• Journal of Chest Surgery
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• v.56 no.2
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• pp.67-74
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• 2023

Perioperative treatment with conventional cytotoxic chemotherapy for resectable non-small cell lung cancer (NSCLC) has proven clinical benefits in terms of achieving a higher overall survival (OS) rate. With its success in the palliative treatment of NSCLC, immune checkpoint blockade (ICB) has now become an essential component of treatment, even as neoadjuvant or adjuvant therapy in patients with operable NSCLC. Both pre- and post-surgery ICB applications have proven clinical efficacy in preventing disease recurrence. In addition, neoadjuvant ICB combined with cytotoxic chemotherapy has shown a significantly higher rate of pathologic regression of viable tumors compared with cytotoxic chemotherapy alone. To confirm this, an early signal of OS benefit has been shown in a selected population, with programmed death ligand 1 expression ≥50%. Furthermore, applying ICB both pre- and post-surgery enhances its clinical benefits, as is currently under evaluation in ongoing phase III trials. Simultaneously, as the number of available perioperative treatment options increases, the variables to be considered for making treatment decisions become more complex. Thus, the role of a multidisciplinary team-based treatment approach has not been fully emphasized. This review presents up-to-date pivotal data that lead to practical changes in managing resectable NSCLC. From the medical oncologist's perspective, it is time to dance with surgeons to decide on the sequence of systemic treatment, particularly the ICB-based approach, accompanying surgery for operable NSCLC.

• Proceedings of the IEEK Conference
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• 2004.08c
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• pp.890-895
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• 2004

This paper describes constant alarm rates process of millimeter wave radar that exits on non-stationary target detection schemes in the ground clutter conditions. The comparison of various CFAR processes such as CA(Cell-Average)-CFAR, GO(Greatest Of)/SO(Smallest Of)-CFAR and OS(Order Statistics)-CFAR performance are applied. Using matlab software, we show the performance and loss between detection probability and signal to noise ratio. When rang bins increase, this results show the OS-CFAR process performance is better than any others and satisfies the optimal detection probability without loss of detection in the homogeneous clutter.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.44 no.5
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• pp.207-211
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• 2018

Among different graft materials for craniofacial reconstruction, calcium phosphate cements have the advantages of alloplastic grafts and wide use. The authors report a case of foreign body reaction following frontal reconstruction with JectOS (an injectable calcium orthophosphate cement; Kasios) and reviewed the literature on complications of this material after craniofacial reconstruction from 2002 to 2017. Complications were categorized into two groups: immunologic reactions (consisting of seroma collection, chronic sinus mucosa swelling, and foreign body reaction) and non-immune events (infection, fragmentation, and ejection). It is wise to use calcium phosphate-based material only in selected cases with small defects, and long-term follow-up is needed to observe their consequences.

• International Journal of Aeronautical and Space Sciences
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• v.6 no.1
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• pp.8-16
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• 2005

This paper describes target detection performance of millimeter wave radar that exits on non-stationary target detection schemes in the ground clutter conditions. The comparison of various CFAR process schemes such as CA(Cell-Average)-CFAR, GO(Greatest Of)/SO(Smallest Of)-CFAR, and OS(Order Statistics)-CFAR performance are applied. Using matlab software, we show the performance and loss between target detection probability and signal to noise ratio. This paper concludes the OS-CFAR process performance is better than any others and satisfies the optimal detection probability without loss of detection in the homogeneous clutter, When range bins increase.

• BMB Reports
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• v.44 no.10
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• pp.680-685
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• 2011

The AT-hook motif is a small DNA-binding protein motif that has been found in the high mobility group of non-histone chromosomal proteins. The Arabidopsis genome contains 29 genes encoding the AT-hook motif DNA-binding protein (AHL). Recent studies of Arabidopsis genes (AtAHLs) have revealed that they might play diverse functional roles during plant growth and development. In this report, we mined 20 AHL genes (OsAHLs) from the rice genome database using AtAHL genes as queries and characterized their molecular features. A phylogenetic tree revealed that OsAHL proteins can be classified into 2 evolutionary clades. Tissue expression pattern analysis revealed that all of the OsAHL genes might be functionally expressed genes with 3 distinct expression patterns. Nuclear localization analysis using transgenic Arabidopsis showed that several OsAHL proteins are exclusively localized in the nucleus, indicating that they may act as architectural transcription factors to regulate expression of their target genes during plant growth and development.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.30 no.6
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• pp.1141-1149
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• 2020

Most of the industrial control network is an independent closed network, which is operated for a long time after installation, and thus the OS is not updated, so security threats increase and security vulnerabilities exist. The zero-day attack defense must be applied with the latest patch, but in a large-scale industrial network, it requires a higher level of real-time and non-disruptive operation due to the direct handling of physical devices, so a step-by-step approach is required to apply it to a live system. In order to solve this problem, utility-specific patch impact assessment is required for reliable patch application. In this paper, we propose a method to test and safely install the patch using the regression analysis technique and show the proven results. As a patch impact evaluation methodology, the maximum allowance for determining the safety of a patch was derived by classifying test types based on system-specific functions, performance, and behavior before and after applying the patch. Finally, we report the results of case studies applied directly to industrial control networks, the OS patch has been updated while ensuring 99.99% availability.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.24 no.6
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• pp.818-825
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• 2020

The embedded system can be defined as a special purpose system with a built-in computer, and has a wide variety of applications such as home appliances, office equipment, and weapon systems. A well-defined taxonomy in a specific field is advantageous for learning and education, however, the classification scheme for embedded systems is difficult to find. In this paper, we propose a taxonomy for embedded systems. First, the generalized structure of the embedded system was presented. And, it is divided into two parts: "firmware based" and "embedded OS based". In addition, according to the characteristics of embedded system applications, it is divided into two categories: "non-dependable" application and "dependable" application, which makes 4 planes. We describe the features of each quadrant and show that the classification is well suited by showing examples. Our taxonomy can be used to set teaching and learning methods of embedded systems.

• Annals of Hepato-Biliary-Pancreatic Surgery
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• v.28 no.1
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• pp.1-13
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• 2024

Hepatocellular carcinoma (HCC) is the sixth most diagnosed cancer worldwide. Healthcare resource constraints may predispose treatment delays. We aim to review existing literature on whether delayed treatment results in worse outcomes in HCC. PubMed, Embase, The Cochrane Library, and Scopus were systematically searched from inception till December 2022. Primary outcomes were overall survival (OS) and disease-free survival (DFS). Secondary outcomes included post-treatment mortality, readmission rates, and complications. Fourteen studies with a total of 135,389 patients (delayed n = 25,516, no delay n = 109,873) were included. Age, incidence of male patients, Child-Pugh B cirrhosis, and Barcelona Clinic Liver Cancer Stage 0/A HCC were comparable between delayed and no delay groups. Tumor size was significantly smaller in delayed versus no delay group (mean difference, -0.70 cm; 95% confidence interval [CI]: -1.14, 0.26; p = 0.002). More patients received radiofrequency ablation in delayed versus no delay group (OR, 1.22; 95% CI: 1.16, 1.27; p < 0.0001). OS was comparable between delayed and no delay in HCC treatment (hazard ratio [HR], 1.13; 95% CI: 0.99, 1.29; p = 0.07). Comparable DFS between delayed and no delay groups (HR, 0.99; 95% CI: 0.75, 1.30; p = 0.95) was observed. Subgroup analysis of studies that defined treatment delay as > 90 days showed comparable OS in the delayed group (HR, 1.04; 95% CI: 0.93, 1.16; p = 0.51). OS and DFS for delayed treatment were non-inferior compared to no delay, but might be due to better tumor biology/smaller tumor size in the delayed group.

• Journal of Korean Neurosurgical Society
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• v.64 no.2
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• pp.271-281
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• 2021

Objective : Immune checkpoint inhibitors (ICIs) are approved for treating non-small-cell lung cancer (NSCLC); however, the safety and efficacy of combined ICI and Gamma Knife radiosurgery (GKS) treatment remain undefined. In this study, we retrospectively analyzed patients treated with ICIs with or without GKS at our institute to manage patients with brain metastases from NSCLC. Methods : We retrospectively reviewed medical records of patients with brain metastases from NSCLC treated with ICIs between January 2015 and December 2017. Of 134 patients, 77 were assessable for brain responses and categorized into three groups as follows : group A, ICI alone (n=26); group B, ICI with concurrent GKS within 14 days (n=24); and group C, ICI with non-concurrent GKS (n=27). Results : The median follow-up duration after brain metastasis diagnosis was 19.1 months (range, 1-77). At the last follow-up, 53 patients (68.8%) died, 20 were alive, and four were lost to follow-up. The estimated median overall survival (OS) of all patients from the date of brain metastasis diagnosis was 20.0 months (95% confidence interval, 12.5-27.7) (10.0, 22.5, and 42.1 months in groups A, B, and C, respectively). The OS was shorter in group A than in group C (p=0.001). The intracranial disease progression-free survival (p=0.569), local progression-free survival (p=0.457), and complication rates did not significantly differ among the groups. Twelve patients showed leptomeningeal seeding (LMS) during follow-up. The 1-year LMS-free rate in treated with ICI alone group (69.1%) was significantly lower than that in treated with GKS before ICI treatment or within 14 days group (93.2%) (p=0.004). Conclusion : GKS with ICI showed no favorable OS outcome in treating brain metastasis from NSCLC. However, GKS with ICI did not increase the risk of complications. Furthermore, compared with ICI alone, GKS with ICI may be associated with a reduced incidence of LMS. Further understanding of the mechanism, which remains unknown, may help improve the quality of life of patients with brain metastasis.

• Transactions of Materials Processing
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• v.8 no.6
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• pp.591-603
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• 1999

A computer-aided process planning system for rotationally symmetric deep drawing products has been developed. The application for non-axisymmetric components, however, has been reported yet. Therefore, this study investigates process sequence design in deep drawing process and constructs a computer-aided process planning system for non-axisymmetric motor frame products with elliptical shape. The system developed consists of three modules. The first one os a 3-dimensional modeling module to calculate surface area for non-axisymmetric products. The second one is a blank design module that creates an oval-shaped blank with the identical surface area. The third one is a process planning module based on production rules that play the best important roles in an expert system for manufacturing. The production rules are generated and upgraded by interviewing with field engineers. Especially, drawing coefficient, punch and die radii are considered as main design parameters. The constructed system for elliptical deep drawing products would be very useful to reduce lead time and improve accuracy for production.