• The Korean Journal of Cytopathology
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• v.6 no.2
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• pp.169-173
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• 1995

Nocardia, aerobic members of the order of Actinomycetaceae, produces infections in human lung. Nocardial infection is associated with underlying diseases of immuno-suppression or treatment with corticosteroid. It is difficult to detect Nocardia by sputum examination or histologic sections and it has rarely been diagnosed by fine needle aspiration of the lung. We describe a case of pulmonary nocardiosis in a 72 year-old man, diagnosed by fine needle aspiration, which was confirmed by culture of aspirates. The aspirates showed neutrophil-predominant inflammatory cells with microorganisms demonstrated by Gomori methenamine silver and Gram stain. The organisms had characteristic long blanching filamentous structures. The lesions on chest X-ray were in resolution with antimicrobial therapy.

• The Journal of the Korean Society for Microbiology
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• v.10 no.1
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• pp.25-32
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• 1975

The majority of Nocardial infections reported in North America areIN. ;asteroides while those in Latin America are N. brasiliensis species. Infection with N. brasiliensis, to our knowledge, has not previously been reported in Korea. The auther isolated one strain of Nocardia brasiliensis from the abscess of right bottock of 23 month old female leukemic patient who was treated with methotrixate for five months at the Seoul National University Hospital. The morphological characteristics and biological properties were similar with the R.E. Gordon's description. The results are summarized as follow: 1. After 5 days incubation on Sabouroud's glucose agar, the acid fast character appeared partially. 2. Tyrosine, casein and urea were decomposed by 7 days incubation both at room temperature and at $37^{\circ}C$. 3. Sod, citrate and sod. acetate were utilized at $22^{\circ}C\;and\;37^{\circ}C$ after 28 days incubation while the sod. benzoate utilization was negative. 4. The survival range of temperature was from $10^{\circ}C\;to\;40^{\circ}C$. 5. Dulcitol, galactose, glycerol, lactose, maltose, mannitol, raffinose, rhamnose, sorbitol, trehalose and xylose fermentations were not observed up to 28 days, while the fermentation of glucose and inositol were positive.

• Tuberculosis and Respiratory Diseases
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• v.77 no.6
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• pp.271-273
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• 2014

Disease flare-up after discontinuing epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) has been considered as a critical issue in lung cancer patients who have experienced radiologic progression after showing initial durable response. This is a case of systemic nocardiosis that occurred after chronic steroid use for radionecrosis from stereotactic radiosurgery. It was initially thought as a disease flare-up after stopping EGFR-TKI.

• Clinical and Experimental Pediatrics
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• v.53 no.6
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• pp.722-726
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• 2010

Chronic granulomatous disease (CGD) is an uncommon inherited disorder caused by mutations in any of the genes encoding subunits of the superoxide-generating phagocyte NADPH oxidase system, which is essential for killing catalase producing bacteria and fungi, such as $Aspergillus$ species, $Staphylococcus$ $aureus$, $Serratia$ $marcescens$, $Nocardia$ species and $Burkholderia$ $cepacia$. In case of a history of recurrent or persistent infections, immune deficiency should be investigated. Particularly, in the case of uncommon infections such as aspergillosis in early life, CGD should be considered. We describe here a case of CGD that presented with invasive pulmonary aspergillosis in a 2-month-old girl. We confirmed pulmonary aspergillosis noninvasively through a positive result from the culture of bronchial alveolar lavage fluid, positive serological test for $Aspergillus$ antigen and radiology results. She was successfully treated with Amphotericin B and recombinant IFN-${\gamma}$ initially. Six weeks later after discharge, she was readmitted for pneumonia. Since there were infiltrates on the right lower lung, which were considered as residual lesions, voriconazole therapy was initiated. She showed a favorable response to the treatment and follow-up CT showed regression of the pulmonary infiltrates.

• Tuberculosis and Respiratory Diseases
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• v.57 no.1
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• pp.61-65
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• 2004

Even though nocardiosis is one of opportunistic infections, and can occur in Cushing's syndrome, it rarely occurs in patients with Cushing's disease. Herein, a case with Cushing's disease in whom nocardiosis had manifested as a pulmonary lesion, which after percutaneous needle aspiration, empyema and a breast abscess were also noted.