• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.2195-2199
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• 2014

Background: Despite being rare in incidence, malignant tumors of major salivary glands show diverse histological variation. There are limited data on major salivary gland tumor management and outcome from Pakistan. The objective of this study was to share our experience with management of malignant tumors of major salivary glands. Materials and Methods: Patients who received treatment at Shaukat Khanum Cancer Hospital and Research Center from July 2002 to June 2011 with an underlying diagnosis of a major salivary gland malignancy were included. Patient characteristics and treatment modalities were assessed. Local, regional and distant failures were determined. Disease free survival (DFS) and overall survival (OS) were calculated using Kaplan Meier curves and the Log rank test was used to determine statistical significance. Univariate and multivariate analyses were performed using Cox proportional hazard regression. Results: The parotid gland was the primary site of origin in 104 (80%) patients. Mucoepidermoid carcinoma (43%) and adenoid cystic carcinoma (24%) were the most common histological types. Surgery followed by adjuvant radiation remained the mainstay treatment modality with 81 (62%) patients. Nineteen (15%) patients were treated with surgery alone and 30 (23%) patients with locally advanced surgically inoperable tumors received radiation only. Forty one (32%) patients failed the treatment (local 12, regional 11, locoregional 5, distant 13). The expected 5 year DFS and OS were 65% and 74% respectively. On multivariate analysis, grade was the only independent predictor of DFS and nodal involvement was the only independent predictor of overall survival. Conclusions: Employing existing standards of treatment, comparable survival can be achieved in Pakistani population with major salivary gland malignancies as elsehwere in the world.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.29 no.9 s.240
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• pp.1209-1216
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• 2005

Three methods for design sensitivity such as numerical differentiation, analytical method and semi-analytical method have been developed for the last three decades. Although analytical design sensitivity analysis is exact, it is hard to implement for practical design problems. Therefore, numerical method such as finite difference method is widely used to simply obtain the design sensitivity in most cases. The numerical differentiation is sufficiently accurate and reliable for most linear problems. However, it turns out that the numerical differentiation is inefficient and inaccurate because its computational cost depends on the number of design variables and large numerical errors can be included especially in nonlinear design sensitivity analysis. Thus semi-analytical method is more suitable for complicated design problems. Moreover semi-analytical method is easy to be performed in design procedure, which can be coupled with an analysis solver such as commercial finite element package. In this paper, implementation procedure for the semi-analytical design sensitivity analysis outside of the commercial finite element package is studied and computational technique is proposed, which evaluates the pseudo-load for design sensitivity analysis easily by using the design variation of corresponding internal nodal forces. Errors in semi-analytical design sensitivity analysis are examined and numerical examples are illustrated to confirm the reduction of numerical error considerably.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.9 no.3
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• pp.1-12
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• 1989

The nonlinearity of a cable-stayed bridge results from the large displacement of main girder due to a long span, the catenary action of cables and the flexural stiffness reduced by large axial forces. The dynamic behaviour of a cable-stayed bridge plays an important role in determining its safety. Especially, when the eccentrically moving load is applied to a cable-stayed bridge, the torsional vibration and vertical vibration are coupled and moreover the variation of cable tensions shows important dynamic characteristics. This dissertation presents a theoretical study and a finite element procedure for analysis of a cable-stayed bridge under a eccentrically moving load. Attention is focused on the dynamic behaviours such as dynamic increments of cable tensions and nodal displacements, with the variety of velocities and eccentricities of moving load. It is found that a moving load with eccentricity can have significant effects upon the responses; the torsion of bridge deck and the increments of cable tensions, according to the present results in this study.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.18 no.1
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• pp.116-121
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• 2009

Thermosonic flip chip bonding is an important technology for the electronic packaging due to its simplicity, cost effectiveness and clean and dry process. Mechanical properties of the horn and the shank, such as the natural frequency and the amplitude, have a great effect on the bonding capability of the transverse flip chip bonding system. In this research, two kinds of study are performed. The first is the new design of the clamp and the second is the effect of tolerance parameters to the performance of the system. The clamp with a bent shape is newly designed to hold the nodal point of the flip chip. The second is the effect of the design parameters on the vibration amplitude and planarity at the end of the shank. The variation of the tolerance parameters changes the amplitude and the frequency of the vibration of the shank. They, in turn, have an effect on the quantity of the plastic deformation of the gold ball bump, which determined the quality of the flip chip bonding. The tolerance parameters that give the great effect on the amplitude of the shank are determined using Taguchi's method. Error of set-up angle, the length and diameter of horn and error of the length of the shank are determined to be the parameters that have peat effect on the amplitude of the system.

• Restorative Dentistry and Endodontics
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• v.20 no.2
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• pp.655-669
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• 1995

Restorative procedures can lead to weakening tooth due to reduction and alteration of tooth structure. It is essential to prevent fractures to conserve tooth. Among the several parameters in cavity designs, cavity isthmus is very important. In this study, amalgam 0 cavity was prepared on maxillary first premolar. Two dimensional finite element models were made by serial photographic method and isthmus(1/4, 1/3, 1/2, 2/3 of intercuspal distance) were varied. Three or four-nodal mesh were used for the two dimensional finite element models. The periodontal ligament and alveolar bone surrounding the tooth were excluded in these models. 1S model was sound tooth with no amalgam cavity. B model was assumed perfect bonding between the restoration and cavity wall. Both compressive and tensile forces were distributed directly to the adjacent regions. A load of 500N was applied vertically at the first node from the lingual slope of the buccal cusp tip. This study analysed von Mises stress, 1 and 2 directional normal stress and Y and Z axis translation with FEM software Super SAPII Version 5.2 (Algor Interactive System Co.) and hardware 486 DX2 PC. The results were as :follows : 1. 1S model was slightly different with 1B model in stress distibution. 1S, 2B, 3B, 4B models showed similiar stress distribution. 2. 1S model and four B models showed similiar pattern in Y axis and Z axis translation. 3. 1S model and four B models showed the bending phenomenon in the translation. 4. As increasing of the width of the cavity, experimental group was similiar with the control group in stress distribution. 5. As increasing of the width of the cavity, experimental group was similiar with the control group in Y and Z axis tranlation.

• Journal of Korean Society of Water and Wastewater
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• v.13 no.3
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• pp.73-82
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• 1999

In this study, the optimal analysis for pipe network is performed for the combined ideal pipe network system(CASE 1, CASE 2 and CASE 3) which is composed of 25 nodes, 41 elements, and 1 fixed nodal head with evaluating pressure variation distribution of main and branch in grid composed drainage pipe network. The linear analysis technique used as the analysis method in this study, the KYPIPE being used extensively as the linear technique to design and analysis of pipe network is applied. Firstly, in the analysis of pipe network, the CASE 2 and CASE 3 supply same thing(value) in the result of considering the total flow provided each pipeline, but in the general intension in the case of CASE 2, relative width of supply is more large than CASE 1 and CASE 3. Secondly, in the analysis technique of pipe network, CASE 3 is analysed largest as a result of comparing with same heads, and in the order of their size CASE 2 and CASE 1 were determined but the difference doesn't appear to be obvious. Thirdly, as the result of determining main factor, pressure in the design and analysis of net work. CASE 3 is from Node 3 to 25 than CASE 1 and CASE 2 and it is determined in the order of their size, CASE 2 and CASE 1. Finally, in this study, discharge flow distribution is evaluated in the same condition with 3-type CASE in the case of branch position for designing optimal composed drainage pipe network. As the result of that, branch pipe perform. Therefore, it is thought that the efficient and reasonable management of water supply and sewerage design will be possible if it give all our energies to study at the pipe system design in and out of country in the future.

• 한국균학회소식:학술대회논문집
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• 2015.05a
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• pp.53-53
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• 2015

Agrobacterium tumefaciens-mediated transformation(ATMT) of Flammulina velutipes was used to produce a diverse number of transformants to discover the functions of gene that is vital for its variation color, spore pattern and cellulolytic activity. Futhermore, the transformant pool will be used as a good genetic resource for studying gene functions. Agrobacterium-mediated transformation was conducted in order to generate intentional mutants of F. velutipes strain KACC42777. Then Agrobacterium tumefaciens AGL-1 harboring pBGgHg was transformed into F. velutipes. This method is use to determine the functional gene of F. velutipes. Inverse PCR was used to insert T-DNA into the tagged chromosomal DNA segments and conducting sequence analysis of the F. velutipes. But this experiment had trouble in diverse morphological mutants because of dikaryotic nature of mushroom. It needed to make monokaryotic fruiting varients which introduced genes of compatible mating types. In this study, next generation sequencing data was generated from 28 strains of Flammulina velutipes with different phenotypes using Illumina Hiseq platform. Filtered short reads were initially aligned to the reference genome (KACC42780) to construct a SNP matrix. And then we built a phylogenetic tree based on the validated SNPs. The inferred tree represented that white- and brown- fruitbody forming strains were generally separated although three brown strains, 4103, 4028, and 4195, were grouped with white ones. This topological relationship was consistently reappeared even when we used randomly selected SNPs. Group I containing 4062, 4148, and 4195 strains and group II containing 4188, 4190, and 4194 strains formed early-divergent lineages with robust nodal supports, suggesting that they are independent groups from the members in main clades. To elucidate the distinction between white-fruitbody forming strains isolated from Korea and Japan, phylogenetic analysis was performed using their SNP data with group I members as outgroup. However, no significant genetic variation was noticed in this study. A total of 28 strains of Flammulina velutipes were analyzed to identify the genomic regions responsible for producing white-fruiting body. NGS data was yielded by using Illumina Hiseq platform. Short reads were filtered by quality score and read length were mapped on the reference genome (KACC42780). Between the white- and brown fruitbody forming strains. There is a high possibility that SNPs can be detected among the white strains as homozygous because white phenotype is recessive in F. velutipes. Thus, we constructed SNP matrix within 8 white strains. SNPs discovered between mono3 and mono19, the parental monokaryotic strains of 4210 strain (white), were excluded from the candidate. If the genotypes of SNPs detected between white and brown strains were identical with those in mono3 and mono19 strains, they were included in candidate as a priority. As a result, if more than 5 candidates SNPs were localized in single gene, we regarded as they are possibly related to the white color. In F. velutipes genome, chr01, chr04, chr07,chr11 regions were identified to be associated with white fruitbody forming. White and Brown Fruitbody strains can be used as an identification marker for F. veluipes. We can develop some molecular markers to identify colored strains and discriminate national white varieties against Japanese ones.