• Journal of the Korean GEO-environmental Society
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• v.14 no.6
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• pp.5-11
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• 2013

Because the regulation for a noise and a vibration in our country has been being reinforced more and more, a more environment-friendly pile construction method than a current low-noise and low-vibration method was needed for the close construction in the downtown area. In this study, the characteristics of a screw concrete pile method for noise and vibration-free method was explained, and it's vertical bearing capacity was studied in the base of the static pile load test data of the screw concrete piles. Constructed by two methody; a pre-digging shoe type construction method and a toe-jetting shoe type construction method. The vertical load bearing capacity of a screw pile constructed by the former was more about 70% than that of a screw pile constructed by the latter.

• Biomolecules & Therapeutics
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• v.18 no.2
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• pp.152-158
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• 2010

Melanin concentrating hormone is a neuropeptide highly expressed in the brain that regulates several physiological functions mediated by receptors in the G-protein coupled receptor family, especially plays an important role in the complex regulation of energy balance and body weight mediated by the melanin concentrating hormone receptor subtype 1 (MCH1). Compelling pharmacological evidence implicating MCH1 signaling in the regulation of food intake and energy expenditure has generated a great deal of interest by pharmaceutical companies as MCH1 antagonists may have potential therapeutic benefit in the treatment of obesity and metabolic syndrome. Although fluorescence-based calcium mobilization assay platform has been one of the most widely accepted tools for receptor research and drug discovery, fluorescence interference and shallow assay window limit their application in high throughput screening and have led to a growing interest in alternative, luminescence-based technologies. Herein, a luminescence-based functional assay system for the MCH1 receptor was developed and validated with the mitochondrial targeted aequorin. Aequorin based functional assay system for MCH1 presented excellent Z' factor (0.8983) and high signal-to-noise ratio (141.9). The nonpeptide MCH1 receptor antagonist, SNAP 7941 and GSK 803430, exhibited $IC_{50}$ values of 0.62 ${\pm}$ 0.11 and 12.29 ${\pm}$ 2.31 nM with excellent correlation coefficient. These results suggest that the aequorin based assay system for MCH1 is a strong alternative to the traditional GPCR related tools such as radioligand binding experiments and fluorescence functional determinations for the compound screening and receptor research.

• Journal of Biomedical Engineering Research
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• v.14 no.1
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• pp.41-50
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• 1993

This paper proposes an adaptive technique for the cardiac output regulation of a pendulum type electromechanical TAH. This techinque, which consists of two RLSE's and two PASTC' 5, performs Its controllability over the TAIB so that the m(RAP) and m(LAP) values re- main close to their desired values under she assumption that the variation of m(RAP) and m (LAP) are dominated by the variation of C.0. and the difference between the left and right ventricular output, respectively. To evaluate the performance of the proposed control system, a simulation is performed by using a human model which contains physiologic, drug and treatment, artificial heart and noise models. As a result, dual adaptive controller showed that abnormal m(LAP) and m(RAP) could be recovered to the normal range within 10minute and maintained desired value in steady state. The operation of this controller prored to be robust in spite of the rapid variation of human status.

• BMB Reports
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• v.51 no.6
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• pp.280-289
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• 2018

Previously considered as a component of transcriptional noise, long noncoding RNAs (lncRNAs) were neglected as a therapeutic target, however, recently increasing evidence has shown that lncRNAs can participate in numerous biological processes involved in genetic regulation including epigenetic, transcriptional, and post-transcriptional regulation. In this review, we discuss the fundamental functions of lncRNAs at different regulatory levels and their roles in metabolic balance. Typical examples are introduced to illustrate their diverse molecular mechanisms. The comprehensive investigation and identification of key lncRNAs will not only contribute to insights into diseases, such as breast cancer and type II diabetes, but also provide promising therapeutic targets for related diseases.

• Journal of the Korean Society for Precision Engineering
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• v.15 no.1
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• pp.117-129
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• 1998

Micro-hole drilling (holes less than 0.5 mm in diameter with aspect ratio larger than 10) is recently having more attention in a wide spectrum of precision production industries. Alternative methods such as EDM. laser drilling, etc. can sometimes replace the mechanical micro-hole drilling but are not acceptable in PCB manufacture because of the inferior hole quality and accuracy. The major difficulties in micro-hole drilling are related to small signal to noise ratios, wandering motions of the inlet stage, high aspect ratios, high temperatures and so forth. Of all the difficulties. the most undesirable one is the increase of drilling force as the drill proceeds deeper into the hole. This is caused mainly from the chip effects. Peck-drilling is thus widely used for deep hole drilling despite that it suffers from low productivity. In the paper, a method of cutting force regulation is proposed to achieve continuous drilling. A PD and a sliding mode control algorithms were implemented through controlling the spindle rotating frequency. Experimental results show that the sliding mode control reduces the nominal cutting force and the variation of the cutting force better than the PD control. The advantages of the regulation, such as increase of drill life, fast stabilization of a wandering motion, and the precise positioning of the hole are verified in experiment.

• Journal of the Korean Society of Safety
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• v.29 no.4
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• pp.172-179
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• 2014

This research suggests that the regulation, design and improvement of domestic and international ambulances so that make the basis for the future ambulance in Korea. It is true that the diversification of current disasters, increasing elderly population, the increase in emergency patients, due to the lack of effective transfer system, emergency vehicle's performance problem, and the aging of ambulances cause have difficulty in providing effective emergency services in domestic country. Therefore, in order to improve the effectiveness of ambulance, the history of ambulance, other relevant provisions include international, design and directions to be improved were investigated, and also research directions of the ambulance are suggested in domestic country. In this research, suggests the following conclusions to improve domestic ambulance 1. Through standardization of the spacing and location of an ambulance is needed to maximize the treatment room. 2. The interior of the ambulance design for hygiene and infection control should be included. 3. Stretcher and equipment are designed to be fitted to each other should be standardized. 4. Especially during transfer maintain the road, noise, vibration, and shock-absorbing function to emphasize the importance. 5. The improvement of ergonomic design is necessary for the possibility of applying to many people.

• Transactions of the Korean Society of Automotive Engineers
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• v.22 no.7
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• pp.84-89
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• 2014

Not only the emission regulation of on-road vehicle engine, but also emission regulation of off-road engine have been reinforced. It is the reason of wide application of emission reduction technology for off-road engines. In this study, optimization of engine parameters (Injector hole number, Injection timing and EGR rate) for reduction of NOx and smoke emissions were conducted by using the analysis of sensitivity and S/N ratio of Taguchi method(DOE). As results, this paper shows optimum value of the parameters for NOx and smoke emission reduction. From the result of reproducibility verification, it is final that the prediction value of NOx and smoke has the error of below 10%. Consequently, the method and results of this study will be used for quantitative reference to EGR control mapping in next study.

• Journal of Navigation and Port Research
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• v.33 no.3
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• pp.175-180
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• 2009

In this study, the basic data were collected for improving the amenity of indoor environment of a super yacht and the performance of indoor environment was analyzed by utilizing measured data during summer period. Through the results of examination, the following conclusions are drawn. 1) It is estimated that, in case of closing the door of Saloon connected with outside, there is little inflow of exhaust gas, but when the door is open, the indoor-air might be polluted so fast. Therefore, it is necessary to make a counter plan about the method of ventilation and amount of ventilation to keep the indoor aerial environment agreeable. 2) It is urgent to conceive countermeasure against engine noise because the noise level of all rooms exceeds 60dB, which is regulation of noise for protecting crew established in ship's classification, during the sailing. 3) State cabin and Guest cabin are super cooled by operating air conditioner exceeding agreeableness extent and it is needed to prevent them.

• Journal of Preventive Medicine and Public Health
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• v.10 no.1
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• pp.94-101
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• 1977

Noise pollution, both in the environment and in the workplace, has been recognized as a major health hazard -one that can impair not only a person's hearing but also his physical and mental well-being. As industrialization progresses, the prevalence rate of occupational diseases is increasing, especially hearing loss, which has the highest prevalence rate among the occupational diseases. The major cause of noise is the construction of various large industries without any regulation of noise sources. Therefor, we must establish an enactment to control mechanical noise sources. as soon as possible. For the purpose of controlling the noise source, we must have exact data about such things as the sound level, the frequency of the peak sound and the revolutions per minute (r.p.m.) of the machine (a measure of the power of its motor). This study was undertaken in order to define the noise characteristics, the power of the machine's motor, the change of the sound level and the peak sound as the r.p.m. increases, and the permissible exposure time. The sample size of this study was 74 machines at 11 plants in 6 industries. The results are as follows; 1. The breakdown of the types of mechanical noise noted was : 63.6% continuous normal sound, 26.9% intermittent sound, 4.7% continuous repeating sound and 4.6% impulsive sound. 2. With respect to the type of industry, the overall sound level was the highest in the mechanical industry, with $103.8{\pm}2.8dB(A)$, and lowest in the textile industry, with $89.2{\pm}1.43dB(A)$. 3. With respect to the type of machine, the highest sound level was 124 dB(A) caused by Gauzing(II), in the mechanical industry, and the lowest was 76 dB(A) caused by Attachment (Jup Chack) (I) in the timber industry. 4. The shortest permissible exposure time to Gauzing(II) in the mechanical industry was less than 15 minutes. 5. Among 74 machines, 68.2% of the peak sound was situated in the high frequency range (52.7% at 2 KHz, 4.1% at 4 KHz and 1.4% at 8 KHz). 41.8% of the peak sound was in the middle frequency range (4.1% at 250Hz, 14.8% at 500Hz and 22.9% at 1KHz). 6. If one machine had two motors or more, the peak sound was shifted to the low frequency range. 7. As the r.p.m. increased, the overall and peak sound levels were increased without any change of the frequency of the peak sound. 8. Whenever the machines had the same kind and the same r.p.m., the overall and peak sounds were changed by the physicochemical characteristics of the raw materials and the management.

• Journal of Korean Society of Environmental Engineers
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• v.31 no.8
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• pp.635-640
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• 2009

After 1960s, in accordance with getting bigger in changing range of annual rain precipitation, those dams were built in order to prevent any drought and flood through the regulation of flux. In case of such dam, when it reaches to some definite pondage, for its regulation of water volume, numerous volume of water in the reservoir should be discharged by opening the floodgate, at this time a severe damage can be occurred to those lives and properties of the residents and tourists at the river or riverside. Accordingly, despite the sounding alarm broadcasting for prevention and notice such damage could be clearly travelled to those people without influence by the discharging noise or other neighboring environmental factor, since it was only empirically installed without any peculiar research until now, the alarm broadcasting could not effectively travel, and the travelling distance also could not known correctly. On such point of view, this Study has ever grasped the characteristics by frequencies and its sound pressure level about the discharge noise and the alarm broadcasting of Daechung Dam, one of multipurpose dams through the measurement and analysis by distances, and based on this, also has ever presupposed the proper location of additional alarm broadcasting spot using a simulation program named Cadna-A.