• Journal of Yeungnam Medical Science
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• v.20 no.2
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• pp.117-128
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• 2003

Thallium-201 scintigraphy is used to discriminate the malignant bone tumor from the benign by qualitatively and quantitatively, and to predict the response of preoperative chemotherapy in osteosarcoma, by comparing the changes of thallium uptake ratio after chemotherapy to the tumor necrosis ratio. Thallium-201 scintigraphy scan should be done prior to surgical biopsy. PICKER Prism 2000 gamma camera with high resolution parallel hole collimator is usually used for scanning. The patient is injected with 2-3mCi of Tl-201 and the early phase is checked in 30 minutes and delayed phase in 3 hours. The scan images are visually evaluated by a blinded nuclear medicine physician. We could evaluate true positive, true negative, false positive and false negative by the comparison of results with those of biopsy, and calculate positive and negative predictive value(%), sensitivity(%), specificity(%) and diagnostic accuracy(%). For the quantitative analysis of thallium uptake, we drew the region of interest on the tumor side and contralateral normal side as mirror image, and calculated the uptake ratio with dividing the amount of gamma count in tumor side by normal side. We could calculate the percent changes of thallium uptake ratio in early and delayed phase, and compare them to the ratio of tumor necrosis. Thallium-201 scintigraphy proved as useful imaging study to discriminate malignant bone tumor from benign, but had exception in giant cell tumor and low grade malignant bone tumors. We can use T1-201 scan to differentiate the benign from the malignant tumor, and to evaluate the response of preoperative chemotherapy or radiotherapy, and to determine the residual tumor or local recurrence. For the better result, we need to have a more detail information about false positive cases and a more objective and quantitative reading technique.

• Journal of the East Asian Society of Dietary Life
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• v.25 no.1
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• pp.64-72
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• 2015

Menstrual problem (premenstrual syndrome (PMS) and dysmenorrhea) is a common gynecological complaints among women in reproductive age. The aim of this study was to compare the effects of isoflavone and Cynanchum wilfordii for improvement of premenstrual syndrome, dysmenorrhea. Subjects were 30 college women in Busan, divided into three groups (CG; control group, n=10; IS group; isoflavone supplement group, n=10; CS group; Cynanchum wilfordii supplement group, n=10). They showed 5.0 or higher for menstrual pain when tested by the VAS. IS group was allocated a isoflavone pill (500 mg/day) for 8 weeks, and CS group was allocated a Cynanchum wilfordii pill (6 g/day) for 8 weeks. We administered a menstrual distress questionnaire (MDQ), and visual analogue scale(VAS). There were no differences among the three groups in general characteristics, nutrients intake, MDQ, or VAS. In the CG group, there were no differences in MDQ, or VAS after 8 weeks. In the IS group, negative emotions, behavioral changes, concentration, pain, autonomic nervous system response, water retention, and skin changes significantly improved (P<0.05). In the CS group, negative emotions, pain, autonomic nervous system response, and water retention significantly decreased after 8 weeks (P<0.05). Changes in negative emotion, pain, autonomic nervous system response, water retention, skin changes significantly improved in the CS group compared to the control group (P<0.05). VAS significantly decreased in the IS and CS groups (P<0.05). The decrease in VAS differed among three groups, with the CS group showing a larger decrease than the control group and IS group (P<0.001).

• Journal of International Academy of Physical Therapy Research
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• v.5 no.2
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• pp.723-729
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• 2014

The purpose of this study is to understand the relationship between female college students' stress level and premenstrual syndrome so that it can provide baseline data on how to cope with the syndrome. The study subjects are 250 female college students in Gyungbook area. This study chose 199 appropriate subjects and collected data. As per general menstrual phases, this study investigated the age when one had her first period, regularity and duration of period, and amount of bleeding. It used a measurement tool to measure stress level and premenstrual syndrome. Most of the subjects experienced their first period before the age of 13. The menstrual period was irregular with the duration of less than 7 days. 123 subjects had normal amount of bleeding. 121 subjects were experiencing high level of stress over 2.4. The correlation between the level of stress and premenstrual syndrome factors showed significant static correlation for each factor. Especially, the correlation between digestive system and response of autonomic nervous system was .996 and negative emotion and behavioral change was .635, and negative emotion and pain was .614 which were relatively high. The regression analysis of factors of premenstrual syndrome depending on the subjects' stress level indicated that response of autonomic nervous system had the biggest effect in the low stress group while behavioral change, negative emotion, pain, decreased concentration, water congestion, response of autonomic nervous system, and skin change had the biggest effect in the high stress group with statistical significance. Based on the result, it can be said that higher premenstrual stress is closely related to the premenstrual syndrome one experiences for some female college students.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.2
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• pp.116.1-116.1
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• 2012

When an interplanetary (IP) shock passes over the Earth's magnetosphere, the geosynchronous magnetic field strength near the noon is always enhanced, while the geosynchronous magnetic field near the midnight decreases or increases. In order to understand what determines the positive or negative magnetic field response at nightside geosynchronous orbit to sudden increases in the solar wind dynamic pressure, we have examined 120 IP shock-associated sudden commencements (SC) using magnetic field data from the GOES spacecraft near the midnight (MLT = 2200~0200) and found the following magnetic field perturbation characteristics. (1) There is a strong seasonal dependence of geosynchronous magnetic field perturbations during the passage of IP shocks. That is, the SC-associated geosynchronous magnetic field near the midnight increases (a positive response) in summer and decreases (a negative response) in winter. (2) These field perturbations are dominated by the radial magnetic field component rather than the north-south magnetic field component at nightside geosynchronous orbit. (3) The magnetic elevation angles corresponding to positive and negative responses decrease and increase, respectively. These field perturbation properties can be explained by the location of the cross-tail current enhancement during SC interval with respect to geosynchronous spacecraft position.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.28 no.2
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• pp.187-195
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• 2015

The gas explosions in offshore installations are known to be very severe according to its geometry and environmental conditions such as leak locations and wind directions, and a dynamic response of structures due to blast loads depends on the load profile. Therefore, a parametric study has to be conducted to investigate the effects of the dynamic response of structural members subjected to various types of load shapes. To do so, a series of CFD analyses was performed using a full-scale FPSO topside model including detail parts of pipes and equipments, and the time history data of the blast loads at monitor points and panels were obtained by the analyses. In this paper, we focus on a structural dynamic response subjected to blast loads changing the magnitude of positive/negative phase pressure and time duration. From the results of linear/nonlinear transient analyses using single degree of freedom(SDOF) and multi-degree-of freedom(MDOF) systems, it was observed that dynamic responses of structures were significantly influenced by the magnitude of positive and negative phase pressures and negative time duration.

• Korean Journal of Biological Psychiatry
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• v.7 no.2
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• pp.159-163
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• 2000

Background : Dopamine receptors are strong candidates for involvement in schizophrenia and are target of a wide variety of antipsychotics. Dopamine $D_5$ receptor(DRD5) gene polymorphisms may be associated with various treatment response. The purpose of our study was define to what significance can be held as a predictor of treatment response in this polymorphism. Method : The total number of 116 Korean chronic schizophrenic patients was assessed after 48 weeks treatment. The Positive and Negative Syndrome Scale(PANSS) was rated for the clinical response to various antipsychotics. With the use of polymerase chain reaction amplification, we assessed this dopamine $D_5$ receptor polymorphism in schizophrenic patients who had been treated with antipsychotics, and related genotype with treatment response, to test the hypothesis that DRD5 polymorphism may lead to varying response to antipsychotics. Result : DRD5 polymorphism was not associated with treatment response to a variety of antipsychotics in chronic schizophrenic patients. Conclusion : Genetic variation of $D_5$ receptors do not predict treatment response to antispychotics.

• Current Research on Agriculture and Life Sciences
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• v.18
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• pp.27-31
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• 2000

Preferences on the change of color and aroma of soybean sprout was surveyed. Negative response of 'bad' or 'very bad' on pink (72%), red (60%), and green (44%) coloring was obtained. However, yellow coloring showed about 55% of positive response of 'good' or 'very good'. Thus yellow is the only color which received highly positive response among altered-color soybean sprouts. Significantly different result was observed when various aroma was added to soybean sprout. 80% of peanut scent-added soybean sprout and 76% of melon scent-added soybean sprout received positive response of 'good' or 'very good' while only 20% of the response was negative. In conclusion, altering color to yellow and addition of peanut scent or melon scent could increase the general preference of soybean sprout.

• The Korean Journal of Physiology
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• v.29 no.2
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• pp.203-216
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• 1995

The effects of ${\alpha}_1-adrenergic$ receptor stimulation on membrane potential, intracellular $Na^+$ activity, and twitch force were investigated in ventricular muscles from guinea-pig hearts. Action potentials, intracellular $Na^+$ activity, and twitch force of ventricular papillary muscles were measured simultaneously under various experimental conditions. Stimulation of the ${\alpha}_1-adrenergic$ receptor by phenylephrine produced variable changes in action potential duration, a slight hyperpolarization of the diastolic membrane potential, a decrease in intracellular $Na^+$ activity, and a biphasic inotropic response in which a transient negative inotropic response was followed by a sustained positive inotropic response. These changes were blocked by prazosin, an antagonist of the ${\alpha}_1-adrenergic$ receptor, but not by atenolol, an antagonist of the ${\beta}-adrenergic$ receptor. This indicates that the changes in membrane potential, intracellular $Na^+$ activity, and twitch force are mediated by stimulation of the ${\alpha}_1-adrenergic$ receptor, but not by stimulation of ${\beta}-adrenergic$ receptor. The decrease in intracellular $Na^+$ activity was not observed in quiescent muscles, depending on the rate of the action pontentials in beating muscles. The intracellular $Na^+$ activity decrease was substantially inhibited by tetrodotoxin. However, the decrease in intracellular $Na^+$ activity was not affected by an inhibition of the $Na^+-K^+$ pump. Therefore, the decrease in intracellular $Na^+$ activity mediated by the ${\alpha}_1-adrenergic$ receptor appears to be due to a reduction of $Na^+$ influx during the action potential, perhaps through tetrodotoxin sensitive $Na^+$ channels. Our study also revealed that the decrease in intracellular $Na^+$ activity might be related to the transient negative inotropic response. The intracellular $Na^+$ activity decrease could lower intracellular $Ca^{2+}$ through the $Na^+-Ca^{2+}$ exchanger and thereby produce a decline in twitch force.

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.6
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• pp.806-812
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• 2003

Attempts have been made to establish relationship between the response to ACTH challenge in female calves, growth and first lactation performance. A total of 19 Holstein calves weighing 100 kg i. v. were given 0.50 IU of ACTH/kg $BW^{.75}$ (EXACTHIN inj., Richter G., Budapest) at 60 days of age. Serial blood samples were taken at times 0, 0.5, 1, 2, 3, 4 and 5 hours and analyzed for cortisol, glucose insulin and FFA levels. From challenge series the area under the curve from time of administration and the following 5 h were calculated. Negative, and mostly loose relationship between response to ACTH challenge for cortisol, insulin, or FFA and ADWG during growth have been established (p>0.05) with positive one for glucose. Bivariate coefficients of correlation varied within the range from -0.35 to 0.15. Estimations reveal negative correlation between the length of first lactation and cortisol or insulin (r=-0.80, p<0.001 and r=-0.45, p<0.10, resp.) Close association between cortisol or insulin and actual first lactation milk yield was found (r=-0.48, p<0.10; r=-0.64, p<0.01, resp.). Close relationship between the response to ACTH challenge and milk protein yield was present only for insulin (r=-0.59, p<0.05).

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.3223-3228
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• 2013

Gene expression profiling (GEP) has identified several molecular subtypes of breast cancer, with different clinico-pathologic features and exhibiting different responses to chemotherapy. However, GEP is expensive and not available in the developing countries where the majority of patients present at advanced stage. The St Gallen Consensus in 2011 proposed use of a simplified, four immunohistochemical (IHC) biomarker panel (ER, PR, HER2, Ki67/Tumor Grade) for molecular classification. The present study was conducted in 75 newly diagnosed patients of breast cancer with large (>5cm) tumors to evaluate the association of IHC surrogate molecular subtype with the clinical response to presurgical chemotherapy, evaluated by the WHO criteria, 3 weeks after the third cycle of 5 flourouracil, adriamycin, cyclophosphamide (FAC regimen). The subtypes of luminal, basal-like and HER2 enriched were found to account for 36.0 % (27/75), 34.7 % (26/75) and 29.3% (22/75) of patients respectively. Ten were luminal A and 14 luminal B (8 HER2 negative and 6HER2 positive). The triple negative breast cancer (TNBC) was most sensitive to chemotherapy with 19% achieving clinical-complete-response (cCR) followed by HER2 enriched (2/22 (9%) cCR), luminal B (1/6 (7%) cCR) and luminal A (0/10 (0%) cCR). Heterogeneity was observed within each subgroup, being most marked in the TNBC although the most responding tumors, 8% developing clinical-progressive-disease. The study supports association of molecular subtypes with response to chemotherapy in patients with advanced breast cancer and the existence of further heterogeneity within subtypes.