• BMB Reports
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• v.46 no.10
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• pp.484-489
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• 2013

Piperlonguminine (PL), an important component of Piper longum fruits, is known to exhibit anti-hyperlipidemic, antiplatelet and anti-melanogenic activities. Here, the anticoagulant activities of PL were examined by monitoring activated-partial-thromboplastin-time (aPTT), prothrombin-time (PT), and the activities of thrombin and activated factor X (FXa). The effects of PL on the expressions of plasminogen activator inhibitor type 1 (PAI-1) and tissue-type plasminogen activator (t-PA) were also tested in tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) activated HUVECs. The results showed that PL prolonged aPTT and PT significantly and inhibited the activities of thrombin and FXa. PL inhibited the generation of thrombin and FXa in HUVECs. In accordance with these anticoagulant activities, PL prolonged in vivo bleeding time and inhibited TNF-${\alpha}$ induced PAI-1 production. Furthermore, PAI-1/t-PA ratio was significantly decreased by PL. Collectively, our results suggest that PL possesses antithrombotic activities and that the current study could provide bases for the development of new anticoagulant agents.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1997.10a
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• pp.1028-1031
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• 1997

The SS (Semi-solid) diecasters usually cany out the SS d~ecastmg experiments before producing new products. At the SS diecasting stages, the runner-gate part is always repeatedly corrected, which leads to a lengthened processing time and increased processing cost. The SS diecasting die design should consider component system factors. such as runner, gate, biscuit, overflow and airvent. A large amount of experience is essential in manual assessment and if the design is defective, much time and a great deal of efforts will be wasted in the modification of the d~e. Thus human negligence should be minimized. In this study, die design system for SS diecasting process has been developed to present algonthm of die design, especially runner-gate system. In addition, specific rules and equations for runner-gate system have been presented to avoid too many trials and errors with expensive equipment. It is possible for engineers to be efficient die design of SS diecasting and it will result in reduction of expense and time to be required. And we developed CAD system for SS diecasting die design by AutoLISP language under AutoCAD using proposed algorithm and the database. In addition, we developed the vector analysis program for filling pattern of SS metals.

• The Journal of the Acoustical Society of Korea
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• v.20 no.3
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• pp.83-90
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• 2001

Conventional SAW duplexer filters employ a 1/4 wavelength transmission line, which causes difficulty in fabrication of the strip line on the package. Its manufacturing process is also complicated, because it needs integrating process of the separate transmitting filter, receiving filter and isolation circuits. This paper concerns development of a new structure of the duplexer filter that has all the transmitting filter, the receiving filter and the isolation circuit as a one chip device. For composition of the duplexer, we design the component SAW ladder filters and the isolation network consisting of lumped inductor and capacitor elements. Performance of the whole duplexer is optimized by the nonlinear multivariable minimization of a proper target function, and the result is compared with that of commercial filters.

• The Journal of the Acoustical Society of Korea
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• v.20 no.3
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• pp.91-97
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• 2001

Since the new field information of target signal is important in the development and verification of active sonar system, experimental method and simulation technique are widely used in order to analyze the detail characteristics of target scattered echoes. Therefore, in this paper, the scale target experiment is performed to develope and Improve the target signal simulation model. Since the experimental results show that the specular reflection is the major component among scattering mechanisms, the target signal simulation model based on the Geometric Optics Theory (GOT) is developed. Complex target is separated into simple shapes, known as canonical shape. The contribution from individual canonical shapes are summed with proper phase and amplitude to produce the target strength of the whole complex body. Simulated target signal is compared with the experimental results and discussed.

• Plant Biotechnology Reports
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• v.5 no.1
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• pp.1-7
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• 2011

Secondary walls have recently drawn research interest as a primary source of sugars for liquid biofuel production. Secondary walls are composed of a complex mixture of the structural polymers cellulose, hemicellulose, and lignin. A matrix of hemicellulose and lignin surrounds the cellulose component of the plant's cell wall in order to protect the cell from enzymatic attacks. Such resistance, along with the variability seen in the proportions of the major components of the mixture, presents process design and operating challenges to the bioconversion of lignocellulosic biomass to fuel. Expanding bioenergy production to the commercial scale will require a significant improvement in the growth of feedstock as well as in its quality. Plant biotechnology offers an efficient means to create "targeted" changes in the chemical and physical properties of the resulting biomass through pathway-specific manipulation of metabolisms. The successful use of the genetic engineering approach largely depends on the development of two enabling tools: (1) the discovery of regulatory genes involved in key pathways that determine the quantity and quality of the biomass, and (2) utility promoters that can drive the expression of the introduced genes in a highly controlled manner spatially and/or temporally. In this review, we summarize the current understanding of the transcriptional regulatory network that controls secondary wall biosynthesis and discuss experimental approaches to developing-xylem-specific utility promoters.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.33 no.2
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• pp.109-113
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• 2020

A power device is a component used as a switch or rectifier in power electronics to control high voltages. Consequently, power devices are used to improve the efficiency of electric-vehicle (EV) chargers, new energy generators, welders, and switched-mode power supplies (SMPS). Power device designs, which require high voltage, high efficiency, and high reliability, are typically based on MOSFET (metal-oxide-semiconductor field-effect transistor) and IGBT (insulated-gate bipolar transistor) structures. As a unipolar device, a MOSFET has the advantage of relatively fast switching and low tail current at turn-off compared to IGBT-based devices, which are built on bipolar structures. A superjunction structure adds a p-base region to allow a higher yield voltage due to lower R_DS (on) and field dispersion than previous p-base components, significantly reducing the total gate charge. To verify the basic characteristics of the superjunction, we worked with a planar type MOSFET and Synopsys' process simulation T-CAD tool. A basic structure of the superjunction MOSFET was produced and its changing electrical characteristics, tested under a number of environmental variables, were analyzed.

• The Korean Journal of Mycology
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• v.35 no.1
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• pp.43-46
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• 2007

It was investigated that systemic acquired resistance (SAR) was induced in plant treated with a elicitor, which was derived from a non-virulent fungus. The elicitor, a hyphal cell wall component derived from fungus, induced a production of phytoalexin and a generation of reactive oxygen species (ROS) in potato treated with its low level concentrations. The effect of the fungus-derived elicitor was better than that of virulent pathogen-derived elicitor, which was well known in potato. These results, therefore, suggested potentcial use of fungus-derived elicitor as a new plant protector for commercial development.

• The Transactions of the Korean Institute of Power Electronics
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• v.9 no.4
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• pp.319-325
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• 2004

The major factors that make ZEV affordable are the range and cost. The development of advanced batteries such as Ni-MH battery can solve the problem partly； on the hand the battery management system is an efficient way. Ni-MH battery and battery ECU is a key component influencing ZEV performance, such as range, acceleration and hill-climbing capability. Because most problems related to battery such as short circuit, over-discharge and overcharge occur easily during operation, it is necessary to develop a dedicated battery ECU for HEV. This paper proposes a new SOC algorithm for the HEV based on the terminal voltage and current integration. And battery ECU was designed and analyzed. Also, the validity is confirmed through experiment.

• Transactions of the Korean Society of Automotive Engineers
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• v.4 no.4
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• pp.87-96
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• 1996

The proportional pressure control valve(PCV) is an essential component in the open loop controlled rear wheel steering gear of the four wheel steering(4WS) system on the passenger car. The valve should have versatile functions and higher performance. But, it is hard to find the proportional pressure control valve suitable for the 4WS system. In this paper, the determination of the valve parameters was studied by the stability discrimination and the characteristic analysis for the purpose of the development of a new PCV for the 4WS. The mathematical model of the valve was derived from the valve-cylinder system and the programme for numerical computation was developed. The transfer function of the system was obtained from the mathematical model. The characteristics of the valve were inspected through the experiment and compared to those obtained by numerical method. And then the stability discrimination of the system was done by root locus and the analysis of characteristics was done by the developed programme. From the experiment and the analysis of characteristics was done by the developed programme. From the experiment and the inspection, the appropriation of mathematical model and the usefulness of the programme were confirmed. And the parameters which might affect the performance of the valve can be determined by considering the stability discrimination, the characteristics analysis and required functions.

• International Journal of Aeronautical and Space Sciences
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• v.16 no.3
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• pp.463-474
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• 2015

Future Ground Control Stations (GCSs) for Unmanned Aerial Vehicles (UAVs) teleoperation targets better situational awareness by providing extra motion cues to stimulate the vestibular system. This paper proposes a new virtual environment for long range Unmanned Aerial Vehicle (UAV) control via Non-Line-of-Sight (NLoS) communications, which is based on motion platforms. It generates motion cues for the teleoperator for extra sensory stimulation to enhance the guidance performance. The proposed environment employs the distributed component simulation over GSM network as a simulation platform. GSM communications are utilized as a multi-hop communication network, which is similar to global satellite communications. It considers a UAV mathematical model and wind turbulence effects to simulate a realistic UAV dynamics. Moreover, the proposed virtual environment simulates a Multiple Axis Rotating Device (MARD) as Human Machine Interface (HMI) device to provide a complete delay analysis. The demonstrated measurements cover Graphical User Interface (GUI) capabilities, NLoS GSM communications delay, MARD performance, and different software workload. The proposed virtual environment succeeded to provide visual and vestibular feedbacks for teleoperators via GSM networks. The overall system performance is acceptable relative to other Line-of-Sight (LoS) systems, which promises a good potential for future long range, medium altitude UAV teleoperation researches.