• Progress in Medical Physics
• /
• v.25 no.3
• /
• pp.151-156
• /
• 2014

The purpose of this study was to confirm the feasibility of imaging of therapy region from the boron neutron capture therapy (BNCT) using the measurement of the prompt gamma ray depending on the neutron flux. Through the Monte Carlo simulation, we performed the verification of physical phenomena from the BNCT; (1) the effects of neutron according to the existence of boron uptake region (BUR), (2) the internal and external measurement of prompt gamma ray dose, (3) the energy spectrum by the prompt gamma ray. All simulation results were deducted using the Monte Carlo n-particle extended (MCNPX, Ver.2.6.0, Los Alamos National Laboratory, Los Alamos, NM, USA) simulation tool. The virtual water phantom, thermal neutron source, and BURs were simulated using the MCNPX. The energy of the thermal neutron source was defined as below 1 eV with 2,000,000 n/sec flux. The prompt gamma ray was measured with the direction of beam path in the water phantom. The detector material was defined as the lutetium-yttrium oxyorthosilicate (Lu0,6Y1,4Si0,5:Ce; LYSO) scintillator with lead shielding for the collimation. The BUR's height was 5 cm with the 28 frames (bin: 0.18 cm) for the dose calculation. The neutron flux was decreased dramatically at the shallow region of BUR. In addition, the dose of prompt gamma ray was confirmed at the 9 cm depth from water surface, which is the start point of the BUR. In the energy spectrum, the prompt gamma ray peak of the 478 keV was appeared clearly with full width at half maximum (FWHM) of the 41 keV (energy resolution: 8.5%). In conclusion, the therapy region can be monitored by the gamma camera and single photon emission computed tomography (SPECT) using the measurement of the prompt gamma ray during the BNCT.

• Nuclear Engineering and Technology
• /
• v.55 no.5
• /
• pp.1587-1592
• /
• 2023

Time-encoded imagers (TEI) are important class of instruments to search for potential radioactive sources to prevent illicit transportation and trafficking of nuclear materials and other radioactive sources. The energy of the radiation cannot be known in advance due to the type and shielding of source is unknown in practice. However, the response function of the time-encoded imagers is related to the energy of neutrons or gamma-rays. An improved image reconstruction method based on MLEM was proposed to correct for the energy induced response difference. In this method, the count vector versus time was first smoothed. Then, the preset response function was adaptively corrected according to the measured counts. Finally, the smoothed count vector and corrected response were used in MLEM to reconstruct the source distribution. A one-dimensional dual-particle time-encode imager was developed and used to verify the improved method through imaging an Am-Be neutron source. The improvement of this method was demonstrated by the image reconstruction results. For gamma-ray and neutron images, the angular resolution improved by 17.2% and 7.0%; the contrast-to-noise ratio improved by 58.7% and 14.9%; the signal-to-noise ratio improved by 36.3% and 11.7%, respectively.

• Journal of Radiopharmaceuticals and Molecular Probes
• /
• v.1 no.1
• /
• pp.23-30
• /
• 2015

Radioisotopes emitting low-range highly ionizing radiation such as ${\beta}$-particles are of increasing significance in internal radiotherapy. Among the ${\beta}$-particle emitting radioisotopes, $^{67}Cu$ is an attractive radioisotope for various nuclear medicine applications due to its medium energy ${\beta}$-particle, gamma emissions, and 61.83-hour half-life, which can also be used with $^{64}Cu$ for PET imaging. The production and application of the ${\beta}$-emitting radioisotope $^{67}Cu$ for therapeutic radiopharmaceutical are outlined, and different production routes are discussed. A survey of copper chelators used for antibody labeling is provided. It has been produced via proton, alpha, neutron, and gamma irradiations followed by solvent extraction, ion exchange, electrodeposition. Clinical studies using $^{67}Cu$-labelled antibodies in lymphoma, colon carcinoma and bladder cancer patients are reviewed. Widespread use of this isotope for clinical studies and preliminary treatments has been limited by unreliable supplies, cost, and difficulty in obtaining therapeutic quantities.

• Nuclear Engineering and Technology
• /
• v.53 no.4
• /
• pp.1304-1310
• /
• 2021

Two-phase flow, especially gas-liquid two-phase flow, has a wide application in industrial field. The diagnosis of two-phase flow parameters, which directly determine the flow and heat transfer characteristics, plays an important role in providing the design reference and ensuring the security of online operation of two-phase flow system. Computer tomography (CT) is a good way to diagnose such parameters with imaging method. This paper has proposed a novel image reconstruction method for thermal neutron CT of two-phase flow with improved simulated annealing (ISA) algorithm, which makes full use of the prior information of two-phase flow and the advantage of stochastic searching algorithm. The reconstruction results demonstrate that its reconstruction accuracy is much higher than that of the reconstruction algorithm based on weighted total difference minimization with soft-threshold filtering (WTDM-STF). The proposed method can also be applied to other types of two-phase flow CT modalities (such as X(𝛄)-ray, capacitance, resistance and ultrasound).

• Nuclear Engineering and Technology
• /
• v.53 no.3
• /
• pp.949-959
• /
• 2021

The current study aims to explore the shielding properties of multi-component borate-based glass series. Seven glass-samples with composition of (80-y)H₃BO₃-10ZnO-10Na₂O-yBaO where (y = 0, 5, 10, 15, 20, 25 and 30 mol.%) were synthesized by melt-quench method. Various shielding features for photons, neutrons, and protons were determined for all prepared samples. XCOM, Phy-X program, and SRIM code were performed to determine and explain several shielding properties such as equivalent atomic number, exposure build-up factor, specific gamma-ray constants, effective removal cross-section (Σ_R), neutron scattering and absorption, Mass Stopping Power (MSP) and projected range. The energy ranges for photons and protons were 0.015-15 MeV and 0.01-10 MeV, respectively. The mass attenuation coefficient (μ/ρ) was also determined experimentally by utilizing two radioactive sources (¹⁶⁶Ho and ¹³⁷Cs). Consistent results were obtained between experimental and XCOM values in determining μ/ρ of the new glasses. The addition of BaO to the glass matrix led to enhance the μ/ρ and specific gamma-ray constants of glasses. Whereas the remarkable reductions in Σ_R, MSP, and projected range values were reported with increasing BaO concentrations. The acquired results nominate the use of these glasses in different radiation shielding purposes.

• The Bulletin of The Korean Astronomical Society
• /
• v.40 no.1
• /
• pp.53.3-54
• /
• 2015

We are developing large arrays of X-ray microcalorimeters for applications in X-ray astronomy. X-ray microcalorimeters can detect the energy of X-rays with extremely high resolution. High-resolution Imaging spectroscopy enabled by these arrays will allow us to study the hot and energetic nature of the Universe through the detection of X-rays from astronomical objects such as neutron stars or black holes. I will introduce the state-of-the-art X-ray microcalorimeters being developed at NASA/GSFC and the future X-ray observatory missions based on microcalorimeters.

• Journal of Radiopharmaceuticals and Molecular Probes
• /
• v.8 no.1
• /
• pp.39-44
• /
• 2022

The development of methods for the inert and stable radiohalogenation of targeted radiopharmaceuticals is a prerequisite for real-time diagnosis and therapy using radiohalogenated radiopharmaceuticals. Radiohalogenated carboranes demonstrate superior stability in vivo and versatile applications compared with directly labeled tyrosine analogues or synthetically modified organic compounds. Herein, we focus on the most common approaches for the radioiodination (¹²³l, ¹²⁴l, ¹²⁵l, and ¹³¹l) of carborane derivatives.

• Journal of the Korean Society of Radiology
• /
• v.14 no.7
• /
• pp.937-946
• /
• 2020

The grating interferometer provides the differential phase contrast image of an phase object due to refraction of the wavefront by the object, and it needs to be converted to the phase contrast image. The line-integration process to obtain the phase contrast image from a differential phase contrast image accumulates noise and generate stripe artifacts. The stripe artifacts have noise and distortion increases to the integration direction in the line-integrated phase contrast image. In this study, we have configured and compared several machine learning methods to reduce the artifacts. The machine learning methods have been applied to simulated numerical phantoms as well as experimental data from the X-ray and neutron grating interferometer for comparison. As a result, the combination of the wavelet preprocessing and machine learning method (WCNN) has shown to be the most effective.

• Journal of Space Technology and Applications
• /
• v.1 no.2
• /
• pp.160-177
• /
• 2021

The Solar and Space Environment Division of the Korean Space Science Society investigated the use and possession of ground and satellite observations and models of solar and planetary data operated by domestic research institutes and universities. Based on the findings, we would like to introduce observational instruments, data, and models in solar and interplanetary fields in this paper to improve understanding and use of each data and explore opportunities for interdisciplinary research. The ground and satellite observations, which require a lot of investment, were mainly held by research institutes (National Meteorological Satellite Center, Polar Research Institute, Korean Space Weather, Korea Astronomy and Space Science Institute and KAIST Satellite Research Institute), and model development was overwhelmingly carried out at Kyung Hee University. In solar and interplanetary fields, we introduce Fast Imaging Solar Spectrograph (FISS), neutron monitors, and the analysis models [for the Solar Dynamics Observatory/Atmospheric Imaging Assembly (SDO/AIA) and Hinode/X-Ray Telescope (XRT) observations] in nonequilibrium ionization state as representatives. Survey on solar and interplanetary fields can be downloaded from the website of the Korean Space Science Society (http://ksss.or.kr/). The paper makes know the importance of long-term and continuous management of space science-related materials, and hopes to contribute to enhancing the status of domestic space science data by utilizing locally produced data by various personnel participating in space science research.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2016.02a
• /
• pp.425.1-425.1
• /
• 2016

고온의 플라즈마를 긴 펄스 및 장시간 연속운전 유지기술 개발 및 연구를 위해서는 플라즈마는 더욱 가열되어야 하고, 고온 고밀도의 플즈마 상태를 유지시켜야 한다. 이러한 고성능 플라즈마 개발은 향후 핵융합 에너지의 상용화를 위한 절대필수적 기반기술이다. 현재 KSTAR 토카막에서는 플라즈마를 가열하기 위한 장치들 중 하나로서, 출력 6 MW 급의 중성입자빔을 입사하는 NBI (Neutral Beam Injection) 가열장치가 설치 운영 중에 있다. 이 NBI 가열장치는 진공환경에서 고온, 고압, 고전압 방전 및 수냉 등이 작동 및 운전되고 있기 때문에, 구성 부품 들의 미세한 구조적 결함에도 장치의 치명적 failed로 이어질 수 있다. 이번 연구에서는 NBI 가열장치의 특성상 극한 운전 환경에 있는 진공용기 부품 중 하나 인 빔인출을 위한 가속 그리드 (accelerating grid)의 구조적 손상및 결함 여부를 고속중성자 이미지 기법을 적용하여 내부를 투시 진단하였다. 가속 그리드는 copper로 제작되었고, 빔인출을 위한 원형의 구멍과 냉각관을 가진 평면판 형태로 되었다. 본 연구에서 내부투시 및 진단할 수 있는 고속중성자 이미징 기법의 적용으로 진공용기 부품 및 장치의 구조적 결함 및 손상 여부를 판단 가능하다는 연구 결과를 얻었다.