test ranges where the live fire tests can cause serious hazards. During the tests, a special care must be taken to protect the test and evaluation (T&E) personnel and also test assets from potential danger and hazards. Thus, the development and management of the range safety process is quite important in the tests of guided missiles and artillery considering the explosive power of the destruction. Note also that with a newly evolving era of weapon systems such as laser, EMP and non-lethal weapons, the test procedure for such systems is very complex. Therefore, keeping the safety level in the test ranges is getting more difficult due to the increased unpredictability for unknown hazards. The objective of this paper is to study on how to enhance the safety in the test ranges. To do so, an approach is proposed based on model-based systems engineering (MBSE). Specifically, a functional architecture is derived utilizing the MBSE method for the design of the range safety process under the condition that the derived architecture must satisfy both the complex test situation and the safety requirements. The architecture developed in the paper has also been investigated by simulation using a computer-aided systems engineering tool. The systematic application of this study in weapon live tests is expected to reduce unexpected hazards and test design time. Our approach is intended to be a trial to get closer to the recent theme in T&E community, "Testing at the speed of stakeholder's need and rapid requirement for rapid acquisition."

• Smart Structures and Systems
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• v.32 no.3
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• pp.135-151
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• 2023

Using 3D asphalt pavement surface data, a deep and multiscale network named CrackNet-M is proposed in this paper for pixel-level crack detection for improvements in both accuracy and robustness. The CrackNet-M consists of four function-specific architectural modules: a central branch net (CBN), a crack map enhancement (CME) module, three pooling feature pyramids (PFP), and an output layer. The CBN maintains crack boundaries using no pooling reductions throughout all convolutional layers. The CME applies a pooling layer to enhance potential thin cracks for better continuity, consuming no data loss and attenuation when working jointly with CBN. The PFP modules implement direct down-sampling and pyramidal up-sampling with multiscale contexts specifically for the detection of thick cracks and exclusion of non-crack patterns. Finally, the output layer is optimized with a skip layer supervision technique proposed to further improve the network performance. Compared with traditional supervisions, the skip layer supervision brings about not only significant performance gains with respect to both accuracy and robustness but a faster convergence rate. CrackNet-M was trained on a total of 2,500 pixel-wise annotated 3D pavement images and finely scaled with another 200 images with full considerations on accuracy and efficiency. CrackNet-M can potentially achieve crack detection in real-time with a processing speed of 40 ms/image. The experimental results on 500 testing images demonstrate that CrackNet-M can effectively detect both thick and thin cracks from various pavement surfaces with a high level of Precision (94.28%), Recall (93.89%), and F-measure (94.04%). In addition, the proposed CrackNet-M compares favorably to other well-developed networks with respect to the detection of thin cracks as well as the removal of shoulder drop-offs.

• Journal of Digital Convergence
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• v.14 no.9
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• pp.553-561
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• 2016

The purpose of this study was to compare cardiopulmonary function, RPE(Rating of perceived exertion), and blood lactate when examining the GXT(Graded exercise testing) of wheelchair treadmill and arm ergometer. Participants were 11 wheelchair basketball players with non disability. While examining the GXT of wheelchair treadmill and arm ergometer, cardiorespiratory functional capacity was measured by using $Quarkb^2$ and Polar and RPE was measured through Borg Scale. The lactate analyser, YSI-2000 was used to measure blood lactate level when resting, right after exercise, two minutes, four minutes, six minutes, and ten minutes of recovery. Data was analyzed by paired t-test using SPSS 18.0 program and significance for all statistical analysis was fixed at .05 confidence level(p<0.05). The conclusion of this study is below. First, maximal oxygen uptake which is a factor of cardiopulmonary function showed the highest with arm ergometer, the rate of respiratory exchange showed the highest with wheelchair treadmill, and maximal heart rate showed the highest with wheelchair treadmill. Second, subjective exercise intensity showed the highest with arm ergometer at the end point. Third, blood lactate level showed the highest with arm ergometer right after exercise.

• Journal of the Korean Chemical Society
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• v.67 no.6
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• pp.420-428
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• 2023

Crosslinking was introduced into vinylized-mesoporous silica and recycled polyethylene. By introducing a vinyl group into the mesoporous silica, it becomes a material capable of inducing cross-linking with non-polar polyethylene. By synthesizing vinylized-mesoporous silica and inducing crosslinking with recycled polyethylene, a recycled polyethylene composite with improved physical properties than existing recycled polyethylene was synthesized. In addition, even when a small amount is added according to the grade of recycled polyethylene using vinylized-mesoporous silica, the crosslinking reaction proceeds and all physical properties are improved. Four types of vinylized-mesoporous silica were synthesized, and the shape, microstructure, and functional groups were analyzed by TEM, BET, FT-IR, and XRD. Using vinylized-mesoporous silica, three types of compounds were blended by crosslinking reaction with recycled polyethylene. In order to confirm the presence or absence of crosslinking, analysis was performed using XPS and FT-IR, and physical properties such as tensile strength, elongation, flexural strength, and flexural modulus were confirmed using a universal testing machine. As a result, by applying vinylized-mesoporous silica to recycled polyethylene in various grades, the weak physical properties of existing recycled polyethylene were overcome. By applying the vinylized-mesoporous silica, recycled polyethylene composite material that overcomes the weak physical properties to the normal polyethylene, it shows the optimal physical property index that can be used commercially. Therefore, it is expected that it can potentially increase the use of recycled polyethylene and recycle resources.

• Textile Coloration and Finishing
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• v.28 no.1
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• pp.48-56
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• 2016

Improvement of heat sink technology related to the continuous implementation performance and extension of device-life in circumstance of easy heating and more compact space has been becoming more important issue as multi-functional integration and miniaturization trend of electronic gadgets and products has been generalized. In this study, it purposed to minimize of decline of the heat diffusivity by gluing polymer through compounding of inorganic particles which have thermal conductive properties. We used NH-9300 as base resin and used inorganic fillers such as silicon carbide(SiC), aluminum nitride(AlN), and boron nitride(BN) to improve heat diffusivity. After making film which was made from 100 part of acrylic resin mixed hardener(1.0 part more or less) with inorganic particles. The film was matured at $80^{\circ}C$ for 24h. Diffusivity were tested according to sorts of particles and density of particles as well as size and structure of particle to improve the effect of heat sink in view of morphology assessing diffusivity by LFA(Netzsch/LFA 447 Nano Flash) and adhesion strength by UTM(Universal Testing Machine). The correlation between diffusivity of pure inorganic particles and composite as well as the relation between density and morphology of inorganic particles has been studied. The study related morphology showed that globular type had superior diffusivity at low density of 25% but on the contarary globular type was inferior to non-globular type at high density of 80%.

• Journal of Aerospace System Engineering
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• v.15 no.5
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• pp.81-88
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• 2021

In general, a non-explosive nylon wire cutting-based holding and release mechanism has been used to store and deploy deployable solar panels of CubeSat. However, with this method, accessing the solar panel's access port for charging the cube satellite's battery and electrical inspection and testing of the PCB and payloads while the solar panel is in storage is difficult. Additionally, the mechanism must have a reliable release function in an in-orbit environment, and reusability for stow and deploy of the solar panel, which is a hassle for the operator and difficult to maintain a consistent nylon wire fastening process. In this study, we proposed a pin-puller-based solar panel holding and release mechanism that can easily deploy a solar panel without cutting nylon wires by separating constraining pins. The proposed mechanism's release function and performance were verified through a solar panel deployment test and a maximum separation load measurement test. Through this, we also verified the design feasibility and effectiveness of the pin-puller-based separation device.

• Journal of the korean academy of Pediatric Dentistry
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• v.46 no.2
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• pp.165-172
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• 2019

The purpose of this study was to evaluate the effect of application time and phosphoric acid etching of 8th generation adhesives containing functional monomer on adhesive performance in primary teeth. 80 extracted non-carious human primary teeth were selected and divided into 8 groups based on 3 factors: (1) adhesive: G-Premio bond and Single bond universal; (2) application time: shortened time and manufacture's instruction; (3) acid etching mode: self-etching and total-etching. Shear bond strength was measured using a universal testing machine, and fractured surface were observed under scanning electron microscope. Microleakage was evaluated by dye penetration depth. G-Premio bond were not significant different in shear bond strength and microleakage depending on application time of adhesive and acid etching mode. In Single bond universal, shear bond strength of short application time was significantly lower than that of long adhesive application time (p = 0.014). Clinically applicable shear bond strength values (> 17 MPa) were identified in all groups. These results suggested that G-Premio bond be used clinically for a short application time without phosphoric acid etching.