• The Korean Journal of Pain
• /
• 제20권2호
• /
• pp.190-194
• /
• 2007

Complex regional pain syndrome (CRPS), which is a syndrome that is defined by pain and sudomotor and/or vasomotor instability, is usually resistant to conventional treatment. Here, a case involving a 30-year-old male patient with CRPS type I who showed severe intractable right shoulder pain with allodynia and hyperalgesia despite being treated with oral medications, nerve blocks including thoracic sympathetic neurolysis, and spinal cord stimulation is described. The patient frequently visited the emergency room due to severe uncontrollable breakthrough pain. Although a favorable effect was observed in response to intermittent ketamine infusion therapies that were performed on an outpatient basis, acute exacerbation of pain occurred frequently during the night and could not be controlled. Therefore, subcutaneous ketamine infusion therapy using a patient-controlled analgesic system was attempted and found to effectively control acute exacerbation of pain during 6 weeks of infusion without serious complications.

• 한국정보통신학회논문지
• /
• 제8권3호
• /
• pp.670-678
• /
• 2004

한의학에서 경락은 생체에너지의 전달 통로이며, 진단치료의 기본대상이다. 그러나 서양의학에서는 경락을 신경-면역계통의 활동통로로 간주하고 있다. 침구치료 효과를 단순한 자극에 의한 인체의 반응으로 간주하고 있다. 본 논문에서는 시술자의 생체에너지가 전달될 때와 전달되지 않을 때, 즉 절연자침과 비절연자침을 시행하였을 경우, 경락과 비경락에서의 전위를 측정하였다. 그 결과 비절연자침 시행시에는 각 시술에 대한 반응이 뚜렷하게 나타나고 있으나 절연자침 시행시에는 첫 번째 자침 시술에만 반응하였다. 이는 침구치료의 효과가 단순한 침자극에 의한 효과라기 보다는 시술자의 생체에너지 전달과 더 밀접한 관계가 있음을 의미한다. 따라서, 침 자극에 의한 생체에너지 전달에 의한 인체의 반응을 전위의 변화로 분석하여 침구치료효과를 규명하였다.

• 정보처리학회논문지B
• /
• 제9B권5호
• /
• pp.635-642
• /
• 2002

정보 기술 분야의 지능화 요구는 매우 빠르게 증가하고 있다. 특히 대량의 데이터로부터 지식을 찾아내어 최적의 의사결정을 해야하는 KDD(Knowledge Discovery in Database)분야에서는 그 요구가 더욱 더 크게 된다. 지능화된 의사결정을 위해서는 대용량 지식 베이스(Knowledge Base)의 효율적인 관리가 무엇보다도 중요하다. 본 논문에서는 이러한 지식 베이스로부터 의사결정 관리에 필요한 지식을 얻기 위해 효율적으로 지식 베이스를 검색하고 갱신하는 관리 방법을 위해 자율학습 신경망인 자기조직화 지도에 확률적 분포 이론을 결합한 하이브리드(Hybrid) SOM을 제안한다. 제안 방법을 이용한 효율적 지식 베이스의 관리를 시뮬레이션 실험을 통하여 수행하였다. 실험을 통해 본 논문에서 제안하는 Hybrid SOM이 지식 베이스 관리에 효율적인 성능을 나타냄이 증명되었다.

• 동의생리병리학회지
• /
• 제21권3호
• /
• pp.709-713
• /
• 2007

Basement membranes (BMs) are extracellular matrices associated with epithelia, endothelia, muscle, fat and peripheral nerve. They are involved in cell survival, migration, differentiation. BMs functions also include tissue formation and provide mechanical stability as a selective barriers. Laminins are heterotrimeric glycoproteins found in BMs and have a crucial role in cell adhesion and signalling. Madin-Darby canine kidney (MDCK) cells are the best established mammalian model for studying epithelial cell biology The cells form an epithelial monolayer, with tight junctions separating an apical surface from a basolateral membrane facing the filter support and neighboring cells. In this study, using MDCK cells, the synthesis of the BM protein such as laminin with or without methanol extract of Chrysanthemum morifolium (CM) stimulation was analyzed by immunoblotting and CM showed significant increased cell density and enhanced synthesis of laminin.

• Korean Journal of Acupuncture
• /
• 제22권1호
• /
• pp.133-150
• /
• 2005

Objective : The purpose of this study is to examine the tendency of experimental studies on the physiological effects of acupuncture at $ST_{36}$(Zusanli). Methods : We investigated 69 theses (10 Korean and 59 international) which were searched by the keyword 'Zusanli' through PubMed website, and that were experimented with manual acupuncture or electroacupuncture on healthy human subjects or normal animals. Results : The 69 theses were classified into iou groups based on the main topic which is related with the influence of acupuncture stimulation at $ST_{36}$(Zusanli), such as digestive system, nervous system, immune system, and cardiovascular system. The main results found in this study are : 1. Acupuncture at $ST_{36}$(Zusanli) increases gastric mobility. And such effect is related with vagal nerve and opioid pathway. 2. Acupuncture at $ST_{36}$(Zusanli) is valuably related with cerebral cortex. And it influences on the cerebrum activities. 3. Acupuncture at $ST_{36}$(Zusanli) has noticeable analgesic effect, which is related with Opioid mechanism, Gate control and SP 4. Acupuncture at $ST_{36}$(Zusanli) increases immunity Conclusion . Acupuncture at $ST_{36}$(Zusanli) has many effects on digestive system, nervous system, immune system, and cardiovascular system.

• Korean Journal of Anesthesiology
• /
• 제71권6호
• /
• pp.476-482
• /
• 2018

Background: Several types of receptors are found at neuromuscular presynaptic membranes. Presynaptic inhibitory $A_1$ and facilitatory $A_{2A}$ receptors mediate different modulatory functions on acetylcholine release. This study investigated whether adenosine $A_1$ receptor agonist contributes to the first twitch tension (T1) of train-of-four (TOF) stimulation depression and TOF fade during rocuronium-induced neuromuscular blockade, and sugammadex-induced recovery. Methods: Phrenic nerve-diaphragm tissues were obtained from 30 adult Sprague-Dawley rats. Each tissue specimen was randomly allocated to either control group or 2-chloroadenosine (CADO, $10{\mu}M$) group. One hour of reaction time was allowed before initiating main experimental data collection. Loading and boost doses of rocuronium were sequentially administered until > 95% depression of the T1 was achieved. After confirming that there was no T1 twitch tension response, 15 min of resting time was allowed, after which sugammadex was administered. Recovery profiles (T1, TOF ratio [TOFR], and recovery index) were collected for 1 h and compared between groups. Results: There were statistically significant differences on amount of rocuronium (actually used during experiment), TOFR changes during concentration-response of rocuronium (P = 0.04), and recovery profiles (P < 0.01) of CADO group comparing with the control group. However, at the initial phase of this experiment, dose-response of rocuronium in each group demonstrated no statistically significant differences (P = 0.12). Conclusions: The adenosine $A_1$ receptor agonist (CADO) influenced the TOFR and the recovery profile. After activating adenosine receptor, sugammadex-induced recovery from rocuronium-induced neuromuscular block was delayed.

• 융합정보논문지
• /
• 제9권10호
• /
• pp.220-226
• /
• 2019

본 연구는 발바닥 굽힘근에 저주파 치료인 경피신경전기자극과 중주파 치료인 간섭전류가 뇌졸중 환자의 보행 및 발목 관절가동범위에 즉각적인 영향을 미치는지 알고자 한다. 30명의 연구대상자는 경피신경전기자극군과 간섭전류군으로 동일하게 나누어 마비측 장딴지근에 각각 통전하였다. 60분 통전 직후 스마트폰을 이용한 보행 평가와 발등 굽힘 관절가동범위를 측정하였다. 연구결과 두 전기치료 방법 모두 보행속도, 분속수, 발목 관절가동범위에 유의한 증가를 보였다. 두 전기치료 방법 모두 뇌졸중 환자의 보행 및 발목 관절가동범위를 증가시킬 수 있는 중재 방법이었지만 두 전기치료방법 간의 차이는 더 많은 대상자 모집을 통해 확인되어야 할 것이다.

• 대한암한의학회지
• /
• 제25권2호
• /
• pp.37-49
• /
• 2020

Objective: Constipation is the most common adverse effect of opioid analgesic therapy in cancer patients. This can be associated with physical and emotional distress to cancer patients. The purpose of this study is to review the standard and alternative interventions of the management for opioid-induced constipation (OIC). Methods: The studies were searched from databases, including Pubmed, Google scholar, KISS, NDSL, and OASIS. The main search terms included such as constipation, opioid, opioid-induced constipation, cancer, management, herb, and acupuncture. Results: The prevention and usual care of constipation is a key tool for the management of OIC. Also, prophylactic laxatives starting concurrently with opiates helped to prevent developing constipation. Peripherally acting μ-opioid receptor antagonists (PAMORAs) significantly reduced OIC and well-tolerated. In addition, acupuncture, herb medicines, and interferential current or transcutaneous electrical nerve stimulation to acupoints had effectiveness in reducing constipation. Conclusion: Preliminary data indicate that PAMORAs and Traditional Korean Medicine may be considered as the management of unresolved OIC. However, due to the limited articles, more systematic and rigorous clinical trials are needed.

• 한국융합학회논문지
• /
• 제12권2호
• /
• pp.61-66
• /
• 2021

본 연구의 목적은 지연성근육통의 통증 변화가 자율신경계와 뇌파에 미치는 영향을 알아보고자 하였다. 지연성 근육통이 유발된 28명을 대조군(n=14)과 실험군(경피신경자극과 키네시오테이핑 적용, n=14)으로 구분하였다. 중재는 지연성근육통 유발 1일 후부터 5일 동안 실시하였다. 평가는 VAS(visual analog scale), 심박변이, 뇌파를 사용하여 지연성근육통 유발 전, 유발 24시간 후, 5일 치료 후, 치료 중단 3일 후에 측정하였다. 실험 결과 지연성근육통이 발생하면 교감신경계의 활성 증가 또는 부교감신경계 활성 억제가 되며, 중재로 인한 통증 감소는 반대의 활동이 나타났다. 통증 발생 시 alpha파의 감소가 나타났으나 유의하지 않았다. 본 연구 결과 통증 변화는 자율신경계와 뇌파에 영향을 미침을 알 수 있었으며, 이러한 결과는 통증 관리와 치료 전략 개발 및 연구에 도움이 될 것이다.

• Biomolecules & Therapeutics
• /
• 제30권4호
• /
• pp.360-367
• /
• 2022

Tropomyosin receptor kinase A (TrkA) protein is a receptor tyrosine kinase encoded by the NTRK1 gene. TrkA signaling mediates the proliferation, differentiation, and survival of neurons and other cells following stimulation by its ligand, the nerve growth factor. Chromosomal rearrangements of the NTRK1 gene result in the generation of TrkA fusion protein, which is known to cause deregulation of TrkA signaling. Targeting TrkA activity represents a promising strategy for the treatment of cancers that harbor the TrkA fusion protein. In this study, we evaluated the TrkA-inhibitory activity of the benzoxazole compound KRC-108. KRC-108 inhibited TrkA activity in an in vitro kinase assay, and suppressed the growth of KM12C colon cancer cells harboring an NTRK1 gene fusion. KRC-108 treatment induced cell cycle arrest, apoptotic cell death, and autophagy. KRC-108 suppressed the phosphorylation of downstream signaling molecules of TrkA, including Akt, phospholipase Cγ, and ERK1/2. Furthermore, KRC-108 exhibited antitumor activity in vivo in a KM12C cell xenograft model. These results indicate that KRC-108 may be a promising therapeutic agent for Trk fusion-positive cancers.