• 대한생식의학회:학술대회논문집
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• 2004.06a
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• pp.60.1-60.1
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• 2004

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.05a
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• pp.216-216
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• 2004

본 논문은 우리가 일상 생활에서 접하는 에어컨의 핵심 부품인 열 교환기의 제작과정 중에서 확관 공정에서의 확관속도 최적화에 관한 것이다 여기서 열 교환기는 구멍 뚫린 박판형태의 방열핀과 이 구멍을 통과하는 구리재질의 관인 헤어핀의 2가지 주요 부품으로 구성되어있다 그리고 확관기(Fig. 1)에 있어서의 확관공정은 Fig. 2에서 보는 바와 같이 소성변형을 통한 관의 반지름 방향의 팽창으로 방열핀과 헤어핀을 결합시켜주는 높은 정밀도를 요구하는 작업이다.(중략)

• International Journal of Stem Cells
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• v.15 no.1
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• pp.95-103
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• 2022

Background and Objectives: In recent years, brain organoid technologies have been the most innovative advance in neural differentiation research. In line with this, we optimized a method to establish cerebral organoids from feeder-free cultured human pluripotent stem cells. In this study, we focused on the consistent and robust production of cerebral organoids comprising neural progenitor cells and neurons. We propose an optimal protocol for cerebral organoid generation that is applicable to both human embryonic stem cells and human induced pluripotent stem cells. Methods and Results: We investigated formation of neuroepithelium, neural tube, and neural folding by observing the morphology of embryoid bodies at each stage during the cerebral organoid differentiation process. Furthermore, we characterized the cerebral organoids via immunocytochemical staining of sectioned organoid samples, which were prepared using a Cryostat and Vibratome. Finally, we established a routine method to generate early cerebral organoids comprising a cortical layer and a neural progenitor zone. Conclusions: We developed an optimized methodology for the generation of cerebral organoids using hESCs and hiPSCs. Using this protocol, consistent and efficient cerebral organoids could be obtained from hiPSCs as well as hESCs. Further, the morphology of brain organoids could be analyzed through 2D monitoring via immunostaining and tissue sectioning, or through 3D monitoring by whole tissue staining after clarification.

• Applied Microscopy
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• v.29 no.1
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• pp.105-124
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• 1999

Histological and ultrastructural differentiations of the neuroepithelial cells in the mouse embryo during neurulation were observed. The neural plates and grooves consisted of pseudostratified columnar epithelium in the embryonic day (ED) 8 embryo were developed. In the ED 9 embryo, the neural tube was developed in all body length of embryo except both the cephalic and caudal ends. Secondary neurulation was shown at the tail bud of the ED 10 embryo. In the ED 8 embryo, the primitive streak was shown in the posterior end of the embryonic disc. The neuroepithelium, notochord and mesenchyme were well differentiated in the cephalic and cervical portions. In the ED 9 and 10 embryos, the roof plates of neural tubes were constituted of the closing of the surface ectodermal cells in the hindbrain and the neuroepithelial cells in the spinal cord. The floor plate of neural tube were consisted of the low pseudostratified columnar epithelium. The spinal motor nerve fibers were initially differentiated in the ED 10 embryo. According to the electron density of the cell and the differentiation of tell organelles, the neuroepithelial cells in the ED 9 and 10 embryos were classified into three types: dark, intermediate and light types. All types in the ED 9 embryo were observed but the dark cell in the ED 10 embryo was not done. The free ribosomes and polysomes in all neuroepithelial cells were developed. The RER and lipid droplets in the dark cell and the Golgi complex in the intermediate and light cells were observed. Many microfilaments in the cytoplasmic processes of intermediate cell and the microfilaments and microtubules in the light cell processes were observed to be well differentiated.

• Journal of the Korean Society for Nondestructive Testing
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• v.29 no.1
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• pp.27-35
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• 2009

In this paper, we study the classification of steam generator tube defects using an improved feature extraction. We consider 4 axisymmetric defect patterns of tube: I-In type, I-Out type, V-In type, and V-Out type. Through numerical analysis program based on finite element modeling, 400 ECT signals are generated by varying width and depth of each defect type. From those generated ECT signals, we propose new feature vectors that include an angle between the two points where the Maximum impedance and half the Maximum impedance, and angles between Maximum impedance point and 10%, 20%, 30%, 40% of Maximum impedance points. Also, multi-layer perceptron with one hidden layer is used to classify the defect patterns. Through the computer simulation study, it is shown that the proposed method achieves an improved defect classification performance in terms of Maximum Error and mean square Error.

• Steel and Composite Structures
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• v.27 no.4
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• pp.427-438
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• 2018

In this paper, the single and multi-objective optimization of thin-walled conical tubes with different types of indentations under axial impact has been investigated using surrogate models called metamodels. The geometry of tapered thin-walled tubes has been studied in order to achieve maximum specific energy absorption (SEA) and minimum peak crushing force (PCF). The height, radius, thickness, tapered angle of the tube, and the radius of indentation have been considered as design variables. Based on the design of experiments (DOE) method, the generated sample points are computed using the explicit finite element code. Different surrogate models including Kriging, Feed Forward Neural Network (FNN), Radial Basis Neural Network (RNN), and Response Surface Modelling (RSM) comprised to evaluate the appropriation of such models. The comparison study between surrogate models and the exploration of indentation shapes have been provided. The obtained results show that the RNN method has the minimum mean squared error (MSE) in training points compared to the other methods. Meanwhile, optimization based on surrogate models with lower values of MSE does not provide optimum results. The RNN method demonstrates a lower crashworthiness performance (with a lower value of 125.7% for SEA and a higher value of 56.8% for PCF) in comparison to RSM with an error order of $10^{-3}$. The SEA values can be increased by 17.6% and PCF values can be decreased by 24.63% by different types of indentation. In a specific geometry, higher SEA and lower PCF require triangular and circular shapes of indentation, respectively.

• Nutrition Research and Practice
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• v.7 no.4
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• pp.315-325
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• 2013

We evaluated folate status of child-bearing age women diagnosed with abnormal pap smear in the US post-folic acid (FA) fortification era and assessed the determinants of NTD-protective and supra-physiologic (SP) concentrations of folate. The distribution of 843 women according to NTD-protective concentrations of RBC folate, plasma folate and SP concentrations of plasma folate were tested in relation to demographic and life-style factors. Logistic regression models specified NTD-protective concentrations of RBC and plasma folate or SP concentrations of plasma folate as dependent variables and demographic and life-style factors as independent predictors of interest. More than 82% reached NTD-protective concentrations of RBC and plasma folate and ~30% reached SP concentrations of plasma folate. FA supplement use was associated with having SP concentrations of plasma folate rather than NTD-protective concentrations of folate. African American (AA) women and smokers were significantly less likely to achieve NTD-protective concentrations of RBC and plasma folate. A large majority of women reached NTD-protective concentrations of folate with the current level of FA fortification without using supplementary FA. Therefore, the remaining disparities in AA women and in smokers should be addressed by targeted individual improvements in folate intake.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.21 no.3
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• pp.99-105
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• 2021

In addition to the OTT video production service represented by Nexflix and YouTube, a personalized recommendation system for content with artificial intelligence has become common. YouTube's personalized recommendation service system consists of two neural networks, one neural network consisting of a recommendation candidate generation model and the other consisting of a ranking network. Netflix's video recommendation system consists of two data classification systems, divided into content-based filtering and collaborative filtering. As the online platform-led content production is activated by the Corona Pandemic, the field of virtual influencers using artificial intelligence is emerging. Virtual influencers are produced with GAN (Generative Adversarial Networks) artificial intelligence, and are unsupervised learning algorithms in which two opposing systems compete with each other. This study also researched the possibility of developing AI platform based on individual recommendation and virtual influencer (metabus) as a core content of OTT in the future.

• Women's Health Nursing
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• v.29 no.4
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• pp.291-301
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• 2023

Purpose: This study aimed to investigate the current status of effective folic acid intake and the level of folic acid knowledge of Chinese pregnant women and to analyze the relationship between effective folic acid intake and folic acid knowledge. Methods: From November 2021 to May 2022, 140 pregnant women at Yantai Yuhuangding Hospital in the Chinese province of Shandong, answered questions about their general characteristics, folic acid intake, and folic acid knowledge. The data were analyzed using the t-test, chi-square test, and logistic regression analysis, and were presented with frequency with percentage or mean±standard deviation. Results: Only 16.4% of the pregnant women (n=23) took folic acid effectively, using the following four criteria. Of all pregnant women who took folic acid, 72.2% took folic acid starting 1 month before pregnancy, 70.8% took folic acid up to 3 months after pregnancy, 36.8% took 400 ㎍ every time, and 78.6% took folic acid more than 24 days every month. The score for folic acid knowledge was relatively high (5.61±2.18 on a scale of 0-9). A higher folic acid knowledge score correlated with more effective folic acid intake (t=4.10, p<.001). Conclusions: Our study shows that the current recommendations to prevent neural tube defects through effective folic acid intake supplementation are not being fully implemented in China. Furthermore, folic acid knowledge was positively correlated with the effectiveness of its intake. Future education related to effective folic acid intake should emphasize the four methods of effective folic acid intake, especially regarding the recommended dose of 400 ㎍ every time.

• Journal of the Korean Society for Nondestructive Testing
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• v.24 no.1
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• pp.8-14
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• 2004

Model-based inversion tools for eddy current signals have been developed by combining neural networks and finite element modeling, for quantitative flaw characterization in steam generator tubes. In the present work, interpretation of experimental eddy current signals was carried out in order to validate the developed inversion tools. A database was constructed using the synthetic flaw signals generated by the finite element model. The hybrid neural networks composed of a PNN classifier and BPNN size estimators were trained using the synthetic signals. Experimental eddy current signals were obtained from axisymmetric artificial flaws. Interpretation of flaw signals was conducted by feeding the experimental signals into the neural networks. The interpretation was excellent, which shows that the developed inversion tools would be applicable to the Interpretation of real eddy current signals.