• Nuclear Engineering and Technology
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• 제52권9호
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• pp.2072-2077
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• 2020

The purpose of this study was to demonstrate the feasibility of sensing changes in a tumor during boron neutron capture therapy (BNCT) using a Monte Carlo simulation tool. In the simulation, an epi-thermal neutron source and a water phantom including boron uptake regions (BURs) were simulated. Moreover, this simulation also included a detector for positron emission tomography (PET) scanning and an adaptively-designed collimator (ADC) for PET. After the PET scanning of the water phantom, including the 511 keV source in the BUR, the ADC was positioned in the PET's gantry. Single prompt gamma rays were collected through the ADC during neutron irradiation. Then, single prompt gamma ray-based tomography images of different sized tumors were acquired by a four-step process. Both the signal-to-noise ratio (SNR) and tumor size were analyzed from each step image. From this analysis, we identified a decreasing trend of both the SNR and signal intensity as the tumor size decreased, which was confirmed in all images. In conclusion, we confirmed the feasibility of sensing changes in a tumor during BNCT using PET and an ADC through Monte Carlo simulation.

• Journal of Radiation Protection and Research
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• 제14권2호
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• pp.45-50
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• 1989

원자력병원 싸이클로트른 중성자선(中性子線) 치료실의 방사선 준위(準位)를 측정함으로써 방사선 안전도를 검토하여 보았다. 중성자선 치료실내 방사선 노출은 주로 isocentric gantry에 내장된 중성자선 표적(標的)과 조사야(照射野)를 결정하는 collimator의 방사화(放射化)로 인한 잔류방사능(殘留放射能) (remanent radioactivity)에 의해 결정 된다. 측정결과 선량율(線量率)은 과다하지 않았고 개인 집적선량(集積線量)도 허용치 이내였다. 방사선 작업종사자로서의 의료기사는 환자치료 시 매 조사(照射) 완료 직후부터 5분간 멸살(滅殺)시간을 갖도록 조치하였다.

• 한국의학물리학회지:의학물리
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• 제27권3호
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• pp.162-168
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• 2016

Proton therapy is increasingly being actively used in the treatment of cancer. In contrast to photons, protons have the potential advantage of delivering higher doses to the cancerous tissue and lower doses to the surrounding normal tissue. However, a range shifter is needed to degrade the beam energy in order to apply the pencil beam scanning technique to tumors located close to the minimum range. The secondary neutrons are produced in the beam path including within the patient's body as a result of nuclear interactions. Therefore, unintended side effects may possibly occur. The research related to the secondary neutrons generated during proton therapy has been presented in a variety of studies worldwide, since 2007. In this study, we measured the magnitude of the secondary neutron dose depending on the location of the detector and the use of a range shifter at the beam nozzle of the proton scanning mode, which was recently installed. In addition, the production of secondary neutrons was measured and estimated as a function of the distance between the isocenter and detector. The neutron dose was measured using WENDI-II (Wide Energy Neutron Detection Instruments) and a Plastic Water phantom; a Zebra dosimeter and 4-cm-thick range shifter were also employed as a phantom. In conclusion, we need to consider the secondary neutron dose at proton scanning facilities to employ the range shifter reasonably and effectively.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1995년도 추계학술발표회논문집(2)
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• pp.937-942
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• 1995

Great interest has prompted Boron Neutron Capture Therapy (BNCT) as a new treatment for brain tumors. The use of $^{252}$Cf as a neutron source for BNn makes the in-hospital treatments of tumors to be possible. Newly proposed subcritical multiplying assemblies (SMA) are explored to improve relatively tow neutron fluxes of the source and construct the feasibilities of $^{252}$Cf as a neutron source. The MCNP code has been used to evaluate the effective multiplication factor of the entire system and the intensities and percentages of epithermal neutron flux at the patient-end surface of the system. The neutron beam using SMA shows the epithermal neutron flux enhancement of about 13 times as large as the beam without using SMA. It is expected that the neutron beam proposed in this research will be more effective for treatment of tumors due to the increased therapeutic neutron fluxes.

• 대한방사성의약품학회지
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• 제6권1호
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• pp.10-19
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• 2020

Boron Neutron Capture Therapy (BNCT) has the advantage of selectively removing cancer cells ingesting boron compounds. In this study, the benefits for treatment time and boron compound injection dose were compared between current neutron sources and a high current neutron sources to be developed in near future. The time-activity curve (TAC) of GBM (Glioblastoma) for one bolus injection was obtained by applying modified 3 compartment model. The treatment time was determined for an accelerator-based neutron sources at the present time and a high current accelerator based neutron source to be developed in the near future. In the case of the double amount of IAEA-recommended neutron flux, the treatment time was shortened to 15 minutes. In the case of high current accelerators, which are five times the amount of IAEA-recommended neutron flux, the irradiation time is within 5 minutes. The use of a high current accelerator based neutron source in BNCT is advantageous in terms of treatment time. In addition, it can increase the efficiency of use of neutrons and reduce the boron compound injection dose to patients, thus reducing pharmacological toxicity.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2006년도 제33회 추계학술대회 발표논문집
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• pp.131-131
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• 2006

• 대한방사성의약품학회지
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• 제8권1호
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• pp.17-23
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• 2022

Boron neutron capture therapy is a precision treatment technology that selectively destroys only tumor cells by irradiating thermal neutrons after accumulating boron drugs in tumor cells. Brain tumor is difficult to diagnose and treat due to the low permeability and targeting of drugs caused by the blood-brain-barrier. Crossing the BBB is essential for drug delivery to the brain. In this study, we designed and synthesized a novel compound incorporating benzothiazole to develop a boron drug with high BBB permeability and selectivity for brain tumor cells. In addition, their potential as a BNCT drugs was evaluated.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 1999년도 Japanese Journal of Medical Physics
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• pp.62-65
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• 1999

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 1999년도 Japanese Journal of Medical Physics
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• pp.58-61
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• 1999

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2001년도 추계학술발표회요약집
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• pp.319.2-319
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• 2001