• Journal of Korean Neurosurgical Society
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• 제56권5호
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• pp.431-435
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• 2014

A fifty-year-old female non-smoker with no other specific medical history visited our institute. She complained of axial back pain with no other neurological deficit. Chest X-ray, chest computed tomography (CT) scan, CT-guided needle aspiration biopsy, whole-body positron emission tomography, spine CT and spine magnetic resonance image findings suggested NSCLC with epidermal growth factor receptor (EGFR) mutation, multiple brain metastases, and two isolated metastases to the T3 and L3 vertebral bodies. She underwent chemotherapy with gefitinib ($Iressa^{TM}$) for NSCLC and gamma knife surgery for multiple brain metastases. We performed a two-staged, total en bloc spondylectomy of the T3 and L3 vertebral bodies based on several good prognostic characteristics, such as the lack of metastases to the appendicular bone, good preoperative performance status, and being an excellent responder (Asian, never-smoker and adenocarcinoma histology) to EGFR inhibitors. Improved axial back pain after the surgery enabled her to walk with the aid of a thoracolumbosacral orthosis brace on the third postoperative day. Her Karnofsky performance status score (KPS) was 90 at the time of discharge and has been maintained to date 3 years after surgery. In selected NSCLC patients with good prognostic characteristics, we suggest that locally curative treatment such as total en bloc spondylectomy or radiosurgery should be emphasized to achieve longer term survival for the selected cases.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5171-5174
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• 2013

Background: This study aimed to explore potential associations between single nucleotide polymorphisms (SNPs) of the x-ray repair cross-complementing group 1 (XRCC1) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) and non-small cell lung cancer (NSCLC) susceptibility in non-smoker Chinese patients. Methods: A total of 200 NSCLC patients and 200 healthy controls with matched age and gender were recruited for genotyping of XRCC1 SNPs (rs2256507 and rs1001581) and CLPTM1L SNPs (rs401681 and rs4975616). Association of these SNPs with NSCLC risk was evaluated by computing the odds ratio (OR) and 95% confidence interval (CI) from multivariate unconditional logistic regression analyses with adjustment for gender and age. Results: The frequencies of genotype and allele in these four loci (rs2256507, rs1001581, rs401681, and rs4975616) were not significantly different between the cases and controls, or between either of the histological subgroups (adenocarcinoma and squamous cell carcinoma) and controls. Conclusions: Although these SNPs are associated with NSCLC risk in patients with a tobacco-smoking habit, this study demonstrated that XRCC1 and CLPTM1L gene SPNs are not linked with NSCLC risk in non-smoking patients, indicating that molecular mechanisms of NSCLC betwee tobacco smokers and non-smokers may be different. Future studies are needed to uncover the underlying molecular mechanisms for NSCLC in non-smokers.

• Osong Public Health and Research Perspectives
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• 제9권6호
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• pp.289-298
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• 2018

Objectives: To describe the distribution of social factors, lifestyle habits and anthropometric measurements according to hypertension and Type-2 diabetes. Methods: A cross-sectional study was conducted in Gaza City, Palestine that included 379 patients (20-60 years) who had hypertension and/or diabetes. Three groups of patients were involved; 106 hypertensive (HT), 109 diabetic (T2DM) and 164 hypertensive diabetics (HT + T2DM). Results: The HT + T2DM group were older and had a higher body mass index compared to HT and T2DM groups. There were 62.3% patients who were female, 49.2% were highly educated HT patients, and 49.3% patients had a low level of education and were HT + T2DM. There were 55.8% patients who lived in large families. Patients who were passive smokers or never smoked before were mostly HT + T2DM, while active smokers and past smokers had T2DM. There were 48.2% patients who were highly physically active who had HT, 40.9% whom were moderately active had T2DM, and 53.8% of patients who had a low level of activity were HT + T2DM. Multivariate linear regression showed that having a diseased mother, living in a large family, being a past or passive smoker, or never having smoked, having a low or moderate level of activity, and having HT or HT + T2DM, were significantly associated with an increased body mass index. Conclusion: Parental health/disease conditions and environmental factors (social network and lifestyle habits) played the greatest role in the development of obesity and disease.

• Tuberculosis and Respiratory Diseases
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• 제62권1호
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• pp.27-32
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• 2007

연구배경: 폐암환자를 대상으로 의무기록에서 흡연 습관의 정확성을 평가하고, 이에 영향을 미치는 요인들을 분석하고자 한다. 연구방법: 폐암을 진단받고 입원한 225예 환자를 대상으로 흡연 습관에 대한 일대일 면접 설문조사와 의무기록 사이의 일치도를 평가하였다. 의무기록의 흡연정보 누락과 두 자료원의 불일치에 기여하는 요인을 평가하기 위하여 다변량 로지스틱 회귀분석을 시행하였다. 결 과: 흡연 습관은 전반적으로 증등도의 일치도 (${\kappa}=0.60$)를 보였으며, 과거 흡연의 일치도(${\kappa}=0.49$)가 가장 낮았다. 의무기록의 흡연정보 누락률은 18.2%였으며, 세포형에 따라 유의한 차이를 보여, 편평상피세포암에 비하여 선암 환자에서의 누락률이 3배 높았다. 두 자료원 사이의 불일치는 65세 미만에 비해 65세 이상에서 3배 많았다. 결 론: 의무기록의 흡연 정보는 중등도의 정확성을 가진다. 임상 시험에서 흡연 습관에 대한 자료원으로 의무기록 정보를 이용하는데 세심한 주의가 필요하다고 판단한다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6971-6978
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• 2013

Background: Smoking among adolescents has been linked to a variety of adverse and long term health consequences. "Susceptibility to smoking" or the lack of cognitive commitment to abstain from smoking is an important predictor of adolescent smoking. In 2008, we conducted a study to determine the psycho-sociological factors associated with susceptibility to smoking among secondary school students in the district of Kota Tinggi, Johor. Materials and Methods: Two thousand seven hundred students were randomly selected by proportional stratified sampling. Analyses on 1,736 non-smoking students revealed that prevalence of adolescents susceptible to smoking was 16.3%. Results: Male gender (aOR=2.05, 95%CI= 1.23-3.39), poor academic achievement (aOR 1.60, 95%CI 1.05-2.44), ever-smoker (aOR 2.17, 95%CI 1.37-3.44) and having a smoking friend (aOR 1.76, 95%CI 1.10-2.83) were associated with susceptibility to smoking, while having the perception that smoking prohibition in school was strictly enforced (aOR 0.55, 95%CI 0.32-0.94), and had never seen friends smoking in a school compound (aOR 0.59, 95%CI 0.37-0.96) were considered protective factors Conclusions: These results indicate that follow-up programmes need to capitalise on the modifiable factors related to susceptibility to smoking by getting all stakeholders to be actively involved to stamp out smoking initiation among adolescents.

• 대한한의학회지
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• 제22권4호
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• pp.69-78
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• 2001

Objectives : It is known that cigarette smoking is associated with increased risk of both thrombotic and hemorrhagic stroke. However, in Korea, especially in the academic world of Korean Medicine, there is a lack of study about the relation between cigarette smoking and stroke. We carried out a case-control study to clarify the relation between cigarette smoking and stroke. Method : We interviewed 441 stroke patients (236 men, 205 women) as a case group and 432 non-stroke patients (208 men, 224 women) as a control group. We investigated the smoking pattern of all patients and stroke-subtype of the case group. Smoking pattern is classed into two (Class I), four (Class II) and five groups (Class III). Class I consists of current non-smokers and current smokers. Class II consists of non-smokers, former smokers, current light smokers and current heavy smokers. Class III consists of never smoked, secondhand smokers, former smokers, Current light smokers and current heavy smokers. Stroke-subtype consists of cerebral infarction and cerebral hemorrhage. Results : The percentage of current smokers of case group is higher significantly than that of control group. The number of cigarettes smoked per day is associated positively with the risk of stroke. According to our study, generally cigarette smoking is related with ischemic stroke. The percentage of secondhand smokers of the case group is lower than that of the control group. According to our study, characteristically secondhand smoking is associated with hemorrhagic stroke. Conclusions : From the above results we found that cigarette smoking is an important risk factor of stroke - especially cerebral infarction - and the number of cigarettes smoked per day is associated positively with the risk of stroke. Characteristically according to our study, secondhand smoking is associated with hemorrhagic stroke. Overall we conclude that cigarette smoking may be an important preventable factor for stroke.

• Child Health Nursing Research
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• 제18권3호
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• pp.143-149
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• 2012

Purpose: The aim was to explore the relationship between health status/life style and prevalence of atopic dermatitis in adolescents. Methods: Data from 1,743 adolescents (aged 13 to 18 years) derived from the fourth Korea National Health and Nutrition Examination Survey (KNHANES) were analyzed using binary logistic regression and the classification and regression tree (CART) model. Results: The prevalence rate of atopic dermatitis was 10.3%. Third quartile income class (OR=2.19, 95% CI=1.20-4.00), fair and unhealthy self-rated health (OR=1.49, 95% CI=1.06-2.11; OR= 2.73, 95% CI=1.64-4.55), past or current smoker (OR=0.41, 95% CI=0.20-0.85; OR=0.44, 95% CI=0.21-0.92), and more than average stress (OR=1.43, 95% CI=1.03-1.99) were related with increased prevalence of atopic dermatitis. The high prevalence risk groups for atopic dermatitis were adolescents who perceived themselves to be healthy on self-rated health and had more than average stress and those who perceived themselves to be unhealthy and who never smoked. Conclusion: The results of the study indicate that health status, smoking, and stress are associated with a prevalence risk for adolescent atopic dermatitis in different degrees. Therefore, for control of atopic dermatitis, various interventions for smoking and stress need to be reinforced for the high prevalence atopic dermatitis groups.

• Journal of Preventive Medicine and Public Health
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• 제42권1호
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• pp.59-66
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• 2009

Objectives : This study was performed using a longitudinal approach to explore the predictors for current smoking among male high school students. Methods : Baseline data was collected in May 2004 through a self-administrated questionnaire completed by 607 male students in a technical high school in Daegu city, Korea. Subsequently, their smoking behaviors were followed one year after. Among the 544 followed participants, data for 439 non-smokers in the first year was used in longitudinal analysis. Current smokers were defined as those respondents who had smoked one or more cigarettes within the 30 days preceding the survey. Several potential predictors for smoking were investigated including smoking history(never, experimental, former smoker), sociodemographic factors, environmental factors, attitudes toward smoking, and behavioral factors. Logistic regression was used to predict smoking with SPSS ver. 12.0. Results : According to multiple logistic regression analysis, those students who were more likely to smoke after one year were former smokers(OR: 2.12, 95% CI=1.01-4.44), current drinkers(OR: 2.55, 95% CI=1.33-4.89), who had four or five smokers among five best friends(OR: 3.43. 95% CI=1.14-10.30). In addition, those who had smokers among family members besides parents or siblings(OR: 1.66, 95% CI=0.92-2.98), exhibited a high level of subjective stress(OR: 1.77, 95% CI=0.96-3.26), or had a very good relationship with friends(OR: 1.93, 95% CI=0.99-3.75) were also more likely to smoke albeit with marginal statistical significance(p<0.1). Conclusions : A smoking prevention program aimed at high school students may be more effective with due consideration of the predictors highlighted in this study. However, further studies with larger sample size and various target populations are necessary to find potential predictors not found in this study but suggested in other longitudinal studies.

• 문화기술의 융합
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• 제8권2호
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• pp.299-307
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• 2022

본 연구는 성인 만성폐쇄성폐질환(Chronic Obstructive Pulmonary Disease, COPD) 환자의 인플루엔자 접종률과 접종에 영향을 미치는 요인을 파악하기 시행하였다. 2014년부터 2018년까지 5년간의 국민건강영양조사에 참여한 대상자 중 만 40세 이상이며 폐기능 검사 판정결과 폐쇄성환기장애(FEV1/FVC<0.7)로 나타난 2,370명을 대상으로 인플루엔자 예방접종률과 접종에 미치는 영향요인을 분석하였다. 민간강영양조사 데이터를 분석한 결과 만 40세 이상 성인 COPD 환자의 인플루엔자 예방접종률은 59.2%이었으며, 예방접종에 영향을 미치는 요인은 65세 이상, 낮은 경제수준, 과거흡연자이거나 비흡연자, 최근 2년 이내 건강검진을 받은 경우이었다. COPD가 있는 성인의 예방접종률을 높이기 위하여 인플루엔자 예방접종에 영향을 주는 요인들을 고려하여 예방접종률을 높이기 위한 방안을 모색해야 할 것이다.

• Tuberculosis and Respiratory Diseases
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• 제71권3호
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• pp.195-201
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• 2011

Background: Osteopontin (Opn) is recognized as an important adhesive bone matrix protein and a key cytokine involved in immune cell recruitment and tissue repair and remolding. However, serum levels of osteopontin have not been evaluated in patients with chronic obstructive pulmonary disease (COPD). Thus, the aim of this study was to evaluate and compare the serum levels of osteopontin in patients experiencing COPD exacerbations and in patients with stable COPD. Methods: Serum samples were obtained from 22 healthy control subjects, 18 stable COPD patients, and 15 COPD with exacerbation patients. Serum concentrations of osteopontin were measured by the ELISA method. Results: Serum levels of osteopontin were higher in patients with acute exacerbation than with stable COPD and in healthy control subjects ($62.4{\pm}51.9ng/mL$, $36.9{\pm}11.1ng/mL$, $30{\pm}11ng/mL$, test for trend p=0.003). In the patients with COPD exacerbation, the osteopontin levels when the patient was discharged from the hospital tended to decrease compared to those at admission ($45{\pm}52.1ng/mL$, $62.4{\pm}51.9ng/mL$, p=0.160). Osteopontin levels significantly increased according to patient factors, including never-smoker, ex-smoker and current smoker ($23{\pm}5.7ng/mL$, $35.5{\pm}17.6ng/mL$, $58.6{\pm}47.8ng/mL$, test for trend p=0.006). Also, osteopontin levels showed a significantly negative correlation with forced expiratory volume in one second ($FEV_1$%) predicted in healthy controls and stable COPD patients (r=-0.389; p=0.013). C-reactive protein (CRP) was positively correlated with osteopontin levels in patients with COPD exacerbation (r=0.775; p=0.002). Conclusion: The serum levels of osteopontin increased in patients with COPD exacerbation and tended to decrease after clinical improvement. These results suggest the possible role of osteopontin as a biomarker of acute exacerbation of COPD.