• Proceedings of the Korean Geotechical Society Conference
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• 2007.09a
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• pp.542-557
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• 2007

Contamination of subsurface results in degradation of geomaterials (i.e., soils and rock mass), in the long run. This is mainly due to the presence of chemical and/or radiological materials in undesirable concentrations and at elevated temperatures. However, as contaminant-geomaterial interaction is an extremely slow and complex process, which primarily depends on their physical, chemical and mineralogical properties, it is quite difficult to study this interaction under laboratory or in situ conditions. In such a situation, accelerated physical modeling, using a geotechnical centrifuge, and finite element/difference based numerical modeling techniques are found to be quite useful. This paper presents details of various modeling techniques developed by the researchers at the Indian Institute of Technology Bombay, Mumbai, India, for studying heat migration, flow and interaction (fate) of reactive and non-reactive contaminants in the geoenvironment, under saturated and unsaturated conditions. In addition, paper presents details of the technique that can be employed for determining susceptibility of a material to undergo physico-chemico-mineralogical alterations due to its interaction with contaminants.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.28 no.9
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• pp.67-72
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• 2014

Inflow or outflow from the water treatment plant and the sewage water has potential energy. If this potential energy can be converted into electrical energy by water turbine generator, it can help to save energy because of the high capacity utilization. So recently, micro hydro power plant is reviewed in the water treatment facility. If generation capacity is low, induction generator is primarily used. If output capacity is low, generated power is supplied to the inside load. Induction generator can cause voltage drop by the inrush current at a start-up and requires reactive power for magnetization. In this study, we analyzed the flow of power and voltage variation against inrush current that occurs when the induction generator starts under the terms that loads of linear and non-linear of the water purification plant are used. Analysis results are that the voltage drop is within an allowable range and the power factor is slightly reduced by the need of reactive power.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.37 no.12
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• pp.1079-1089
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• 2013

The flow characteristics in a solid particle incinerator are investigated numerically for high burning rate of wastes. The studied incinerator employs both a swirl flow used in the furnace of powerplants and a design concept applied to a rocket combustor. As the first step, the non-reactive flow field is analyzed in the incinerator with primary and secondary injectors through which solid fuel and air are injected. The deflection angle of a primary injector, inclination angle of a secondary injector, and gap between the two types of injectors are selected as design parameters. The swirl number is adopted for evaluating the degree of swirl flow and estimated over wide ranges of three parameters. The swirl number increases with deflection angle, but it is affected little by inclination angle. Recirculation zones are formed near the injectors, and their size affects the swirl number. The swirl number decreases with the zonal size of recirculation. From the numerical results, the design points can be found with strong swirl flow.

• International Journal of Oral Biology
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• v.41 no.1
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• pp.17-23
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• 2016

Chronic/cyclic neutropenia, leukocyte adhesion deficiency syndrome, Papillon-$Lef{\grave{e}}vre$ syndrome, and $Ch{\grave{e}}diak$-Higashi syndrome are associated with severe periodontitis, suggesting the importance of neutrophils in the maintenance of periodontal health. Various Toll-like receptor (TLR) ligands are known to stimulate neutrophil function, including FcR-mediated phagocytosis. In the present study, the effect of TLR2 activation on the non-opsonic phagocytosis of oral bacteria and concomitant production of reactive oxygen species (ROS) by human neutrophils was evaluated. Neutrophils isolated from peripheral blood were incubated with Streptococcus sanguinis or Porphyromonas gingivalis in the presence of various concentrations of $Pam_3CSK_4$, a synthetic TLR2 ligand, and analyzed for phagocytosis and ROS production by flow cytometry and chemiluminescence, respectively. $Pam_3CSK_4$ significantly increased the phagocytosis of both bacterial species in a dose-dependent manner. However, the enhancing effect was greater for S. sanguinis than for P. gingivalis. $Pam_3CSK_4$ alone induced ROS production in neutrophils and also increased concomitant ROS production induced by bacteria. Interestingly, incubation with P. gingivalis and $Pam_3CSK_4$ decreased the amounts of ROS, as compared to $Pam_3CSK_4$ alone, indicating the possibility that P. gingivalis survives within neutrophils. However, neutrophils efficiently killed phagocytosed bacteria of both species despite the absence of $Pam_3CSK_4$. Although P. gingivalis is poorly phagocytosed even by the TLR2-activated neutrophils, TLR2 activation of neutrophils may help to reduce the colonization of P. gingivalis by efficiently eliminating S. sanguinis, an early colonizer, in subgingival biofilm.

• Proceedings of the KSME Conference
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• 2001.06d
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• pp.864-870
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• 2001

Flame propagation along vortex tube was experimentally investigated. The vortex tube was generated by the ejection of propane from a nozzle through a single stroke motion of a speaker and the ignition was induced from a single pulse laser. Non-reactive flow fields were visualized using shadow technique. From these images, vortex ring size and translational velocity were measured in order to determine the ignition time and position. Flame structure and flame speed were measured using high speed CCD camera. Flame speed was accelerated during the initial stage of flame kernel growth, and reached near constant value during steady propagation period. Near the completion of propagation, flame speed was decelerated and then extinguished. Flame speed along the non-premixed vortex tube was found to be linearly proportional to circulation, which was similar to that of the flame propagation along premixed vortex ring. Ignition position minimally affects the propagation characteristics. These imply that flame is propagating along the maximum speed locus expected to be along stoichiometric contour and also support the existence of tribrachial flames.

• 한국연소학회:학술대회논문집
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• 2012.11a
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• pp.39-41
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• 2012

The influence of coal blending methods such as out-furnace (external or pre-mixed) blending and in-furnace (initially non-mixed) blending with different excess oxygen (highest, medium, and lowest stoichiometric conditions) on unburned carbon and NOx emissions of blend combustion in an entrained flow reactor (EFR) has been analyzed, using experimental and numerical approaches for binary coals used by Korean power plants. The results confirm that under the medium condition, contrasting processes such as reactive and un-reactive effects occur with SBRs in the out-furnace blending method. The in-furnace blending method results in an improvement in the efficiency of unburned carbon fractions and a further reduction in the NOx emission. Under the highest condition, the unburned carbon fraction in both the out-furnace and the in-furnace blending methods corresponds with the tendency under the medium condition with contrasting processes of lower magnitude, whereas the NOx emission in the highest condition increases slightly. Under the lowest conditions, the unburned carbon fraction in the out-furnace blending method gradually decreases as SBR decreases, without a competition effect. The reduction of NOx emission under the lowest conditions is more effective than those under other conditions for the two blending methods because of a homogeneous and heterogeneous NOx reduction mechanism.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.64 no.9
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• pp.1288-1296
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• 2015

The ac side current of a line commutated converter(LCC) high voltage direct current (HVDC) is characterized by highly non-sinusoidal waveform. If the harmonic current is allowed to flow in the connected ac network, it may cause unacceptable levels of distortion. Therefore, ac side filters are required as part of the total HVDC converter station, in order to reduce the harmonic distortion of the ac side current and voltage to acceptably low levels. The ac filters are also employed to compensate the requested reactive power because LCC HVDC also consume substantial reactive power. Among different types of filters, triple-tuned filters have been widely utilized for HVDC system. This paper presents two design methods of triple-tuned filter; equivalent method and parametric method. Using a parametric method, in particular this paper proposes a design algorithm for a triple tuned filter. Finally, the performance of the design algorithm is evaluated for a 250kV HVDC system in Jeju island. The results cleary demonstrate the effectiveness of proposed design method in harmonics reduction.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.61 no.9
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• pp.1232-1241
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• 2012

The ac side current of an high voltage direct current (HVDC) converter is characterized by highly non-sinusoidal waveform. If the harmonic current is allowed to flow in the connected ac system, it may cause unacceptable levels of distortion. Therefore, ac side filters are required as part of the total HVDC converter station, in order to reduce the harmonic distortion of the ac side current and voltage to acceptably low levels. The ac side filters are also employed to compensate network requested reactive power because HVDC converters also consume substantial reactive power. Among different types of filters, double-tuned filters have been widely utilized for HVDC system. This paper presents two design methods of double-tuned filter; equivalent method and parametric method. Using a parametric method, in particular the paper proposes a new design algorithm for a realistic system. Finally, the performance of the design algorithm is evaluated for a 80kV HVDC system in Jeju island with PSCAD/EMTDC program. The results cleary demonstrate the effectiveness of proposed design method in harmonics elimination and steady-state stability.

• International Journal of Oral Biology
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• v.37 no.2
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• pp.69-75
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• 2012

Although neutrophils function in both defense and tissue destruction, their defensive roles have rarely been studied in association with periodontitis. We hypothesized that peripheral neutrophils are pre-activated in vivo in periodontitis and that hyperactive neutrophils would show enhanced phagocytic ability as well as an increased production of reactive oxygen species (ROS). Peripheral blood neutrophils from patients with aggressive periodontitis and age/gender-matched healthy subjects (10 pairs) were isolated. The levels of CD11b and CD64 expression on the neutrophils and the level of plasma endotoxin were determined by flow cytometry and a limulus amebocyte lysate test, respectively. In addition, neutrophils were subjected to a flow cytometric phagocytosis assay and luminol-enhanced chemiluminescence for non-opsonized Fusobacterium nucleatum in parallel. The neutrophilsfrom most patients expressed increased levels of both CD11b and CD64. In addition, the plasma from these patients tended to contain a higher level of endotoxin than the healthy controls. In contrast, no differences were found between the two groups with regard to phagocytosis or ROS generation by F. nucleatum. The ability to phagocytose F. nucleatum was found to positively correlate with the ability to produce ROS. In conclusion, peripheral neutrophils from patients with aggressive periodontitis are hyperactive but not hyperreactive to F. nucleatum.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.4
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• pp.2325-2331
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• 2013

Objective: To detect effects of plumbagin on proliferation and apoptosis in non-small cell lung cancer cell lines, and investigate the underlying mechanisms. Materials and Methods: Human non-small cell lung cancer cell lines A549, H292 and H460 were treated with various concentrations of plumbagin. Cell proliferation rates was determined using both cell counting kit-8 (CCK-8) and clonogenic assays. Apoptosis was detected by annexin V/propidium iodide double-labeled flow cytometry and TUNEL assay. The levels of reactive oxygen species (ROS) were detected by flow cytometry. Activity of NF-${\kappa}B$ was examined by electrophoretic mobility shift assay (EMSA) and luciferase reporter assay. Western blotting was used to assess the expression of both NF-${\kappa}B$ regulated apoptotic-related gene and activation of p65 and $I{\kappa}B{\kappa}$. Results: Plumbagin dose-dependently inhibited proliferation of the lung cancer cells. The IC50 values of plumbagin in A549, H292, and H460 cells were 10.3 ${\mu}mol/L$, 7.3 ${\mu}mol/L$, and 6.1 ${\mu}mol/L$ for 12 hours, respectively. The compound concentration-dependently induced apoptosis of the three cell lines. Treatment with plumbagin increased the intracellular level of ROS, and inhibited the activation of NK-${\kappa}B$. In addition to inhibition of NF-${\kappa}B$/p65 nuclear translocation, the compound also suppressed the degradation of $I{\kappa}B{\kappa}$. ROS scavenger NAC highly reversed the effect of plumbagin on apoptosis and inactivation of NK-${\kappa}B$ in H460 cell line. Treatment with plumbagin also increased the activity of caspase-9 and caspase-3, downregulated the expression of Bcl-2, upregulated the expression of Bax, Bak, and CytC. Conclusions: Plumbagin inhibits cell growth and induces apoptosis in human lung cancer cells through an NF-${\kappa}B$-regulated mitochondrial-mediated pathway, involving activation of ROS.