• Journal of KIISE:Information Networking
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• v.29 no.4
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• pp.375-385
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• 2002

The IETF has defined the Intserv model and the RSVP signaling protocol to improve QoS capability for a set of newly emerging services including voice and video streams that require high transmission bandwidth and low delay. However, since the current Intserv model requires each router to maintain the states of each service flow, the complexity and the overhead for processing packets in each rioter drastically increase as the size of the network increases, giving rise to the scalability problem. This motivates our work; namely, we investigate and devise new control schemes to enhance the scalability of the Intesev model. To do this, we basically resort to the SCORE network model, extend it to fairly well adapt to the three services presented in the Intserv model, and devise schemes of the QoS scheduling, the admission control, and the edge and core node architectures. We also carry out the computer simulation by using ns-2 simulator to examine the performance of the proposed scheme in respects of the bandwidth allocation capability, the packet delay, and the packet delay variation. The results show that the proposed scheme meets the QoS requirements of the respective three services of Intserv model, thus we conclude that the proposed scheme enhances the scalability, while keeping the efficiency of the current Intserv model.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.49 no.5
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• pp.77-83
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• 2012

The importance of mobility management is becoming to be one of the upcomming issues to be addressed to provide the converged services and the convergence of the heterogeneous network environments. In this paper, the new user mobility management scheme which can be utilized to model the user's mobility behaviors for interworking with heterogeneous overlay convergent networks under the time-varying radio propagation environment has been proposed. Thus user mobility management scheme based on user mobility model is considered in order to optimize the dwell time of users in the overlay convergent networks. This Mobile IP user mobility management will be very useful to model the user mobility behaviors and can be used to estimate the signaling traffic and frequency spectrum demands for massive data transfer for the heterogeneous overlay convergent networks.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.46 no.6
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• pp.37-47
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• 2009

In this paper fast mobile multicast handover mechanism based on IEEE 802.21 MIH (Media Independent Handover) is proposed. We solve long multicast handover delay time caused by L3 movement detection mechanism of the existing mobile multicast methods. The proposed architecture adopts multicast manager concept to MIH framework in order to efficiently perform mobile multicast handover, and adds the new MIH messages dedicated for mobile multicast. Since multicast channel zapping operations of mobile users effectively make a mobile terminal handover, the architecture should consider the situations. Multicast network selection algorithm is designed by means of terminal speed and fair selection algorithm named AHP/GRA. Finally the performance of the proposed architecture against the legacy mobile multicast mechanisms is evaluated in terms of signaling cost and multicast handover delay time.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.42 no.4 s.334
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• pp.45-52
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• 2005

This paper presents the characterization of through hole vias on printed circuit board (PCB) through the time domain and frequency domain measurements. The time domain measurement was performed on a single via using the TDR, and the model parameters were extracted by the fitting simulation using HSPICE. The frequency domain measurement was also performed by using 2 port VNA, and the model parameters were extracted by fitting simulation with ADS. Using the ABCD matrices, the do-embedding equations were derived probing in the same plane in the VNA measurement. Based on the single via characterization, the differential via characterization was also performed by using TDR measurements. The time domain measurements were performed by using the odd mode and even mode sources in TDR module, and the Parameter values were extracted by fitting with HSPICE. Comparing measurements with simulations, the maximum calculated differences were $14\%$ for single vias and $17\%$ for differential vias.

• Journal of Internet Computing and Services
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• v.12 no.4
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• pp.15-26
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• 2011

As quick and secure mobility service is becoming a critical issue in the ubiquitous environment. Internet Engineering Task Force (IETF) has done a lot of meaningful work in order to cope with the critical issues, which is a key technology of guaranteeing the legally and safely using of network resources, they has proposed Hierarchical Mobile IPv6 (HMIPv6) to complement for such problems as handover latency and signaling overhead in existing MIPv6. Most of the current research about HMIPv6 focuses on how to optimize the interactive processes between the HMIPv6 and AAA (Authentication, Authorization, Accounting) protocol. This paper describes a cost-effective hierarchical authentication scheme, which makes its focus on minimizing the authentication latency in AAA processing. In this scheme, a hierarchical AAA architecture is proposed, in which the AAA servers are deployed on the Mobility Anchor Point (MAP), the Root AAA server manages several Leaf AAA servers and the Brokers on behalf of the AAA server in home domain. The simulation results shows that the proposed scheme reduces the handoff and authentication latency evidently compared to the previous traditional authentication combination modeling.

• IMMUNE NETWORK
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• v.9 no.5
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• pp.192-202
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• 2009

Background: Little information is available the role of Nitric Oxide (NO) in host defenses during human tuberculosis (TB) infection. We investigated the modulating factor(s) affecting NO synthase (iNOS) induction in human macrophages. Methods: Both iNOS mRNA and protein that regulate the growth of mycobacteria were determined using reverase transcriptase-polymerase chain reaction and western blot analysis. The upstream signaling pathways were further investigated using iNOS specific inhibitors. Results: Here we show that combined treatment with 1,25-dihydroxyvitamin D3 (1,25-D3) and Interferon (IFN)-${\gamma}$ synergistically enhanced NO synthesis and iNOS expression induced by Mycobacterium tuberculosis (MTB) or by its purified protein derivatives in human monocyte-derived macrophages. Both the nuclear factor-${\kappa}B$ and MEK1-ERK1/2 pathways were indispensable in the induction of iNOS expression, as shown in toll like receptor 2 stimulation. Further, the combined treatment with 1,25-D3 and IFN-${\gamma}$ was more potent than either agent alone in the inhibition of intracellular MTB growth. Notably, this enhanced effect was not explained by increased expression of cathelicidin, a known antimycobacterial effector of 1,25-D3. Conclusion: These data support a key role of NO in host defenses against TB and identify novel modulating factors for iNOS induction in human macrophages.

• The KIPS Transactions:PartC
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• v.14C no.1 s.111
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• pp.55-64
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• 2007

Behind the popularity of VoIP in these days, it may present significant security challenges in privacy and accounting. Authentication and message encryption are considered to be essential mechanisms in VoIP to be comparable to PSTN. SIP is responsible for setting up a secure call in VoIP. SIP employs TLS, DTLS or IPSec combined with TCP, UDP or SCTP as a security protocol in VoIP. These security mechanisms may introduce additional overheads into the SIP performance. However, this overhead has not been understood in detail by the community. In this paper we present the effect of the security protocol on the performance of SIP by comparing the call setup delays among security protocols. We implement a simulation of the various combinations of three security protocols and three transport layer protocols suggested for SIP. UDP with any combination of security protocols performs a lot better than the combination of TCP. TLS over SCTP may impose higher impact on the performance in average because TLS might have to open secure channels as the same number of streams in SCTP. The reasons for differences in the SIP performances are given.

• Journal of Internet Computing and Services
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• v.1 no.1
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• pp.35-46
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• 2000

One of the main chalenges in personal communication services (PCS) is to locate many mobile terminals that may move frequently from place to place. Such a system operation is called location management. Many network signaling traffic, and database queries are required to achieve such a task. Several strategies have been proposed to improve the efficiency of location management. These strategies use location register databases to store the current location on mobile terminals, and are vulnerable to failure of the location registers. In this paper, we propose a fault-tolerant pointer forwarding with distributed home location register (FT-RFDHLR) to tolerate the failure of location registers. The performance of the proposed method is evaluated by an analytical model, and is compared with thew pointer forwarding with the single home location register (PFSHLR), the pointer forwarding with distributed home location register (PFDHLR), Biaz's bypass forwarding strategy (BFS) and two-path forwarding strategy (TPFS).

• Journal of Plant Biotechnology
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• v.37 no.4
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• pp.472-482
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• 2010

For the massive screening of the genes related to oxidative stress, a cDNA library was constructed from hot pepper (Capsicum annuum L. cv. Nockkwang) leaves treated with methyl viologen. From this library, 1,589 cDNA clones were sequenced from their 5' ends. The sequences were clustered into 1,252 unigenes comprised of 152 contigs and 1,100 singletons. Similarity search against NCBI protein database identified 1,005 ESTs (80.3%) as Known, 197 ESTs (15.7%) as Unknown, and 50 ESTs (3.99%) as No hit. In the ESTs, oxidative stress-related genes such as ascorbate peroxidase, catalase, and osmotin precursor were highly expressed. The cDNA microarray containing 1,252 unigenes was constructed and used to analyze their expression upon methyl viologen treatment. Analyses of the hybridization revealed that various stress-related genes such as peroxidase, tyrosine aminotransferase, and omega-6 fatty acid desaturase, were induced and some metabolism related genes such as aldolase and ketol-acid reductoisomerase, were repressed by methyl viologen treatment, respectively. The information from this study will be used for further study on the functional roles of oxidative stress-related genes and signaling network of oxidative stress in hot pepper.

• Herbal Formula Science
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• v.31 no.4
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• pp.295-313
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• 2023

Objectives : While treatments for cancer are advancing, the development of effective treatments for cancer metastasis, the main cause of cancer patient death, remains insufficient. Recent studies on Dichroae Radix have revealed that its active ingredients have the potential to inhibit cancer metastasis. This study aimed to investigate the cancer metastasis inhibitory effect of Dichroae Radix using network pharmacological analysis. Methods : The active compounds of Dichroae Radix have been identified using Traditional Chinese Medicine System Pharmacology Database and Analysis Platform. The UniProt database was used to collect each of information of all target proteins associated with the active compounds. To find the bio-metabolic processes associated with each target, the DAVID6.8 Gene Functional classifier tool was used. Compound-Target and Target-Pathway networks were analyzed via Cytoscape 3.40. Results : In total, 25 active compounds and their 62 non-redundant targets were selected through the TCMSP database and analysis platform. The target genes underwent gene ontology and pathway enrichment analysis. The gene list applied to the gene ontology analysis revealed associations with various biological processes, including signal transduction, chemical synaptic transmission, G-protein-coupled receptor signaling pathways, response to xenobiotic stimulus, and response to drugs, among others. A total of eleven genes, including HSP90AB1, CALM1, F2, AR, PAKACA, PTGS2, NOS2, RXRA, ESR1, ESR2, and NCOA1, were found to be associated with biological pathways related to cancer metastasis. Furthermore, nineteen of the active compounds from Dichroae Radix were confirmed to interact with these genes. Conclusions : The results provide valuable insights into the mechanism of action and molecular targets of Dichroae Radix. Notably, Berberine, the main active ingredient of Dichroae Radix, plays a significant role in degrading AR proteins in advanced prostate cancer. Further studies and validations can provide crucial data to advance cancer metastasis prevention and treatment strategies.