• Journal of information and communication convergence engineering
• /
• 제5권1호
• /
• pp.50-53
• /
• 2007

This paper presents face features detection and a new physiological neuro-fuzzy learning method by using two-dimensional variances based on variation of gray level and by learning for a statistical distribution of the detected face features. This paper reports a method to learn by not using partial face image but using global face image. Face detection process of this method is performed by describing differences of variance change between edge region and stationary region by gray-scale variation of global face having featured regions including nose, mouse, and couple of eyes. To process the learning stage, we use the input layer obtained by statistical distribution of the featured regions for performing the new physiological neuro-fuzzy algorithm.

• 한국지능시스템학회논문지
• /
• 제12권2호
• /
• pp.144-150
• /
• 2002

본 논문에서는 지연시간을 갖는 비선형 시스템의 효율적 제어를 위해 퍼지-신경망에 기반한 지연시간 보상기를 제안하였다. 제안된 제어시스템은 ANFIS(Adaptive Neuro-Fuzzy Inference System)라고 불리는 두개의 퍼지-신경망으로 구성되며 이중 하나는 직-병렬 방식으로 동작하고 다른 하나는 병렬 방식으로 동작한다. 직-병렬 방식으로 동작하는 퍼지-신경망은 지연시간을 갖는 비선형 시스템의 응답을 추종하는 특성을 갖으며 병렬 방식으로 동작하는 퍼지-신경망은 지연시간을 보상하기 위한 시스템 출력을 예측하는 기능을 수행한다. 따라서 본 연구에서 제안된 시스템은 전형적인 Smith 예측기의 비선형 시스템에의 적용을 위한 확장이라고 생각할 수 있다. 본 논문에서는 제안된 지연시간 보상기의 상세한 설계과정을 보였으며 또한 제안된 제어기 설계 기법의 유용성 화인을 위해 비선형 수치데이터에 대한 컴퓨터 모의실험을 수행하였다.

• 정보처리학회 논문지
• /
• 제13권2호
• /
• pp.13-17
• /
• 2024

본 논문에서는 규칙의 수를 줄여 간결한 지식 기반을 보장할 수 있는 합 기반의 전건부를 가지는 뉴로-퍼지 제어기를 제안하였다. 제안된 뉴로-퍼지 제어기는 모든 입력 변수의 AND 조합을 전건부로 하는 구조의 퍼지 규칙보다 더 큰 입력 영역을 커버하기 위해 전건부에 입력 퍼지 집합의 합집합 연산을 허용하였다. 이러한 뉴로-퍼지 제어기를 구성하기 위해 본 논문에서는 OR 및 AND 퍼지 뉴런으로 구성된 multiple-term unified logic processor (MULP)를 고려하였다. 이러한 OR 및 AND 퍼지 뉴런은 조정 가능한 연결 강도 집합을 가지므로 학습을 통하여 최적의 연결 강도 집합을 찾을 수 있다. 초기 최적화 단계에서 유전 알고리즘은 제안된 뉴로 퍼지 제어기의 최적화된 이진 구조를 구성하고, 이후 확률에 기반한 강화 학습은 성능 지수를 더욱 향상시켜서 유전 알고리즘에 의해 최적화된 제어기의 이진 연결을 개선하였다. 역진자 시스템을 제어하기 위한 모의실험 및 실험을 통해 제안된 방법의 유효성을 검증하였다.

• 융합정보논문지
• /
• 제8권6호
• /
• pp.15-20
• /
• 2018

본 연구는 뉴로피드백 훈련을 적용하여 생활습관을 조절하는 자기조절력과 키 성장간의 상관성을 규명함으로 써 키 성장의 효과적인 중재 방안에 대한 해법을 제시하고자 실시하였다. 이를 위해 키 성장 프로그램을 실시하고 있는 초등학교 2학년~4학년 학생 40명(실험군 20명, 대조군 20명) 대상으로 뉴로피드백 훈련 전 후의 변화를 확인하였다. 실험기간은 3개월간(주 2회), 훈련시간은 1회 30분이였다. 뉴로피드백 훈련을 적용한 실험군과 대조군의 자기조절력 차이를 분석한 후, 키 성장 차이를 비교 분석하였다. 첫째, 뉴로피드백 훈련을 적용한 실험군이 대조군에 비해 자기조절력에 유의미한 변화가 있었다. 둘째, 뉴로피드백 훈련을 적용한 실험군이 대조군에 비해 더 크게 키 성장의 변화가 있었다. 이상의 결과를 종합하면 뉴로피드백 훈련이 성장기 학생들에게 있어 키 성장의 후천적 요인들 중 생활습관을 조절하는 자기조절력에 긍정적인 영향을 미치며, 그로 인해 키 성장에도 긍정적인 영향을 미친다는 것이 확인되었다.

• Bulletin of the Korean Chemical Society
• /
• 제32권6호
• /
• pp.2008-2014
• /
• 2011

Serotonin or 5-hydroxytryptamine subtype 2C ($5-HT_{2C}$) receptor belongs to class A amine subfamily of G-protein-coupled receptor (GPCR) super family and its ligands has therapeutic promise as anti-depressant and -obesity agents. So far, bovine rhodopsin from class A opsin subfamily was the mostly used X-ray crystal template to model this receptor. Here, we explained homology model using beta 2 adrenergic receptor (${\beta}$2AR), the model was energetically minimized and validated by flexible ligand docking with known agonists and antagonists. In the active site Asp134, Ser138 of transmembrane 3 (TM3), Arg195 of extracellular loop 2 (ECL2) and Tyr358 of TM7 were found as important residues to interact with agonists. In addition to these, V208 of ECL2 and N351 of TM7 was found to interact with antagonists. Several conserved residues including Trp324, Phe327 and Phe328 were also found to contribute hydrophobic interaction. The predicted ligand binding mode is in good agreement with published mutagenesis and homology model data. This new template derived homology model can be useful for further virtual screening based lead identification.

• Bulletin of the Korean Chemical Society
• /
• 제35권8호
• /
• pp.2304-2310
• /
• 2014

The synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl)quinoline (MPEQ) 3 as a potential mGluR5 selective radioligand is described. We have identified MPEQ 3 exhibiting the analgesic effect in the neuropathic pain animal model. The effect of mGluR5 on neuronal activity in rat brain was evaluated through FDG/PET imaging in the presence of MPEQ 3. In addition, the PET study of [$^{11}C$]MPEQ 3 proved that accumulation of [$^{11}C$]MPEQ 3 in rat brain was correlated to the localization of the mGluR5.

• Bulletin of the Korean Chemical Society
• /
• 제32권6호
• /
• pp.2015-2020
• /
• 2011

A series of isoxazol-indolin-2-one was designed for GSK-3${\beta}$ inhibitors as novel anticancer agents based on their binding mode analysis in GSK-3${\beta}$ crystal structure. Total 21 compounds were synthesized and evaluated for their inhibitory activity against two tumor cell lines (DU145 and HT29). Most of the synthesized compounds were potent with above 80% inhibitory activity at 100 ${\mu}M$, and several compounds were examined for inhibitory activity against GSK-3${\beta}$. Among them, 15(Z) ($R_1$=H, $R_2$=3-Cl-phenyl) was most active with 78% inhibition of tumor cell line (HT29) at 20 ${\mu}M$ and 72% inhibition of GSK-3${\beta}$ at 20 ${\mu}M$.

• The Korean Journal of Pain
• /
• 제20권2호
• /
• pp.181-185
• /
• 2007

Background: The first pain clinic opened in korea in 1973 at Yonsei University Hospital, however, since then the number of pain clinics has gradually increased, as has the number of patients visiting them. This increase in patient has caused concerns about the way in which pain is managed, therefore, we conducted a retrospective review of data according to the sex, age and disease in an attept to aid us in planning for the future of our pain clinic. Methods: We analyzed 1,282 new patients who had visited our pain clinic and 828 inpatients who were admitted to our pain clinic between March 2006 and February 2007. Results: The most frequent age group was in the sixties in outpatient and in the seventies in inpatient. In addition, the incidence of disease in new patients and inpatients was as follows: in new patients, lumbar herniated intervertebral disc 16.5%, hyperhidrosis 12.3%, cervical disc disorder 10.5%, acute herpes zoster 8.2%, postherpetic neuralgia 7.9%, and trigeminal neuralgia 7.0%; in admitted patients, acute herpes zoster 17.6%, trigeminal neuralgia 15.6%, lumbar herniated intervertebral disc 13.0%, postherpetic neuralgia 11.2%, hyperhidrosis 9.8%, and complex regional pain syndrome 7.0%. Conclusions: The patients visiting our pain clinic have presented with a wide variety of diseases. This improved care reflects an effort to expand our fields not only to the management of outpatients but also inpatients, as well as to the treatment of new fields of disease. In the future, We need to manage various pain patients not only in outpatients but also in inpatients to expand our field even through pain clinic is rapidly growing in Korea.

• Journal of Korean Neurosurgical Society
• /
• 제52권5호
• /
• pp.488-490
• /
• 2012

Behçet's disease (BD) is an inflammatory systemic disorder with oral and genital ulcers, as well as ophthalmologic and cutaneous symptoms. Neurological manifestations in BD represent between 2.2% to 50% of the cases. The 25-year-old male patient, diagnosed with BD three years earlier, was admitted to our clinic with complaints of recurrent headaches. Tumor-like-parenchimal involvement was detected on a cranial magnetic resonance imaging. The lesion was removed surgically and then he suffered from right hemiparesis and epilepsy. Pathological examination of the lesion noted a demyelinating non-tumoural etiology. A neuro-Beh$\check{g}$et's case with parenchymal involvement has been examined in light of the literature, in terms of a tumor and a demyelinating disease differential diagnosis.

• Structural Engineering and Mechanics
• /
• 제51권2호
• /
• pp.249-265
• /
• 2014

The mechanical characteristics of materials are very essential in structural analysis for the accuracy of structural calculations. The estimation modulus of elasticity of concrete ($E_c$), one of the most important mechanical characteristics, is a very complex area in terms of analytical models. Many attempts have been made to model the modulus of elasticity through the use of experimental data. In this study, the neuro-fuzzy (NF) technique was investigated in estimating modulus of elasticity of concrete and a new simple NF model by implementing a different NF system approach was proposed. A large experimental database was used during the development stage. Then, NF model results were compared with various experimental data and results from several models available in related research literature. Several statistic measuring parameters were used to evaluate the performance of the NF model comparing to other models. Consequently, it has been observed that NF technique can be successfully used in estimating modulus of elasticity of concrete. It was also discovered that NF model results correlated strongly with experimental data and indicated more reliable outcomes in comparison to the other models.