• 대한후두음성언어의학회지
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• 제8권2호
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• pp.166-172
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• 1997

Background : For example, aerodynamic study, vibratory study, acoustic study, neuro-muscular test and psychoacoustic evaluation, a number of objective methods are now available for assessing pathologic voice change. They help to differentiate pathologic condition from normal condition and to monitor pathologic and aging change. These laboratory analyses are used commonly to monitor speech therapy and to follow a patient's recovery after surgery. Objectives : We investigated the values of jitter, shimmer and NNE of normal person and hoarseness patients in Korea. The values of Jitter and shimmer might be meaningful parameters distinguishing pathologic vibration from normal and recovery after surgery. Materials and Methods : Statistical significance between normal control and 48 subjects taken microlaryngeal surgery were compared with Dr. speech science program that is computerized system for acoustic analysis of voice production employed to determine vocal characteristics of pitch perturbation(jitter) and amplitude perturbation(shimmer). Results : The mean normal values of jitter and shimmer were 0.226${\pm}$0.110(%), 2.200${\pm}$0.421(%) in male and 0.164${\pm}$0.060(%), 2.063 ${\pm}$0.575(%) in female. In patients with vocal nodule, the preoperative and postoperative values of jitter and shimmer were valueless. In patients with vocal polyps, the preoperative and postoperative values of jitter and shimmer were valuable. Conclusion : Dr. speech science program was effective to monitor laryngeal disease and aging changes.

• 대한한의학방제학회지
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• 제25권4호
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• pp.483-497
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• 2017

Background : Behavioral stress has been suggested as one of the significant factors that is able to disrupt physiological systems and cause depression as well as changes in various body systems. The stressful events can alter cognition, learning, memory and emotional responses, resulting in mental disorders such as depression and anxiety. Results : We used a restraint stress model to evaluate the alteration of behavior and stress-related blood parameter. The animals were randomly divided into two groups of five animals each group. Furthermore, we assessed the change of body weight to evaluate the locomotor activity as well as status of emotional and anxiety in mice. After 7 days of restraint stress, the body weight had significantly decreased in the restraint stress group compared with the control group. We also observed stress-associated behavioral alterations, as there was a significant decrease in open field and forced swim test, whereas the immobilization time was significantly increased in the stress group compared to the control group. We observed the morphological changes of neuronal death and microglia by immunohistochemistry and western blot. In our study restraint stress did not cause change in neuronal cell density in the frontal cortex and CA1 hippocampus region, but there was a trend for an increased COX-2 and iNOS protein expression and microglia (CD11b) in brain, which is restraint stress. Conclusion : Our study, there were significant alterations observed in the behavioral studies. We found that mice undergoing restraint stress changed behavior, confirming the increased expression of inflammatory factors in the brain.

• 대한간호학회지
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• 제22권4호
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• pp.620-635
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• 1992

This study identified correlations between perceived family support and hopelessness in patients admitted to Neuro - surgical Intensive Care Units. The purpose was to enhance theoretical understanding of the relationships of these two variables. The subjects of this study were 51 patients admitted to N-lCU, at three general hospitals in Seoul. Data were collected by researcher in structured interviews from Aug. 12 to Oct. 13, 1992. The research tools were parts of the Moos Family Environment Scale and the Beck Hopelessness Scale. The general characteristic data were analyzed for frequency and percentage ; the hypothesis was tested by the pearson product Moment Correlation Coefficient. After normality tests by using Kolmogorov - Sminorvtest, and T- test, ANOVA and Mann-Whitney U test, Kruskal -Wallis test were used on the Family Support and the Hopelessness about general charcteristics. The results of the above analysis were as follows 1) The average family support score for the group was 63.61 (tool average 51) and item average was 3.74 (tool item average 3) : the family support score of this sample was higher than average. The average family cohesion score of family support was 35.25 (tool average 27) and item average was 3.91 (tool item average 3). The average family expression score of family support was 28.35 (tool average 24) and item average was 3.57 (tool average 3). In this sample, perceived family expression was lower than family cohesion. 2) The average hopelessness score was 45.88 (tool average 60) and item average was 2.29 (tool item average 3) : the hopelessness score of this sample was low in comparison to the average. 3) The hypothesis in this study was supported. The main hypothesis that the higher the perceived family support level, the lower the level Of the hopelessness, was Supported (r＝-.3869 p＝.003). The sub-hypothesis that the higher the perceived family cohesion level, the lower the level of hopelessness, was supported(r＝-.3688 p＝.004). The sub-hypothesis that the higher the perceived family expression level, the lower the level of hopelessness, was supported (r＝-.3068 p＝.014). 4) General characteristics of the objects related to family support were ‘economic status’(p＝.025) and ‘helping person’(P＝.044) : the higher the economic status, the greater the family support. When the patient identified the helping person as a spouse, family support was rated more highly. The only general characteristic related to family cohesion was ‘helping person’(p＝.041). No general characteristics were related to family expression. 5) The one general characteristic related to hopelessness was ‘education’(p＝.002) : the higher their education, the lower their hopelessness. For these ICU patients, were related perceived family support and hopelessness, and family expression level was low in comparison to family cohesion level. The perceived family support of these seriously ill patients in situational crisis may have influenced the patient's emotional reaction of hopelessness. This study concluded that nurses in the ICU confirm the family support of the patient, and involve the family as the most intimate support systems in the care of the patient to help reduce the patient's hopelessness.

• 감성과학
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• 제20권1호
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• pp.31-40
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• 2017

이 연구는 뉴로 마케팅의 여러 연구 기법들 중 시선추적 기술(Eye-tracking)을 이용하여 농구 경기 장면 중 남성의 동공이 전체 데이터의 3시그마 범위를 벗어난 상위 0.135 % 비율로 동공이 확장 되었을 때의 시선 관찰 및 관심도를 측정하였다. 특히 동공 크기 확장과 관련해서 시선추적 기술의 데이터 중 어느 정도의 범위일 때의 크기가 유의미하다고 밝히기는 힘들기 때문에 이 연구에서는 전체 데이터 중 상위 3시그마 범위를 동공이 확장되어지는 범위로 설정하였다. 실험에 사용된 장면은 농구 경기 중 한 상황으로 설정하였으며, 총 7,200개의 데이터 중 유효율 90 %가 넘는 유효데이터가 산출되었고 이를 통해 34명의 데이터 중 유효데이터에 해당하지 않아 사용할 수 없는 데이터를 제외한 29명의 데이터를 사용하였다. 동공의 크기를 구하기 위해 동공의 너비(Pupil Width)와 높이(Pupil Height) 값을 [동공의 크기 = 동공의 너비/2${\times}$동공의 높이/$2{\times}{\pi}$] 공식에 대입하였다. 분석한 결과 농구경기장 내 마케팅으로 활용되기 위해 사용된 광고판들은 크게 영향력을 끼치지 않았다. 관중으로서의 피험자들의 동공의 크기가 커졌을 때, 경기장내에 광고판 보다는 선수들 혹은 주변 배경에 주시빈도가 높았다. 이 연구를 통하여 무분별하게 광고판을 사용하기보다는 뉴로마케팅을 이용하여 경기장내 마케팅 및 광고판 효용성을 높이는 방안의 필요성이 요구된다.

• 한국산학기술학회논문지
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• 제20권5호
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• pp.372-383
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• 2019

본 연구는 정신병원 간호사를 대상으로 낙상에 대한 지식, 태도 및 환자안전문화인식이 낙상예방활동에 미치는 영향을 파악하기 위한 목적으로 시도되었다. 연구방법은 부산광역시와 경상남도 지역의 7개 기관의 정신병원에 근무하는 간호사 153명을 대상으로 한 서술적 조사연구로, 2018년 3월 5일부터 2018년 3월 30일까지 자료를 수집하였다. 연구통계방법은 IBM SPSS/win 24.0 프로그램을 t-test, ANOVA 그리고 다중회귀분석을 이용하였다. 그 결과, 연구 대상자의 면허나 자격에 따라 낙상태도에 차이가 있었고, 교육수준이 높을수록 환자안전문화인식정도가 높았으며, 근무경력이 많을수록 낙상예방활동이 높았다. 그리고 환자안전문화인식이 높을수록 낙상간호에 대한 태도가 높았으며, 낙상예방활동이 높을수록 낙상태도와 낙상안전문화인식이 높은 것으로 나타났다. 연구대상자의 낙상에 대한 지식, 태도, 환자안전문화인식이 낙상예방활동에 미치는 영향을 다중회귀분석 한 결과, 낙상예방활동에 대한 설명력은 12.5%로 나타났다. 그러므로 정신병원 간호사의 낙상예방활동을 증진시키기 위해서는 계속적인 교육을 통해 지식을 확장하며 낙상태도를 변화시킬 수 있는 교육프로그램 개발 및 제공이 요구된다. 또한 병원조직 차원에서 안전에 대한 전반적인 인적, 제도적 환경의 변화 등 다방면의 지원이 요구된다.

• 한국농업기계학회:학술대회논문집
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• 한국농업기계학회 2000년도 THE THIRD INTERNATIONAL CONFERENCE ON AGRICULTURAL MACHINERY ENGINEERING. V.II
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• pp.124-131
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• 2000

In this study, the NEURAL NETWORK (hereinafter referred to as NN) was applied to control of the nonlinear factors for turning movement of the crawler vehicle and experiment was carried out using a small model of crawler vehicle in order to inspect an application of NN. Furthermore, CHAOS NEURAL NETWORK (hereinafter referred to as CNN) was also applied to this control so as to compare with conventional NN. CNN is especially effective for plane in many variables with local minimum which conventional NN is apt to fall into, and it is relatively useful to nonlinear factors. Experiment of turning on the slope of crawler vehicle was performed in order to estimate an adaptability of nonlinear problems by NN and CNN. The inclination angles of the road surface which the vehicles travel on, were respectively 4deg, 8deg, 12deg. These field conditions were selected by the object for changing nonlinear magnitude in turning phenomenon of vehicle. Learning of NN and CNN was carried out by referring to positioning data obtained from measurement at every 15deg in turning. After learning, the sampling data at every 15deg were interpolated based on the constructed learning system of NN and CNN. Learning and simulation programs of NN and CNN were made by C language ("Association of research for algorithm of calculating machine (1992)"). As a result, conventional NN and CNN were available for interpolation of sampling data. Moreover, when nonlinear intensity is not so large under the field condition of small slope, interpolation performance of CNN was a little not so better than NN. However, when nonlinear intensity is large under the field condition of large slope, interpolation performance of CNN was relatively better than NN.

• Journal of Photoscience
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• 제9권2호
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• pp.475-478
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• 2002

In zoological research, penetration of light has been reported of the frontal bones of fish, birds, and reptiles, suggesting the existence of physiologically direct photic routes to frontal lobes and/or deep parts of the brain. We studied the influences of frontal exposure to photodiode light on frontal alpha wave and peripheral NK cells. Repetitive exposure of the subject's forehead to a red light diode (660nm) significantly increased the effective amplitude of the frontal alpha waves (using a mean frequency with a range of +1.0 Hz), peripheral NK activity, and the level of CD57-CD16+. Frontal alpha wave activity and the level of CD57-CD16+ increased, suggesting the possibility of a non-invasive procedure for the activation of the frontal lobe and the increase of NK cells. This light is considered to penetrate the frontal bones of humans directly, and to act on the frontal lobe and/or other immunological regulatory centers in the brain, resulting in some neuro-immunological changes.

• 한국멀티미디어학회논문지
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• 제23권7호
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• pp.862-869
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• 2020

This study attempted to analyze human brain responses toward visual content through EEG signals and intended to measure brain wave reactions of different age groups to determine the sexuality level of the media. The experimental stimuli consist of three different video footage (rated ages 12, 15, and 18) to analyze how subjects react in situations where they actually watch sexual content. For measuring and analyzing brain wave reactions, EEG equipment records alpha, beta, and gamma wave responses of the subjects' left and right frontal lobes, temporal lobes, and occipital lobes. The subjects of this study were 28 total and they are divided into two groups. The experiment configures a sexual content classification scale with age or gender as a discriminating variable and brain region-specific response frequencies (left/right, frontal/temporal/occipital, alpha/beta/gamma waves) as independent variables. The experimental results showed the possibility of distinguishing gender and age differences. The apparent differences in brain wave response areas and bands among high school girls, high school boys, and college students are found. Using these brain wave response data, this study explored the potential of developing algorithm for measurement of age-specific responses to sexual content and apply it as a film rating.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4793-4799
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• 2012

Hypoxia is commonly featured during glioma growth and plays an important role in the processes underlying tumor progression to increasing malignancy. Here we compared the gene expression profiles of rat C6 malignant glioma cells under normoxic and hypoxic conditions by cDNA microarray analysis. Compared to normoxic culture conditions, 180 genes were up-regulated and 67 genes were down-regulated under hypoxia mimicked by $CoCl_2$ treatment. These differentially expressed genes were involved in mutiple biological functions including development and differentiation, immune and stress response, metabolic process, and cellular physiological response. It was found that hypoxia significantly regulated genes involved in regulation of glycolysis and cell differentiation, as well as intracellular signalling pathways related to Notch and focal adhesion, which are closely associated with tumor malignant growth. These results should facilitate investigation of the role of hypoxia in the glioma development and exploration of therapeutic targets for inhibition of glioma growth.

• 대한의생명과학회지
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• 제24권2호
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• pp.64-75
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• 2018

CCN3 (also known as NOV, Nephroblastoma overexpressed) proteins are involved in various pathologies during different developmental stages. We have previously shown that intracellular levels and normal extracellular secretion of CCN3 are important for neuronal differentiation. Furthermore, we demonstrated that a single amino acid in the CCN3 TSP-1 domain is important for extracellular secretion and that palmitoylation of CCN3 is required in this process. However, the effect of abnormal CCN3 accumulation on cells remains to be studied. Here, we found mutations in the TSP-1 domain of CCN3 that led to intracellular accumulation and abnormal aggregation of CCN3. It was observed that this mutation resulted in a phenomenon similar to neurodegeneration when overexpressed in the developing mouse cortex. This mutation also confirmed the activation of apoptotic gene expression in Neuro2a cells. In addition, we confirmed the in vivo transcriptional changes induced by this mutation using microarray analysis. We observed a significant increase in the expression of Anp32a, an apoptosis-related gene. Collectively, these results indicate that a single mutation in CCN3 can lead to abnormal cell death if it shows intracellular accumulation and abnormal aggregation.