• 제어로봇시스템학회논문지
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• 제11권6호
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• pp.524-529
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• 2005

In this paper, a novel neural network compensation technique for PD like fuzzy controlled robot manipulators is presented. A standard PD-like fuzzy controller is designed and used as a main controller for controlling robot manipulators. A neural network controller is added to the reference trajectories to modify input error space so that the system is robust to any change in system parameter variations. It forms a neural-fuzzy control structure and used to compensate for nonlinear effects. The ultimate goal is same as that of the neuro-fuzzy control structure, but this proposed technique modifies the input error not the fuzzy rules. The proposed scheme is tested to control the position of the 3 degrees-of-freedom rotary robot manipulator. Performances are compared with that of other neural network control structure known as the feedback error learning structure that compensates at the control input level.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1993년도 한국자동제어학술회의논문집(국내학술편); Seoul National University, Seoul; 20-22 Oct. 1993
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• pp.14-19
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• 1993

In this paper, we proposed an indirect learning and direct adaptive control schemes using neural networks, i.e., composite adaptive neural control, for a class of continuous nonlinear systems. With the indirect learning method, the neural network learns the nonlinear basis of the system inverse dynamics by a modified backpropagation learning rule. The basis spans the local vector space of inverse dynamics with the direct adaptation method when the indirect learning result is within a prescribed error tolerance, as such this method is closely related to the adaptive control methods. Also hash addressing technique, similar to the CMAC functional architecture, is introduced for partitioning network hidden nodes according to the system states, so global neuro control properties can be organized by the local ones. For uniform stability, the sliding mode control is introduced when the neural network has not sufficiently learned the system dynamics. With proper assumptions on the controlled system, global stability and tracking error convergence proof can be given. The performance of the proposed control scheme is demonstrated with the simulation results of a nonlinear system.

• 전자공학회논문지B
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• 제30B권1호
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• pp.79-89
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• 1993

This paper deals with a computer aided control of an adjustment process for the complete electronic devices by means of an application of artificial neural network and an implementation of neuro-controller for intelligent control. Multi-layer neural network model is employed as artificial neural network with the learning method of the error back propagation. Information initially available from real plant under control are the initial values of plant output, and the augmented plant input and its corresponding plant output at that time. For the intelligent control of adjustment process utilizing artificial neural network, the neural network emulator (NNE) and the neural network controller(NNC) are developed. The initial weights of each neural network are determined through off line learning for the given product and it is also employed to cope with environments of the another product by on line learning. Computer simulation, as well as the application to the real situation of proposed intelligent control system is investigated.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 2011년도 한국우주과학회보 제20권1호
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• pp.32.2-32.2
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• 2011

State dependent Riccati equation (SDRE) control technique has been widely used in the control society. Although it solves nonlinear optimal control problems, which minimizes state error and control efforts simultaneously, it has drawbacks when it is to be applied to the real time systems in that it requires much computational efforts. So the real time system whose computational ability is limited (for example, satellites) cannot afford to use SDRE controller. To solve this problem, a hybrid controller which is based on MSDRE (Modified SDRE) and ANFIS (Adaptive Neuro-Fuzzy Inference System) has been proposed by Abdelrahman et al. (2010). We propose a hybrid controller based on SDRE and ANFIS, and apply the hybrid controller to the hardware attitude simulator to perform a HIL (Hardware-In-the-Loop) simulation. Through HIL simulation, it is demonstrated that the hybrid controller satisfies the control requirement and the computation load is reduced significantly. In addition, the effects of statistical properties of the ANFIS training data to the performance of the ANFIS controller have been analyzed.

• 한국산학기술학회논문지
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• 제9권5호
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• pp.1178-1183
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• 2008

슬라이딩 모드를 가진 가변 구조 제어(VSC)는 비선형 시스템의 현대제어에서 중요하고 흥미로운 주제이다. 그러나, VSC에서의 불연속적인 제어 법칙은 실제로 바람직하지 못한 떨림 현상을 발생시킨다. 본 논문에서는 이러한 문제점을 해결하기 위해 신경망 슬라이딩 곡면을 갖는 VSC 구조를 제안한다. 불연속 제어 법칙을 해결하기 위해 경계층을 가진 신경망 슬라이딩 곡면이 도입된다. 제안된 제어기는 보편적인 VSC의 떨림 현상 문제를 해결할 수 있다. 제안된 제어 구조의 효과는 시뮬레이션을 통해 증명하였다.

• Journal of KIEE
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• 제10권1호
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• pp.16-22
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• 2000

The Main role of the gas turbine lies in the utilization of waste heat which may be found in exhaust gases from the gas turbine or at some other points of the process to produce additional electricity. Up to date, the PID controller has been used to operate under such difficult conditions, but since the gain of PID controller manually experience. In this paper parameter separation type 2-DOF PID controllers are proposed based on the gas turbine control system. Gas turbine transfer function is achieved from operation data of Gun-san gas turbine and Tuning algorithms of parameter separation type 2-DOF PID controller is ANFIS. Results represents satisfactory response.

• Journal of Microbiology and Biotechnology
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• 제11권2호
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• pp.234-241
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• 2001

The C-terminal 393 bp region of the human interleukin-16 (IL-16) gene was cloned and expressed in E. coli along with mammalian cell lines. Recombinant IL-16 expressed from E. coli was 22 kDa on SDS-PAGE and showed 260% of chemoattractant activity at a concentration of $0.1\;{\mu}g/ml$. HeLa, COS, and Neuro-2a cells were transduced by recombinant retrovirus vector pLNC/IL-16/IRES/TK and the intracellular and secreted amounts of IL-16 produced by HeLa/IL-16/TK, COS/IL-16/TK, and Neuro-2a/IL-16/TK cells were determined by enzyme-linked immunosorbent assay (ELISA). HeLa/IL-16/TK $(1{\times}10^5)$ and COS/IL-16/TK $(1{\times}10^5)$ cells secreted 36.1 and 13.3 ng of IL-16 for 48 h, respectively. Forty-nine ng and 86.4 ng of IL-16 remained in the cell lysates of HeLa/IL-16/TK and COS/IL-16/TK. Intracellular and secreted amounts of IL-16 from Neuro-2a/IL-16/TK $(5{\times}10^5)$ cells during 24 h cultivation were 50 ng and 3.3 ng, respectively. Also, HeLa and COS cells wee stably transfected with mammalian expression vector pCRIII/IL-16. Both culture media and cell lysates prepared from HeLa/IL-16 cells and COS/IL-16 cells showed chemoattractant activity ranging from 190% to 460% as compared to the control experiment. Expression of the herpes simplex virus thymidine kinase (HSV0tk) gene in pLNC/IL-16/ IRES/TK bicistronic retroviral expression vector was verified by performing a genciclovir (GCV) sensitivity assay. Finally, IL-16 repressed Tat-transactivated human immunodeficiency virus type 1 long terminal repeat (HIV-1 LTR) promoter activity.

• 동의신경정신과학회지
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• 제18권2호
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• pp.13-24
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• 2007

Objective : Recent studies indicate that the deposition of ${\beta}-amyloid$ ($A{\beta}$) is related in the pathogenesis of Alzheimer's disease (AD), but the underlying mechanism is still not clear. Method : To investigate the potential cellular functions of APP and water extract of the JangwonHwangagambang (JWHG), we use as in vitro model, neuro 2A cells were treated with either JWHG or its oriental medicines, and the effect in APP expression was determined by MTT and LDH assay. JWHG have been shown to be neuroprotective in different model systems. We asked whether JWHG treatment would influence cell survival and AD-like pathology in APP-induced neuronal cells. Result : JWHG and water extracts of some oriental medicine has attenuated high cell death in vitro. JWHG-treated cells increased percentage of cell survival more longly than controls. JWHG had significantly increas neurite outgrowth in the as compared to control cells. Conclusion : These results suggest that JWHG prevent APP-induced neurotoxicity through attenuating oxidative stress, and may be useful as potential therapeutic agents for AD.

• Biomolecules & Therapeutics
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• 제27권1호
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• pp.92-100
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• 2019

Ginger, one of worldwide consumed dietary spice, is not only famous as food supplements, but also believed to exert a variety of remarkable pharmacological activity as herbal remedies. In this study, a ginger constituent, 12-dehydrogingerdione (DHGD) was proven that has comparable anti-inflammatory activity with positive control 6-shogaol in inhibiting LPS-induced interleukin (IL)-6, tumor necrosis factor $(TNF)-{\alpha}$, prostaglandin (PG) $E_2$, nitric oxide (NO), inducible NO synthase (iNOS) and cyclooxygenase (COX)-2, without interfering with COX-1 in cultured microglial cells. Subsequent mechanistic studies indicate that 12-DHGD may inhibit neuro-inflammation through suppressing the LPS-activated $Akt/IKK/NF-{\kappa}B$ pathway. Furthermore, 12-DHGD markedly promoted the activation of NF-E2-related factor (Nrf)-2 and heme oxygenase (HO)-1, and we demonstrated that the involvement of HO-1 on the production of pro-inflammatory mediators such as NO and $TNF-{\alpha}$ by using a HO-1 inhibitor, Zinc protoporphyrin (Znpp). These results indicate that 12-DHGD may protect against neuro-inflammation by inhibiting $Akt/IKK/I{\kappa}B/NF-{\kappa}B$ pathway and promoting Nrf-2/HO-1 pathway.

• Journal of Korean Neurosurgical Society
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• 제64권4호
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• pp.631-643
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• 2021

Objective : Here, we evaluated whether cerebrospinal fluid (CSF) profiles and their changes after intraventricular chemotherapy for leptomeningeal carcinomatosis (LMC) could predict the treatment response or be prognostic for patient overall survival (OS) along with clinical factors. Methods : Paired 1) pretreatment lumbar, 2) pretreatment ventricular, and 3) posttreatment ventricular samples and their CSF profiles were collected retrospectively from 148 LMC patients who received Ommaya reservoir installation and intraventricular chemotherapy. CSF profile changes were assessed by calculating the differences between posttreatment and pretreatment samples from the same ventricular compartment. CSF cell counts were further differentiated into total and other based on clinical laboratory reports. Results : For the treatment response, a decreased CSF 'total' cell count tended to be associated with a 'controlled' increase in intracranial pressure (ICP) (p=0.059), but other profile changes were not associated with either the control of increased ICP or the cytology response. Among the pretreatment CSF profiles, lumbar protein level and ventricular cell count were significantly correlated with OS in univariable analysis, but they were not significant in multi-variable analysis. Among CSF profile changes, a decrease in 'other' cell count showed worse OS than 'no change' or increased groups (p=0.001). The cytological response was significant for OS, but the hazard ratio of partial remission was paradoxically higher than that of 'no response'. Conclusion : A decrease in other cell count of CSF after intraventricular chemotherapy was associated with poor OS in LMC patients. We suggest that more specific CSF biomarkers of cancer cell origin are needed.