• Natural Product Sciences
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• 제25권1호
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• pp.16-22
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• 2019

Inula helenium L. is rich source of eudesmane-type sesquiterpene lactones, mainly alantolactone and isoalantolactone, which have the various pharmacological functions. In this study, we examined the inhibitory effects of nitric oxide (NO) production of hexane, methylene chloride, ethyl acetate, butanol, and water fractions from I. helenium and investigated the anti-inflammatory effect of hexane fraction of I. helenium (HFIH) in LPS-induced RAW 264.7 cells. Quantification of alantolactone and isoalantolactone from HFIH was carried out for the standardization by multiple reaction monitoring using triple quadrupole mass spectrometer. HFIH significantly inhibited inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) protein as well as their downstream products NO and prostaglandin $E_2$ ($PGE_2$) in LPS-stimulated RAW 264.7 cells. Moreover, HFIH suppressed $NF-{\kappa}B$ transcriptional activity by decreasing the translocation of p65 to the nucleus. The in vivo study further confirmed that HFIH attenuated the paw edema induced by carrageenan in an acute inflammation model. These findings suggest that HFIH may be useful as a promising phytomedicine for inflammatory-associated diseases.

• 대한방사선기술학회지:방사선기술과학
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• 제30권2호
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• pp.147-151
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• 2007

AAPM TG43 프로토콜에서 선원 강도의 측정은 공기커마강도로 권고하고 있다. 본 연구는 제조사에서 제공되는 공기커마강도의 정확성이 ${\pm}5%$ 범위 이내에 있는지 측정으로 검증하는데 목적이 있다. Standard imaging사의 MAX-4001 Electrometer와 HDR 1000 Plus, 그리고 6 french bronchial Applicator를 재료로 사용하여, 이온함의 중심축의 바닥으로부터 10 mm 지점에서 90 mm 지점까지 이온화 전류를 측정하였다. 측정된 이온화 전류 곡선에서 최대 이온화 전류를 나타내는 거리를 교정의 기준점으로 정하고, 이 이온화 전류 측정치로부터 공기커마강도를 구하였다. 이온화 전류 곡선의 정점인 최대 이온화 전류에 대응하는 거리는 50 mm이었다. 이 거리는 UW-ADCL의 교정 검증서의 선원의 기준점과 완전히 일치하였다. 측정으로 계산된 공기커마강도는 제조사에서 제공된 교정치보다 약 0.5% 더 높게 측정되었다. 제조사에서 제공되는 교정 검증서의 공기커마강도는 신뢰할 수 있는 정확성을 가졌다는 결과를 얻었다. 측정에서 우물형 이온함 안의 dead space의 길이와 선원의 dwell position으로 이동 오차 그리고 산란선의 영향 등을 고려하면, 정확한 측정과 교정의 결과를 얻을 수 있다고 생각된다.

• 대한지리학회지
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• 제45권4호
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• pp.431-443
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• 2010

한반도 남부 13개 선상지를 일본, 대만, 필리핀의 690개 선상지와 비교, 분석하였다. 선상지 경사와 함양역 면적, 선상지 경사와 함양역 기복비, 선상지 면적과 함양역 면적, 그리고 함양역 면적과 함양역 기복비와의 관계를 정량적으로 검토한 결과, 한반도 남부의 선상지는 아시아의 선상지 특성과 잘 부합되지만, 선상지 빈도와 밀도가 낮다. 또한 선상지 하천의 함양역 규모가 작고, 기복비가 커서 선상지 규모가 작고 경사가 급하다. 36개 주요 하천 곡구부에서 선상지가 형성되지 않는 것은 상대적으로 낮은 산지고도와 함양역의 기복비 때문이다. 한국의 선상지에서는 Blair and McPherson이 주장한 지형면 경사의 공백을 확인할 수 없으며, 경주 선상지는 경사가 완만한 하성 선상지의 가능성이 높다.

• 생약학회지
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• 제47권1호
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• pp.1-6
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• 2016

Phytochemical investigation of the twigs of Corylopsis coreana afforded 10 phenolic compounds, bergenin (1), 6'-O-galloylbergenin (2), 3'-O-galloylbergenin (3), (-)-catechin (4), (-)-epicatechin (5), (-)-epicatechin-3-O-galloyl ester (6), 4-methoxy-3,-5-dihydroxybenzoic acid (7), gallic acid (8), 2,4,6-trimethoxyphenol-1-O-${\beta}-\small{D}$-glucopyranoside (9), and 2,4,6-trimethoxyphenol-1-O-${\beta}-\small{D}$-(6-O-galloyl)-glucopyranoside (10). Their structures were characterized by spectroscopic data and identified by comparing these data with those in the literatures. The compounds 3, 9 and 10 were isolated for the first time from this source. All the isolates (1-10) were tested for their cytotoxic activity against A549, SK-OV-3, SK-MEL-2, and HCT15 cell lines in vitro using the SRB bioassay. The compounds 5, 7 and 8 exhibited selective cytotoxic activity against SK-MEL-2 cell line.

• 한국조경학회지
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• 제24권2호
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• pp.25-42
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• 1996

During the last two and a half decades, philosophical interest in the aesthetics of nature and environment has been gained momentum. One of the most coherent theories in this arena of debate has been developed over a series of articles by Allen Carlson. The purpose of this paper is to examine Carlson's theory critically and suggest an alternative aspect that remains untouched by his model. Briefly stated, Carlson's view of the appreciation of nature is that it is a matter of under standing nature under suitable scientific categories. His argument, based on the objectivist epistemology, is basically a disjunctive syllogism : a) The concept of appreciation, derived from traditional disinterestedness and Stolnitz's aesthetic attitude, provides an insight into the explanation of aesthetic appreciation of nature, and is objectivistic in the light of its object-oriented character. b) Nature must be appreciated as nature itself, and the natural environmental model is the appropriate loci of our nature appreciation. c) The paradigmatic form of our nature appreciation is order appreciation. d) There can be a correct and objective aesthetic judgment of nature, and the sources of guiding categories pertinent to it is natural science and natural history. In regarding nature as an environment and as natural, his natural environmental model is meaningful. Nevertheless, his stance results in some serious problems : a) The natural environmental model excludes certain very common appreciative responses to nature-responses of a less intellective, more visceral sort. Therefore, the arousal model with appropriate emotions might be one of our characteristic forms of nature appreciation. b) Even if we consider the scientific knowledge as an objective source of our nature appreciation, this gives rise to the question of whether the natural science can be objective or not. Is there an objectivist aesthetic appreciation of nature\ Does aesthetic appreciation of nature need to be science-based\

• Journal of Plant Biotechnology
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• 제50권
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• pp.115-126
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• 2023

A hydroponics experiment was performed to study the physiological and biochemical changes in Moroccan barley (Hordeum vulgare L.) varieties cultivated under salt stress conditions. Four barley varieties were grown under exposure to three salt concentrations, including 0, 200, and 300 mM NaCl. The ANOVA for both salt stress-sensitive and resistant varieties indicated that salt treatment represented the main source of variability in all studied traits. Salt treatment significantly reduced root and shoot dry weight (RDW and SDW), relative water content (RWC), and chlorophyll content (Chl a, Chl b, and Chl T). However, increases in electrolyte leakage (EL) along with proline and total soluble sugar (TSS) contents were recorded. In addition, large variations in all measured traits were found between varieties. The 'Massine' and 'Laanaceur' varieties displayed relatively higher RDW and SDW values. The 'Amira' and 'Adrar' varieties showed lower RWC values and Chl contents than those of the controls indicating their relative sensitivity to salt stress. Principal component analysis revealed that most of the variation was captured by PC1 (72% of the total variance) which grouped samples into three categories according to salt treatment. Correlation analyses highlighted significant associations between most parameters. Positive relationships were found between RDW, SDW, RWC, Chl content, and soluble proteins contents, while all of these parameters were negatively associated with EL intensity, proline content, and TSS content. The results from this study showed that the 'Massine' and 'Laanaceur' varieties were relatively salt-tolerant. These two salt-tolerant varieties present a good genetic background for breeding of barley varieties showing high salt tolerance.

• 한국수자원학회논문집
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• 제40권5호
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• pp.373-382
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• 2007

수로가 시작되는 지점의 정확한 위치를 찾는 것은 구릉지 사면상의 물의 동적거동으로 인하여 매우 어렵다. 이러한 목적을 위하여, 김주철과 김재한(2007)은 DEM을 이용한 경사와 면적 사이의 규모에 따른 거동특성에 따라 실제 유역내 수로망을 제시한 바 있다. 본 연구는 이들의 연구 성과의 연장으로서, 배수밀도와 수원유역의 기하학적 특성을 기반으로 하여 DEM으로부터 동정된 가설수로망의 신뢰성을 평가하여 보았다. 그 결과 경사-면적한계기준에 의한 가설수로망이 자연유역의 배수구조를 매우 잘 묘사하고 있음을 확인할 수 있었다. 또한 지형학적 동질성을 가진 지역내 수원유역의 형상들 사이에는 훌륭한 기하학적 상사성이 존재함을 추론할 수 있었다. 면적한계기준은 수원유역의 형상을 구속하여 왜곡된 배수구조를 야기할 수도 있었다. 그럼에도 불구하고 DEM으로부터 동정된 가설수로망들이 공간 채움 구조를 잘 표현하고 있는 점이 특히 주목된다.

• 한국태양에너지학회 논문집
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• 제27권4호
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• pp.175-182
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• 2007

Geothermal-energy has been getting popular as a natural energy source for green buildings these days. As a result Geothermal Source Heat Pump System (GSHPs) was being recognized effective alternative systems to conventional heating and cooling systems owing to their higher energy utilization efficiency. But GSHPs has not been popularized thereby the large amount of initial cost of the system and insufficiency of studies for economic estimation. Therefore GSHPs are being developed to make up for the weak points that are the large amount of initial cost of the system and much annual electricity consumption. In this paper, economic estimation was conducted by payback period method and it shows that the pay back period of Heat Storage Type GSHPs was calculated 6.8 years compared with the absorption Chiller-Heater system and 8.2 years compared with the Ice storage-Boiler system. Heat Storage Type GSHPs also has the lower annual source energy consumption than the conventional heating and cooling systems because of using nighttime electricity.

• Journal of Microbiology
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• 제44권6호
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• pp.583-590
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• 2006

In this study, an organic solvent tolerant bacterial strain was isolated. This strain was identified as Pseudomonas sp. strain S5, and was shown to degrade BTEX (Benzene, Toluene, Ethyl-Benzene, and Xylene). Strain S5 generates an organic solvent-tolerant lipase in the late logarithmic phase of growth. Maximum lipase production was exhibited when peptone was utilized as the sole nitrogen source. Addition of any of the selected carbon sources to the medium resulted in a significant reduction of enzyme production. Lower lipase generation was noted when an inorganic nitrogen source was used as the sole nitrogen source. This bacterium hydrolyzed all tested triglycerides and the highest levels of pro-duction were observed when olive oil was used as a natural triglyceride. Basal medium containing Tween 60 enhanced lipase production to the most significant degree. The absence of magnesium ions ($Mg^{2+}$) in the basal medium was also shown to stimulate lipase production. Meanwhile, an alkaline earth metal ion, $Na^+$, was found to stimulate the production of S5 lipase.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2000년도 춘계 학술발표회 논문집 Proceedings of EESK Conference-Spring
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• pp.63-69
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• 2000

Korea Institute of Geology Mining and Materials(KIGAM) cooperating with Southern Methodist University(SMU) has been operating seismo-acoustic array in Chul-Won area to discriminate man-made explosions from natural earthquakes since at the end of July 1999. In order to characterize propagation parameters of detected seismo-acoustic signal and to associate these signals as a blast event accompanying seismic and acoustic signals simultaneously it is necessary to understand infrasound wave propagation in the atmosphere. Two comparable Effective Sound Velocity Structures(ESVS) in atmosphere were constructed by using empirical model (MSISE90 and HWM93) and by aerological observation data of Korea Meteorological Administration (KMA) at O-San area. Infrasound propagation path computed by empirical model resulted in rare arival of refracted waves on ground less than 200km from source region. On the other hand Propagation paths by KMA more realistic data had various arrivals at near source region and well agreement with analyzed seismo-acoustic signals from Chul-Won data. And infrasound propagation in specific direction was very influenced by horizontal wind component in that direction. Linear travel time curve drawn up by 9 days data of the KMA in autumn season showed 335.6m/s apparent sound velocity in near source region. The propagation characteristics will be used to associate seismo-acoustic signals and to calculate propagation parameters of infrasound wave front.