• Journal of the Korean Society of Visualization
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• v.14 no.1
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• pp.33-39
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• 2016

Radio-cephalic arteriovenous fistula(RC-AVF) is the most recommended operation of achieving access for hemodialysis. However, it has high rates of early failure depending on the many haemodynamic conditions. To increase RC-AVF patency rate, many researches were performed by in-vitro experiment via artificial vessel and blood analogue fluid, and there were conflicting opinions about whether the non-Newtonian properties of blood have an influence on the flow in large arteries. To investigate the influence of viscoelasticity of blood within the RC-AVF, we fabricated three dimensional artificial RC-AVF and two kinds of blood analogue fluid. The velocity field of two fluids within the vessel were measured by micro-particle velocimetry(m-PIV) and compared with each other. The velocity profiles of both fluids for systolic phase were matched well while those for diastolic phase did not correspond. Therefore, it is desired to use non-newtonian fluid for in-vitro experiment of RC-AVF.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.8 no.3
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• pp.307-316
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• 1996

The objective of present study is to obtain information on the stenosis effects in the branch tubes for industrial piping system and atherogenesis processing in human arteries. Numerical solutions for flows of Newtonian and non-Newtonian fluids in the branch tubes are obtained by the finite volume method. Centerline velocity and pressure along the bifurcated tubes for water, blood and aqueous Separan AP-273 solution are computed and the numerical results of blood and the Separan solution are compared with those of water. Flow phenomena in the stenosed branch tubes are discussed extensively and predicted effectively. The effects of stenosis on the pressure loss coefficients are determined.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.20 no.5
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• pp.1603-1612
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• 1996

The pressure loss coefficient of Newtonian and non-Newtonian fluids such as water, aqueous solutions of Carbopol-934 and Separan AP-273 and blood in the stenotic tubes are determined experimentally and numerically. The numerical analyses for flows of non-Newtonian fluids in the stenotic tubes are conducted by the finite element method. The effect of the contraction ratio and the ratio of length to diameter on the pressure drop are investigated by the experiments and numerical analysis. The pressure loss coefficients are significantly dependent upon the Reynolds number in the laminar flow regime. As Reynolds number increases, the pressure loss coefficients of both Newtonian and non-Newtonian fluids decrease in the laminar flow regime. As the ratio of length to diameter increases the maximum pressure loss coefficient increases in the laminar flow regime for both Newtonian and non-Newtonian fluids. Newtonian fuid shows the highest values of pressure loss coefficient and blood the next, followed by Carbopol solution and Separan solution in order. Experimental results are used to verify the numerical analyses for flows of Newtonian and non-Newtonian fluids. Numerical results for the maximum pressure loss coefficient in the stenotic tubes are in fairly good agreement with the experimental results. The relative differences between the numerical and experimental results of the pressure loss coefficients in the laminar flow regime range from 0.5% to 14.8%.

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.216.2-216.2
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• 2008

• Journal of Biomedical Engineering Research
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• v.18 no.2
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• pp.179-186
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• 1997

Steady and physiological flows of a Newtonian fluid and blood in the abdominal gorta/iliac artery bifurcation are numerically simulated to understand the etiology and pathogenesis of atherosclerosis. Distributions of velocity, pressure, and wall shear stress in the bifurcated arterial vessel model are calculated to investigate the differences of flow characteristics between steady and physiological flows and to compare flow characteristics of blood with that of a Newtonian fluid For the given Reynolds number the flow characteristics of physiological flows for a Newtonian fluid and blood in the bifurcated arterial vessel are quite different from thcse of steady flows. No flow separation or flow reversal in the bifurcated region appears downstream of a stenosis during the acceleration phase. However, during the deceleration phase the flow exhibits flow separation in the outer walls of daugtlter branches, which extends to the entire wall region.

• Journal of Mechanical Science and Technology
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• v.15 no.5
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• pp.613-622
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• 2001

Interaction of blood flow and leaflet behavior in a bileaflet mechanical heart valve was investigated using computational analysis. Blood flows of a Newtonian fluid and a non-Newtonian fluid with Carreau model were modeled as pulsatile, laminar, and incompressible. A finite volume computational fluid dynamics code and a finite element structure dynamics code were used concurrently to solve the flow and structure equations, respectively, where the two equations were strongly coupled. Physiologic ventricular and aortic pressure waveforms were used as flow boundary conditions. Flow fields, leaflet behaviors, and shear stresses with time were obtained for Newtonian and non-Newtonian fluid cases. At the fully opened phase three jets through the leaflets were found and large vortices were present in the sinus area. At the very final stage of the closing phase, the angular velocity of the leaflet was enormously large. Large shear stress was found on leaflet tips and in the orifice region between two leaflets at the final stage of closing phase. This method using fluid-structure interaction turned out to be a useful tool to analyze the different designs of existing and future bileaflet valves.

• Journal of computational fluids engineering
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• v.16 no.2
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• pp.81-87
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• 2011

The importance of shear thinning non-Newtonian blood rheology on the hemodynamic characteristics of idealized cerebral saccular aneurysms were investigated by carrying out CFD simulations assuming two different non-Newtonian rheology models (Carreau and Ballyk models). To explore effects of vessel curvature, a straight and a curved vessel geometry were considered. The wall shear stress(WSS), relative residence time(RRT) and velocity distribution were compared at the different phases of cardiac cycle. As expected, blood entered the aneurysm at the distal neck and created large vortex in both aneurysms, but with higher momentum on the curved vessel. Hemodynamic characteristics such as WSS, and RRT exhibited only minor effects by choice of different rheological models although Ballyk model produced relatively higher effects. We conclude that the assumption of Newtonian fluid is reasonable for studies aimed at quantifying the hemodynamic characteristics, in particular, WSS-based parameters, considering the current accuracy level of medical image of cerebral aneurysm.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.6 no.3
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• pp.227-236
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• 1994

Steady flows of Newtonian and non-Newtonian fluids in the stenotic tubes with various stenotic shapes are numerically simulated. Validity of the modified power-law model as a constitutive equation for the purely viscous non-Newtonian fluid is discussed and the results of the power-law model are compared with those of the Carreau model, the Powell-Eyring model and experimental data for blood. Flow characteristics and reattachment lengths for non-Newtonian fluids in the stenotic tubes are presented extensively. Also, the analysis is extended to predict the influences of diameter ratio, stenosis spacing, number of stenosis and Reynolds number on the flow characteristics in the multiple stenotic tubes.

• Korea-Australia Rheology Journal
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• v.19 no.2
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• pp.89-95
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• 2007

The flow characteristics of chicken blood in a micro-tube with a $100{\mu}m$ diameter are investigated using a micro-Particle Image Velocimetry (PIV) technique. Chicken blood with 40% hematocrit is supplied into the micro-tube using a syringe pump. For comparison, the same experiments are repeated for human blood with 40% hematocrit. Chicken blood flow has a cell-free layer near the tube wall, and this layer's thickness increases with the increased flow speed due to radial migration. As a hemorheological feature, the aggregation index of chicken blood is about 50% less than that of human blood. Therefore, the non-Newtonian fluid features of chicken blood are not very remarkable compared with those of human blood. As the flow rate increases, the blunt velocity profile in the central region of the micro-tube sharpens, and the parabolicshaped shear stress distribution becomes to have a linear profile. The viscosity of both blood samples in a low shear rate condition is overestimated, while the viscosity in a high shear rate range is underestimated due to radial migration and the presence of a cell-depleted layer.

• Journal of Mechanical Science and Technology
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• v.16 no.12
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• pp.1719-1724
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• 2002

A previously designed capillary viscometer with measuring differential pressure was modified to measure the viscosity of non-Newtonian fluids including unadulterated blood continuously over numerous shear rates in a single measurement. Because of unavoidable experimental noise and a limited number of data, the previous capillary viscometer experienced an inaccuracy and could not directly determine a viscosity without an iterative calculation. However, in the present measurement there are numerous data available near the point of interest so that the numeric value of the derivative, d(In Q)/d(In Q$\sub$w/), is no longer sensitive to the method of differentiation. In addition, relatively low and wide shear rate viscosity measurements were possible because of the present precision pressure-scanning method with respect to time. For aqueous polymer solutions, excellent agreement was found between the results from the pressure-scanning capillary viscometer and those from a commercially available rotating viscometer. In addition, the pressure-scanning capillary viscometer measured the viscosity of unadulterated whole blood without adding any anticoagulants.