• Title/Summary/Keyword: Nodules

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Gene Regulations in HBV-Related Liver Cirrhosis Closely Correlate with Disease Severity

  • Lee, Se-Ram;Kim, So-Youn
    • BMB Reports
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    • v.40 no.5
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    • pp.814-824
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    • 2007
  • Liver cirrhosis (LC) is defined as comprising diffuse fibrosis and regenerating nodules of the liver. The biochemical and anatomical dysfunction in LC results from both reduced liver cell number and portal vascular derangement. Although several studies have investigated dysregulated genes in cirrhotic nodules, little is known about the genes implicated in the pathophysiologic change of LC or about their relationship with the degree of decompensation. Here, we applied cDNA microarray analysis using 38 HBsAg-positive LC specimens to identify the genes dysregulated in HBV-associated LC and to evaluate their relation to disease severity. Among 1063 known cancer- and apoptosis-related genes, we identified 104 genes that were significantly up- (44) or down- (60) regulated in LC. Interestingly, this subset of 104 genes was characteristically correlated with the degree of decompensation, called the Pugh-Child classification (20 Pugh-Child A, 10 Pugh-Child B, and 8 Pugh-Child C). Patient samples from Pugh-Child C exhibited a distinct pattern of gene expression relative to those of Pugh-Child A and B. Especially in Pugh-Child C, genes encoding hepatic proteins and metabolizing enzymes were significantly down-regulated, while genes encoding various molecules related to cell replication were up-regulated. Our results suggest that subsets of genes in liver cells correspond to the pathophysiologic change of LC according to disease severity and possibly to hepatocarcinogenesis.

Two Cases of Non-Calcifying Pilomatrixoma in Elderly Individuals (성인에서 발생한 비석회화 모기질종 2예)

  • Lee Dong-Hee;Jun Beom-Cho;Song Chang-Eun;Im Dong-Jae
    • Korean Journal of Head & Neck Oncology
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    • v.22 no.1
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    • pp.55-57
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    • 2006
  • Pilomatrixoma is an unusual benign cutaneous tumor, originating from precursor cells that normally differentiate into hair matrix cells. The majority of pilomatrixoma is seen in the first two decades of life, and they are extremely rare in older patients. Thus, pilomatrixoma is often not considered in the clinical differential diagnosis of solitary, firm nodules in older adults. Most present as firm, solid nodules in the head and neck region. We present two cases of a non-calcifying pilomatrixoma in older patients. One lesion arose from the upper neck in 54 year-old male and the other from the cavum concha of left ear in 35 year-old male.

Rare Form of Rheumatoid Nodule around Ischial Tuberosity Mimicking Ischiogluteal Bursitis

  • Lim, Joo Hee;Shim, Jae-Chan;Yoon, Byung-Ho;Kang, Yun Kyung;Lee, Kyoung Eun;Kim, Ho Kyun;Lee, Ghi Jai;Suh, Jung Ho
    • Investigative Magnetic Resonance Imaging
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    • v.21 no.2
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    • pp.97-101
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    • 2017
  • We are reporting about a case of a rheumatoid nodule, beneath the ischial tuberosity, mimicking ischiogluteal bursitis. Rheumatoid nodules are frequently seen, at the subcutaneous soft tissues of repetitive mechanical irritation points, and prominent bones. There have been no reported cases of rheumatoid nodules, extending just beneath the ischial tuberosity bone. A 68-year-old woman with a seven-year history of rheumatoid arthritis, suffered for six months, from right buttock swelling and discomfort in seating. A cystic lesion postero-inferior to the ischial tuberosity, was noted in the MRI scan, which was thought to be ischiogluteal bursitis, because of its characteristic location and appearance. Histopathologic analysis and gross findings on the operation, revealed no evidence of bursitis.