• Journal of Digestive Cancer Research
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• v.10 no.2
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• pp.107-111
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• 2022

In 2019, coronavirus disease (COVID-19), which originated in Wuhan, has spread worldwide. In most people, COVID-19 symptoms are not severe. However, the mortality rate and severity were high in risk groups such as in older people and patients with underlying diseases. As patients with cancer are one of the risk groups, the vaccination for COVID-19 is emphasized in these patients. However, COVID-19 vaccines are not tested enough in special groups such as in patients with cancer because these vaccines are developed at an unprecedented speed. This causes confusion about whether patients undergoing chemotherapy should be vaccinated or not. In this study, international guidelines and studies were reviewed. Most of the studies recommended vaccination. No evidences of any negative effects for the efficacy or safety were recorded in patients undergoing cytotoxic, targeted, and immune agents. However, in critical conditions such as cytopenia, vaccination must be decided according to the patient's condition. COVID-19 vaccines were also recommended for patients on surgery or radiation therapy. If possible, vaccine is given before surgery to avoid confusion between surgical complications and side effects of the vaccine. The radiation recall phenomenon after vaccination has been reported in some cases of radiation therapy. Clinicians should consider these situations before vaccinating each patient. We hope that clearer guidelines will be established by accumulating verified data.

• IMMUNE NETWORK
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• v.16 no.2
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• pp.99-108
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• 2016

Colorectal cancer is the third leading cancer worldwide. Although incidence and mortality of colorectal cancer are gradually decreasing in the US, patients with metastatic colorectal cancer have poor prognosis with an estimated 5-year survival rate of less than 10%. Over the past decade, advances in combination chemotherapy regimens for colorectal cancer have led to significant improvement in progression-free and overall survival. However, patients with metastatic disease gain little clinical benefit from conventional therapy, which is associated with grade 3~4 toxicity with negative effects on quality of life. In previous clinical studies, cell-based immunotherapy using dendritic cell vaccines and sentinel lymph node T cell therapy showed promising therapeutic results for metastatic colorectal cancer. In our preclinical and previous clinical studies, cytokine-induced killer (CIK) cells treatment for colorectal cancer showed favorable responses without toxicities. Here, we review current treatment options for colorectal cancer and summarize available clinical studies utilizing cell-based immunotherapy. Based on these studies, we recommend the use CIK cell therapy as a promising therapeutic strategy for patients with metastatic colorectal cancer.

• Journal of Korean Neurosurgical Society
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• v.29 no.1
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• pp.126-130
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• 2000

A 40-year-old female with hypertensive thalamic hemorrhage, secondary intraventricular hemorrhage, and hydrocephalus was treated with extraventricular drainage. She developed catheter-related ventriculitis caused by gram-negative rods, Enterobacter aerogenes. She was treated with systemic pefloxacine, ceftazidime, amikin and intraventricular vancomycin, gentamicin was unsuccessful. The ventriculitis was successfully controlled by intraventricular administration of the pefloxacine. Regarding their excellent activity against gram-negative rods, Enterobacter aerogenes, and probable safety when administered intraventricularly, administration of the pefloxacine, may be considered in the treatment of ventriculitis if the pathogen is resistant to other conventional antibiotics.

• Journal of Haehwa Medicine
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• v.13 no.1
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• pp.345-353
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• 2004

This study analyzed the contents of the research papers concerning the obesity from a psychiatrical point of view. As a result, the following conclusion was drawn. 1. In obese people, negative emotions, especially depression were frequently reported. 2. Negative feelings, especially anger, anxiety, depression, induce binge eating and can lead to obesity. 3. Depression was related to the wrong body image more than to the body mass index. 4. Wrong body image affects eating attitudes, which may cause eating disorders. 5. To treat obesity or eating disorders, we must use psychosocial treatment, for example, supportive, cognitive or behavior therapy.

• Journal of Chest Surgery
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• v.24 no.10
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• pp.979-986
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• 1991

From October 1988 to November 1989, seven patients underwent valve replacement during the active phase of native valve endocarditis. There were 4 males and 3 females whose mean age was 41 years[range, 16 to 68 years]. Preoperative two-dimensional and Doppler echocardiography showed vegetations and severe valvular regurgitation in all patients. Blood cultures were positive in 4, and negative in 3 patients Organisms were alpha-hemolytic Streptococcus in 2, Staphylococcus epidermidis in 1, Erysipelothrix rhusiopathiae in 1 patient Valve tissue cultures were negative in all patients. Intravenous antibiotic therapy had been done for 3 to 18 days in 5 patients pre-operatively and was not done in 2 patients, Indications for operation were heart failure in h, and systemic emboli in 1 patient. The aortic valve was involved in 3, mitral in 1, and both aortic and mitral in 3 patients, One operative death[14.4%] occurred in patient with cardiogenic shock before operation. Late death occurred in one on 14 months after operation. The remaining 5 patients were followed up over a two year period in good condition. In conclusion, native valve endocarditis with severe heart failure must be considered for early operation.

• IMMUNE NETWORK
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• v.16 no.2
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• pp.134-139
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• 2016

Programmed death-1 (PD-1) is a strong negative regulator of T lymphocytes in tumor-microenvironment. By engaging PD-1 ligand (PD-L1) on tumor cells, PD-1 on T cell surface inhibits anti-tumor reactivity of tumor-infiltrating T cells. Systemic blockade of PD-1 function using blocking antibodies has shown significant therapeutic efficacy in clinical trials. However, approximately 10 to 15% of treated patients exhibited serious autoimmune responses due to the activation of self-reactive lymphocytes. To achieve selective activation of tumor-specific T cells, we generated T cells expressing a dominant-negative deletion mutant of PD-1 (PD-1 decoy) via retroviral transduction. PD-1 decoy increased IFN-γ secretion of antigen-specific T cells in response to tumor cells expressing the cognate antigen. Adoptive transfer of PD-1 decoy-expressing T cells into tumor-bearing mice potentiated T cell-mediated tumor regression. Thus, T cell-specific blockade of PD-1 could be a useful strategy for enhancing both efficacy and safety of anti-tumor T cell therapy.

• Journal of Digital Convergence
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• v.14 no.5
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• pp.485-491
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• 2016

The purpose of this study was to compare of the fall risk factors for elderly in the city. 62 people aged 65 years or older were classified as fallers and nonfallers based on experience of their falls in the previous year. By comparing the difference between the groups via evaluations of general characteristics, health related behavior and chronic disease, balance-related psychological (K-ABC) and physical measurement (BBS), depression (SGDS), and the correlations between the significant differences in variables were identified. According to the results, K-ABC, BBS, and SGDS are statistically significant differences between fallers and nonfallers (P<0.05). Also it has positive correlations between BBS and K-ABC (r=0.499) whereas negative correlation between K-ABC and SGDS(r=-0.472).

• Journal of Korean Physical Therapy Science
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• v.18 no.2
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• pp.73-80
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• 2011

Purpose: The purpose of this study was to investigate the correlation between the visual perception ability and the static dynamic balance ability in health elderly. Method: The Motor Free Visual Perception Test-Row Score(MVPT-RS) and MVPT-Process Time(MVPT-PT) were used for evaluating the visual perception abilities. Assessment of the balance ability was taken by using Good Balance System. In the assessment using Good Balance System, X, Y coordinate speed, anterior-posterior direction, medial-lateral direction and Velocity Movement(VM) in standing posture when eye open were measured as static balance abilities. Thirty-seven healthy elderly who live in Gwangyang participated in the experiment for 2 months, from October to November 2010. Results: 1. There were statistically significant differences of MVPT-RS, MVPT-PT, NSB-X, NSB-Y, NSB-VM, OLB-X, and OLB-VM based on the gender(p<0.05). 2. The negative correlations of MVPT-RS:NSB-Y(r=-0.354), MVPT-RS:OLB-X(r=-0.4), MVPT-RS: OLB-Y(r=-0.371), but positive correlations of MVPT-PT:DTB-T showed a statistical significance(r=0.45, p<0.05). 3. The positive correlations of NSB-X:NSB-Y(r=0.54), NSB-X: NSB-VM(r=0.848), NSB-Y:NSB-VM(r=0.531), OLB-X:OLB-Y(r=0.876), OLB-X:OLB-VM(r=0.872), and OLB-Y:OLB-VM(r=0.787) showed statistical significances(p<0.05). Conclusion: These results showed that the visual perception ability was correlated with some balance ability in health elderly. Especially the perception test process time(MVPT-PT) has closely related with the DTB-T. The visual perception ability is considered as a factor on the balance ability in health elderly. Further study will focus on the development of improving program of visual perception ability as an improving method of balancing ability in health elderly.

• Journal of Korean Physical Therapy Science
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• v.24 no.3
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• pp.56-63
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• 2017

Purpose: This study aimed to investigate the effects of sitting posture on cervical flexion angle and pain during smart phone use. Method: This research was performed on 10 adult female students who use smart phones regularly, Each of the two groups of participants used the provided smart phone for 20 minutes while maintaining the given default posture. The evaluation order was randomly selected and the two groups were photographed twice before and after the experiment and were asked to answer if they felt pain during or after the experiment. Result: First, both upright sitting position and vertebra bent position pre and post experiment readings showed significant statistical difference (p<.05). And it is shown to be a factor that induces pain around the neck via increase in neck flexion angle. Second, although there were no significant statistical difference between the pre and post experiment readings of the upright sitting position results and the vertebra bent position results, the vertebra bent position readings showed bigger changes to the neck flexion angle then the upright sitting position readings. Third, all participants from both groups claimed pain in all the tested postures of smart phone usage. Conclusion: Smart phone usage for an extended amount of time in all body postures may prove to have a negative effect making the "optimal" smart phone usage position as a controlled time with neck stretches included in between short sessions.

• Research in Community and Public Health Nursing
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• v.10 no.1
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• pp.19-31
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• 1999

This study was conducted to investigate the effect. of group recreation therapy as a community nursing intervention on depression, self-esteem and life satisfaction. The period of data collection was from september 7, 1998 to November 14, 1998 and a total of 46 elderly were studied at a nursing home in Taegu, Korea. Among them, 25 elderly received group recreation therapy(experimental group) and the other 21 didn't(control group). The study design was a non-equivalent control group pretest -posttest design considered to quasi-experimental research. The data analysis of this study was computerized by using an SPSS/PC and hypothesis testing was done with an ANCOVA and pearson correlation coefficient. The results are as follows. 1. The depression of the experimental group was significantly reduced compared with the control group(F=37.797, P=.000). 2. The self-esteem of the experimental group was increased compared with the control group, but significant differences were not found(F=1.604, P=.212). 3. The life satisfaction of the experimental group was increased compared with the control group (F = 37.420, P=.000). 4. A significant negative correlation between depression and self-esteem and life satisfaction of the elderly(r=. -620, r=. -555, P<.001) was observed, a significant positive correlation between self-esteem and life satisfaction was observed(r=.477, P=<.001). In conclusial, it was found that group recreation therapy was an effective tool to redue depression and increase life satisfaction, thus helping the elderly cope with the problems of age.