• 수면정신생리
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• 제2권2호
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• pp.105-114
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• 1995

Schiophrenia is characterized by a variety of cognitive dysfunctions. A number of research findings suggest that schizophrenic patients have global deficits in cognitive functions, such as attention, memory, executive functions, and motor functions. These cognitive deficits, once they arise, tend to become relatively stable. In spite of much efforts to search for the cognitive dysfunctions in schizophrenia, there are no specific deficits or localizations found. It is necessary that future neuropsychological research of schizophrenia should include relationships between symptoms and cognitive dysfunctions and their relationships to treatment.

• 수면정신생리
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• 제6권2호
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• pp.143-148
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• 1999

목 적: 지각 장애가 어떤 뇌의 부위와 기능에 장애가 있을 때 발생되는지를 알아보기 위해 정신과와 뇌손상 환자에서 신경심리 검사와 지각 장애와 관계성을 조사하였다. 방 법: 정신과 환자 69명, 뇌손상 환자 50명, 총 119명에서 Halstead Reitan 신경 심리 검사와 K-WAIS, MMPI를 시행하였다. MMPI 항목 중 지각 장애와 관계되는 9개 항목에서 산출된 점수와 신경심리 검사의 결과와의 상관 관계를 조사하였다. 또 정신과 환자에서 지각 장애 점수가 높은 지각 장애군 21명과 지각 장애가 없는 지각 장애 17명을 t-test로 비교하였다. 결 과: 뇌손상 환자군에서 지각 장애가 전두엽 기능을 보는 범주화 검사, 선로 잇기 검사, 촉각 수행 검사, 손끝 숫자 쓰기 검사와 우측 반구 기능을 보는 촉각 수행 검사의 위치, 동작성 점수, 빠진곳 찾기, 차례 맞추기, 토막 짜기 등과 유의한 상관 관계를 보였다. 또 피질하 기능을 보는 숫자 상징, 산수, 숫자 외우기와 유의한 상관 관계를 보였다. 정신과 환자의 높은 지각 장애군은 우측 반구 편측화 지수와 빠진 곳 찾기, 토막 짜기와 같은 우측 반구 기능에서 유의한 차이가 있었고, 또 이해, 어휘, 공통성과 같은 좌측 반구 기능에서도 유의한 차이가 있었다. 결 론: 지각 장애는 전두엽, 우측 반구, 피질하 구조의 기능과 깊은 연관성을 가지고 발생이 되며, 정신과 환자군에서는 좌측 반구의 기능도 영향을 주는 것으로 생각된다.

• 수면정신생리
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• 제1권1호
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• pp.76-86
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• 1994

연구배경 : 사건관계 전위와 신경심리 검사의 상호관계를 연구함으로 각각의 사건 관계 전위의 신경심리학적 의미와 그 전위가 발생되기 위해 어떠한 뇌 기능과 뇌 구조가 연관되는지를 조사해 보려고 하였다. 연구방법 : 56 명의 환자에서 시각 유발 전위 P100과 사건 관계 전위 N120 과 P300 의 전위 및 잠복기와 여러 신경심리 검사의 상호관계를 조사하였다. 결 과 : 시각 유발 전위 (VEP) 의 P100의 잠복기와 상관 관계를 보인 신경심리 검사는 시각지속수행 검사, 조건화 지속 수행 검사였다. 그러나 P100 의 전위와는 유의한 상관관계가 있는 검사는 없었다. N120 잠복기와 범주 검사, KWIS 의 언어성 지능 등이 유의한 상관관계를 보였다. N120 전위는 수지력 검사, 시각 지속 수행 검사, 조건화 지속 수행 검사, 숫자 상정 검사 등이었다. P300 의 잠복기는 선로 잇기 A 검사와 Stroop 검사와 유의한 상관관계를 보였다. P300의 전위는 선로 잇기 B 검사, 숫자 상정 검사, Wechsler 기억 척도, 수지력 검사, Stroop 검사, 시각 지속 수행 검사, 조건화 지속 수행 검사 등과 유의한 상관관계를 보였다. 결론 : N120 은 전두엽의 내측을 가장 예민하게 반영할 수 있는 검사이며 P300 은 내측두엽, 해마체, 시상, 기저핵 및 내전두엽 동의 피질하 구조가 밀집하게 관계되어 발생되는 전위로 생각된다.

• 대한조현병학회지
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• 제23권1호
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• pp.15-28
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• 2020

Objectives: This study investigated the relationship between clock-drawing test (CDT) performance and neuropsychological functions in patients with chronic schizophrenia. Methods: Thirty-one patients with schizophrenia and 30 healthy controls participated in this study. The CDT was administered in three conditions and analyzed using both quantitative and qualitative scoring systems. Comprehensive neuropsychological tests were administered. Results: The results of the quantitative analysis showed that the schizophrenia group performed significantly worse in all three conditions of the CDT compared with the control group. However, no significant differences were observed between the two groups, when the IQ and educational level were controlled. The qualitative analysis showed that the schizophrenia group exhibited significantly more errors in "graphic difficulty" compared with the control group. In addition, CDT quantitative scores were significantly correlated with visuospatial function, memory, attention and executive functions in patients with schizophrenia. Conversely, each qualitative error type was correlated with specific cognitive domains. Furthermore, "graphic difficulty" and "spatial/planning deficit" were identified as predictors of depression symptoms in patients with schizophrenia. Conclusion: The present study demonstrated that the CDT is useful for assessing cognitive dysfunctions in patients with schizophrenia, while qualitative analyses provide more specific information about cognitive deficits compared with quantitative analyses.

• 동의생리병리학회지
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• 제27권5호
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• pp.553-562
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• 2013

This study was performed to develop cold-heat and deficiency-excess pattern identification for dementia, as well as for standard Korean medicine diagnosis and treatment. Five experts comprised of 4 neuropsychiatrists of Korean medicine and 1 statistician to develop cold-heat and deficiency-excess pattern identification for dementia. We searched studies about pattern identification and selected 507 articles using Oasis search terms provided by the KIOM. As a result, 10 pattern identification research study were recruited. Moreover, we analyzed neuropsychological assessments for dementia that evaluate Behavioral and Psychological Symptoms of Dementia (BPSD) and cognitive function using experts conferences and we selected neuropsychological instruments using pattern identification. Six cold patterns, six heat patterns, ten deficiency patterns, and four excess patterns were identified according to the cold-heat and deficiency-excess pattern identification of dementia. We selected the Caregiver-Administered Neuropsychiatric Inventory and the Korean Mini-Mental State Examination as neuropsychological assessments of dementia, which examine behavioral symptoms and cognitive function, suspectively. We formed positive and negative correlation between Korean medicine pattern identification and neuropsychological assessments for dementia. We developed and suggested a forecast module of pattern identification for dementia. But, it is necessary to perform additional clinical trials to verify its validity and accuracy.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제25권4호
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• pp.209-216
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• 2014

Objectives : Alcohol use disorder (AUD) is often comorbid with adult attention-deficit hyperactivity disorder (ADHD) and other psychiatric illnesses. When associated with other mental problems, the prognosis of the AUD can be more serious. This study shows research on the clinical and neuropsychological characteristics according to whether or not ADHD symptoms and AUD were comorbid. Methods : A total of 64 adult inpatients who completed AUD scales about adult ADHD, alcohol dependence, depression, anxiety, and impulsiveness. They also completed neuropsychological tests about attention and executive function. According to the Adult ADHD Self-Report Scale score, patients were categorized into two groups (ADHD symptom positive/negative group). Results : Fourteen among the 64 subjects were part of the ADHD symptom positive group (21.9%). They had statistically significant shorter abstinence periods and a higher rate of history of 'rule violation during school' and 'physical damage in childhood' compared to the ADHD symptom negative group. Conclusion : The comorbidity rate with ADHD symptom in adult AUD is higher than the general population. The ADHD symptom positive group suffered from more severe and refractory AUD. Considering the more frequent history of rule violation during school in the ADHD symptom positive group, the association between ADHD and AUD may be mediated by conduct disorder. Therefore we suggest the necessity of careful evaluation and intervention in children and adolescents with ADHD and conduct disorder.

• 수면정신생리
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• 제6권2호
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• pp.149-157
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• 1999

정신과 임상에서 편리하게 사용할 수 있는 전산화 신경심리 검사 시스템을 개발하였다. 이 시스템은 뇌의 전반적인 인지 기능과 뇌의 기능적 국재화를 평가할 수 있는 14개의 신경심리 검사로 구성되어 있다. 개발된 시스템은 멀티미디어와 객체 지향 개념에 의해 설계, 구현되었고, 마이크로 소프트 Windows에 기반을 둔 그래픽 인터페이스를 채용하여 운용이 용이하도록 하였다. 또한 마우스와 터치 스크린을 이용하여 피검사자로부터 입력을 손쉽게 받아드릴 수 있도록 하였으며, 색채 단어 검사, 범주 검사, 그리고 언어 기억 검사, 언어 지각 검사 등은 한글화하여 검사의 효율성을 향상시켰다. 개발된 시스템을 뇌손상 환자와 정신과 환자에 적용한 결과 그 인지 장애와 뇌의 기능적 국재화를 평가하는데 유용하게 사용될 수 있었다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제24권3호
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• pp.157-163
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• 2013

Objectives : Previous studies reported that attention-deficit hyperactivity disorder (ADHD) resulted from a deficit of selective attention and sustained attention. In this study, we assessed the result of methylphenidate-induced changes of the cerebral frontal executive functions in patients with ADHD. Methods : The subjects in this study consisted of 16 ADHD patients whose age ranged from 7 to 12. We used ADHD Diagnostic System (ADS) for the attention improvement, and the Stroop Test for the executive function response to pharmacotherapy with MPH. Results : After pharmacotherapy with methylphenidate for 12 weeks, the study group showed improvement in the clinical aspects through Clinical Global Impression-Severity, ADHD-rating scale and Inattention/Overactivity With Aggression Conner's Parents Rating Scale. In the ADS test, only in auditory task there was a decrease of both the response time and the standard deviation of the response time significantly. In the Stroop Test, there was a decrease in the word task, color task and color-word task significantly. Conclusion : Our results show that psychostimulant medication improves neuropsychological function, including the cerebral frontal executive function. This study implies that we have to consider the improvement of executive function, as well as attention when evaluating the efficacy of treatment.

• Clinical and Experimental Pediatrics
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• 제55권10호
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• pp.383-387
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• 2012

Purpose: Although benign rolandic epilepsy (BRE) is a benign condition, it may be associated with a spectrum of behavioral, psychiatric, and cognitive disorders. This study aimed to assess the cognitive and other neuropsychological profiles of children with BRE. Methods: In total, 23 children with BRE were consecutively recruited. All children underwent sleep electroencephalography (EEG) and were assessed on a battery of comprehensive neuropsychological tests including the Korean versions of the Wechsler intelligence scale for children III, frontal executive neuropsychological test, rey complex figure test, Wisconsin card sorting test, attention deficit diagnostic scale, and child behavior checklist scale. Results: The study subjects included 13 boys and 10 girls aged $9.0{\pm}1.6$ years. Our subjects showed an average monthly seizure frequency of $0.9{\pm}0.7$, and a majority of them had focal seizures (70%). The spike index (frequency/min) was $4.1{\pm}5.3$ (right) and $13.1{\pm}15.9$ (left). Of the 23 subjects, 9 showed frequent spikes (>10/min) on the EEG. The subjects had normal cognitive and frontal executive functions, memory, and other neuropsychological sub-domain scores, even though 8 children (35%) showed some evidence of learning difficulties, attention deficits, and aggressive behavior. Conclusion: Our data have limited predictive value; however, these data demonstrate that although BRE appears to be benign at the onset, children with BRE might develop cognitive, behavioral, and other psychiatric disorders during the active phase of epilepsy, and these problems may even outlast the BRE. Therefore, we recommend scrupulous follow-up for children with BRE.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제16권1호
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• pp.33-46
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• 2005

본고에서는 인간의 뇌 발달과 주의력, 지각, 기억, 언어 등 다양한 인지기능의 발달과의 관계를 살펴본 후, Luria의 발달 신경심리 이론 및 그에 입각하여 개발된 아동용 Luria-Nebraska신경심리검사를 간략하게 소개하였다. 마지막으로, 현재 국내, 외에서 널리 사용되는 주의력 검사, 시-지각 검사, 시각-운동 협응 능력 검사, 그리고 전두엽의 집행기능검사 등을 포함한 아동용 신경심리 평가도구에 대해 고찰해보았다.