• 약학회지
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• 제17권4호
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• pp.235-243
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• 1973

Determinations of the compositioin ofl chinoform metal chelates by elemental analysis and molar ratio method showed that the ratios of the ligand to metals in chinoform Cu(II) chelate, chinofrm Ni (II) chelate, and chinoform CO(II) chelate were 2:1 respectively and that the ratio in chinoform Fe(III) chelate was 3:1. It was found that diffe rential thermal values vary with the center metalic ions and that the thermal stability was in anorder of Fe>Cu>Co>Ni. The indices of over-all stability constant of chinoform Cu(II) chelate, Ni(II) chelate, Co(II) chelate, and Fe(III) chelate were 15.57, 15.16, 15.40 and 20.76, respectively, and the over-all stability was in an order of Fe>Cu>Co>Ni. The tests of the natibacterial activity in vitro of the chinoform metal chelates against Staphylococcus aureus ATCC G538, Pseudomonas aeruginosa 2131, Serratia marcescens 3357, Klebsiella pneumoniae 8899, Enterococcus 3309, Streptococcus pyogenes 507, and Escherichia coli 125 showed that the Cu(II) chelate generally had greater activity than chinoform, that it had four-fold activity particularly against Streptococcus pyogenes 507 and Staphylococcus awreus ATCC 6538, that the Ni(II) and Co(II) chelates had almost same activity, and that the Fe chelate had strong activity against Escherichia coli 125.

• 대한화학회지
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• 제42권2호
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• pp.197-202
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• 1998

1-(2-Pyridylazo)-2-Naphthol (PAN)은 많은 금속이온들과 착색된 착물을 형성함으로 분광시약 또는 금속지시약으로 널리 사용된다. 본 연구는 PAN을 이동상에 첨가하여 Cu(II), Ni(II) , Zn(II), Co(II) , 및 Fe(III)이온들과 착물을 형성시켜 역상 액체크로마토그래피법으로 분리하였다. 이들 금속착물들은 570nm에서 분광광도 검출기로 검출되었고, 이들 금속이온의 머무름을 조사하기 위하여 이동상의 pH, 이온세기 및 유기용매 조성의 변화에 따른 크로마토그램과 용량인자를 측정하였다. 이상의 실험결과에서 얻은 최적조건하에서 금속이온을 분리한 결과 좋은 크로마토그램을 얻었으며, 검출한계(S/N)도 ppb단위까지 검출이 가능함을 알 수 있었다.

• 대한화학회지
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• 제35권5호
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• pp.527-533
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• 1991

포름알데히드, 테트라아민류 및 디아민류의 Ni(II) 또는 Cu(II) 이온 존재하에서의 주형축합반응으로부터 헥사아자 거대세고리 및 거대네고리 리간드의 평형사각형 착물 $[M(L)]^{2+}$(M = Ni(II) 또는 Cu(II); L = 4-메틸-1,3,6,8,11,14-헥사아자트리시클로[12,2,1,$1^{8,11}$]옥타데칸(C), 1,3,10,12,15,18-헥사아자테트라시클로[6,2,1,$1^{12,15},0^{4,9}]$도코산(D), 4-메틸-1,3,6,8,12,15-헥사아자트리시클로[13,3,1,$1^{8,12}$]에이코산(F) 또는 1,3,10,12,16,19-헥사아자테트라시클로[l7,3,1,$1^{12,16},0^{4,9}]$테트라코산(G))를 합성하였다. 이들 착물의 여섯 원자 킬레이트고리에는 두개 씩의 1,3-디아자시클로펜탄 도는 1,3-디아자시클로헥산 고리가 있다. C와 F의 착물의 다섯원자 킬레이트고리에는 메틸기가 그리고 D와 G의 경우에는 시클로헥산 고리가 있다. 이들 니켈(Ⅱ) 및 구리(Ⅱ) 착물의 합성과 특성, 그리고 수용액에서의 $[Ni(L)]^{2+}+2H_2O{\rightleftharpoons}[Ni(L)(H_2O)_2]^{2+}$의 평형에 미치는 리간드 구조의 영향이 논의 된다.

• 대한화학회지
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• 제30권1호
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• pp.69-75
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• 1986

8-히드록시퀴놀린, 또는 8-히드록시퀴놀린-살리실산을 모체로 하고, 레졸신을 가교제로 하여 그것들을 포름알데히드와 축중합시켜, 8-히드록퀴놀린-레졸신(8-HQR) 및 8-히드록시퀴놀린-레졸신-살리실산(8-HQRS)킬레이트 수지를 합성하였다. 8-HQR 및 8-HQRS수지의 이온교환용량은 각각 4.1 meq/g 및 5.4 meq/g이었다. 이들 수지에 대한, Fe(III), Cu(II), Pb(II), Co(II) 및 Ni(II)금속이온들의 흡착과 분포계수에 대하여 논의하였다. 이들 킬레이트 수지들에 대한 금속이온들의 흡착은, pH=7에서 가장 크게 나타났다. 그리고 이들 금속이온들의 분포계수는, 염산의 농도가 감소함에 따라 증가하였다.

• 분석과학
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• 제8권4호
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• pp.519-527
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• 1995

The retention mechanism of Ni(II)-${\alpha}$-isonitroso-${\beta}$-diketone imine chelates in reversed-phase HPLC has been studied by examining the effect of temperature, mobile phase composition in acetonitrile-water mixture, and molecular structure on retention. The empirical retention equation was investigated to evaluate the properties of S (hydrophilic index). The value of the S index of the Ni(II) chelates decrease with the increasing column temperature and a linear relationship between S and log $k{_w}^{\prime}$ has been found. The results showed that the S index is influenced by the interaction between Ni(II) chelates and mobile phase. Molecular properties, van der Waals molar volume, polarizability and dipole moment, of the Ni(II) chelates were calculated by Cerius 2 program and the calculations were performed at Universal Force Field (UFF) model. The S value and log $k{_w}^{\prime}$ increase with decreasing the dipole moment of Ni(II) chelates.

• Bulletin of the Korean Chemical Society
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• 제11권5호
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• pp.431-434
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• 1990

Template condensation reaction of diethylenetriamine, ethylenediamine, methylamine, and formaldehyde in the presence of Ni(II) or Cu(II) ion yields new saturated hexaaza macrobicyclic complexes $[Ni(C)]^{2+}\;and\;[Cu(C)]^{2+}$, where C is 8-methyl-1,3,6,8,10,13-hexaazabicyclo[11,2,1]hexad ecane. The macrobicyclic complexes contain one 1,3-diazacyclopentane ring and one methyl pendant arm in the ligand C and have square planar geometry with 5-6-5-6 chelate ring sequence. Synthesis, characterization, and the properties of the macrobicyclic complexes are described.

• Bulletin of the Korean Chemical Society
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• 제25권4호
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• pp.545-548
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• 2004

A sensitive, selective and rapid method for the determination of nickel based on the rapid reaction of nickel(II) with QADMAA and the solid phase extraction of the Ni(II)-QADMAA chelate with $C_{18}$ membrane disks has been developed. In the presence of pH 6.0 buffer solution and sodium dodecyl sulfonate (SDS) medium, QADMAA reacts with nickel to form a violet complex of a molar ratio of 1 : 2 (nickel to QADMAA). This chelate was enriched by solid phase extraction with $C_{18}$ membrane disks. An enrichment factor of 50 was obtained by elution of the chelates form the disks with the minimal amount of isopentyl alcohol. The molar absorptivity of the chelate was $1.32{\times}10^5L\;mol^{-1}cm^{- 1}$ at 590 nm in the measured solution. Beer's law was obeyed in the range of 0.01-0.6 ${\mu}$g/mL. This method was applied to the determination of nickel in water and biological samples with good results.

• 대한화학회지
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• 제33권5호
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• pp.510-515
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• 1989

테트라에틸렌펜타아민과 포름알데히드의 주형축합반응으로부터 새로운 펜타아자 거대두고리 리간드인 1,3,6,9,12-펜타아자비시클로[10,2,1]펜타데칸(D)의 니켈(II) 및 구리(II) 착화합물 $[Ni(D)]^{2+},\;[Cu(d)]6{2+}\;그리고\;[Cu(D)Cl]^+$를 합성하였다. 거대두고리 리간드인 D에는 한 개의 이미다졸리딘 고리가 있다. $[Ni(D)]^{2+}와 [Cu(D)]^{2+}$는 5-5-5-6 킬레이트고리 배열로 된 평면사각형 구조를 이루며, 5-배위 착이온인 $[Cu(D)Cl]^+$의 구조는 그의 전자스펙트럼으로 볼 때 사각피라미드일 것으로 보인다. 이들 니켈(II) 및 구리(II) 착화합물의 합성과 확인 그리고 분광학적인 특성과 화학적인 특성이 논의된다.

• Bulletin of the Korean Chemical Society
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• 제29권10호
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• pp.1905-1910
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• 2008

The reaction of 3,14-dimethyl-2,6,13,17-tetraazatetracyclo[16.4.0$0^{1.18}.0^{7.12}$]docosane ($L^1$) with formaldehyde in warm methanol yielded 3,14-dimethyl-2,6,13,17-tetraazatetracyclo[16.4.$1^{2.6}.0^{1.18}.0^{7.12}$]tricosane ($L^7$) containing one 1,3-diazacyclohexane subunit. In methanol, $L^7$ readily reacts with $Cu^{2+}$ ion to form [$CuL^7(H_2O)$]$^{2+}$ which is extremely inert against methanolysis. In the solution containing $Ni^{2+}$ ion, however, $L^7$ reacts with methanol to yield [$NiL^3$]$^{2+}$ ($L^3$ = 2-(methoxymethyl)-5,16-dimethyl-2,6,13,17-tetraazatricyclo[16.4.$0^{1.18}.0^{7.12}$]- docosane), in which one N-$CH_2OCH_3$ pendant arm is appended. The copper(II) complex [$CuL^7(H_2O)$]- $(ClO_4)_2{\cdot}3H_2O\;(I{\cdot}3H_2O)$ has a severely distorted trigonal bipyramidal coordination geometry with a 4-5- 6-5 chelate ring sequence. The crystal structure of [$NiL^3$]$(PF_6)_2{\cdot}2H_2O$ (IIb) shows that the N-$CH_2OCH_3$ pendant arm is not coordinated to the metal ion in the solid state. In various solvents (S), however, the nickel(II) complex exists as a mixture of [$NiL^3$(S)]$^{2+}$, in which the N-$CH_2OCH_3$ group as well as S is coordinated to the metal ion, and [$NiL^3$]^{2+}.

• Bulletin of the Korean Chemical Society
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• 제18권8호
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• pp.850-856
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• 1997

A series of tetradentate Schiff-base ligands; 1,3-bis(salicylideneimino) propane, 1,4-bis(salicylideneimino)butane, and 1,5-bis(salicylideneimino)pentane, and their Cu(Ⅱ) and Ni(Ⅱ) complexes have been synthesized. The properties of ligands and complexes have been characterized by elemental analysis, IR, NMR, UV-Vis spectra, molar conductance, and thermogravimetric anaylsis. The mole ratio of Schiff base to metal at complexes was found to be 1 : 1. All complexes were four-coordinated configuration and non-ionic compound. The electrochemical redox processes of the ligands and their complexes in DMF solution containing 0.1 M TEAP as supporting electrolyte have been investigated by cyclic voltammetry, chronoamperometry, differential pulse voltammetry at glassy carbon electrode, and by controlled potential coulometry at platinum gauze electrode. The redox process of the ligands was highly irreversible, whereas redox process of Cu(Ⅱ) and Ni(Ⅱ) complexes was observed as one electron transfer process of quasi-reversible and diffusion-controlled reaction. Also the electrochemical redox potentials of complexes were affected by chelate ring size of ligands. The diffusion coefficients of Cu(Ⅱ) and Ni(Ⅱ) complexes in DMF solution were determined to be 4.2-6.6×10-6 cm2/sec. Also the exchange rate constants were determined to be 3.6-9.7×10-2 cm/sec.