• 한국언론정보학보
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• 제61권
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• pp.5-27
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• 2013

유명인의 자살이 잇달아 발생하고 그 원인으로 우울증이 지목되면서 언론보도 전반에서 우울증에 대한 보도량이 늘고 있다. 그러나 선행연구의 부족으로 이러한 보도들이 질적인 측면에서 우울증을 건강행동이 필요한 질병으로 심층적으로 다루고 있는지는 불분명하다. 본 연구는 이를 알아보기 위해 2007년부터 약 5년간 온라인 전문 뉴스 미디어의 우울증 보도를 살펴보았다. 정신질환에 대한 선행연구들이 신문과 텔레비전 같은 전통적인 미디어에 초점을 맞춘데 반해, 본 연구는 최근 이용 빈도와 사회적 영향력 측면에서 중요한 온라인 보도를 분석했다. 연구 결과, 우울증 보도에 가장 많이 등장하는 정보원은 연예인, 스포츠스타, 정/재계 인사를 비롯한 유명인 환자였고, 일반인 환자와 비교해 4배 정도 많이 나타났다. 심지어 환자가 아닌 유명인도 일반인 환자보다 2배 이상 많이 등장했고, 의사를 비롯한 전문가도 유명인 환자의 절반 수준 밖에 등장하지 않았다. 또한 분석대상 기사의 약 3분의 1이 우울증의 원인에 대해 전혀 언급하지 않았고, 불우한 환경이나 소심한 성격 등 사회 심리 환경적 원인을 언급한 기사가 전체의 절반이 넘었으며 소수의 기사만이 뇌신경 손상, 호르몬 변화와 같은 신경생물학적 원인을 언급했다. 우울증의 치료방식 역시 분석 대상 기사의 절반 이상에서 전혀 언급되지 않았고, 의사 상담과 약물치료 같은 적극적 치료방식을 제시한 기사가 식이요법, 운동 및 주변 사람들과의 대화와 같은 소극적 치료방식을 제시한 기사에 비해 2배 이상 많았다. 전반적으로 우울증의 원인과 치료방식에 관해 언급하는 정도는 유명인 환자 중심의 기사에서 보다 일반인 환자 중심의 기사에서 높게 나타났다. 원인과 치료방식이 제시되는 정도 간 관계를 분석한 결과, 기사 내에서 우울증의 원인으로 신경생물학적 원인이 많이 제시될수록 적극적 치료방식과 소극적 치료방식 모두 제시되는 정도가 높게 나타났다. 한편 우울증 보도에 가장 많이 나타난 뉴스 프레임은 개인이 겪은 일화를 소개하는 인간적 흥미 프레임이었고, 사건, 사고, 분쟁을 다룬 갈등 프레임과 홍보 및 프로모션을 목적으로 한 상업적 프레임이 그 뒤를 따랐다. 또한 우울증 관련 보도에 한때 우울증을 겪었던 사람들이 회복한 후 이룬 긍정적인 업적이나 성취와 같은 내용이 나타나는 경우는 매우 적었다.

• 생약학회지
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• 제49권2호
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• pp.182-187
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• 2018

Many plant derived phytochemicals have been considered as the main therapeutic strategy against Alzheimer's disease (AD). AD is a progressive neurodegenerative disorder, and the most predominant cause of dementia in the elderly. Cholinergic deficit, senile plaque/${\beta}$-amyloid ($A{\beta}$) peptide deposition and oxidative stress have been identified as three main pathogenic pathways which contribute to the progression of AD. We screened many different plant species for their effective use in both modern and traditional system of medicines. In this study, we tested that MeOH extract of the stem bark of Hopea chinensis (Merr.) Hand.-Mazz. (HCM) affects on the processing of Amyloid precursor portein (APP) from the APPswe over-expressing Neuro2a cell line. We showed that HCM reduced the secretion level of $A{\beta}42$ and $A{\beta}40$ in a dose dependent manner. We found that HCM increased over 1.5 folds of the secretion level of $sAPP{\alpha}$, a metabolite of ${\alpha}$-secretase. Furthermore, we found that HCM inhibited acetylcholinesterase activity in vitro. We suggest that the stem bark of Hopea chinensis may be a useful source to develop a therapeutics for AD.

• Journal of Korean Biological Nursing Science
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• 제1권1호
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• pp.100-114
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• 1999

This study was done to investigate the effects of rapidly-rotating shift work of two-day interval on fatigue level and the concentration of urinary 17-KS, $Na^+,\;Cl^-$. The subjects were 20 nursing college students(control group) and 15 nurses in a university hospital and the study was done from Apr. 21 to May 4th, 1999. In the test group, each 5 nurses were allocated to day shift(8 AM-4 PM), evening shift(4 PM-12 MN) and night shift(12 MN-8 AM) respectively. The fatigue level were measured 30 minutes after work start on the 2nd day of work shift. Urine specimens were collected at 8 AM, 4 PM and 12 MN on the 2nd day of work shift in the control group and 30 minutes before and after work on the 2nd day of work shift in the test group. The data were analyzed with SPSS(for Window, ver 7.5). Statistical analysis was performed by using t-test, paired t-test and ANOVA. The results were as follows. 1. The perceived fatigue level in shift work 1) The physical and mental fatigue level were significantly higher in night shift than that in day or evening shift(p<0.05). In the neuro-sensory fatigue level, night shift showed higher tendency than that in day or evening shift, but there were no significant differences between each shifts. 2) Comparison between the control group and the test group: Physical fatigue level was significantly higher in night shift than that in day or evening shift of the control group(P<.001). Mental fatigue level was significantly higher in day or night shift than that in evening shift of the control group(P<.05). In the neuro-sensory fatigue level, test group showed higher tendency than that in the control group, but there were no significant differences between two groups. 3) The total fatigue level was higher in night shift than that in day shift or evening shift(P<.05). In comparing with the control group, night shift and day shift showed higher total fatigue level than that in the control group(p<0.05). 2. The concentration of urinary 17-KS, $Na^+$ and $Cl^-$ In the control group, urinary 17-KS, $Na^+$ and $Cl^-$ showed higher level in afternoon that in morning and night. In the test group, cr in day and evening shift and $Na^+$ in evening shift showed higher level at the end of work. The 17-KS concentration at the begining and the end of work in three shift groups were lower than those in control group(p<0.05), however, $Cl^-$ concentration at the begining of work in day shift, and the end of work in day and evening shift were higher than those in control group(p<0.05). $Cl^-$ concentration at the begining and end of work in night shift were considerably higher than those in control group repectively(p<0.1, p<001). $Na^+$ concentration showed a higher tendency in three shift groups except at the begining of work in night shift, but there were no statistical difference. In comparing concentration of the 17-KS, $Na^+$ and $Cl^-$ among the shift groups, 17-KS concentration showed a lower tendency and $Na^+,\;Cl^-$ showed a higher tendency in night shift: The result of this study showes that biorhythm of shift work nurse was irregular. Fatigue level as the subjective index for evaluating the health problem concerning shift work was higher in night shift and proved to be in accordance with the concentration of urinary 17-KS, $Na^+$ and $Cl^-$ used as objective indices. Disturbation of biorhythm and work stress due to night shift seems to cause the health problem of nurses and decrease of work efficiency. It is considered that work regualtion is necessary for the rational management of the nursing administration.