• Journal of Pharmaceutical Investigation
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• v.25 no.4
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• pp.331-338
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• 1995

In order to screen appropriate preservatives for the suspension containing sucralfate, neusilin and hydrotalcite, the patterns and mechanism of the adsorption and desorption of several preservatives on these antacids were studied. The employed preservatives were parabens(methyl, propyl, butyl), chlorhexidine diacetate and sorbic acid. While none of parabens were adsorbed on three antacids, chlorhexidine diacetate was strongly adsorbed on all the antacids employed, especially on hydrotalcite. Sorbic acid was not adsorbed on neusilin and hydrotalcite, however, 65% of sorbic acid was adsorbed on sucralfate. The adsorption of chlorhexidine diacetate on neusilin and hydrotalcite was partly physical and partly chemical, while its adsorption on sucralfate was almost chemical. Sorbic acid was completely deserted from sucralfate. In all cases, the adsorption isotherms were fitted well to both Freundlich equation and Langmuir equation. Based on these results, parabens and sorbic acid were the preservatives of choice for the suspension containing sucralfate, neusilin and hydrotalcite.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.93-93
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• 1995

The three combined products were prepared as suspended solutions composed of various ratio of Sucralfate, Hydrotalcite and Neusilin, into which 30% ethanol extracts of Machili cortex, and of Atractylodis rhizoma were added. The efficacy for these products was examined in vivo using a pyrous ligation method in rats. The influence of these products on the intestinal motility was also examined in mice. In all experimental setting, the antisecretory effect of the combined treatment was more pronounced than that of each drug alone. The combined treatment consisted of Sucralfate, Hydrotalcite, Neusilin ratios of 2:2:1 produced the highest inhibitory effect for the gastric secretion. The intestinal motility was not influenced significantly by the treatment of all experimental setting. The above results revealed that the therapeutic dose of Sucralfate, Hydrotalcite, Neusilin given in combination showed a synergistic effect for the inhibition of gastric secretion and little side effect on the intestinal motility. Therefore, the combined product with Sucralfate, Hydrotalcite, Neusilin ratio of 2:2:1 is recommended for the useful drug to heal the gastrointestinal diseases with no side effect on the intestinal motility.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.12
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• pp.329-334
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• 2017

In this study, a new granular type mouthwash with equivalent antibacterial activity to marketed liquid type mouthwash was developed using a material called magnesium aluminometasilicate (Neusilin). This material adsorbs the surface of granules to improve the flowability of granules due to the formation of a eutectic mixture of the main constituents, which have improved flow properties and rapid disintegration time and little residue in the oral cavity. The characteristics of the granules were improved when the amount of Neusilin was 10% or more according to measurements of the granule properties, such as flowability. In addition, a disintegration test in artificial saliva and a sensory test in the human oral cavity were carried out to confirm the improved disintegration characteristics and sensory test results. The antimicrobial test confirmed similar antibacterial activity to that of the liquid oral cleanser already sold in the market. The granular oral cleanser composition prepared in this study can be used for the development of pharmaceuticals containing different drugs with similar characteristics as eutectic mixtures at the same time, which is considered to be useful in the development of medicines in the pharmaceutical industry.