• Journal of Gastric Cancer
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• 제11권2호
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• pp.69-77
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• 2011

Purpose: In an effort to examine the clinicopathological characteristics of GC and the status of its surgical treatment, the Korean Gastric Cancer Association (KGCA) conducted a nationwide survey targeting surgically-treated gastric cancer patients in 2009. Materials and Methods: A standardized electrical case report was sent to every member institution of the KGCA via E-mail with detailed instructions regarding the survey data. Completed data forms were retrieved from each institution and analyzed by the KGCA information committee. Results: Data on 14,658 patients was collected from 59 institutions. The mean patient age was $59.2{\pm}11.9$ years with a male to female ratio of 2.05 : 1. Lower third cancer (56.0%) was the most common among all gastric cancers. The histological type revealed poorly differentiated adenocarcinoma (34.1%) to be the most common, and the Lauren classification revealed the intestinal type (50.0%) to be the most prevalent. Curative surgery was performed in 92.4% of patients with laparoscopic surgery in 25.8% of patients. A Billroth I reconstruction was performed most frequently after a distal gastrectomy (63.4% of distal gastrectomy). T1 cancers accounted for 57.6% of all cases, and 62.6% of patients showed no lymph node metastasis. Compared to previous reports, it was found that patients are becoming older, laparoscopic surgery is being performed increasingly, and the proportion of T1 cancer is increasing with time. Conclusions: This survey presented the clinicopathological characteristics and current status of the surgical treatment of gastric cancer in Korea. This survey is expected aid research studies as well as planning and evaluation programs targeting cancer control.

• Journal of Gastric Cancer
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• 제14권4호
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• pp.252-258
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• 2014

Purpose: The macroscopic diagnosis of tumor invasion through the serosa during surgery is not always distinct in patients with gastric cancer. The prognostic impact of the difference between macroscopic findings and pathological diagnosis of serosal invasion is not fully elucidated and needs to be re-evaluated. Materials and Methods: A total of 370 patients with locally advanced pT2 to pT4a gastric cancer who underwent curative surgery were enrolled in this study. Among them, 155 patients with pT3 were divided into three groups according to the intraoperative macroscopic diagnosis of serosal invasion, as follows: serosa exposure (SE)(-) (no invasion, 72 patients), SE(${\pm}$) (ambiguous, 47 patients), and SE(+) (definite invasion, 36 patients), and the clinicopathological features, surgical outcomes, and disease-free survival (DFS) were analyzed. Results: A comparison of the 5-year DFS between pT3_SE(-) and pT2 groups and between pT3_SE(+) and pT4a groups revealed that the differences were not statistically significant. In addition, in a subgroup analysis of pT3 patients, the 5-year DFS was 75.1% in SE(-), 68.5% in SE(${\pm}$), and 39.4% in SE(+) patients (P<0.05). In a multivariate analysis to evaluate risk factors for tumor recurrence, macroscopic diagnosis (hazard ratio [HR], SE(-) : SE(${\pm}$) : SE(+)=1 : 1.01 : 2.45, P=0.019) and lymph node metastasis (HR, N0 : N1 : N2 : N3=1 : 1.45 : 2.20 : 9.82, P<0.001) were independent risk factors for recurrence. Conclusions: Gross inspection of serosal invasion by the surgeon had a strong impact on tumor recurrence in gastric cancer patients. Consequently, the gross appearance of serosal invasion should be considered as a factor for predicting patients' prognosis.

• Journal of Gastric Cancer
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• 제16권3호
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• pp.141-151
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• 2016

Purpose: The aim of the present study was to elucidate the clinicopathological significance and diagnostic accuracy of immunohistochemistry (IHC) for determining the mesenchymal epidermal transition (c-MET) expression in patients with gastric cancer (GC). Materials and Methods: The present meta-analysis investigated the correlation between c-MET expression as determined by IHC and the clinicopathological parameters in 8,395 GC patients from 37 studies that satisfied the eligibility criteria. In addition, a concordance analysis was performed between c-MET expression as determined by IHC and c-MET amplification, and the diagnostic test accuracy was reviewed. Results: The estimated rate of c-MET overexpression was 0.403 (95% confidence interval [CI], 0.327~0.484) and it was significantly correlated with male patients, poor differentiation, lymph node metastasis, higher TNM stage, and human epidermal growth factor receptor 2 (HER2) positivity in IHC analysis. There was a significant correlation between c-MET expression and worse overall survival rate (hazard ratio, 1.588; 95% CI, 1.266~1.992). The concordance rates between c-MET expression and c-MET amplification were 0.967 (95% CI, 0.916~0.987) and 0.270 (95% CI, 0.173~0.395) for cases with non-overexpressed and overexpressed c-MET, respectively. In the diagnostic test accuracy review, the pooled sensitivity and specificity were 0.56 (95% CI, 0.50~0.63) and 0.79 (95% CI, 0.77~0.81), respectively. Conclusions: The c-MET overexpression as determined by IHC was significantly correlated with aggressive tumor behavior and positive IHC status for HER2 in patients with GC. In addition, the c-MET expression status could be useful in the screening of c-MET amplification in patients with GC.

• 한국인터넷방송통신학회논문지
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• 제14권6호
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• pp.75-84
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• 2014

과부하 및 단일장애점(Single Point of Failure), 경로 비최적화, 망 확장성 등의 문제점을 가지고 있는 기존 중앙 집중형 이동성 관리 프로토콜들의 문제점을 해결하기 위해 최근 IETF를 중심으로 분산 이동성 관리 방안이 활발히 연구되고 있다. 본 논문에서는 망기반 부분분산형 이동성 관리 메커니즘 pDMMv6를 제시하고, 시뮬레이션을 통해 다양한 사용자 트래픽 환경에서 기존의 PMIPv6 및 MIPv6 프로토콜과의 성능 비교를 수행하였다. 성능분석 결과로는 UDP 트래픽의 전송율, 단대단 패킷 전송지연시간, 신호 메시지 바인딩 지연시간, 노드별 CPU 점유율 및 다양한 서버-클라이언트 TCP 응용에 따른 응답시간(웹 브라우징, 이메일 송수신, 텔넷 원격접속, FTP 파일전송, 데이터베이스 액세스 등)들을 제시하였다.

• 한국인터넷방송통신학회논문지
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• 제13권6호
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• pp.203-210
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• 2013

무선 애드혹 네트워크에서는 제한된 대역폭, 간섭, 높은 패킷 에러율로 인하여 영상과 같은 고속 데이터 전송 시 높은 전송 품질을 제공하기 어렵다. 본 논문에서는 이러한 제약을 극복하고 고품질의 고속 멀티미디어 데이터 전송을 제공하기 위하여 패킷전송성공률 기반의 종단간 경로 품질과 각 중계노드에서의 잔여 대역폭 예측을 이용하는 PBBR (Path-Quality and Bandwidth-Estimation Based Routing) 프로토콜을 제안한다. 제안된 프로토콜의 성능을 검증하기 위하여 NS2를 이용한 시뮬레이션이 수행되었으며, 시뮬레이션 결과는 제안되는 프로토콜이 기존의 라우팅 프로토콜에 비해 높은 Throughput을 획득할 수 있음을 보인다.

• Journal of Communications and Networks
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• 제7권3호
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• pp.325-336
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• 2005

Mobile ad hoc networks (MANET) are composed of moving wireless hosts which, within range of each other, form wireless networks. For communication to occur between hosts that are not within each other's range, routes involving intermediate nodes must be established; however, since the hosts may be in motion, a host that was part of a route may move away from its upstream and downstream partners, thus breaking the route. In this paper, we propose anticipated route maintenance (ARM) protocol with two extensions to route discovery based routing scheme: Extend the route when nodes on a link move apart from each other and they have common neighbor that can be 'inserted' in the path, and shrink route when a node discovers that one of its neighbor which is not the next hop is also on the same route several hops later on. By utilizing only local geographic information (now a part of some route finding algorithms), a host can anticipate its neighbor's departure and, if other hosts are available, choose a host to bridge the gap, keeping the path connected. We present a distributed algorithm that anticipates route failure and performs preventative route maintenance using location information to increase a route lifespan. The benefits are that this reduces the need to find new routes (which is very expensive) and prevents interruptions in service. As the density of nodes increases, the chance to successfully utilize our route maintenance approach increases, and so does the savings. We have compared the performance of two protocols, pure dynamic source routing (DSR) protocol and DSR with ARM. The simulation results show how ARM improves the functionality of DSR by preventing the links in the route from breaking. Packets delivery ratio could be increased using ARM and achieved approximately $\100%$ improvement. The simulations clarify also how ARM shows a noticeable improvement in dropped packets and links stability over DSR, even though there is more traffic and channel overhead in ARM.

• Journal of Advanced Marine Engineering and Technology
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• 제36권6호
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• pp.850-856
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• 2012

고정노드 2개를 사용하는 이변측위 방법은 건물이나 선박의 복도와 같은 좁은 공간에서 실시간 실내위치인식 시스템 분야에 사용되고 있다. 하지만 이러한 공간에서 고정노드 간 거리가 멀어지거나 장애물이 있을 경우 위치정보 수신율 저하로 인하여 이동노드(사용자)의 위치 추정이 어렵게 된다. 본 논문에서는 이와 같은 문제를 보완하기 위하여 IEEE 802.15.4a Chirp 신호를 기반으로 사용자에게 부착된 센서를 통하여 위치를 계산할 수 있는 보폭 측정 알고리즘을 이용하는 새로운 실시간 실내위치인식 시스템을 제안한다. 제안한 시스템은 다리길이 측정을 위한 초음파센서, 사용자의 방향을 인식하는 지자기 센서 및 다리사이 각을 획득하기 위한 관성센서로 구성된다. 실험 결과 제안한 시스템은 통신도달성이 결여된 구간에서 기존 실내위치인식 방법에 비해 2배 이상 정교한 결과를 나타내었다.

• 생물환경조절학회지
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• 제23권2호
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• pp.65-70
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• 2014

개량머루의 시기별 생육 특성을 구명하기 위하여 액아 발달, 과실 품질, 과실 조직의 해부학적 발달과정을 관찰하였다. 액아는 신초 발생부터 낙엽기까지 가지에서 마디 위치에 관계없이 괴사가 전혀 발생하지 않아 모두 충실하였다. 성숙기 과실 특성은 과립중 1.2g, 과립수 98개 및 과방중 128.8g이었고, 당도 $16.9^{\circ}Brix$, 적정산도 1.57%이었다. 당의 조성은 과당과 포도당이었고 성숙기의 과당과 포도당의 비는 1:1에 도달하였다. 사과산이 유기산 중에서 가장 많았으며 시기별 적정 산도의 변화가 일치하였다. 당과 산은 변색 1주전부터 급격하게 변화하였다. 배주의 퇴화는 수정 전후에 모두 발견되었고 성숙기의 과피는 1층의 epidermis와 7~10층의 hypodermis로 구성되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.4077-4080
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• 2015

The chemokine receptor 4 (CXCR4) has been widely used in diagnosis and prognosis of colorectal cancer (CRC). However, there is no current consensus on the impact of CXCR4 on CRC patients. The purpose of this study was to evaluate the prognostic and clinicopathological importance of CXCR4 in CRC patients. Databases, such as PubMed, Cochrane library, CBM and EMBASE updated to 2014 were searched to include eligible articles. We analysed correlations between CXCR4 expression and clinicopathological features and overall survival (OS). A total of 1, 055 CRC patients from twelve studies were included in the study. The pooled odds ratios (ORs) which indicated CXCR4 expression was likely to be associated with TNM stage (OR=0.43, CI=0.34-0.55, P<0.00001), lymph node status (OR=2.23, CI=1.23-4.05, P=0.008) and vascular invasion (OR=2.21, CI=1.11-4.39, P=0.02). Poor overall survival of CRC cancer was found to be significantly related to CXCR4 overexpression (hazard ratio (HR) 1.36 CI=1.17-1.59, P<0.0001), whereas combined ORs revealed that CXCR4 expression had no correlation with gender or differentiation. Based on the published studies, CXCR4 overexpression in patients w ith CRC indicates poor survival outcome and clinicopathological factors.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6335-6338
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• 2015

Background: Cancers have dysfunctional redox regulation resulting in production of reactive oxygen species (ROS), damaging DNA, RNA and free NTPs, and causing the accumulation of oxidative nucleic acids in cytoplasm. The major types are 8-oxo-7,8-dihydroguanine(8-oxoGsn) in RNA and 8-oxo-7,8-dihydro-2' deoxyguanosine(8-oxodGsn) in Mt-DNA. The MTH1 protein sanitizes oxidized nucleotide pools from NTPs to monophosphates, preventing the occurrence of transversion mutations. This study concerned cytoplasmic 8-oxodGsn/Gsn and MTH1 expression in gastric cancer and para-cancer tissues and elucidated roles of nucleic-acid oxidation and anti-oxidation. Materials and Methods: A polymer HRP detection system was used to detect 8-oxo-Gsn/dGsn and MTH1 expression in 51 gastric cancer and para-cancer tissue samples. Analyses of patient clinical and pathological data were also performed. Results: The expression of MTH1 and the 8-oxo-dGsn/Gsn ratio were significantly higher in cancer tissues than para-cancer tissues (P<0.05). Cytoplasmic 8-oxo-Gsn and MTH1 were both found to positively correlate (P<0.05) with tumor differentiation, while no significant associations were found with gender, age, invasion depth, lymph node metastasis and clinical stage (P>0.05). Conclusions: We found 8-oxo-dGsn/Gsn and MTH1 are both highly expressed in gastric cancer tissues, especially in well differentiated lesions. In addition, oxidated mtDNA is prevalently expressed in gastric cancers, while 8-oxo-Gsn expression in cytoplasmic RNA is a bit lower, but more selectively.