• Analytical Science and Technology
• /
• v.36 no.1
• /
• pp.22-31
• /
• 2023

As the use of e-liquid cigarettes is rapidly increasing worldwide, it multiplies the potential risk undisclosed to the health of non- and smokers. To reduce the hazard, each country has its own set of regulations for controlling e-liquids. In Korea, the narrow definition of tobacco makes it difficult and have been steadily occurring tax evasion exploiting the difference in natural and artificial nicotine. Therefore, it is very important to distinguish source of nicotine for their regulation. To find biochemical discriminant markers, this study established analysis methods based on high-performance liquid chromatography coupled with diode array detector (HPLC-DAD) and high-performance liquid chromatography coupled with triple Quadrupole mass spectrometry (HPLC-MS/MS) for nicotine enantiomers and tobacco alkaloids targeted using the difference in pathways of nicotine biosynthesis and chemical synthesis. The method was validated by experimenting linearity (R² > 0.999), recovery (80.99-108.41 %), accuracy (94.11-109.73 %) and precision (0.04-8.27 %). Then, the results for discrimination of the nicotine obtained from analysis of 65 commercial e-liquid products available in Korean market was evaluated. The method successfully applied to the e-liquids and one sample labelled 'synthetic nicotine' for tax exemption was found to contain a natural nicotine product. This method can be used to determine whether an e-liquid product uses natural or artificial nicotine and monitor non-taxable e-liquid products. The method is more scientific than the existing one, which relies only on field evidence.

• Genomics & Informatics
• /
• v.12 no.2
• /
• pp.64-70
• /
• 2014

Human papillomavirus (HPV) infection is the leading cause of cancer mortality among women worldwide. The life-threatening infection caused by HPV demands the need for designing anticancerous drugs. In the recent years, different compounds from natural origins, such as carrageenan, curcumin, epigallocatechin gallate, indole-3-carbinol, jaceosidin, and withaferin, have been used as a hopeful source of anticancer therapy. These compounds have been shown to suppress HPV infection by different researchers. In the present study, we explored these natural inhibitors against E6 oncoprotein of high-risk HPV-16, which is known to inactivate the p53 tumor suppressor protein. A robust homology model of HPV-16 E6 was built to anticipate the interaction mechanism of E6 oncoprotein with natural inhibitory molecules using a structure-based drug designing approach. Docking analysis showed the interaction of these natural compounds with the p53-binding site of E6 protein residues 113-122 (CQKPLCPEEK) and helped the restoration of p53 functioning. Docking analysis, besides helping in silico validation of natural compounds, also helps understand molecular mechanisms of protein-ligand interactions.

• Korean Journal of Human Ecology
• /
• v.18 no.4
• /
• pp.913-922
• /
• 2009

The purpose of this study was to investigate and offer useful information on natural dyeing underwear industry through an analysis of 20's purchasing behavior and design preference between male and female. From 600 questionnaires that were distributed, 512 with usable data were coded for further statistical analysis including descriptive statistics(frequency and chi-square test), by using SPSS 12.0 and the major results were as follows. Given that a large number of 20's purchase men's underwear by their parents, and women's of their own. It was found that the underwear for men in their 20's should be developed in an attempt to place greater emphasis on improving functions as an outerwear. It is important to strengthen the design and marketing strategy specially tailored to 20's of natural dyeing underwear products.

• Industrial Engineering and Management Systems
• /
• v.14 no.2
• /
• pp.129-158
• /
• 2015

It is necessary for retailers to determine the optimal ordering policy of products considering supply disruptions due to a natural disaster and a production process failure as quality and machine breakdowns. Under the situation, a dualsourcing supply chain (DSSC) is one of effective SC for retailers to order products reliably. This paper proposes the optimal ordering policy of a product in a DSSC with a retailer and two manufacturers. Two manufacturers may face supply disruptions due to a natural disater and a production process failure after they received the retailer's order of products. Here, two scenarios of demand information of products are assumed: (i) the demand distribution is known (ii) mean and variance of the demand are known. Under above situations, two types of DSSC are discussed. Under a decentralized DSSC (DSC), a retailer determines the optimal ordering policy to maximize his/her total expected profit. Under the integrated DSSC (ISC), the optimal ordering policy is determined to maximize the whole system's total expected profit. Numerical analysis investigates how demand information and supply disruptions affect the optimal decisions under DSC and ISC. Besides, profitability of supply chain coordination adjusting the wholesale price is evaluated to encourage the optimal decision under ISC.

• Fashion & Textile Research Journal
• /
• v.14 no.3
• /
• pp.430-437
• /
• 2012

This study analyzed the sensibility of eco-friendly fabrics for college students and investigated their attitude on environmental problems, trust reliability onto eco-apparel products, and their purchase state. We tested 6 eco-friendly fabrics (recycled polyester, organic cotton, green tea, charcoal, bamboo, and nettle) through a survey using the Likert scale of 12 polar sensibility words. Most fabrics showed feelings that were smooth, natural, female, and country these were followed by fashion, cheap, functional, sustainable, warm, and vintage. In addition, nettle fabric showed 'rough' feeling, and recycled polyester fabric showed an 'artificial' feeling. Correspondence analysis showed the distance and direction between fabric types and sensibility words with a 2D diagram where the X axis was named with 'Soft <-> Hard' and Y axis was with 'Environmental <-> Manmade' to represent the relationship between fabric types and the sensibility words. According to the results of the multiple regression analysis, the cognition level of the consumer for environmental problems was found to be the most influential variable on the loyalty purchase of eco-friendly products; however, the trust reliability level of consumer onto eco-friendly apparel products was found to be the most influential variable on the conditional purchase of eco-friendly apparel products.

• Natural Product Sciences
• /
• v.17 no.3
• /
• pp.250-255
• /
• 2011

The immune system is finely balanced by the activities of pro-inflammatory and anti-inflammatory mediators or cytokines. Unregulated activities of these mediators can lead to the development of various inflammatory diseases. A variety of safe and effective anti-inflammatory agents are available with many more drugs under development. Of the natural compounds, the sesquiterpenes (nootkatone, ${\alpha}$-cyperone, valencene and ${\alpha}$-selinene) isolated from C. rotundus L. have received much attention because of their potential antiinflammatory effects. However, limited studies have been reported regarding the influence of sesquiterpene structure on anti-inflammatory activity. In the present study, the anti-inflammatory potential of four structurally divergent sesquiterpenes was evaluated in lipopolysaccaride (LPS)-stimulated RAW 264.7 cells, murine macrophages. Among the four sesquiterpenes, ${\alpha}$-cyperone and nootkatone, showed stronger anti-inflammatory and a potent NF-${\kappa}B$ inhibitory effect on LPS-stimulated RAW 264.7 cells. Molecular analysis revealed that various inflammatory enzymes (iNOS and COX-2) were reduced significantly and this correlated with downregulation of the NF-${\kappa}B$ signaling pathway. Additionally, electrophoretic mobility shift assays (EMSA) elucidated that nootkatone and ${\alpha}$-cyperone dramatically suppressed LPS-induced NF-${\kappa}B$-DNA binding activity using 32Plabeled NF-${\kappa}B$ probe. Hence, our data suggest that ${\alpha}$-cyperone and nootkatone are potential therapeutic agents for inflammatory diseases.

• Journal of the Korean Recycled Construction Resources Institute
• /
• v.2 no.2
• /
• pp.158-165
• /
• 2014

The enormous quantity of 'Bayer-Process by-products' (BP by-products) discharged by industries producing alumina from bauxite represents an environmental and economical problem. As it is mainly composed of $Fe_2O_3$, $Al_2O_3$, $SiO_2$, CaO and $Na_2O$, it is thought that using BP by-products as a construction material is an effective way to consume such a large quantity of alkaline waste. In this study, This study evaluates the effect of alkali-activated binder based on recycling BP by-products on soil improvement through the evaluation of slope stability and seepage flow numerical analysis. The results of analysis of ground slope safety at dry season and wet season meet standard (Ministry of Land, Infrastructure and Transport, 2006) Especially, when wet season, the ground used soil improving material meet standard, while the ground used soil-nailing method doesn't. Also, permeability coefficient of improved soil is smaller than that of natural soil and saturation depth of reinforced ground surface with improve soil is lower than that of natural soil.

• Korean Institute of Interior Design Journal
• /
• v.15 no.5 s.58
• /
• pp.298-305
• /
• 2006

The purpose of this study is to figure out the profiles of eco-friendly finishing materials and intoner products through content analysis on the advertisements of three domestic interior design magazines, which have been published for 4 years since 2002. The amount of advertisements has been continuously increasing due to the public concerns on well-being. Finishing material types absolutely took the greatest proportion (92.8%), while products such as furniture and household equipments were only 7.2% among the advertisements. Charcoal, natural jade, yellow soil and nano-silver were the frequently mentioned health-related components in the finishing material. Only 35.7% of the finishing materials hold certification on indoor air quality. Among the interior products, phytonchid in air cleaner was the only advertised component related to health. In conclusion, controlling pollutants of indoor air quality, such as HCHO, VOC, seems to be the big issue in both materials and products due to the concern of Sick Building Syndrome. However, more scientific and objective guidelines are necessary for consumers to live in healthy interior environment.

• Archives of design research
• /
• v.15 no.1
• /
• pp.299-308
• /
• 2002

Along with the increasing social concern on cultural products and corresponding policy development by government many domestic regions have been trying to establish their own cultural identity. Based on the case stuffy for Gwang-Ju, this paper provides a methodology of developing cultural products from the unique regional resource. Its scope was classified into three categories: alread-developed, regional character and regional theme products. For this purpose, marketing strategies were established for quality improvement and promotion of cultural products through analysis on the current products including a questionnaire to customers. Then, conceptual designs for each scope were developed through the five steps of "selection of items", "target customer analysis", "concept establishment", "extraction of cultural factos7" and "derivation of conceptual design". The concept establishment was based on the expression of the material characteristics, the harmony of tradition and modernity, symbolization of images and so on. The cultural factors taken into account included the natural resources, historical heritages and landmarks. Finally, several examines of the conceptual designs were illustrated for commercial products. This study could be extended further in the future by introducing potential immaterial resources into the cultural factors.

• Journal of People, Plants, and Environment
• /
• v.22 no.5
• /
• pp.455-466
• /
• 2019

This study was carried out to analyze trends in floral products and services through the big data analysis of various social networking services (SNSs) and then to provide objective marketing directions for the floricultural industry. To analyze the big data of SNSs, we used four analytical methods: Cotton Trend (Social Matrix), Naver Big Data Lab, Instagram Big Data Analysis, and YouTube Big Data Analysis. The results of the big data analysis showed that SNS users paid positive attention to flower one-day classes that can satisfy their needs for direct experiences. Consumers of floral products and services had their favorite designs in mind and purchased floral products very actively. The demand for flower items such as bouquets, wreaths, flower baskets, large bouquets, orchids, flower boxes, wedding bouquets, and potted plants was very high, and cut flowers such as roses, tulips, and freesia were most popular as of June 1, 2019. By gender of consumers, females (68%) purchased more flower products through SNSs than males (32%). Consumers preferred mobile devices (90%) for online access compared to personal computers (PCs; 10%) and frequently searched flower-related words from February to May for the past three years from 2016 to 2018. In the aspect of design, they preferred natural style to formal style. In conclusion, future marketing activities in the floricultural industry need to be focused on social networks based on the results of big data analysis of popular SNSs. Florists need to provide consumers with the floricultural products and services that meet the trends and to blend them with their own sensitivity. It is also needed to select SNS media suitable for each gender and age group and to apply effective marketing methods to each target.