• 전자통신동향분석
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• 제38권5호
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• pp.61-70
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• 2023

We investigated technological trends in an electrocardiogram (ECG)-based biometric cryptosystem that uses physiological features of ECG signals to provide personally identifiable cryptographic key generation and authentication services. The following technical details of the cryptosystem were investigated and analyzed: preprocessing of ECG signals, extraction of personally identifiable features, generation of quantified encryption keys from ECG signals, reproduction of ECG encryption keys under time-varying noise, and new security applications based on ECG signals. The cryptosystem can be used as a security technology to protect users from hacking, information leakage, and malfunctioning attacks in wearable/implantable medical devices, wireless body area networks, and mobile healthcare services.

• 센서학회지
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• 제33권1호
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• pp.48-55
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• 2024

Metal-oxide-based semiconductor gas sensors are widely used because of their advantages, such as high response and simple sensing mechanism. Recently, with the rapid progress in sensor networks, computing power, and microsystem technology, sensor applications are expanding to various fields, such as food quality control, environmental monitoring, healthcare, and artificial olfaction. Therefore, the development of highly selective gas sensors is crucial for practical applications. This article reviews the developments in novel sensor design consisting of sensing films and physical and chemical filters for highly selective gas sensing. Unlike conventional sensors, the sensor structures with filters can separate the sensing and catalytic reactions into independent processes, enabling selective and sensitive gas sensing. The main objectives of this study are directed at introducing the role of various filters in gas-sensing reactions and promising sensor applications. The highly selective gas sensors combined with a functional filter can open new pathways toward the advancement of high-performance gas sensors and electronic noses.

• 대한의용생체공학회:의공학회지
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• 제30권6호
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• pp.503-509
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• 2009

The development of technology has led to ubiquitous health care service, which enables many patients to receive medical services anytime and anywhere. For the ubiquitous health care environment, real-time measurement of biomedical signals is very important, and the medical instruments must be small and portable or wearable. So, such devices have been developed to measure biomedical signals. In this study, we develop the biomedical monitoring device which is sensing the PPG signal, one of the useful signal in the field of ubiquitous healthcare. We design a watch-like biomedical signal monitoring system without a finger probe to prevent the user's inconvenience. This system obtains the PPG from the radial artery using a sensor in the wrist band. But, new device developed in this paper is easy to get the motion artifacts. So, we proposed new algorithm removing the motion artifacts from the PPG signal. The method detects motion artifacts by changing the degree of brightness of the light source. If the brightness of the light source is reduced, the PPG pulses will disappear. When the PPG pulses have disappeared completely, the remaining signal is not the signal that results from the changing blood flow. We believe that this signal is the motion artifact and call it the noise reference signal. The motion artifacts are removed by subtracting the noise reference signal from the input signal. We apply this algorithm to the system, so we can stabilize the biomedical monitoring system we designed.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제34권4호
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• pp.192-203
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• 2023

Digital therapeutics based on software, such as artificial intelligence, virtual reality, games, and smartphone applications, are in the spotlight as new therapeutic alternatives in child and adolescent psychiatry. It draws attention to overcoming conventional therapeutics' limitations, such as toxicity, cost, and accessibility, and encourages patients to participate in the treatment attractively. The growth potential of the digital therapeutics market for psychiatric disorders in children and adolescents in Korea and abroad has been highlighted. Clinical studies and Food and Drug Administration approvals for digital therapeutics have increased, and cases approved by the Ministry of Food and Drug Safety have emerged in Korea. As seen above, digital transformation in child and adolescent psychiatry will change treatment paradigms significantly. Therefore, as this new field has just begun to emerge, it is necessary to verify the effectiveness and scope of the application of digital therapeutics and consider preparing a compensation system and institutional arrangements. Accordingly, this study analyzed the development trends and application status of digital therapeutics in children and adolescents and presented limitations and development directions from the perspective of application in healthcare. Further, the study is expected to identify the utility and limitations of digital therapeutics for children and adolescents and establish effective application measures.

• 보건행정학회지
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• 제30권3호
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• pp.270-276
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• 2020

Entering the fourth industrial revolution era, health technology is rapidly developing and the people's needs for medical services are gradually increasing. Establishing a life cycle management of health technology has emerged as a new policy agenda to cope with these changes. However, the management of health technology have been conducted without continuity and with several problems pointed out. Therefore, we suggest the reform agendas by stages to establish system for a life cycle management of health technology in the fourth industrial revolution era as follows. In the stage of development, it is important not only to provide research funding, but also consulting by professional about whole cycle of health technologies. In the phase of market entry, there are needs for enhance the system that would expand the early adoption for innovative technology and increase its effectiveness. After the spread of health technology to clinical settings, a reassessment and post management system should be established that have an institutional framework with strong price adjustment and exit mechanism. Furthermore, we hope that discussions will be brisk in macro perspective on the balancing of development in healthcare industry, health of people and national health insurance finance.

• 한국의학물리학회지:의학물리
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• 제27권3호
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• pp.139-145
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• 2016

With the development in field of industry and medicine, new machines and techniques are being launched. Moreover, the complexity of the techniques is associated to an increasing risk of incident. Especially, a small error in radiotherapy can lead to a serious patient-related incident, risk management is necessary in radiotherapy in order to reduce the risk of incident. However, in field of radiotherapy, there are no legally binding clauses for risk management and there is an absence of risk management systems at an institutional level. Therefore, we analyzed institutional status of risk management, reporting & classification systems, and risk assessment & analysis in 31 countries. For risk management and reporting systems, 65% of countries investigated had legislation or regulations; however, only 35% of countries used classification systems. It was found that 43% more countries had legislation for risk management in healthcare than those for radiotherapy; 19% more countries had reporting systems for healthcare than those for radiotherapy. For classification systems, 60% more countries had legislation, recommendation, and guidelines in the field of radiotherapy than those for healthcare. Recently, international institutes have published several reports for risk management and patient safety in radiotherapy, owing to which, countries adopting risk management for radiotherapy will gradually increase. Before adopting risk management in Korea, we should precisely understand the procedures and functions of risk management, in order to increase efficiency of risk management because classification & reporting system and risk assessment & analysis are connected organically, and institutional management is needed for high quality of risk management in Korea.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2013년도 춘계학술대회
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• pp.677-680
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• 2013

최근 IT, BT, NT 등의 융합과 정보시스템의 비약적 발전으로 정보통신 서비스가 활성화되면서 SNS, 클라우드 서비스 등 신규서비스가 증가함에 따라 개인정보의 유출위험이 증대되고 있다. 특히 IT와 의료 분야는 지속적인 경제 발전과 고령화 사회 진입으로부터 발생되는 문제를 해결하고 삶의 질 향상에 대한 요구에 따라 IT 기술을 활용한 새로운 의료기기 및 유헬스 서비스의 새로운 시장을 형성을 기대할 수 있다. 하지만 이러한 IT 기술의 도입으로 대부분의 의료 정보 시스템이 전산화 되면서 의료기관간에도 의료정보정보의 교환 및 전송이 자주 발생함에 따라 의료 정보유출 및 보안에 대한 위험성이 커지고 있다. 따라서 본 연구에서는 개인 의료정보 보호와 관련 주요 법 제도와 관리적, 기술적 보호 방법을 검토 및 분석한다.

• Journal of Microbiology and Biotechnology
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• 제27권3호
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• pp.507-513
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• 2017

Bacillus subtilis spores can be used for protein display to engineer protein properties. This method overcomes viability and protein-folding concerns associated with traditional protein display methods. Spores remain viable under extreme conditions and the genotype/phenotype connection remains intact. In addition, the natural sporulation process eliminates protein-folding concerns that are coupled to the target protein traveling through cell membranes. Furthermore, ATP-dependent chaperones are present to assist in protein folding. CotA was optimized as a whole-cell biocatalyst immobilized in an inert matrix of the spore. In general, proteins that are immobilized have advantages in biocatalysis. For example, the protein can be easily removed from the reaction and it is more stable. The aim is to improve the pH stability using spore display. The maximum activity of CotA is between pH 4 and 5 for the substrate ABTS (ABTS = diammonium 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate). However, the activity dramatically decreases at pH 4. The activity is not significantly altered at pH 5. A library of approximately 3,000 clones was screened. A E498G variant was identified to have a half-life of inactivation ($t_{1/2}$) at pH 4 that was 24.8 times greater compared with wt-CotA. In a previous investigation, a CotA library was screened for organic solvent resistance and a T480A mutant was found. Consequently, T480A/E498G-CotA was constructed and the $t_{1/2}$ was 62.1 times greater than wt-CotA. Finally, E498G-CotA and T480A/E498G-CotA yielded 3.7- and 5.3-fold more product than did wt-CotA after recycling the biocatalyst seven times over 42 h.

• 대한소아치과학회지
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• 제43권4호
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• pp.473-479
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• 2016

의료와 관련하여 디자인은 대표적으로 시각디자인(Visual Communication Design), 제품디자인(Product Design) 그리고 환경디자인(Environment Design)이 의료 환경을 미적으로 아름답고 편리하도록 지원하는 형태로 관계를 형성하고 발달해왔다. 그러나 근래 디자인에 있어서 전문성이 증대되고, 다양한 영역과 학문과 융합하여 세분화되고 전문화된 영역이 새롭게 생성되고 있다. 더불어 디자인은 기술의 발달로 인하여 다양한 산업, 학문, 서비스와 융합하여 새로운 형태의 모델을 만들며 끝임 없이 변화하고 있는 상황이다. 이러한 디자인의 변화와 발달의 상황을 인식하고 의료 서비스에 있어서 디자인 활용에 대한 연구를 진행하여, 전통적인 디자인의 영역에 한정적으로 활용되던 디자인에서 벗어나 새로운 가치를 창출할 수 있는 의료 서비스 디자인으로 발전해 나가는 연구를 제안한다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.2440-2443
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• 2005

We propose a new early rehabilitation training system for postural control using a tilting bed and a force plate. The conventional rehabilitation systems for postural control cannot be applied to the patients lying in bed because the rehabilitation training using those systems is possible only when the patient can stand up by himself or herself. Moreover, there has not existed any device that could provide the sense of balance or the sensation of walking to the patients in bed. By using a tilting bed, a visual display, and a force plate, we have developed a new rehabilitation training system for balance control of the patients in bed providing sense of balance and the sensation of walking to the patient. Through the experiments with real people, we verified the effectiveness of the new early rehabilitation training system. The results showed that this system is an effective system for the early rehabilitation training and that our system might be useful as clinical equipment.