• IE interfaces
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• v.10 no.3
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• pp.125-132
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• 1997

We proposed a 2-step neural network approach for estimating machining parameters of electric discharge wire cut. The first step net, which is described as a backward neuro-estimation, is designed for estimating coarse cutting parameters while the second phase net, as a polishing forward neuro-estimation, is utilized for determining fine parameters. Sequential estimation procedure, based on backward and forward net, is performed using the net's approximation capability which is M to 1 and 1 to M mapping property. Experimental results an given to evaluate the accuracy of the proposed 2-step neuro-estimation.

• Clinical and Experimental Pediatrics
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• v.45 no.3
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• pp.354-361
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• 2002

Purpose : Selective introduction of genes conferring chemosensitivity into proliferating tumor cells may be used to treat cancer. We first investigated the bystander effect of retrovirus-mediated gene transfer of herpes simplex virus thymidine kinase(HSV-TK) gene to murine neuroblstoma cell line(neuro-2a) in vitro and in vivo. Second, we examined the mechanism and its enhancement of the bystander effect in murine neuroblastoma. Methods : To investigate the bystander effect, we studied tumor growth and survival time after HSV-TK/ganciclovir(GCV) treatment in a syngenic A/J mouse neuroblastoma model by mixing various ratios of HSV-TK-expressing neuro-2a cells with wild type neuro-2a cells followed by GCV treatment. To investigate the mechanism of the bystander effect in murine neuroblastoma, immunohistochemistry using connexin 43, CD4 and CD8-specific monoclonal antibodies was analyzed. We studied whether IL-2-secreting neuro-2a cells(neuro-2a/IL-2) would potentiate the bystander effect. Results : A strong bystander effect was observed in vitro and in vivo. The bystander effect in murine neuroblastoma was dependent on the immune response rather than connexin-mediated gap junction. Neuro-2a/IL-2 treatment enhanced the bystander effect in the HSV-TK/GCV system in murine neuroblastoma model. Conclusion : We conclude that the bystander effect in murine neuroblastoma depends on immune response and is enhanced by neuro-2a/IL-2.

• Journal of Marine Life Science
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• v.9 no.1
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• pp.9-21
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• 2024

Paralytic shellfish poisoning (PSP) including Saxitoxin (STX) is caused by harmful algae, and poisoning occurs when the contaminated seafood is consumed. The mouse bioassay (MBA), a standard test method for detecting PSP, is being sanctioned in many countries due to its low detection limit and the animal concerns. An alternative to the MBA is the Neuro-2a cell-based assay. This study aimed to establish various test conditions for Neuro-2a assay, including cell density, culture conditions, and STX treatment conditions, to suit the domestic laboratory environment. As a result, the initial cell density was set to 40,000 cells/well and the incubation time to 24 hours. Additionally, the concentration of Ouabain and Veratridine (O/V) was set to 500/50 μM, at which most cells died. In this study, we identified eight concentrations of STX, ranging from 368 to 47,056 fg/μl, which produced an S-shaped dose-response curve when treated with O/V. Through inter-laboratory variability comparison of the Neuro-2a assay, we established five Quality Control Criteria to verify the appropriateness of the experiments and six Data Criteria (Top and Bottom OD, EC₅₀, EC₂₀, Hill slop, and R² of graph) to determine the reliability of the experimental data. The Neuro-2a assay conducted under the established conditions showed an EC₅₀ value of approximately 1,800~3,500 fg/μl. The intra- & inter-lab variability comparison results showed that the coefficients of variation (CVs) for the Quality Control and Data values ranged from 1.98% to 29.15%, confirming the reproducibility of the experiments. This study presented Quality Control Criteria and Data Criteria to assess the appropriateness of the experiments and confirmed the excellent repeatability and reproducibility of the Neuro-2a assay. To apply the Neuro-2a assay as an alternative method for detecting PSP in domestic seafood, it is essential to establish a toxin extraction method from seafood and toxin quantification methods, and perform correlation analysis with MBA and instrumental analysis methods.

• Journal of the Korean Institute of Intelligent Systems
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• v.17 no.2
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• pp.276-283
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• 2007

It has been shown that the structure identification of a neuro-fuzzy model improves their accuracy performances in a various modeling problems. In this paper, we claim that the structure identification of a neuro-fuzzy model can also reduce the degree of inconsistency of its fuzzy rulebase. Thus, the resulting neuro-fuzzy model serves as more like a structured knowledge representation scheme. For this, we briefly review a structure identification method of a neuro-fuzzy model and propose a systematic method to measure inconsistency of a fuzzy rulebase. The proposed method is applied to problems or fuzzy system reproduction and nonlinear system modeling in order to validate our claim.

• The Journal of the Korea institute of electronic communication sciences
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• v.15 no.2
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• pp.285-290
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• 2020

Neuro-feedback is a technology that can identify your brain state and you can intentionally change your brain state. People with attention deficit and hyperactivity disorder need this technology but existing neuro-feedback training has a problem, which is not interesting and maintains a static state for a long time. In this paper, we proposed and implemented a neuro-feedback game that combines neuro-feedback and gun-shooting games to enhance concentration training. The neuro-feedback game has been implemented with the design of EEG measurement system, game controller and gamesoft. We hope that this study will be useful for people suffering from attention deficit and hyperactivity disorder.

• The Korean Journal of Pain
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• v.8 no.2
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• pp.363-366
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• 1995

Blockade of the ganglion impar was performed as an alternertive means of managing intractable neoplastic perineal pain of sympathetic origin. We successively treated a patient who had suffered from excessive perianal sweating with ganglion impar block using pure alcohol. Eight months after block, the patient has no complaint of perianal sweating. Ganglion impar block is an effective method in the treatment of excessive perianal sweating as well as perineal pain of sympathetic origin.

• Journal of The Korea Institute of Healthcare Architecture
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• v.26 no.2
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• pp.63-69
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• 2020

Purpose: The purpose of this study is to identify the neuro architecture items and detailed elements that can be considered for each detailed space in the future medical space design development through the development of a checklist of neuro architecture elements that can be utilized in medical space design. Methods:: This study first develops the neuro architecture element through theoretical research and prepares the basic plan for the checklist through consultation with the employees of the design company in which the researcher works. Finally, a checklist was developed through a survey of nine experts, including designers, hospital staff, and professors. Results: The result of this study 1) The neuro architecture component was developed in seven categories: light, color, sound, air, image, nature, ergonomic furniture and equipment. 2) Specifically, it consists of 49 elements including 7 light elements, 7 color elements, 5 sound elements, 4 air elements, 11 image elements, 6 elements in nature, 9 elements in ergonomic furniture and equipment. It was. 3) Although each of the detailed elements is more preferred according to the space, in general, all the elements should be considered in the context of the hospital space design. Implications: The checklist on the neuro architecture element will enable the development of the most faithful design as an efficient and useful tool for applying the neuro architecture philosophy that considers human beings in hospital design and pursues healing and happiness.

• Korean Journal of Optics and Photonics
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• v.2 no.3
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• pp.172-178
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• 1991

In this paper, we riview a new type of optical computing-optical neuro-computing-which was inspired to emulate the computational capability of the human brain. Also, recent activities at Bellcore for the implementation of optical neuro-computers are described.

• The Korean Journal of Pain
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• v.9 no.2
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• pp.423-425
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• 1996

Tic convulsif is a syndrome restricted to paroxysmal dysfunction of the fifth and seventh cranial nerves. It occurs predominantly in women over the age of 50 years and is usually associated with an ectatic vertebrobasilar artery - less frequently an arteriovenous malformation or cholesteatoma - which compresses the trigeminal and facial nerve roots in the postetior fossa. In rare instances this syndrome may be caused by brain tumor. Because of the high incidence of posterior fossa lesions in painful tic convulsif, a complete neurological evaluation including computerised transaxial tomography should be performed in every case. We experienced a case of trigeminal neuralgia(mandibular division)and contralateral hemifacial spasm.

• Structural Engineering and Mechanics
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• v.87 no.3
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• pp.231-242
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• 2023

A novel combinatorial type-2 adaptive neuro-fuzzy inference system (T2-ANFIS) and robust proportional integral derivative (PID) control framework for intelligent vibration mitigation of uncertain structural system is introduced. The fuzzy logic controllers (FLCs), are designed independently of the mathematical model of the system. The type-1 FLCs, have a limited ability to reduce the effect of uncertainty, due to their fuzzy sets with a crisp degree of membership. In real applications, the consequent part of the fuzzy rules is uncertain. The type-2 FLCs, are robust to the fuzzy rules and the process parameters due to the fuzzy degree of membership functions and footprint of uncertainty (FOU). The adaptivity of the proposed method is provided with the optimum tuning of the parameters using the neural network training algorithms. In our approach, the PID control force is obtained using the generalized type-2 neuro-fuzzy in such a way that the stability and robustness of the controller are guaranteed. The robust performance and stability of the presented framework are demonstrated in a numerical study for an eleven-story seismically-excited building structure combined with an active tuned mass damper (ATMD). The results indicate that the introduced type-2 neuro-fuzzy PID control scheme is effective to attenuate plant states in the presence of the structured and unstructured uncertainties, compared to the conventional, type-1 FLC, type-2 FLC, and type-1 neuro-fuzzy PID controllers.