• Physical Therapy Rehabilitation Science
• /
• 제12권2호
• /
• pp.115-122
• /
• 2023

Objective: A previous study reported that cardiovascular training (CT) decreased interleukin-6 (IL-6), a pro-inflammatory cytokine with bidirectional effects. However, because of conflicting results of increasing and decreasing IL-6 levels in stroke patients, it is essential to clarify the effects of CT on IL-6 levels in this population. Therefore, this review aimed to investigate the effects of CT on IL-6 levels in stroke patients through a meta-analysis of randomized controlled trials (RCTs), synthesizing and analyzing the effects qualitatively and quantitatively. Design: A systematic review and meta-analysis of randomized controlled trials. Methods: In this review, conducted in April 2023, electronic databases (Web of Science, CINAHL, Embase, MEDLINE, Google Scholar) were searched to ascertain the effects of CT on IL-6 levels in stroke patients. For qualitative evaluation, ReVMan, provided by the Cochrane Group, was used, and for quantitative evaluation, a random-effects model and SMD (Standardized Mean Difference) were used. Results: Three RCTs measured IL-6 in 117 patients with stroke. The experimental group to which CT was applied showed no significant change compared to the control group.The result of analysis using the random effect model is SMD=-0.23; 95% confidence interval, -0.66 to 0.20. Conclusions: CT does not affect IL-6 levels in stroke patients. These results suggest that CT can be applied regardless of its positive or negative effect on IL-6 levels in stroke patients.

• 대한통합의학회지
• /
• 제12권1호
• /
• pp.161-169
• /
• 2024

Purpose : This study investigated the correlation between social support and older people's quality of life. Methods : We conducted a questionnaire survey with 350 older participants and analyzed 320 completed surveys. The collected data were analyzed using SPSS 25.0 for Windows. The general characteristics of the participants and quality of life subdomains were analyzed using descriptive statistics and frequency analyses. Furthermore, the differences between the subdomains of social support and quality of life were analyzed using independent t-tests and a one-way ANOVA. Post-hoc tests were performed using the Scheffé test. A significance level of α=.05 was used to verify statistical significance. Results : Upon examining the sub-domain level of social support and considering general characteristics, it was found that older age correlates with increased dependency among patients with associated diseases (p<.05). Similarly, an investigation into participants' quality of life at the subdomain level, considering general characteristics, revealed higher correspondence to lower quality of life (p<.05). Differences emerged between social support and quality of life among older individuals, with a negative correlation observed between the two (p<.05). Conclusion : This study suggests the importance of actively supporting older people with chronic diseases who experience emotional and psychological instability. It advocates for promoting the use of various services, including visiting medical services, convalescent care, and assistance, to meet their needs effectively.

• IMMUNE NETWORK
• /
• 제16권2호
• /
• pp.85-98
• /
• 2016

The mitogen-activated protein kinases (MAPKs) are key regulators of cell growth and survival in physiological and pathological processes. Aberrant MAPK signaling plays a critical role in the development and progression of human cancer, as well as in determining responses to cancer treatment. The MAPK phosphatases (MKPs), also known as dual-specificity phosphatases (DUSPs), are a family of proteins that function as major negative regulators of MAPK activities in mammalian cells. Studies using mice deficient in specific MKPs including MKP1/DUSP1, PAC-1/DUSP2, MKP2/DUSP4, MKP5/DUSP10 and MKP7/DUSP16 demonstrated that these molecules are important not only for both innate and adaptive immune responses, but also for metabolic homeostasis. In addition, the consequences of the gain or loss of function of the MKPs in normal and malignant tissues have highlighted the importance of these phosphatases in the pathogenesis of cancers. The involvement of the MKPs in resistance to cancer therapy has also gained prominence, making the MKPs a potential target for anti-cancer therapy. This review will summarize the current knowledge of the MKPs in cancer development, progression and treatment outcomes.

• Clinical Endoscopy
• /
• 제56권6호
• /
• pp.754-760
• /
• 2023

Background/Aims: Endoscopic vacuum therapy (EVT) can heal a variety of defects within the gastrointestinal (GI) tract via applying negative pressure, which reduces the defect size, aspirates the infected fluid, and promotes granulation tissue. Here we present our experience with EVT as it relates to both spontaneous and iatrogenic upper GI tract perforations, leaks, and fistulas. Methods: This retrospective study was conducted at four large hospital centers. All patients who underwent EVT between June 2018 and March 2021 were included. Data on multiple variables were collected, including demographics, defect size and location, number and intervals of EVT exchanges, technical success, and hospital length of stay. Student t-test and the chi-squared test were used to analyze the data. Results: Twenty patients underwent EVT. The most common defect cause was spontaneous esophageal perforation (50%). The most common defect location was the distal esophagus (55%). The success rate was 80%. Seven patients were treated with EVT as the primary closure method. The mean number of exchanges was five with a mean interval of 4.3 days between exchanges. The mean length of hospital stay was 55.8 days. Conclusions: EVT is a safe and effective initial management option for esophageal leaks and perforations.

• 한국화재소방학회논문지
• /
• 제33권6호
• /
• pp.132-141
• /
• 2019

본 연구는 국립산림치유원에서 실시한 4박 5일형 산림치유프로그램이 소방공무원의 외상 후 스트레스 및 기분상태 변화에 미치는 효과를 알아보고자 수행되었다. 소방공무원 293명을 대상으로 설문조사를 실시하였으며, SPSS 24.0을 활용하여 빈도분석, 대응 t-검정 및 공분산분석을 실시하였다. 산림치유프로그램 참여 전과 후의 외상 후 스트레스, 기분상태의 차이 및 인구학적 특성에 따른 차이를 분석하였다. 외상 후 스트레스 결과, 참여 전 평균 11.38 ± 12.58점에서 참여 후 6.91 ± 10.50점으로 감소하여 통계적으로 유의한 영향을 미치는 것으로 나타났다. 기분상태검사 결과, 긍정적 요인은 증가하였고, 부정적 요인은 감소하였다. 전체 기분상태 또한 프로그램 참여 전 8.58 ± 18.47점에서 참여 후 -0.63 ± 15.83점으로 통계적으로 유의한 영향을 미치는 것으로 나타났다. 수면시간에 따른 스트레스 저감 효과 차이 분석 결과, 외상 후 스트레스는 수면시간이 6~8시간일 때 효과가 높게 나타났다. 본 연구결과는 소방공무원의 외상 후 스트레스 관리와 해소를 위한 방법이 될 수 있는 근거자료로 활용되기를 기대한다.

• 디지털융복합연구
• /
• 제13권12호
• /
• pp.291-301
• /
• 2015

본 연구는 피학대 아동을 위한 중재방법으로 미술치료를 실시하였으며 미술치료전문가와 아동학전문가가 공동으로 참여하여 미술활동이 아동 행동에 미치는 영향을 파악하고자 하는 목적에서 시도되었다. 연구대상자는 00시 00그룹 홈 초등학생 4명으로 2013년 9월부터 2014년 8월까지 주 1회 60분간 48회기 적용하였다. 미술치료효과를 분석하기 위해 연구자들은 매 회기마다 치료적 목표와 함께 대상자들의 정서적 반응과 태도 행동들을 기록하였고 행동변화에 대한 타당도검증을 위해 CDI, TAIC, SAIC, 자아상척도 검사를 실시하였다. 척도는 사전측정(2013년 9월)과 사후측정(2014년8월)하였다. 척도의 신뢰도검사를 위해 SPSS 21.0프로그램을 사용하였다. 연구문제에 대한 결과는 다음과 같다. 첫째, 학대받은 아동들은 작품에서 그들의 정서상태를 표현했고 행동이 변화하였고 친구관계가 향상되었다. 둘째, CDI, STAIC(TAIC, SAIC)서 우울과 불안에 대한 사후검사결과가 사전 검사결과보다 낮았다. 셋째, 자아상 검사결과 사후검사결과가 사전검사결과보다 높았다. 즉 아동들은 충동적 행동이 감소했고 가족, 친구들과 우호적 관계를 유지하였다. 위탁양육자는 아동들을 잘 이해할 수 있었고 그래서 양육의 어려움이 감소하였다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권22호
• /
• pp.9909-9913
• /
• 2014

Background: Helicobacter pylori (H. pylori) remains an important cause of gastric cancer and peptic ulcer disease worldwide. Treatment of H. pylori infection is one of the effective ways to prevent gastric cancer. However, standard triple therapy for H. pylori eradication is no longer effective in many countries, including Thailand. This study was designed to evaluate the efficacy of adding bismuth and probiotic to standard triple therapy for H. pylori eradication. Materials and Methods: In this prospective single center study, H. pylori infected gastritis patients were randomized to receive 7- or 14-day standard triple therapy plus bismuth with probiotic or placebo. Treatment regimen consisted of 30 mg lansoprazole twice daily, 1 g amoxicillin twice daily, 1 g clarithromycin MR once daily and 1,048mg bismuth subsalicylate twice daily. Probiotic bacteria composed of Bifidobacterium lactis, Lactobacillus acidophilus and Lactobacillus paracasei. Placebo was conventional drinking yogurt without probiotic. CYP2C19 genotyping and antibiotic susceptibility tests were also done. H pylori eradication was defined as a negative $^{13}C$-urea breath test at least 2 weeks after completion of treatment. Results: One hundred subjects were enrolled (25 each to 7- and 14-day regimens with probiotic or placebo). Antibiotic susceptibility tests showed 36.7% metronidazole and 1.1% clarithromycin resistance. CYP2C19 genotyping revealed 40.8%, 49% and 10.2% were rapid, intermediate and poor metabolizers, respectively. The eradication rates of 7- or 14 regimens with probiotics were 100%. Regarding adverse events, the incidence of bitter taste was significantly lower in the 7- day regimen with the probiotic group compared with 7- day regimen with placebo (40% vs. 64%; p=0.04). Conclusions: The 7-day standard triple therapy plus bismuth and probiotic can provide an excellent cure rate of H. pylori (100%) in areas with low clarithromycin resistance such as Thailand, regardless of CYP2C19 genotype. Adding a probiotic also reduced treatment-related adverse events.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권3호
• /
• pp.2091-2095
• /
• 2013

Background: The $7^{th}$ TNM staging is the first authoritative standard for evaluation of effectiveness of treatment of gastric cancer worldwide. However, revision of pN classification within TNM needs to be discussed. In particular, the N3 sub-stage is becoming more conspicuous. Methods: Clinical data of 302 pN3M0 stage gastric cancer patients who received radical gastrectomy in Tianjin Medical University Cancer Institute and Hospital from January 2001 to May 2006 were retrospectively analyzed. Results: Location of tumor, depth of invasion, extranodal metastasis, gastric resection, combined organs resection, lymph node metastasis, rate of lymph node metastasis, negative lymph nodes count were important prognostic factors of pN3M0 stage gastric cancers. TNM stage was also associated with prognosis. Patients at T2N3M0 stage had a better prognosis than other sub-classification. T3N3M0 and T4aN3aM0 patients had equal prognosis which followed the T2N3M0. T4aN3bM0 and T4bN3aM0 had lower survival rate than the formers. T4bN3bM0 had worst prognosis. In multivariate analysis, TNM stage group and rate of lymph node metastasis were independent prognostic factors. Conclusions: The sub-stage of N3 may be useful for more accurate prediction of prognosis; it should therefore be applied in the TNM stage system.

• 한국융합학회논문지
• /
• 제11권1호
• /
• pp.89-96
• /
• 2020

본 연구는 대학생의 부모, 교우, 교수지원 특성과 성별 차이, 사회지원 및 대학 생활 만족도 간의 상관성을 알아보고자 강원도 소재 대학생 564명을 대상으로 사회지원 27문항, 대학 생활 만족도 5문항으로 구성된 설문으로 조사하였다. 연구결과 부모, 교우 및 교수지원 순으로 긍정적인 답변이었고 이중 교수지원에서 부정적인 답변이 많았으며 대학생활 만족도도 높지 않았다. 성별 차이에 따른 사회지원 및 대학 생활 만족도는 여학생과 남학생 간 교수지원의 차이를 보였고(p<0.00) 성별, 부모, 교우, 교수지원 및 대학 생활 만족도 간의 상관분석에서 성별과 상관없이 사회지원과 대학생활 만족도에서 통계적으로 유의한 상관성을 보였다(p<0.00). 이를 통해 대학생활 만족도를 향상하기 위하여 부모뿐만 아니라 교우 및 교수의 체계적인 지원으로 상호소통을 증진하여야 할 것이다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권14호
• /
• pp.6089-6092
• /
• 2015

Background: The prevalence of metronidazole-resistant H. pylori is almost 50% in Thailand which severely limits the use of this drug for eradication therapy. The aims of this study were to evaluate the efficacy and safety profiles of 7-day bismuth-based quadruple therapy including metronidazole as an initial treatment for H. pylori infection in a high metronidazole resistance area. Materials and Methods: This study was performed at Thammasat University Hospital and King Chulalongkorn Memorial Hospital during January 2009 to October 2010. Patients with non-ulcer dyspepsia (NUD) with active H. pylori infection were assigned to receive seven days of quadruple therapy (pantoprazole 40 mg bid, bismuth subsalicylate 1,048 mg bid, amoxicillin 1 gm bid and metronidazole 400 mg tid). H. pylori infection was defined as positive H. pylori culture or two positive tests (rapid urease test and histology). Antibiotic susceptibility test for metronidazole by Epsilometer test (E-test) was performed in all positive cultures. At least four weeks after treatment, $^{13}C$ urea breath test ($^{13}C-UBT$) was performed to confirm H. pylori eradication. Results: A total of 114 patients were enrolled in this study, 50 males and 64 females with a mean age of 49.8 years. All 114 patients had a diagnosis of NUD. Overall eradication as confirmed by negative $^{13}C-UBT$ was achieved in 94 out of 114 patients (82.5%). 44 patients had positive cultures and success for E-test. In vitro metronidazole resistance was observed in 22/44 (50%) patients. Eradication rate in patients with metronidazole resistant strains was 16/22 (72.7%) and 20/22 (90.1%) with metronidazole sensitive strains (72.7% vs 90.1%, p-value=0.12; OR=3.75 [95%CI=0.6-31.5]). Minor adverse reactions included nausea, bitter taste, diarrhea and black stools but none of the patients dropped out from the study. Conclusions: Initial treatment with 7-day bismuth-based quadruple therapy including metronidazole, amoxycillin and pantoprazole is highly effective and well tolerated for metronidazole-sensitive H. pylori infections. However, the efficacy markedly decline with metronidazole resistance. Longer duration of this regimen might be required to improve the eradication rate and larger multi-center studies are needed to confirm this hypothesis.