• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2001.09a
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• pp.30-30
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• 2001

Five years old Asian male elephant (Elephas maximus), transported from Malaysia, had showed slight inappetence and mild diarrhea from begining of stay at the zoo, and died after three months clinical therapy. Necropsy of this elephant grossly demonstrated ileocecal intussusception as the cause of the death, coupled with purulent nephritis together and nephrolithiasis, mild liver degeneration, numerous subepiacrdial and subendocardial hemorrhages. Bacteriological culture was conducted from renal pelvis revealing Klebsiella pneumonia infection. Histological findings included diffuse chronic interstitial nephritis with numerous amount of lymphocytes and giant cells. This is a unique combination of pathological findings consisting of intestinal intussusception and purulent pyelonephritis in elephant. This is the first description of intestinal intussusception together with severe nephritis in elephant

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2001.09a
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• pp.27-27
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• 2001

Endocarditis associated with Escherichia coli was diagnosed in a 2-year-old male sea lion (Zalopus californianus). At necropsy, the heart had biventricular dilation with marked attenuation of the apex. Verrucous, grayish-red, vegetative lesions were present in both the aortic and left AV valves. Several discrete hyperemia-rimmed infarcts were noted in the kidneys. (omitted)

• Toxicological Research
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• v.27 no.3
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• pp.149-152
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• 2011

We describe here a multicentric spontaneous malignant schwannoma obtained from one male F344 rat, and this animal was the subject of a carcinogenicity study for which it was treated with diisodecyl phthalate. The animal of the control group not treated with diisodecyl phthalate showed dyspnea and severe lordosis. On the necropsy, two tan, firm, encapsulated masses were observed in the subcutis of the lumbosacral region and the left inguinal region of the abdominal cavity, respectively; the masses were $25{\times}17{\times}8$ mm and $16{\times}14{\times}8$ mm in size, respectively. Histologically, the tumor consisted of spindle and pleomorphic cells that grew in various patterns, that was, sweeping fascicles and herringbone and local organoid patterns. The pleomorphic neoplastic cells had more than two nuclei. Additionally, the diagnosis of malignant schwannoma was confirmed by the immune reactivity of the tumor cells for S-100 protein.

• Biomolecules & Therapeutics
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• v.10 no.2
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• pp.114-116
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• 2002

This study was performed to investigate the acute toxicity of PEG-hemoglobin SB1, a blood substitute, in beagle dogs. The male and female dogs were administered intravenously at the doses of 0.4375, 0.875 and 1.75 g/kg body weight, respectively. After a single intravenous administration of SB1 to dogs, we observed them daily for 2 weeks. SB1 did not induce any toxic signs in the mortalities, clinical signs, body weight changes, and gross necropsy findings of dogs. Based on these results, acute toxicity, dogs SB1 may have no side effect and its $LD_{50}$ value may be over 1.75 g/kg (25 ml/kg) of body weight in dogs.

• Journal of Veterinary Clinics
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• v.18 no.2
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• pp.185-188
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• 2001

A weakened wild feral pig (a boar of about 15 kg) with snout distortion and characteristic external lesion of infectious atrophic rhinitis was captured at farm land near low mountains in Chinju, Kyeongnam province. This pig was necropsied and then the snout parts and the parenchymal organs were removed. The snout and nose were transversely sectioned at thickness of 1.5 cm interval. Grossly, the right side of the snout was shorted than that of left by reduction of right nasal turbinate length, but the nasal opening exudate was not observed. At necropsy, degeneration, adhesion, occlusion, and asymmetry of left and right sides on the meatus and turbinate were observed and findings of mild pneumonia were observed. Microscopically, the leukocyte infiltration, hyperemia and hyperplasia on the mucosa of the turbinates and septum were observed. The atrophied periosteum and osseous tissue were also observed. But Bordetella bronchiseptica was not identified in culture from nasal swabs. We expect the possibility that the snout distortion of this pig was due to infectious atrophic rhinitis according to these findings.

• Journal of Veterinary Clinics
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• v.16 no.2
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• pp.529-532
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• 1999

A five-year-old elk (Cervus canadensis) was presented for necropsy to the Veterinary Teaching Hospital, Chungbuk National University, on May 1999. The farmed elk was died on day 5 after velvet antler removal. By history taking, the elk didn't show any clinical signs except for watery diarrhea during 2 days. For the purpose of physical examination at the velvet antler removal, blood was collected from the femoral vein of elk with a mixture of fentanyl-azaperone-xylazine ($Fentazin-10^{\circledR}$). Urine was collected from the bladder within 3 hours after died. Hemato-logical and clincochemical values of the elk showed normal ranges. In the microscopic finding, many round and ellipse sarcocystis were identified in the cardiac muscle fibers without any surrounding inflammatory reaction.

• Korean Journal of Veterinary Service
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• v.24 no.4
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• pp.375-377
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• 2001

Rectal stricture occurred in 2 finishing pigs submitted for necropsy from Moguchon, the meat processing plant, chonbuk. Grossly, the wall of the rectum was harden and thickened by fibrous tissue. Anteriro to the stricture, the descending colon was dilated up to 30cm in diameter, filled with gas and pasty green fluidal feces. Histologically, the epithelia of rectal mucosa were necrotized. The mucosa and submucosa of rectum were infiltrated by macrophages, eosinophils and lymphocytes. This infiltration was the most extensive in the deeper layer of submucosa and intensive fibrosis was observed in deeper submucosa layer. This case is report for rectal stricture of finishing pig.

• Korean Journal of Veterinary Research
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• v.58 no.2
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• pp.103-106
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• 2018

Three aged dogs, all over 15 years old, with multiple seizure events and various neurologic signs such as head turn and ataxia were brought to the referring hospital. Two cases were tentatively diagnosed with intracranial meningioma based on magnetic resonance imaging, and one case was histopathologically confirmed as meningioma at necropsy. All dogs improved after initiation of pulsed high-dose hydroxyurea (HU) treatment. Clinical sign relapses were managed by repeating high-dose HU without obvious side effects. Pulsed high-dose HU can be applied when clinical signs are refractory to the traditionally recommended dosage for intracranial meningioma in dogs.

• Toxicological Research
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• v.15 no.1
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• pp.9-17
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• 1999

This study was performed to evaluate the subacute toxicity of CJ-50002 (Vibrio Vaccine) in SPF Spraqur-Dawley (SD) rats. Vibrio vaccine was administered orally at a dose level of high (167mg/kg/day), medium (16.7mg/kg/day), and low (16.7mg/kg/day) once a day and repeated fro 4 weeks. Ten males and female rats were assigned to each group. After 4 week administration, no significant dose-dependent changes in body weight, water and food consumption rate or organ weight were noted dependent changes in body weight, water and food consumption rate or organ weight were noted among 4 groups. Urinanalysis, hematology, and serum chemistry, also fail to detect any dose-related change among 4 groups tested. During necropsy and histopathological examination, no specific toxicity related to treated material was found. The result of this study demonstrated that vibrio vaccine when administered orally for 4 weeks at a high dose of 167mg/kg/day, no dose-related toxicity was found in treated make and female rats.

• Proceedings of the Korea Society of Poultry Science Conference
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• 2005.11a
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• pp.80-81
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• 2005

The occurrence of HHS was confirmed for the first time in Korea from chickens submitted for diagnosis to our laboratory from broiler and baeksemi farms. Clinical signs included depression, inappetence, ruffled feathers and a increase in mortality. At necropsy, severe hydropericardium and hepatic necrosis was founded characteristically and the most remarkable microscopic changes were seen in the liver. These included basophilic intranuclear inclusion bodies in the hepatocytes, massive hemorrhages and necrosis in the liver parenchyma. We could also identify fowl adeno-virus(FAV) by polymerase chain reaction(PCR) and electro-microscopic confirmation. Abbreviation: HHS=hydropericardium hepatitis syndrome, EM=electron microscopy, FAV=fowl adenovirus, PCR=polymerase chain reaction.