• Title/Summary/Keyword: Natural product

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Molecular Mechanism of Inflammatory Signaling and Predominant Role of Saposhnikovia divaricata as Anti-inflammatory Potential

  • Khan, Salman;Kim, Yeong Shik
    • Natural Product Sciences
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    • v.19 no.2
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    • pp.120-126
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    • 2013
  • Natural products have always been a pivotal source of new drug development. Dry roots of Saposhnikovia divaricata (Turcz.) Schischk. (Umbelliferae) is a perennial herb and is also known as Bang Pung in traditional medicine. Numerous in vitro and in vivo studies have revealed the diverse pharmacological effects of S. divaricata and its role in the treatment of various diseases. This herb has exhibited significant inhibitory effects against inflammation and associated disorders. The present study explored the ethnopharmacological applications and molecular mechanisms behind the anti-inflammatory effects of S. divaricata herb and a single compound blockade of multi-signaling inflammatory cascades. Taken together, this review provides insight into the potential role of S. divaricata against various inflammatory diseases.

Effect of Chlorella vulgaris on gut microbiota through a simulated in vitro digestion process

  • Jin, Jong Beom;Cha, Jin Wook;Shin, Il-Shik;Jeon, Jin Young;An, Hye Suck;Cha, Kwang Hyun;Pan, Cheol-Ho
    • Journal of Applied Biological Chemistry
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    • v.64 no.1
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    • pp.49-55
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    • 2021
  • The diet plays a fundamental role in the formation of the gut microbiota, determining the interrelationship between the gut microbiota and the host. The current study investigated the effect of Chlorella vulgaris on the gut microbiota by using simulated in vitro digestion and colonic fermentation. Bioaccessibility was measured after in vitro digestion, and SCFAs and microbial profiling were analyzed after colonic fermentation. The bioaccessibility of C. vulgaris was 0.24 g/g. The three major SCFAs (acetate, propionate, and butyrate) increased significantly when compared to the control group. In microbial profiling analysis, microorganisms such as Faecalibacterium, Dialister, Megasphaera, Dorea, Odoribacter, Roseburia, Bifidobacterium, Butyricmonas, and Veillonella were high in C. vulgaris group. Among them, Faecalibacterium, Dialister, Megasphaera, Roseburia, and Veillonella were thought to be closely associated with the increased level of SCFAs. Finally, it can be expected to help improve gut microbiota and health through ingestion of C. vulgaris. However, further studies are vital to confirm the changes in the gut microbiota in in vivo, when C. vulgaris is ingested.

Chemical Constituents Isolated from the Moss-derived Fungus Talaromyces sp.

  • Hwang, Hoseong;Kwon, Hak Cheol;Kwon, Jaeyoung
    • Journal of the Korean Magnetic Resonance Society
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    • v.24 no.4
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    • pp.123-128
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    • 2020
  • All plants in natural ecosystems are living in symbiosis with endophytes. Recently, there has been an increasing interest in endophytes since these organisms can interact with the hosts and produce various structurally or biologically interesting molecules. This study aimed to identify these molecules from endophytes. Chemical investigation of Climacium dendroides-derived fungus Talaromyces sp. resulted in the isolation of two diphenyl ether derivatives, purpactin A (1) and penicillide (2), and two steroids, dankasterone A (3) and calvasterol B (4). The structures of the compounds were identified via extensive spectroscopic and spectrometric methods. Four compounds did not show any antioxidative activities in the on-line antioxidant activity screening system.

Natural Product Extracts for Depression: Analysis of Patent Status in South Korea (우울증에 대한 천연물 추출물 국내 특허 동향 분석)

  • Ga-Young Jung;Celine Jang;Sang-Ho Kim
    • Journal of Oriental Neuropsychiatry
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    • v.34 no.3
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    • pp.247-257
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    • 2023
  • Objectives: To analyze the trend of Korean patents of natural product extracts for depression. This study also aimed to enhance the development and application of natural product extracts for depression in Korean herbal medicine. Methods: We searched the Korea Intellectual Property Rights Information Service and Science ON to collect Korean patent data of natural product extracts for depression. Two authors independently screened and assessed full texts of screened patents for eligibility. Included patents were analyzed both quantitatively and qualitatively. Results: A total of 62 patents from 2002 to December 2021 were included for analysis. The number of patents has constantly increased since 2002. Glycyrrhiza uralensis Fischer, Perilla frutescens Britton var. acuta Kudo, Zizyphus jujuba Miller var. inermis Rehder were frequently used among 62 patents. Alcohol extraction was mostly used, followed by water extraction and ethyl extraction regarding extract methods. Eight patents were herbal medicine used for treating depression in Korean Medicine. Conclusions: Various Korean herbal medicine and minerals were used as natural-products for treating depression. These results provide fundamental data that can be used for inventing new patents using Korean herbal medicine, developing new natural product extracts for depression, and extending the range of application of these products in clinical setting.

SOME EINSTEIN PRODUCT MANIFOLDS

  • Park, Joon-Sik;Moon, Kyung-Suk
    • East Asian mathematical journal
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    • v.18 no.2
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    • pp.235-243
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    • 2002
  • In this paper, we get conditions for the natural projections of some product manifolds with varying metrics of two Riemannian manifolds to be harmonic, and necessary and sufficient conditions for some product manifolds with the harmonic natural projections of two Einstein manifolds to be Einstein manifolds.

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RIGHT RÉNYI MEAN AND TENSOR PRODUCT

  • HWANG, JINMI;JEONG, MIRAN;KIM, SEJONG
    • Journal of applied mathematics & informatics
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    • v.39 no.5_6
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    • pp.751-760
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    • 2021
  • We study in this paper the right Rényi mean for a quantum divergence induced from the α - z Rényi relative entropy. Many properties including homogeneity, invariance under permutation, repetition and unitary congruence transformation, and determinantal inequality have been presented. Moreover, we give the identity of two right Rényi means with respect to tensor product.

Analysis of the Conditions and Products of Natural Dyeing Shopping Malls in Japan (일본인 천연염색전문 쇼핑몰 현황 및 상품 분석)

  • Lee, Mi-Suk
    • Journal of the Korean Society of Clothing and Textiles
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    • v.35 no.3
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    • pp.254-266
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    • 2011
  • This study analyzes the state and products of shopping malls that sell naturally dyed products in Japan. In this study, 37 natural dyeing shopping malls were selected. The results of this study are as follows. There are many natural dying internet shopping malls located in the areas of Tokyo, Kyoto, and Okayama. The most frequent dyes were indigo, followed by akane, persimmon, mud, vegetation, and tea. The highest ordered product categories were accessories, followed by adult clothes, and interior decoration products. The most frequent products were adult hats, followed by towels (handkerchiefs), scarves, T-shirts, and bags. For the price of products, 3,000-4,000${\yen}$ was the highest for T-shirts, with 2,000-3,000${\yen}$ and 4,000-S,000${\yen}$ for newborn baby and child clothing, 5,000-10,000${\yen}$ for hats and bags, 3,000-4,000${\yen}$ for scarves, and 1,000-2,000${\yen}$ for towels (handkerchief). Concerning product information, most of the shopping malls offer the product size and the product explanations, but over half of them did not show the properties or directions for handling the product.

Therapeutic potentials and untoward effects of Piper betle and its quid

  • Rai, Sujay;Mal, Mainak;Wahile, Atul;Mukherjee, Pulok K.
    • Advances in Traditional Medicine
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    • v.5 no.4
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    • pp.272-282
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    • 2005
  • Piper betle Linn. (PB), which belongs to the family Piperaceae, is used traditionally in many Asian countries for treatment of a variety of aliments. It has also been used in Ayurveda and Unani systems of medicine. PB leaves are also used as a masticatory in the form of quid. The basic preparation of PB leaves for chewing purposes (PB quid) is known as Paan in India. It is recommended in ancient scripture of Ayurveda and is closely associated with Indian culture. PB is reported to have several therapeutic potentials as well as to produce some untoward effects. The review deals with phytoconstituents present, therapeutic potentials and untoward effects of PB.