• Fisheries and Aquatic Sciences
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• 제12권2호
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• pp.90-97
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• 2009

The cytoskeletal $\beta$-actin gene and its 5'-upstream region were isolated and characterized in the rockbream (Oplegnathus fasciatus). Complementary DNA of the rockbream $\beta$-actin represented a 1,125 bp of an open reading frame encoding 375 amino acids, and the rockbream $\beta$-actin cDNA and deduced amino acid sequences were highly homologous to those of other vertebrate orthologs. At the genomic level, the $\beta$-actin gene also exhibited an organization typical of vertebrate cytoskeletal actin genes (2,159 bp composed of five translated exons interrupted by four introns) with a conserved GT/AG exon-intron splicing rule. The putative non-translated exon predicted in the rockbream $\beta$-actin gene was much more homologous with those of teleostean $\beta$-actin genes than those of mammals. The 5'-upstream regulatory region isolated by genome walking displayed conserved and essential elements such as TATA, CArG and CAAT boxes in its proximal part, while several other immune- or stress-related motifs such as those for NF-kappa B, USF, HNF, AP-1 and C/EBP were in the distal part. Semi-quantitative RT-PCR assay results demonstrated that the rockbream $\beta$-actin transcripts were ubiquitously but different-tially expressed across the tissues of juveniles.

• Earthquakes and Structures
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• 제14권5호
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• pp.389-398
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• 2018

The seismic isolation system makes a structure isolated from ground motions to protect the structure from seismic events. Seismic isolation techniques have been implemented in full-scale buildings and bridges because of their simplicity, economic effectiveness, inherent stability and reliability. As for the responses of an isolated structure due to seismic events, it is well known that the most uncertain aspects are the seismic loading itself and structural properties. Due to the randomness of earthquakes and uncertainty of structures, seismic response distributions of an isolated structure are needed when evaluating the seismic fragility assessment (or probabilistic seismic safety assessment) of an isolated structure. Seismic response time histories are useful and often essential elements in its design or evaluation stage. Thus, a large number of non-linear dynamic analyses should be performed to evaluate the seismic performance of an isolated structure. However, it is a monumental task to gather the design or evaluation information of the isolated structure from too many seismic analyses, which is impractical. In this paper, a new methodology that can evaluate the seismic fragility assessment of an isolated structure is proposed by using stochastic response database, which is a device that can estimate the seismic response distributions of an isolated structure without any seismic response analyses. The seismic fragility assessment of the isolated nuclear power plant is performed using the proposed methodology. The proposed methodology is able to evaluate the seismic performance of isolated structures effectively and reduce the computational efforts tremendously.

• 수산해양교육연구
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• 제19권3호
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• pp.355-365
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• 2007

This study examined the essential elements of urban fishing ports in the region of Busan in terms of the hydrography, geomorphology, and urban functions of each fishing port and then estimated their development potential. The results were as follows: (1) The ports in the eastern and central parts of the Busan region, used mostly for fishing, were open or quasi-open type ports with ${\Omega}>0.8$, while those of the western part tended to show the reverse. (2) Of the 51 fishing ports, 37.3% were located on land inside the coastline, and structures such as breakwaters had been constructed on both sides of the entrance. Of the total, 47.1% were small fishing ports with water depths of 0~1 m. (3) In the Busan region, 39.2% were urban fishing ports, including Daebyeon and Dadaepo, and 60.8% were non-urban fishing ports.

• 한국자동차공학회논문집
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• 제17권1호
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• pp.80-86
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• 2009

Main bearing cap is one of the essential structural elements in internal combustion engine. Main bearing cap guides and holds the crankshaft, withstanding the full combustion and inertia loads of the engine. A seamless design methodology using FEA has been proposed to produce a reliable design of main bearing cap. A Levy's thick cylinder model was applied to calculate the contact pressure between bearing shell and housing bore. A calculated contact pressure at housing bore is within the allowed limit comparing with that from bearing shell model. An adequate FEA model was suggested to obtain reliable solutions for the durability of main bearing cap. 3D global model consists of engine bulkhead, main bearing cap, and bolts. Sub-model consisting of cap and part of bolts is used to get detailed solution of main bearing cap. A very careful contact modeling practice is needed to resolve the convergence problems frequently encountering during combined geometric and material non-linear problems. A proposed methodology has been applied to the main bearing cap model successfully and obtained reliable stress results and fatigue safety factors.

• Nuclear Engineering and Technology
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• 제42권5호
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• pp.546-551
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• 2010

The objective of this research is to estimate the crack location and size of a carbon steel pipe by using a laser ultrasound guided wave for the wall thinning evaluation of an elbow. The wall thinning of the carbon steel pipe is one of the most serious problems in nuclear power plants, especially the wall thinning of the carbon steel elbow caused by Flow-Accelerated Corrosion (FAC). Therefore, a non-destructive inspection method of elbow is essential for the nuclear power plants to operate safely. The specimens used in this study were carbon steel elbows, which represented the main elements of real nuclear power plants. The shape of the wall thinning was an oval with a width of 120mm, a length of 80mm, and a depth of 5mm. The L(0,1) and L(0,2) modes variation of the ultrasound guided wave signal is obtained from the response of the laser generation/air-coupled detection ultrasonic hybrid system represent the characteristics of the defect. The trends of these characteristics and signal processing were used to estimate the size and location of wall thinning.

• KSBB Journal
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• 제25권6호
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• pp.497-506
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• 2010

Vaccine is a protective clinical measure capable of persuading immune system against infectious agents. Vaccine can be categorized as live attenuated and inactivated. Live attenuated vaccines activate immunity similar to natural infection by replicating living organisms whereas inactivated vaccines are either whole cell vaccines, eliciting immune response by killed organisms,or subunit vaccines, stimulating immunity by non-replicating sub cellular parts. The components of vaccine play a critical role in deciding the immune response mediated by the vaccine. The innate immune responds against the antigen component. Adjuvants represent an importantcomponent of vaccine for enhancing the immunogenicity of the antigens. Subunit vaccines with isolated fractions of killed and recombinant antigens are mostly co-administered with adjuvants. The delivery system of the vaccine is another essential component to ensurethat vaccine is delivered to the right target with right dosage form. Furthermore, vaccine delivery system ensures that the desired immune response is achieved by manipulating the optimal interaction of vaccine and adjuvantwith the immune cell. The aforementioned components along with routes of administration of vaccine are the key elements of a successful vaccination procedure. Vaccines can be administered either orally or by parenteral routes. Many groups had made remarkable efforts for the development of new vaccine and delivery system. The emergence of new vaccine delivery system may lead to pursue the immunization goals with better clinical practices.

• 한국소음진동공학회논문집
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• 제12권7호
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• pp.542-549
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• 2002

Computer simulation is essential to design the suspension elements of railway vehicle. By computer simulation, engineers can assess the feasibility of given design variables and chance them to get a bettor design. Even though commercial simulation codes are used, the computational time and cost remains non-trivial. Therefore, malty researchers have used a mesa model made by sampling data through simulation. In this paper, four mesa-models for each index group such as ride comfort, derailment Quotient, unloading radio and stability index, are constructed by use of neural network. After these meta models are constructed, multi-objective optimization are achieved by using the differential evolution. This paper shows that the optimization of design variables using the neural network model is very efficient to solve the complex optimization Problem.

• Gut and Liver
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• 제12권6호
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• pp.615-622
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• 2018

Despite the well-proven, safe and effective therapies for hepatitis B infection, delivery of treatment remains a significant challenge in resource-poor settings. Geopolitical and economic restrictions present additional difficulties in providing care in North Korea. However, treatment of patients with chronic hepatitis B remains a top priority for both the North Korean Ministry of Public Health and international agencies working in North Korean hepatitis healthcare facilities. Working in partnership, a path was created to institute this much-needed program. A consortium of United States and Australian humanitarian non-governmental organizations along with generous individual and corporate donors working in concert with local and national health authorities have succeeded in establishing the first hepatitis B treatment program in North Korea. The essential elements of this program include renovation of existing hepatitis hospitals, access to antiviral medications, establishment of laboratory facilities, creation of medical documentation and record-keeping, training of local health care professionals, and quarterly visits by international volunteer physicians and laboratory experts. Management and treatment decisions are made bilaterally. To date, nearly 1,500 patients have been evaluated, and over 800 have been started on long-term antiviral therapy. It is envisioned that this program will eventually be managed and funded by the Democratic People's Republic of Korea Ministry of Public Health. This program's success demonstrates a potential model for delivery of antiviral therapy for patients suffering from hepatitis B in other developing countries.

• Patent21
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• 통권93호
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• pp.30-37
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• 2011

지적재산(IP)은 때때로 이해당사자들 간의 이익에 대항하여 신뢰의 기반을 약하게 만들고 그 과정을 더디게 만들지만, 표준 발전에 있어서는 필수적이다. 더디게 진행되거나 실재하지 않는 표준의 발전은 국제적으로 인정된 표준을 발전시킬 수 있는 잠재적 시장의 손실로 직결된다. 표준 발전 기관들(SDO)은 공정성과 신뢰를 확실히 다짐으로써 새로운 시장을 형성할 수 있다. IEEE 표준 협회 (IEEE-SA)는 표준발전기관으로서, 국제적으로 인정된 특허 정책을 가지고 그 결과를 용이하게 만들 수 있도록 특정한 단계를 정의하고 있다. 이 칼럼은 IEEE-SA의 정책 수립에 지침서가 되는 근본적인 원칙들과, 정책의 다섯 가지 주요 요소들을 설명하고, 표준개발자들과 관계자들이 표준 형성 과정의 성공과 시장발전의 도모를 위한 특정한 기대치에 동의할 수 있도록 하는 IP와 표준의 통합과정을 제시한다.

• 국제학술발표논문집
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• The 9th International Conference on Construction Engineering and Project Management
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• pp.1059-1066
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• 2022

In 2020, it was estimated that more than 2.4 million households in South Korea are over 30 years old. That is, more than 40% of all houses in Korea are old and that they require proper rehabilitation. The two options to improve poor living conditions are reconstruction and remodeling. Compared to reconstruction, remodeling has advantages in terms of the construction period, cost, and environmental impact. As such, the current Korean regulations are more favorable for remodeling than reconstruction. Typically, several candidate floor plans are presented in the early stages of an apartment remodeling project. Extracting information about bearing walls and other structural elements from the multiple plans to compare those plans quantitatively is one of the essential tasks during the early stage of a project. To cope with this task, an automated data extraction method for walls and slabs from before and after remodeling plans is developed. Through the developed program, load-bearing walls, non-bearing walls, slabs, and weight changes after remodeling can be analyzed and visualized in a fast and automated manner.