• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.10
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• pp.259-269
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• 2019

The purpose of this study is to investigate the necessity and activation plan of trial work to increase the re-employment of injured industrial workers. This study applied an internet and paper questionnaire method to 1,058 employers listed in the Korea Workers' Compensation and Welfare Services. The employers were asked about their experiences with trial work and their preferences for supports. From September 2018, the survey was conducted for 6 weeks and a total of 201 questionnaires were analyzed. Descriptive analysis and t-tests were applied. The results of the study showed that the trial work system satisfied the employers who participated in it. In order for this system to operate smoothly for injured workers, it is necessary to simplify the system's procedures, increase the amount of the trial work subsidy, and improve the amount of support after the workers convert to full time employment. In order for employers to use the new system, $750 per month will be provided for 8 months when hiring one injured worker. Eighty percent of employers stated that they would hire injured workers if the subsidy and application period are accepted. Future study and suggestions for applying the trial work system for injured industrial workers are also discussed.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.51 no.1
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• pp.61-70
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• 2015

In an attempt to improve the maneuvering character of hull form renovated tuna purse seiner. A renovation was carried out on the 3 tuna purse seiner fishing vessel. To grasp the progress of maneuvering and resistance on ship B (730 ton class), new bulbous bow was only attached. The ship A (740 ton class) and C (600 ton class) were modified for new bulbous bow, enlarged slipway and rudder. And then the zigzag and the turning test were carried out. According to the turning test, the advance and the tactical diameter were improved very much for the modified ship. The sea trial was carried out for the original and modified ship A. It is showed that the results of sea trial corresponded with that of the tank test on the whole. In the result of the zigzag test on ship B, the turning ability was improved very much, but the yaw checking ability was deteriorated in just some degree. In the result of the zigzag test on ship C, the turning ability and yaw checking ability were remarkably improved. Ship C was greatly improved among the three ships for the maneuvering character of modified hull form.

• Natural Product Sciences
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• v.10 no.2
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• pp.63-68
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• 2004

From the extracts of Crucianella maritima L. (Rubiaceae), five new anthraquinones namely; 1-hydroxy-2-methyl-6-methoxy anthraquinone, 6-methoxy-2-methyl quinizarin, 6-methyl-anthragallol-2,3-dimethyl ether, 6-methyl-anthragallol-2-methyl ether, and 1-hydroxy-2-carbomethoxyanthraquinone were isolated and identified. In addition, deacetyl asperulosidic acid 6'-glucoside sodium salt, a new iridoid diglucoside, along with twelve known anthraquinones, three flavonols, three sterols, and one triterpene were also isolated and identified for the first time from this plant. Their chemical structures were established by physical, chemical and spectroscopic data, including UV, MS, ID- and 2D-NMR analyses. The antimicrobial, cytotoxic activities and a preliminary clinical trial of the crude extracts and some isolates are also presented. Chemotaxonomical aspects are briefly discussed.

• Journal of Science and Technology Studies
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• v.7 no.1
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• pp.33-66
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• 2007

In the post-catchup era, the probability of technology risk are growing according to technology innovation activities with high uncertainty are increasing. Risk acceptance and management are appearing as a more important policy issue. This paper examines the technology risk as a political and social sight and the character of technological risk in the post-catchup era. In the post-catchup, new technology and policy are more undergone trial and err. In particular, we need new approach and policy countermeasures to cope with risky environment and overcome catchup legacy. Accordingly, Korea risk management is needed reshaping of risk management system, increment of risk communication, risk management according to technology type, precautionary approach, bounded trial and err strategy, knowledge accumulation and learning reinforcement.

• 대한핵의학회:학술대회논문집
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• 1999.05a
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• pp.228-241
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• 1999

Percutaneous coronary angioplasty is well established therapeutic modality in the management of coronary artery disease. However, the high restenosis rate of 30 to 50% limits its usefulness. The principal mechanism of restenosis, intimal hyperplasia, is the proliferative response of vessel wall to injury, which consists largely of smooth muscle cells. A large body of animal investigations and a limited number of clinical studies have established the ability of ionizing radiation to reduce neointimal proliferation and restenosis rate significantly. Human studies have been reported that intravascular radiation after first restenosis inhibits a second restenosis. Encouraged by these reports, we are also conducting a double blind, placebo-controlled, randomized trial to evaluate this new therapeutic modality in patients with coronary artery stenosis. The objective of our trial is to determine the safety and efficacy of catheter-based solutional beta emitting radioisotope system in preventing restenosis after angioplasty. This review describes the vascular brachytherapy systems and isotopes that have been utilized in the initial clinical trials performed in this area of post PTCA coronary restenosis. The results of many worldwide ongoing clinical trials will determine whether this new technology will change the future practice of vascular intervention.

• Communications for Statistical Applications and Methods
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• v.25 no.5
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• pp.501-512
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• 2018

We propose Sequential Patient Recruitment Monitoring (SPRM), a new monitoring procedure for patient recruitment in a clinical trial. Based on the sequential probability ratio test using improved stopping boundaries by Woodroofe, the method allows for continuous monitoring of the rate of enrollment. It gives an early warning when the recruitment is unlikely to achieve the target enrollment. The packet data approach combined with the Central Limit Theorem makes the method robust to the distribution of the recruitment entry pattern. A straightforward application of the counting process framework can be used to estimate the probability to achieve the target enrollment under the assumption that the current trend continues. The required extension of the recruitment period can also be derived for a given confidence level. SPRM is a new, continuous patient recruitment monitoring tool that provides an opportunity for corrective action in a timely manner. It is suitable for the modern, centralized data management environment and requires minimal effort to maintain. We illustrate this method using real data from two well-known, multicenter, phase III clinical trials.

• Korean Journal of Breeding Science
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• v.42 no.3
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• pp.212-217
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• 2010

A new waxy corn hybrid 'Daedukchal 1' was developed from single cross between CNU 504 and CNU 2396 at Chungnam National University in 2007. Inbred CNU 504 used as a seed parent and inbred CNU 2396 as a pollen parent were collected throughout domestic regions. Tasseling date of this hybrid was seven days later than that of check hybrid, 'Chalok 1'. 'Daedukchal 1' was 19.7 cm in ear length and 4.5 cm in ear diameter. On yield trial, ear length of this hybrid was increased 29.7% compared with a check hybrid, 'Chalok 1'. 'Daedukchal 1' had white kernels and good eating quality due to high sugar content and thinner pericarp. The ratio of kernel set length/ear length was similar to 'Chalok 1'. It is moderately resistant to southern leaf blight and northern leaf blight but susceptible to corn borer. The yields of 'Daedukchal 1' in fresh ear weight and in number of fresh ear were 16% and 8%, respectively, higher than those of a check hybrid in regional yield trials for two years. Seed production for this hybrid was better because of the consistency of tasseling dates.

• Journal of Oriental Neuropsychiatry
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• v.33 no.4
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• pp.389-400
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• 2022

Objectives: Depression is a highly prevalent disease, and the market for antidepressant drugs continues to grow at a steady rate. Although current antidepressants are reported to be effective, because of their low remission rate and side effects, new antidepressants are needed. The use of Banhahubak-tang (BHT) to treat the symptoms of depression is supported by experimental evidence. The proposed study will evaluate the efficacy and safety of BHT in treating depression. Methods: A randomized, waitlist-controlled, parallel clinical trial will be conducted to assess the efficacy of BHT in depression. A total of 84 participants with depression will be randomized into the intervention group or waitlist-control group at a 1:1 ratio. Patients in the intervention group will be administered BHT three times a day for four weeks and followed up for four more weeks after therapy completion. Patients in the waitlist-control group will undergo the same intervention and follow-up after a four-week waiting period. The primary outcome is change in the Korean version of the Hamilton Depression Rating Scale (K-HDRS) scores for major depressive disorders after four weeks. The secondary outcomes include scores on the K-HDRS, Korean Symptom Check List 95 (KSCL-95), Insomnia Severity Index (ISI), State-Trait Anxiety Inventory-Korean version (STAI-K), State-Trait Anger Expression Inventory-Korean version (STAXI-K), and the Instrument on Pattern Identifications for Depression and EuroQol-5 Dimension (EQ-5D). Conclusions: This trial will provide high-quality clinical evidence of the efficacy and safety of BHT in the management of depression.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.05a
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• pp.225-228
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• 2002

When the fuzzy logic controller (FLC), which is designed based on the plant model, is applied to the real control system, satisfactory control performance may not be attained due to modeling errors from the plant model. In such cases, the control parameters of the controller must be adjusted to enhance control performance. Until now, the trial and error method has been used, consuming much time and effort. To resolve such problem, response surface methodology (RSM), a new method of adjusting the control parameters of the controller, is suggested. This method is more systematic than the previous trial and error method, and thus optimal solutions can be provided with less tuning. First, the initial values of the control parameters were determined through the plant model and the optimization algorithm. Then, designed experiments were performed in the region around the initial values, determining the optimal values of the control parameters which satisfy both the rise time and overshoot simultaneously.

• Explosives and Blasting
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• v.20 no.3
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• pp.59-71
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• 2002

The points of this design case are the planning and excavation method of a new double-tracked railroad tunnel which is approx. 11∼22 meters apart from existing single-tracked railroad tunnel. For the optimum excavation method some needs are required in design stage, such as the reduction of noise and vibration, public resentment, damage of buildings and construction costs. Hence the estimation and application of allowable noise and vibration criterion is important. The ground coefficient (K, n) of this site is determined by field trial blasting. The excavation method is chosen to satisfy the allowable noise and vibration criterion. In addition, in order to ensure the stability of existing single-tracked railroad tunnel, the instrumentation of maintenance level is accompanied during the construction stage. As a result of this design condition, central diaphragm excavation with line drilling and pre-large hole boring blasting is applied to the area within 15 meters apart from existing tunnel. And above 15 meters apart, pre-large hole boring blasting is designed.