• Title/Summary/Keyword: Natural product

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Steroidal saponins from Dioscorea nipponica Rhizomes and Their Biological Activity (부채마의 스테로이드 사포닌 및 생리활성)

  • Park, Kyoung Jin;Suh, Won Se;Cha, Joon Min;Park, Jong Eel;Woo, Kyeong Wan;Kim, Sun Yeo;Lee, Kang Ro
    • Korean Journal of Pharmacognosy
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    • v.48 no.4
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    • pp.261-267
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    • 2017
  • As part of the search for bioactive constituents of Korean medicinal plants, twelve steroids (1-12) were isolated from the rhizomes of Dioscorea nipponica. The isolated compounds were identified as diosgenin ($3{\beta}$, 25R)-spirost-5-en-3-ol (1), 25(R)-dracaenoside E (2), dioscin (3), gracillin (4), prosapogenin B (5), 25(R)-dracaenoside G (6), diosgenin 3-O-${\beta}$-D-glucopyranosyl($1{\rightarrow}3$)-${\beta}$-D-glucopyranoside (7), ophipogonin C′ (8), 7-oxodioscin (9), protodioscin (10), hypoglaucin F (11), and protoneogracillin (12). Their structures were characterized by spectroscopic data and identified by comparing these data with those in the literatures. All the isolates (1-12) were evaluated for their neuroprotective effects through induction of nerve growth factor in C6 glioma cells and effects on nitric oxide (NO) production in murine microglia cell line BV-2. Compounds 7 and 12 were found to induce upregulation of NGF secretion without causing significant cell toxicity and compound 4 exhibited potent anti-neuroinflammatory activity.

Antitumor effect of Careya arborea against Ehrlich ascites carcinoma with reference to lipid peroxidation and enzymatic and non enzymatic antioxidant system in Swiss albino mice

  • Kumar, R Sambath;Sivakumar, T;Senthil, V;Murthy, N Venkateswara;Balasubramaniam, V;Sabi, R Kanaga;Sundram, R. Shanmuga;Perumal, P;Mazumder, U K;Gupta, M
    • Advances in Traditional Medicine
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    • v.8 no.2
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    • pp.154-163
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    • 2008
  • The methanol extract of stem barks of Careya arborea Roxb. (MECA) (Family- Myrtaceae) was evaluated for antitumor activity and antioxidant status against Ehrlich's Ascites Carcinoma (EAC) bearing Swiss albino mice. After 24 h of tumor inoculation the MECA was administered at the doses of 50, 100 and 200 mg/kg body weight/mice/day for 14 days. After the last dose and 18 h fasting mice were sacrificed. The effect of MECA on the growth of transplantable murine tumor, life span of EAC bearing hosts, hematological profiles, serum and liver biochemical parameters were estimated. The MECA showed significant (P < 0.01) decrease in ascites volume, packed cell volume and viable cell count and prolonged the life span of EAC tumor bearing mice. Hematological profiles reverted to more or less normal levels in extract treated mice. The MECA also produced protective effect by decreasing the activity of serum enzymes, bilirubin and increase the protein and uric acid levels. MECA significantly (P < 0.05) decreased the levels of lipid peroxidation, while significantly (P < 0.05) increased the levels of glutathione content, vitamin C, vitamin E, superoxide dismutase and catalase CAT. The results indicate that MECA exhibited significant antitumor and antioxidant activity in EAC bearing mice.

A Study on the product development of natural body foam which added the palm oil (팜유를 첨가한 천연 바디 폼의 제품개발에 관한 연구)

  • Sung, Ki-Chun;Kim, Ki-Jun
    • Journal of the Korean Applied Science and Technology
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    • v.15 no.4
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    • pp.27-34
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    • 1998
  • The natural body foam product which palm oil is added to this product, differs from products for clothes and Kitchen detergent, industrial and domestic detergent, and It has a various characteristics as a soft detergent for bath and hair product. Up to now, vidal sassoon product which imports form overseas and sells in our country, increases every year in consumption quantity. The development of this product tested to consider the quality of product in the effect of import transfer. First of all, the experiment of this product tested the fundamental items of pH, foam formation force, the moisture effect of product, the biodegradation degree of product. In case of palm oil, when it was added to this product in 0.25wt%, we could get experiment results that pH appeared in 6.2, foam formation force in product 1wt% solution appeared in 104ml per 30sec, the skin moisture effect of product appeared in incleasing from 82 a.u to 90 a.u within one hour since we have used the product, the biodegradation degree of surfactant appeared in 96.7%. According to the experiment result of product, we could know the fact that it has a high quality in comparison with other products.

Phenolic Compounds from the Leaves of Stewartia pseudocamellia Maxim. and their Whitening Activities

  • Roh, Hyun Jung;Noh, Hye-Ji;Na, Chun Su;Kim, Chung Sub;Kim, Ki Hyun;Hong, Cheol Yi;Lee, Kang Ro
    • Biomolecules & Therapeutics
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    • v.23 no.3
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    • pp.283-289
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    • 2015
  • The half-dried leaves of Stewartia. pseudocamellia were extracted with hot water (SPE) and partitioned with n-hexane (SPEH), dichloromethane (SPED), and ethyl acetate (SPEE) successively. SPE and SPEE showed significant inhibitory effects against melanogenesis and tyrosinase activities. By bioassay-guided isolation, ten phenolic compounds were isolated by column chromatography from SPEE. The whitening effect of the isolated compounds from SPEE were tested for the inhibitory activities against melanogenesis using B16 melanoma cells, in vitro inhibition of tyrosinase, and L-3,4-dihydorxy-indole-2-carboxylic acid (L-DOPA) auto-oxidation assay. A cytotoxic activity assay was done to examine the cellular toxicity in Raw 264.7 macrophage cells. Of the compounds isolated, gallic acid and quercetin revealed significant inhibitory activities against melanogenesis compared to arbutin. In particular, quercetin exhibited similar inhibitory activities against tyrosinase and L-DOPA oxidation without cytotoxicity. These results suggested that SPE could be used as a potential source of natural skin-whitening material in cosmetics as well as in food products.

Light Resistance of Natural Dye-colored Veneer and Clear Coated Cylindrical Laminated Veneer Lumber (천연염색 단판 및 투명 도장처리 원통형 단판적층재의 내변퇴색성)

  • Kim, Jong-In;Suh, Jin-Suk;Hwang, Sung-Wook;Park, Ryeong-Jae;Park, Sang-Bum
    • Journal of the Korea Furniture Society
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    • v.23 no.4
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    • pp.407-414
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    • 2012
  • In order to develop the end use of cylindrical laminated veneer lumber (LVL) such as wooden crafts, the light resistance properties of natural dye-colored and finished cylindrical LVL was investigated. The study results were as follows; The cross section of LVL showed the higher light resistance than its tangential section, and the light resistance also increased with surface coated. On the other hand, LVL specimen were colored by 9 natural dyes of amur cork-tree etc., and the natural and apparent hue harmonized with wood was found after coating and light resistance test. Particularly, The dyes extracted from amur cork-tree, persimon and sappan wood showed orange color, reddish brown and red color respectively, giving an accenting effect to original wood color.

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SOME REDUCED FREE PRODUCTS OF ABELIAN C*

  • Heo, Jae-Seong;Kim, Jeong-Hee
    • Bulletin of the Korean Mathematical Society
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    • v.47 no.5
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    • pp.997-1000
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    • 2010
  • We prove that the reduced free product of $k\;{\times}\;k$ matrix algebras over abelian $C^*$-algebras is not the minimal tensor product of reduced free products of $k\;{\times}\;k$ matrix algebras over abelian $C^*$-algebras. It is shown that the reduced group $C^*$-algebra associated with a group having the property T of Kazhdan is not isomorphic to a reduced free product of abelian $C^*$-algebras or the minimal tensor product of such reduced free products. The infinite tensor product of reduced free products of abelian $C^*$-algebras is not isomorphic to the tensor product of a nuclear $C^*$-algebra and a reduced free product of abelian $C^*$-algebra. We discuss the freeness of free product $II_1$-factors and solidity of free product $II_1$-factors weaker than that of Ozawa. We show that the freeness in a free product is related to the existence of Cartan subalgebras in free product $II_1$-factors. Finally, we give a free product factor which is not solid in the weak sense.

Development of Economic Prediction Model for Internal Combustion Engine by Dual Fuel Generation (내연기관엔진의 가스혼소발전 경제성 예측모델 개발)

  • HUR, KWANG-BEOM;JANG, HYUCK-JUN;LEE, HYEONG-WON
    • Transactions of the Korean hydrogen and new energy society
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    • v.31 no.4
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    • pp.380-386
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    • 2020
  • This paper represents an analysis of the economic impact of firing natural gas/diesel and natural gas/by-product oil mixtures in diesel engine power plants. The objects of analysis is a power plant with electricity generation capacity (300 kW). Using performance data of original diesel engines, the fuel consumption characteristics of the duel fuel engines were simulated. Then, economic assessment was carried out using the performance data and the net present value method. A special focus was given to the evaluation of fuel cost saving when firing natural gas/diesel and natural gas/by-product oil mixtures instead of the pure diesel firing case. Analyses were performed by assuming fuel price changes in the market as well as by using current prices. The analysis results showed that co-firing of natural gas/diesel and natural gas/by-product oil would provide considerable fuel cost saving, leading to meaningful economic benefits.

Antioxidant potentials of Hypericum hookerianum (Family: Hypericaceae) on CCl4 induced hepatotoxicity in rats

  • Wahile, Atul;Mukherjee, Kakali;Kumar, Venkatesan;Saha, Bishnu Pada;Mukherjee, Pulok K
    • Advances in Traditional Medicine
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    • v.7 no.1
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    • pp.85-93
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    • 2007
  • Free radicals are known to play important role in pathophysiology of hepatic disorders and antioxidants are employed along with other chemotherapeutic agents in treatment of such diseases. In search of natural antioxidant, successive extracts of Hypericum (H.) hookerianum (Family: Hypericaceae) were evaluated by in vitro and in vivo methods. Extracts of aerial parts of H. hookerianum were subjected for 1,1-diphenyl 2-picryl hydrazyl radical scavenging activity (DPPH assay), nitric oxide radicals scavenging assay and thiobarbituric acid reactive substances (TBARS) assay. Methanolic extract was found to be more active than other extracts in DPPH and in vitro TBARS assay with $IC_{50}$ at 5.82 ${\pm}$ 1.33 ${\mu}g/ml$ and 49.78 ${\pm}$ 3.79 ${\mu}g/ml$ respectively. While petroleum ether extract showed more potentials in scavenging the nitric oxide radicals with $IC_{50}$ 220.97 ${\pm}$ 2.69 ${\mu}g/ml$. The administration of $CCl_{4}$ to the control animals caused decrease in the level of catalase and superoxide dismutase, together with significant increase in the level of TBARS in liver and kidney. Reversal of these changes towards normal group was observed by administration of H. hookerianum methanolic extract at 50 and 100 mg/kg body weight, while other extracts were found to be less active.

The Impact of Product Review Usefulness on the Digital Market Consumers Distribution

  • Seung-Yong LEE;Seung-wha (Andy) CHUNG;Sun-Ju PARK
    • Journal of Distribution Science
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    • v.22 no.3
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    • pp.113-124
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    • 2024
  • Purpose: This study is a quantitative study and analyzes the effect of evaluating the extreme and usefulness of product reviews on sales performance by using text mining techniques based on product review big data. We investigate whether the perceived helpfulness of product reviews serves as a mediating factor in the impact of product review extremity on sales performance. Research design, data and methodology: The analysis emphasizes customer interaction factors associated with both product review helpfulness and sales performance. Out of the 8.26 million Amazon product reviews in the book category collected by He & McAuley (2016), text mining using natural language processing methodology was performed on 300,000 product reviews, and the hypothesis was verified through hierarchical regression analysis. Results: The extremity of product reviews exhibited a negative impact on the evaluation of helpfulness. And the helpfulness played a mediating role between the extremity of product reviews and sales performance. Conclusion: Increased inclusion of extreme content in the product review's text correlates with a diminished evaluation of helpfulness. The evaluation of helpfulness exerts a negative mediating effect on sales performance. This study offers empirical insights for digital market distributors and sellers, contributing to the research field related to product reviews based on review ratings.