• Proceedings of the Korean Society of Toxicology Conference
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• 2006.11a
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• pp.65-74
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• 2006

Modem drug discovery requires rapid pharmacokinetic evaluation of chemically diverse compounds for early candidate selection. This demands the development of analytical methods that offer high-throughput of samples. Naturally, liquid chromatography / tandem mass spectrometry (LC-MS/MS) is choice of the analytical method because of its superior sensitivity and selectivity. As a result of the short analysis time(typically 3-5min) by LC-MS/MS, sample preparation has become the rate- determining step in the whole analytical cycle. Consequently tremendous efforts are being made to speed up and automate this step. In a typical automated 96-well SPE(solid-phase extraction) procedure, plasma samples are transferred to the 96-well SPE plate, internal standard and aqueous buffer solutions are added and then vacuum is applied using the robotic liquid handling system. It takes only 20-90 min to process 96 samples by automated SPE and the analyst is physically occupied for only approximately 10 min. Recently, the ultra-high flow rate liquid chromatography (turbulent-flow chromatography)has sparked a huge interest for rapid and direct quantitation of drugs in plasma. There is no sample preparation except for sample aliquotting, internal standard addition and centrifugation. This type of analysis is achieved by using a small diameter column with a large particle size(30-5O ${\mu}$m) and a high flow rate, typically between 3-5 ml/min. Silica-based monolithic HPLC columns contain a novel chromatographic support in which the traditional particulate packing has been replaced with a single, continuous network (monolith) of pcrous silica. The main advantage of such a network is decreased backpressure due to macropores (2 ${\mu}$m) throughout the network. This allows high flow rates, and hence fast analyses that are unattainable with traditional particulate columns. The reduction of particle diameter in HPLC results in increased column efficiency. use of small particles (<2 urn), however, requires p.essu.es beyond the traditional 6,000 psi of conventional pumping devices. Instrumental development in recent years has resulted in pumping devices capable of handling the requirements of columns packed with small particles. The staggered parallel HPLC system consists of four fully independent binary HPLC pumps, a modified auto sampler, and a series of switching and selector valves all controlled by a single computer program. The system improves sample throughput without sacrificing chromatographic separation or data quality. Sample throughput can be increased nearly four-fold without requiring significant changes in current analytical procedures. The process of Bioanalytical Method Validation is required by the FDA to assess and verify the performance of a chronlatographic method prior to its application in sample analysis. The validation should address the selectivity, linearity, accuracy, precision and stability of the method. This presentation will provide all overview of the work required to accomplish a full validation and show how a chromatographic method is suitable for toxirokinetic sample analysis. A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method developed to quantitate drug levels in dog plasma will be used as an example of tile process.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.25 no.6
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• pp.1435-1447
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• 2015

Finance Companies are operating a security solution such as E-DRM(Enterprise-Digital Right Management), Personal information search, DLP(Data Loss Prevention), Security of printed paper, Internet network separation system, Privacy monitoring system for privacy leakage prevention by insiders. However, privacy leakages are occurring continuously and it is difficult to the association analysis about relating to the company's internal and external distribution of private document. Because log system operated in the separate and independent security solutions. This paper propose a systematic chains that can correlatively analyze business systems and log among heterogeneous security solutions organically and consistently based on security documents. Also, we suggest methods of efficient detection for Life-Cycle management plan about security documents that are created in the personal computer or by individual through the business system and distribution channel tracking about security documents contained privacy.

• The KIPS Transactions:PartD
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• v.14D no.6
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• pp.689-700
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• 2007

Organizations and customers lose if business activities we discontinued by an incident of information systems under the current business environment because they pursue real time enterprise and on demand enterprise. The loss includes the intangible decline in brand image, customer separation, and the tangible loss such as decrease in business profits. Thus. it is necessary to have preparedness in advance and mitigation for minimization of a loss due to the business discontinuity and information system's operational risks. This paper suggests the mitigation model for minimizing the incidents of disk unit in information system's operational risks. The model will be represented by a network model which is composed of the three items as following: (1) causes, attributes, indicators of an operational risk, (2) a periodic time through an analysis of historical data, (3) an index or a regulation related to the examination of causes of an operational risk.

• Korean Institute of Interior Design Journal
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• v.20 no.3
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• pp.119-126
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• 2011

Recently, in the fields of fashion, advertisement, film, literature, philosophy, etc., the word, 'Nomad', is being used frequently across the overall society. The contemporary society is actively incorporating "nomadic thinking" as a new social phenomenon across the boundaries of conventional fields. This is not an exception in the field of space design. This study, via the contemporary nomadic thinking, examined the relationship between space design's application possibility as a new trend and flexible space; then categorized the characteristics of flexible space into flexibility, temporariness, changeability, and correlation; and then analyzed expression characteristics of flexible space. As for unrestricted expression of scene, it was recognized that separation of scene and space leads space to meet the needs of surrounding environment and users; formation of changeable space enables uses of space from various perspectives; and combining external factors (energy, media technologies) with space leads space to self-evolution. Space is perceived as an living organism that is flexibly corresponding, via realistic movement and virtual movement, to the indefinite, diversified thinking of the contemporary society. Therefore, this study illuminates that nomadic thinking has significance as basic thinking to predict development and characteristics of design thinking through understanding the contemporary society with the basic thinking system that has been inherent without restrictions of being fixed to the present, past, and future.

• The KIPS Transactions:PartB
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• v.10B no.3
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• pp.311-320
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• 2003

The Optimal filter yielding optimal texture feature separation is a most effective technique for extracting the texture objects from multiple textures images. But, most optimal filter design approaches are restricted to the issue of supervised problems. No full-unsupervised method is based on the recognition of texture objects in image. We propose a novel approach that uses unsupervised learning schemes for efficient texture image analysis, and the band-pass feature of Gabor-filter is used for the optimal filter design. In our approach, the self-organizing neural network for multiple texture image identification is based on block-based clustering. The optimal frequency of Gabor-filter is turned to the optimal frequency of the distinct texture in frequency domain by analyzing the spatial frequency. In order to show the performance of the designed filters, after we have attempted to build a various texture images. The texture objects extraction is achieved by using the designed Gabor-filter. Our experimental results show that the performance of the system is very successful.

• Journal of IKEEE
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• v.22 no.1
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• pp.136-142
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• 2018

Recently, as the development system has become larger, sequential simulation methods have become impossible to verify systems that take a long time or require real time results. Therefore, a study of a distributed simulation system that simulates several processes has been conducted. In order to simulate real-time systems, efficient data exchange between distributed systems is required. Data Distribution Service is a data-oriented communication middleware proposed by Object Management Group and provides efficient data exchange and various QoS. However, in a large-scale distributed simulation environment distributed over a wide area, there is a problem of Participant Discovery and QoS guarantee due to domain separation in data exchange. Therefore, in this paper, we propose a DDS/SDN architecture that can guaranteed QoS and effective Participant Discovery in an SDN-based network.

• Korean Journal of Social Welfare
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• v.46
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• pp.145-177
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• 2001

This paper seeks to analyze how the welfare state has developed both in the Kim Young Sam government and in the Kim Dae Jung government. Among other things, the two governments share some similarities: compared to the previous authoritarian governments, both of them enjoyed a high level of democratic legitimacy; the two were under pressure to win the elections to acquire and remain in power; and finally, the two tried to strengthen welfare system. But there exist more critical differences. The Kim Dae Jung government was a minority government, while the Kim Young Sam government was a majority one. Compared to the latter one, the former came to power in an extremely bad economic condition. Fortunately, however, the Kim Dae Jung government was able to enjoy a relatively high level of state autonomy resulting from an exceptional situation of foreign currency crisis. In addition, it was more reformist in policy orientation and had a more open cooperative network with civil society. All these differences added up to produce remarkable differences with regard to the improvement in welfare development. Especially, it is noted that the Kim Dae Jung government was very successful in several respects: provision of national minimum, integration of national medical insurance, development of productive welfare system, and final1y increase in welfare spending. Recently, criticisms from the opposition party, the press, and middle and upper class people mount against the Kim Dae Jung government which has made significant mistakes in instituting the separation of medical and pharmaceutical businesses. However, the important improvements in welfare institutions and programs by the Kim Dae Jung government need to be maintained to deal with all the negative effects of a naked market economy. They must also be sustained to keep alive democracy that Korean people have fought for nearly half a century.

• The Journal of Society for e-Business Studies
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• v.22 no.4
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• pp.39-51
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• 2017

In October 2016, the NFSA (National Financial Supervisory Authorities) revised the network separation clause of the Regulation on Supervision of Electronic Financial Activities in order to promote the Cloud Computing implementation in the financial sectors. The new regulation, however, limits the Cloud Computing usage to non-critical information and its processing system. Financial institutions that provide customer data analysis and personalized services based on personal data regard current revision as unchanged as before. The implementation of Cloud Computing has greatly contributed to cost reduction, business innovation and is an essential requirement in ever-changing information communication technology environment. To guarantee both security and reliability of the implementation of the Cloud Computing in financial sectors, a considerable amount of research and debate needs to be done. This paper examines current Cloud Computing policies in the Korean financial sector and the challenges associated with it. Finally, the paper identifies policy suggestions based on both European Union and United States' approach as they have successfully introduced Cloud Computing Services for their financial sectors.

• Journal of The Korean Astronomical Society
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• v.53 no.6
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• pp.161-168
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• 2020

We report the discovery of a giant exoplanet in the microlensing event OGLE-2017-BLG-1049, with a planet-host star mass ratio of q = 9.53 ± 0.39 × 10-3 and a caustic crossing feature in Korea Microlensing Telescope Network (KMTNet) observations. The caustic crossing feature yields an angular Einstein radius of θE = 0.52 ± 0.11 mas. However, the microlens parallax is not measured because the time scale of the event, tE ≃ 29 days, is too short. Thus, we perform a Bayesian analysis to estimate physical quantities of the lens system. We find that the lens system has a star with mass Mh = 0.55+0.36-0.29 M⊙ hosting a giant planet with Mp = 5.53+3.62-2.87 MJup, at a distance of DL = 5.67+1.11-1.52 kpc. The projected star-planet separation is a⊥ = 3.92+1.10-1.32 au. This means that the planet is located beyond the snow line of the host. The relative lens-source proper motion is μrel ~ 7 mas yr-1, thus the lens and source will be separated from each other within 10 years. After this, it will be possible to measure the flux of the host star with 30 meter class telescopes and to determine its mass.

• Journal of Broadcast Engineering
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• v.24 no.1
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• pp.118-131
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• 2019

In order to provide 8K UHD contents of terrestrial broadcasting with a large capacity, the terrestrial broadcasting system has various problems such as limited bandwidth and so on. To solve these problems, UHD contents transmission technology has been actively studied, and an 8K UHD broadcasting system using terrestrial broadcasting network and communication network has been proposed. The proposed technique is to solve the limited bandwidth problem of terrestrial broadcasting network by segmenting 8K UHD contents and transmitting them to heterogeneous networks through hierarchical separation. Through the terrestrial broadcasting network, the base layer corresponding to FHD and the additional enhancement layer data for 4K UHD are transmitted, and the additional enhancement layer data corresponding to 8K UHD is transmitted through the communication network. When 8K UHD contents are provided in such a way, user can receive up to 4K UHD broadcasting by terrestrial channels, and also can receive up to 8K UHD additional communication networks. However, in order to transmit the 4K UHD contents within the allocated bit rate of the domestic terrestrial UHD broadcasting, the compression rate is increased, so a certain level of image deterioration occurs inevitably. Due to the nature of UHD contents, video quality should be considered as a top priority over other factors, so that video quality should be guaranteed even within a limited bit rate. This requires packet scheduling of content generators in the broadcasting system. Since the multiplexer sends out the packets received from the content generator in order, it is very important to make the transmission time and the transmission rate of the process from the content generator to the multiplexer constant and accurate. Therefore, we propose a variable transmission scheduler between the content generator and the multiplexer to guarantee the image quality of a certain level of UHD contents in this paper.