• Title/Summary/Keyword: New Methods Development

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체지방 감소에 대한 털부처꽃 추출물의 효과: 무작위배정, 이중눈가림, 대조군 비교 인체적용시험 프로토콜 (Effect of Lythrum salicaria Extract on Body Fat Reduction: A Protocol for a Randomized, Double-Blinded, Placebo-Controlled Clinical Trial)

  • 박혜진;허인;박예진;안효진;신수;차윤엽
    • 한방비만학회지
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    • 제24권1호
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    • pp.87-93
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    • 2024
  • Objectives: Obesity is a globally prevalent public health issue. Hence, there is a need for the development of safer and more effective anti-obesity drugs. Lythrum salicaria, a traditional medicinal herb used for centuries, has been reported to improve lipid metabolism and fat accumulation. It also has a low toxicity profile. Therefore, its potential as a functional ingredient in health functional foods needs to be evaluated. Methods: In this randomized, double-blind, placebo-controlled clinical trial, 90 participants will be randomly assigned to either the experimental or control group. Each subject will orally receive L. salicaria extract (1,350 mg/day) (500 mg L. salicaria+850 mg lactose as vehicle) or lactose (1,350 mg/day) as a hard capsule formula for 84 days (12 weeks). The primary outcome will be body fat mass (kg), which will be assessed using dual-energy x-ray absorptiometry (DXA) (performed only at visits 2 and 4). Secondary outcomes include body mass index, body weight, waist-to-hip ratio, body fat percentage (%) measured using DXA, lean body mass (kg) measured using DXA (assessed only at visits 2 and 4), lipids (total cholesterol, triglyceride, high-density lipoprotein cholesterol, and calculated low-density lipoprotein cholesterol), free fatty acid, high sensitivity C-reactive protein, adiponectin, and leptin. Conclusions: This protocol will be implemented after approval of Institutional Review Board of Pusan National University Korean Medicine Hospital (approval number: PNUKHIRB-2022-08-002) and registration with the Korean National Clinical Research Information Service (CRIS) (CRIS-KCT0008060). The results of this trial will provide potential of L. salicaria as a new anti-obesity functional food with fat-reducing effects and low toxicity.

해양수산안전 교육시설 설립을 위한 입지평가요인 도출에 관한 연구 (A Study on the Evaluation Indicators for the Establishment of Marine Fisheries Safety Education Facilities)

  • 하신영;김보영;박성호
    • 해양환경안전학회지
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    • 제30권4호
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    • pp.340-347
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    • 2024
  • 본 연구는 델파이 기법 및 전문가 설문을 통해 지역별 교육인프라 격차가 심한 해양수산안전분야의 교육시설을 설립하기 전 평가해야 하는 항목과 지표를 도출하였다. 그 결과 지리적요인, 사회적요인, 행정적요인에서 고려해야 하는 7개의 지표를 선정하였다. 각 지표를 객관적으로 평가하기 위해 '국가균형발전종합정보시스템', '국가통계포털' 등에 공표된 자료를 활용하여 평가할 수 있도록 평가지표를 개발하였다. 각 지표별 가중치 선정을 위해 계층분석(AHP) 방식을 적용하였으며 AHP분석 결과, 해양수산안전 교육시설 입지선정에 가장 중요한 영향을 미치는 10가지 요인은 해기사 분포, 고속·고속화철도 접근성, 5톤미만 소형선박 수, 고속도로 IC접근성, 어선세력 분포, 관련산업 밀접도, 신항만 예정지, 무역항 분포, 해양레저승선인원 수, 지자체의 토지장기무상임대 가능여부 순으로 나타났다. 본 연구에서 개발한 해양수산안전교육시설의 입지평가 지표는 국가 공공데이터를 활용하여 각 지역별로 평가할 수 있는 지표로 객관적인 평가가 가능한 장점을 가지고 있다. 따라서 본 평가지표는 해양수산안전 교육시설 뿐만아니라 다른 해양 관련 시설 설치 타당성을 검증하는 데에도 활용 할 수 있을 것으로 판단된다.

PDA와 광섬유 센서를 이용한 교량의 무선계측 시스템 개발 (Development of Wireless Measurement System for Bridge Using PDA and Fiber Optical Sensor)

  • 곽계환;황해성;장화섭;김우종;김회옥
    • 한국구조물진단유지관리공학회 논문집
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    • 제13권1호통권53호
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    • pp.88-96
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    • 2009
  • 본 연구에서는 FBG 센서 및 PDA를 이용하여 새로운 안전관리 시스템인 무선 계측 시스템을 개발하기 위해 FBG 센서를 이용하여 광섬유 변위(FBG-LVDT) 센서, 광섬유 변형률(FBG-STRAIN) 센서, 광섬유 온도(FBG-TEMP) 센서 그리고 광섬유 가속도(FBG-ACC) 센서를 특별 제작하였다. 또한, 신호처리 시스템에는 적용된 FBG 센서들의 무선송신 시스템이 가능하도록 신호처리 시스템을 구성하였으며, PDA를 이용하여 원격 거리에서도 display가 가능할 수 있도록 프로그램을 개발하였다. 개발된 FBG 센서들과 무선계측 모니터링 시스템의 현장 적용성, 정확성 및 활용 가능성을 검증하고자 현장 교량에서 정적, 동적 재하시험을 실시하였다. 또한, FBG-LVDT 센서, FBG-ACC 센서에 의하여 측정된 동적 데이터들은 Meister의 진동등감각 곡선에 적용시킴으로서 교량의 진동에 대한 사용성 평가를 실시하였고 교량의 진동 사용성을 고려하여 진동 제한 기준을 제시하여 대상 교량의 진동 평가를 위한 방법을 마련하였다.

Lower Atrial Fibrillation Risk With Sodium-Glucose Cotransporter 2 Inhibitors Than With Dipeptidyl Peptidase-4 Inhibitors in Individuals With Type 2 Diabetes: A Nationwide Cohort Study

  • Min Kim;Kyoung Hwa Ha;Junyoung Lee;Sangshin Park;Kyeong Seok Oh;Dae-Hwan Bae;Ju Hee Lee;Sang Min Kim;Woong Gil Choi;Kyung-Kuk Hwang;Dong-Woon Kim;Myeong-Chan Cho;Dae Jung Kim;Jang-Whan Bae
    • Korean Circulation Journal
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    • 제54권5호
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    • pp.256-267
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    • 2024
  • Background and Objectives: Accumulating evidence shows that sodium-glucose cotransporter 2 inhibitors (SGLT2is) reduce adverse cardiovascular outcomes. However, whether SGLT2i, compared with other antidiabetic drugs, reduce the new development of atrial fibrillation (AF) is unclear. In this study, we compared SGLT2i with dipeptidyl peptidase-4 inhibitors (DPP-4is) in terms of reduction in the risk of AF in individuals with type 2 diabetes. Methods: We included 42,786 propensity score-matched pairs of SGLT2i and DPP-4i users without previous AF diagnosis using the Korean National Health Insurance Service database between May 1, 2016, and December 31, 2018. Results: During a median follow-up of 1.3 years, SGLT2i users had a lower incidence of AF than DPP-4i users (1.95 vs. 2.65 per 1,000 person-years; hazard ratio [HR], 0.73; 95% confidence interval [CI], 0.55-0.97; p=0.028]). In individuals without heart failure, SGLT2i users was associated with a decreased risk of AF incidence (HR, 0.70; 95% CI, 0.52-0.94; p=0.019) compared to DPP-4i users. However, individuals with heart failure, SGLT2i users was not significantly associated with a change in risk (HR, 1.04; 95% CI, 0.44-2.44; p=0.936). Conclusions: In this nationwide cohort study of individuals with type 2 diabetes, treatment with SGLT2i was associated with a lower risk of AF compared with treatment with DPP-4i.

Sex-Specific Susceptibility Loci Associated With Coronary Artery Aneurysms in Patients With Kawasaki Disease

  • Jae-Jung Kim;Young Mi Hong;Sin Weon Yun;Kyung-Yil Lee;Kyung Lim Yoon;Myung-Ki Han;Gi Beom Kim;Hong-Ryang Kil;Min Seob Song;Hyoung Doo Lee;Kee Soo Ha;Hyun Ok Jun;Jeong Jin Yu;Gi Young Jang;Jong-Keuk Lee;Korean Kawasaki Disease Genetics Consortium
    • Korean Circulation Journal
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    • 제54권9호
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    • pp.577-586
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    • 2024
  • Background and Objectives: Kawasaki disease (KD) is an acute vasculitis that primarily affects children under age 5 years. Approximately 20-25% of untreated children with KD and 3-5% of those treated with intravenous immunoglobulin therapy develop coronary artery aneurysms (CAAs). The prevalence of CAAs is much higher in male than in female patients with KD, but the underlying factors contributing to susceptibility to CAAs in patients with KD remain unclear. This study aimed to identify sex-specific susceptibility loci associated with CAAs in KD patients. Methods: A sex-stratified genome-wide association study (GWAS) was performed using previously obtained GWAS data from 296 KD patients and a new replication study in an independent set of 976 KD patients by comparing KD patients without CAA (controls) and KD patients with aneurysms (internal diameter ≥5 mm) (cases). Results: Six male-specific susceptibility loci, PDE1C, NOS3, DLG2, CPNE8, FUNDC1, and GABRQ (odds ratios [ORs], 2.25-9.98; p=0.00204-1.96×10-6), and 2 female-specific susceptibility loci, SMAD3 (OR, 4.59; p=0.00016) and IL1RAPL1 (OR, 4.35; p=0.00026), were significantly associated with CAAs in patients with KD. In addition, the numbers of CAA risk alleles additively contributed to the development of CAAs in patients with KD. Conclusions: A sex-stratified GWAS identified 6 male-specific (PDE1C, NOS3, DLG2, CPNE8, FUNDC1, and GABRQ) and 2 female-specific (SMAD3 and IL1RAPL1) CAA susceptibility loci in patients with KD.

저장시스템의 응답 시간 개선을 위한 효율적인 이중 큐 전략 (An Efficient Dual Queue Strategy for Improving Storage System Response Times)

  • 이현섭
    • 사물인터넷융복합논문지
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    • 제10권3호
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    • pp.19-24
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    • 2024
  • 최근 빅데이터, 클라우드 컴퓨팅, 인공지능 등 대용량 데이터 처리 기술의 발전에 따라 데이터센터와 엔터프라이즈 환경에서 고성능 저장장치에 대한 요구가 증가하고 있다. 특히 저장장치의 빠른 데이터 응답 속도는 전체 시스템 성능을 좌우하는 핵심 요소이다. 이에 NVMe(Non-Volatile Memory Express) 인터페이스 기반 SSD(Solid State Drive)가 주목받고 있으나, 다수 호스트의 대량 데이터 입출력 요청을 동시에 처리하는 과정에서 새로운 병목 현상이 발생하고 있다. SSD는 일반적으로 호스트 요청을 내부 큐에 순차적으로 쌓아 처리하는 방식을 취한다. 이때 긴 전송 길이 요청이 먼저 처리되면 짧은 요청들이 장기간 대기하여 평균 응답 시간이 증가한다. 이 문제를 해결하기 위해 데이터 전송 시간제한과 데이터 분할 전송 방법이 제안되었으나 근본적인 해결책이 되지 못했다. 본 논문에서는 저장장치 내부 데이터 처리 스케줄링 전략인 DQBS(Dual Queue Based Scheduling Scheme)를 제안한다. 이 방식은 이중 큐 기반의 스케줄링 전략으로 하나의 큐에서는 요청 순서를, 다른 큐에서는 전송 길이를 기준으로 데이터 전송 순서를 관리한다. 그리고 요청 시간과 전송 길이를 종합적으로 고려하여 효율적인 데이터 전송 순서를 결정한다. 이를 통해 대기 시간이 긴 요청과 짧은 요청을 균형있게 처리할 수 있어 전체 평균 응답 시간을 단축시킬 수 있다. 실제 시뮬레이션 결과, 제안 기법은 기존 순차 처리 방식 대비 월등히 향상된 성능을 보였다. 본 연구는 고성능 SSD 환경에서 데이터 전송 효율을 극대화하는 스케줄링 기법을 제시하여, 차세대 고성능 저장 시스템의 발전에 기여할 수 있을 것으로 기대된다.

Isolation and genetic characterization of canine adenovirus type 2 variant from raccoon dog (Nyctereutes procynoide koresis) in Republic of Korea

  • Dong-Kun Yang;Minuk Kim;Sangjin Ahn;Hye Jeong Lee;Subin Oh;Jungwon Park;Jong-Taek Kim;Ju-Yeon Lee;Yun Sang Cho
    • 대한수의학회지
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    • 제64권3호
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    • pp.21.1-21.9
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    • 2024
  • Canine adenovirus type 2 (CAV-2) is a common causative agent of respiratory disease in canines. There have been no reports of CAV-2 variants isolated from raccoon dogs. This study aims to investigate the biological and genetic characteristics of a novel Korean CAV-2 variant. Madin-Darby canine kidney cells were used to isolate the CAV-2 variant from 45 fecal swab samples. Diagnostic tools such as the cytopathic effect (CPE) assay, electron microscopy, polymerase chain reaction, and immunofluorescence and hemagglutination assays were used to confirm the presence of the CAV-2 isolate. A cross-virus neutralization assay was performed to verify the novelty of this CAV variant. Genetic analysis was performed using nucleotide sequences obtained through next-generation sequencing. The isolate was confirmed to be a CAV-2 variant based on the aforementioned methods and designated CAV2232. The number of bases in the fiber and E3 genes of CAV2232 were 1,626 and 414, respectively. Phylogenetic analysis of the fiber and E3 genes confirmed that CAV2232 was classified into a different clade from the known CAV-1 and CAV-2 strains. Mice inoculated with the CAV2232 vaccine developed high virus neutralization antibody titers of 1,024 (210) against CAV2232, while mice inoculated with CAV-1 and CAV-2 vaccines had low virus neutralization antibody titers of 12.9 (23.7) and 6.5 (22.7), respectively, against CAV2232. CAV2232 isolated from wild raccoon dog feces was classified as a novel CAV-2 variant. CAV2232 may therefore be used as an antigen for new vaccine development and serological investigations.

어촌지도사업의 평가 (An Evaluation on the Operating of Fisheries Extension Services)

  • 최정윤
    • 수산경영론집
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    • 제17권2호
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    • pp.65-106
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    • 1986
  • 1, The Purpose of Study This is a study on the Evaluation of the operating of Fisheries Extension Services of Korea, for performing the activities such as guiding fisheries technique as well as offering industrial information to the fishermen in fishing village. By doing so, the Fisheries Extension Sevices(FES) can materialize the continued growth of fisheries, the social and economic development of fishing village, and the increase in income by enhancing the knowledge level of Fishermen, etc. In performing fisheries policy, this activity plays a great role on the research and development activity, and it has become practical since 1976 in Korea. In order to meet immediately with the problem of fisheries technical innovation and rapid environmental changes surrounding the fisheries, the fishermen should not only enhance their scientific and comprehensive capacity in fisheries technique but abtain various effective information. Generally, as most of all the fishemen are poor in the managerial structure and scattered in fishing villages, they have little opportunity in the contact of information. As a result, it is nessessary for the FES to perform the fishing business by the extension service officials who has received special training and acquired fisheries know-how in these fields. And yet, FES is under the unfullfilled circumstance in such factors as manpower, technical know-how, equipment, and the service system etc., which is required in promoting the social, economic development of fishing village and in resolving the high technique demand of fisherman. This study on the fisheries extension services have been studied from those backgrounds. 2. Research Method The data of collecting methods which were necessary in carrying out this study was adopted by the questionaire research on the present extension service activity, through the subject of the extension services (driving agency of the work and the officials), the object(fishemen) and the 3rd observers to the extension services (the authorities concerned). The research sample was taken by the sampling extraction of total 1, 774 men from the above 3 groups. And the research was carried out from August, 1986 to October, 1986, supported from the Fisheries Extension Office (FEO) located in field during the research process. In this study, the levels of the extension operating were determined and estimated in accordance with the extension service method, morale of extension service officials and the extension service system, etc. through the collected data of the research questionaire paper. And based on this result, the essential conditions of the extension services were grasped, and also we tried to present the various activity plan necessary to promote the operating of the extension services. The questionaire research data was calculated by the computer center of National Fisheries University of Pusan, and the total result was again tried on the one demension analysis along with two dimension analysis to search out the relativity between the questionaire, and the statistical test was done $\chi$$^2$test in significance level of l~5%. 3. Contents of Study This study consists of 7 chapters and the contents are as follows : Chapter I : The object and method of the study Chapter II : The assessment and analysis of the extension services Chapter III : The contents and method of the extension services Chapter IV : Analysis of the essential conditions for the extension services Chapter V : The evaluation of activities of extension services Chapter Ⅵ : Conclusion.4. Results and RecommendationTherefore, the results of this study estimated by logical process and analysis are as follows : 1) Most of Korean fishing villages and coastal fishermen have shown much concerns about fisheries technique and social changes, thus many of them were confronted with new problems on how to adapt and to meet changes. 2) Majority of fishermen estimated FEO as an organization of specific technologies with all the thing concerning the fisheries technique in general. Therefore the fishermen wanted to utilize the FEO as an adaptable method for the modern fisheries techniques as well as the environmental changes. 3) In contrast with the fast changes of the fisheries technique, the complexity and variety of technical system and the broadness of fishing village and fishermen, it was revealed that the necessary factors such as the facilities, manpower, budget, and the level of applying techniques of the FEO located in field were highly insufficient. Accordingly, the guiding efficiency was low and the extension services did not provide full solution to the various request from fishermen. 4) It is possible to classify the activation factor for the extension service into two large dimension ; personal dimension relevant to guidance officials and work dimension relevant to the organization. And it was found that the activation level of the work dimension was far lower than the personal dimension between them. So, the activation should be done first in the dimesion to promote the activation of the extension services. 5) The extension services officials are now demoralized in general, thus it is necessary to take reality into consideration : the expense of activity, the adequate endowment of activity scope and the reasonable operation of the position class, etc to enhance its morale. However, in order to do the FES activation, first of all, the systems should be established which is lain unsettled stage until now. And there must be change in the understanding of government i.e. the fisheries extension services are the essential policy subject to build up the base of fisheries growth and modernize the fisheries management. And it should be driven positively with the recognition of the "lasting project".g project".uot;.

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중국 간호교육관련 연구실태 분석 (An Analysis of Nursing education Research in China : 1990-1998)

  • 고일선;이춘옥;김경애
    • 한국간호교육학회지
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    • 제5권2호
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    • pp.177-190
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    • 1999
  • This study has been conducted on the basis of the literature review of Nursing Education Research in China from 1990 through August 1998. Its purpose was to support the basic data of nursing education which is risen as major revolutionary of nursing in China and those for exchange of information between Korea-China nursing education. It is retrospective and descriptive research analyzing one hundred eighty articles published in The Journal of China Nursing. The results of the study were as follows. 1. Only 33.3% of the professors of Technical Nursing School who have played of major role of nursing education in China have carried out the study related to nursing education. Baccalaureate program professors have marked 22.2% of all studies, and diploma program professors have done 12.2% of all. Therefore, the professors of above the diploma program have done total 44.4%. It explains that the professors of baccalaureate and diploma programs have done more studies related to nursing education than those of Technical Nursing School. 2. In terms of the study design, most of the studies(38.8%) were case studies introducing the curriculum contents that were done at education institutions. And then, 28.5% were reviewing the articles, and 15.6% were descriptive studies. 3. In terms of the content of the study, 38.3% were relevant to education of Technical Nursing School, 15.0% were about baccalaureate education, and 10.4% is about diploma. 4. To analyze the specific contents of the studies ; a. In baccalaureate program, human resources (professor or teaching), course extension, lab, classes, teaching method, education philosophy, goal of education, evaluation method, and human resource development were included. b. In diploma program, teaching contents evaluation method, teaching method, and educational system were included c. In the technical school, there were qualification of professors , teaching method, evaluation method, opening the courses, teaching contents, goal of education and so on. d. Beyond these, there were practice guidance and appraisement, teaching method, and opening new courses which were not specially indicated as educational curriculum and score management as continuing education. What is above tell us that the study regarding development of university system has been progressed actively and widely. It has been for the effort of revolution which based on the China government force to reform of nursing education process during last 10 years. On the base of the result, we suggest the following questions and the alternatives. 1) Since most articles are case studies related to teaching methods and the others doesn't propose the research method. the study which is applied more exact research method is needed. 2) No study is regarding social change and health policy. Because University program, founded in 1983 is on the beginning point, the research about curriculum have to be taken as a top priority as well as to reflect social needs which are based on social changes and national health policy 3) Only one review article study tells nursing Human resource. To appear in large numbers in nursing manpower, avoid the present hospital nurses training system. Then, the study for manpower development which is able to accomplish in many fields has to be advanced. 4) Most studies did not have literature review processes, so it was impossible for researcher to know the past study tendency and there is no relation among studies as to same subject, the education about research method is needed.

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보존유적 현황과 문제 인식을 통한 보존조치 제도 연구 (A Study on Policies for Conservation Measures Based on the Status and Issues of Conserved Remains)

  • 소재윤
    • 헤리티지:역사와 과학
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    • 제53권3호
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    • pp.110-127
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    • 2020
  • 보존유적이라 함은 건설 공사에 따른 구제 발굴로 인하여 중요 유적이 확인될 경우 매장문화재 가치 평가에 따라 보존조치되는 유적을 말한다. 우리나라는 지난 수십 년간 급속한 경제발전으로 토지개발이 이루어지게 되면서 구제 발굴 건수도 급격히 증가하게 되었고 이에 따른 보존유적도 자연히 급증하게 되었다. 현재는 이러한 보존유적의 증가로 토지 수용부터 관리·활용 등에서 여러 문제점들이 나타나고 있으나 이에 대한 명확한 해결 방법은 제시되고 있지 않은 상황이다. 본 연구에서는 유적 보존과 관련된 기술적인 문제보다 주로 제도상의 문제점 인식을 통해 보존유적 관리와 제도에 관심을 가지고 개선안을 제시하고자 하였다. 한정된 재원과 인력으로 보존유적을 효율적으로 관리하기 위해서는 제도의 미비점을 먼저 확인하고 검토하는 것이 우선이라 판단되었기 때문이다. 제도 개선을 요구할 수 있는 여러 안들이 있겠지만 현 제도상에서 우선적으로 검토되어야 하는 것은 보존유적에서 지정문화재로 신속한 전환 혹은 검토라 할 수 있다. 보존유적은 조치 이후 관련 후속 법규가 마련되어 있지 않아 지정문화재와 달리 임시적인 보존 방편에 불과하다. 이를 장기간 유지하게 될 경우 당연히 여러 문제가 발생할 수밖에 없다. 이 문제를 해결하기 위해서는 보존유적을 지정문화재와 거의 유사한 수준으로 관리할 수 있는 법적 제도를 마련하든지 아니면 현 제도상에서 개선 가능한 방법을 모색하여 문제의 최소화를 꾀하는 방법이 있겠다. 본 연구에서는 지정문화재로의 신속한 전환 방법 외에도 제도적 개선이 가능한 부분에 초점을 맞추어 몇 가지 제안을 하였다. 현재의 보존조치 유형은 현지보존, 이전보존, 기록보존 이 세 가지로 구분하고 있는데 이를 다시 두 개의 조치 유형과 그 하위의 네 가지 유형으로 재분류해 보았다. 현지보존은 보존유적과 새롭게 제시한 복토유적 두 가지만 포함시키고, 나머지 이전활용유적과 기록보존유적은 사업 시행이 가능한 보존조치 유형으로써 현지보존과 대비되는 대체보존 유형으로 제시하였다. 복토유적도 보존유적과 다르게 사업 시행이 가능한 유형으로 제시하였다.