• Title/Summary/Keyword: Natural product

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Oriental medicine mangifera indica

  • Rai, Sujay;Basak, Souvik;Mukherjee, Kakali;Saha, BP;Mukherjee, Pulok K
    • Advances in Traditional Medicine
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    • v.7 no.1
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    • pp.1-10
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    • 2007
  • Mangifera indica Linn. (MI) (Family: Anacardiaceae) is commonly known worldwide as mango and ‘Aam’ in India. MI shares an important place in treatment of several diseases in various ancient system of medicine like Ayurveda and other Indian System of Medicine and some other Traditional Medicines world wide. Almost all the parts of MI have been used in oriental medicine, so in this review attempt has being made to review the history, traditional uses, phytoconstituents and therapeutic potentials of mango.

Montmorillonite Clay Catalyzed Three Component, One-Pot Synthesis of 5-Hydroxyindole Derivatives

  • Reddy, B.V. Subba;Reddy, P. Sivaramakrishna;Reddy, Y. Jayasudhan;Bhaskar, N.;Reddy, B. Chandra Obula
    • Bulletin of the Korean Chemical Society
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    • v.34 no.10
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    • pp.2968-2972
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    • 2013
  • A highly efficient and environmentally benign protocol has been developed for the first time to produce a wide range of biologically active 5-hydroxyindole derivatives using montmorillonite KSF clay as a reusable solid acid catalyst. The use of recyclable clay makes this procedure quite simple, more convenient and cost-effective.

Antimicrobial activity of Mongolian medicinal plants

  • Gonchig, Enkhmaa;Erdenebat, Sarnaizul;Togtoo, Ouyntsetseg;Bataa, Sukhkhuu;Gendaram, Odontuya;Kim, Young-Sup;Ryu, Shi-Yong
    • Natural Product Sciences
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    • v.14 no.1
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    • pp.32-36
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    • 2008
  • The antimicrobial activity of seventy five ethanol extracts obtained from 67 different kinds of plant species of the Mongolian flora were evaluated by means of the disc diffusion method against five species of microorganisms, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, Micrococcus luteus and Pseudomonas aeruginosa. Among the plant extracts examined, 34 kinds of extracts demonstrated significant antibacterial activity against one or more species of microorganisms, respectively. Especially, the root extract of Paeonia anomala, the whole herb extract of Myricaria alopecuroides, the whole herb extract of comarum zalesovianum, the whole herb extract of Agrimonia pilosa and some other plant extracts demonstrated a particularly potent antimicrobial activity. The ethylacetate fractions obtained from the whole herb extract of Myricaria alopecuroides and from those of Sedum aizoon, Paeonia anomala, Sedum hybridum and Dasiphora fruticosa exhibited a particularly potent antibacterial activity especially against Staphylococcus aureus and Micrococcus luteus.

Contents Analysis of phenolic compounds from the Leaves of Quercus mongolica (신갈나무 잎으로부터 분리한 페놀성 화합물의 함량분석)

  • Hwang, In Hyeok;Yin, Jun;Youn, Sung Hye;Ahn, Hye Shin;Wang, Hye Soo;Lee, Min Won
    • Korean Journal of Pharmacognosy
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    • v.48 no.4
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    • pp.339-342
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    • 2017
  • Quercus mongolica (QM) is a species of Quercus native to Eastern Mongolia, Siberia, China, Japan, and Korea. QM has been used as Korean traditional medicine for the treatment of inflammation of the skin. Present work, the validation and content determination of the phenolic compounds which were isolated from the leaves of QM, including pedunculagin (1) and kaempferol-3-O-(6"-galloyl)-${\beta}$-D-glucopyranoside (2) were conducted through High-Performance Liquid Chromatography (HPLC). As a result, the contents of these compounds were 4.14% and 0.76% in QM extract, respectively.

Extraction of seven major compounds from Agastache rugosa (Fisch. & C.A.Mey.) Kuntze: optimization study using response surface methodology

  • Yang Hee Jo;Seong Mi Lee;Doo-Young Kim;Yesu Song;Hocheol Kim;Mi Kyeong Lee;Sei-Ryang Oh;Hyung Won Ryu
    • Journal of Applied Biological Chemistry
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    • v.66
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    • pp.81-89
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    • 2023
  • The purpose of this study is to demonstrate the potential enhancement of the flavonoid contents from Agastache rugosa, which can be obtained as raw materials for functional products in the food medicine industry by identifying important factors for efficient preparation to save costs and time in terms of economic factors. For this reason, response surface methodology using Box-Behnken design was used to optimize the extraction conditions for the maximum yield of seven major compounds from A. rugosa. The optimum conditions were obtained with an ethanol concentration of 60.0%, a temperature of 50 ℃, and an extraction time of 33.6 min, meaning that the regression analysis fits the experimental data well. Under these conditions, the seven major compounds 1-7 had observed values of 2.169, 2.135, 0.697, 2.485, 0.105, 1.247, and 0.551%, respectively. These results show that the observed values are in good agreement with the predicted values in the regression model. This process for optimization study exhibited a basic protocol for obtaining stable ingredients from A. rugosa that are appropriate for the development of effective functional products.

A study on the Purchase Appraisal Standard and Post-purchase Satisfaction of Natural Dyeing Products (천연염색제품 구매 평가기준 및 구매 후 만족도)

  • Park, Young-Hee
    • Fashion & Textile Research Journal
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    • v.14 no.1
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    • pp.64-74
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    • 2012
  • The purpose of this study was to find purchase appraisal standard and post-purchase satisfaction for natural dyeing products. The data used for this study were collected from the women in their from 20's to 50's who are living in the regions of Busan, Ulsan, and Gyeongnam in Korea. The questionnaire of 537 copies was used for a statistical analysis. To analyze data, 2-test, t-test, Cronbach's a test, factor analysis, ANOVA, Duncan test, regression analysis, etc. were carried out. A used statistical package was SPSS 14.0. The analysis results were as follows. The purchase appraisal standards for natural dyeing products were identified as practicality and reliability, suitability of use, symbolic property of status, design property, and convenience of buying. As the analysis result for purchase appraisal standard according to the demographic characteristics, the purchase appraisal standard according to most demographic characteristics showed significant difference. The factors of post-purchase satisfaction for natural dyeing products were verified as product modification and durability, design and price, hygienic property and product quality. As the analysis results of post-purchase satisfaction for natural dyeing products according to demographic characteristics, the post-purchase satisfaction according to demographic characteristics showed significant difference. The factors affecting post-purchase satisfaction were verified as product quality, kinds of item, color change, product lifespan, color change, etc. Consequently, because the purchase appraisal standard of natural dyeing product is very various, it is necessary to enhance post-purchase satisfaction of natural dyeing products by reflecting these factors in advance at the product development stage.

Anticomplement Activities of Oleanolic Acid Monodesmosides and Bisdesmosides Isolated from Tiarella polyphylla

  • Park, Si-Hyung;Oh, Sei-Ryang;Jung, Keun-Young;Lee, Im-Seon;Ahn, Kyung-Seop;Kim, Jae-Gil;Lee, Jung-Joon;Lee, Hyeong-Kyu
    • Archives of Pharmacal Research
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    • v.22 no.4
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    • pp.428-431
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    • 1999
  • Seven known oleanolic acid glycosides (1-7) were isolated form the MeOH extract of Tiarella polyphylla. The structures were identified to be 3-O-($\beta$-glucopyranosyl) oleanolic acid (1), 3-O-[$\beta$-D-glucopyranosyl-(1 3)-$\beta$-D-glucopyranosyl] oleanolic acid (2), 3-O-D-[$\beta$-D-glucopyranosyl-(1 2)-$\beta$-D-glycopyranosyl] oleanolic acid (3), 3-O-[$\beta$-D-glucopyranosyl-(1 3)-$\beta$-D-glucopyranosyl] oleanolic acid 28-O-$\beta$D-glucopyranosyl ester (4), 3-O-[$\beta$-D-glucopyranosyl-(1 2)-$\beta$-D-glucopyranosyl] oleanolic acid 28-O-$\beta$-D-glucopyranosyl ester (5), 3-O-[a-L-rahmnopyranosyl-(1 3)-$\beta$-D-glucururonopyranosyl] oleanolic acid (6), and 3-O-[$\alpha$-L-rhamnopyranosyl-(1 3)-$\alpha$-D-glucuronopyranosyl] oleanolic acid 28-O-$\alpha$-D-glucopyranosyl ester (7) on the basis of physicochemical and spectral data. These triterpene glycosides were tested for the anti-complement activity and hemolytic activity. Bisdesmosidic saponins, 4, 5, and 7, showed anti-complement activity; in contrast, monodesmosidic saponins, 1-3, and 6, showed direct hemolytic activity. Methyl esterified monodesmosidic saponins showed anti-complement activity at a low concentration and hemolytic activity at a high concentration.

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LC/MS-based metabolomics approach for selection of chemical markers by domestic production region of Schisandra chinensis (오미자(Schisandra chinensis)의 국내 산지별 화학적마커 선정을 위한 LC/MS 기반의 대사체학 접근법)

  • In Seon Kim;Seon Min Oh;Ha Eun Song;Doo-Young Kim;Dahye Yoon;Dae Young Lee;Hyung Won Ryu
    • Journal of Applied Biological Chemistry
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    • v.66
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    • pp.467-476
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    • 2023
  • Schisandra chinensis (S. chinensis) is a deciduous broad-leaved cave plant belonging to the Schisandraceae family and is widely distributed in East Asia including Korea, Japan, China, and Taiwan. It has been reported that the main components contained in S. chinensis include lignan compounds and triterpenoid compounds. To distinguish the characteristics of S. chinensis by production region of Korea, a discriminant was established by performing metabolite profiling and principal component analysis, a multivariate statistical analysis technique. As a result, 16 types of triterpenoids, 9 types of lignan, and 1 type each of flavonoid, phenylpropanoid, and fatty acid were identified. In addition, through multivariate statistical analysis, it was confirmed that the four groups in Danyang, Moongyeong, Geochang, and Pyeongchang were divided, by applying the s-plot model of orthogonal partial least squares discriminant analysis. Biomarkers were identified: lanostane, cycloartane, schiartane triterpenoid, and dibenzocyclo-octadiene lignan were identified as chemical markers, respectively.

Brine shrimp lethality and cytotoxicity assay of Araucaria bidwillii Hook in human carcinoma cell lines

  • Ahamed, KFH Nazeer;Kumar, V;Manikandan, L;Wahile, Atul M;Mukherjee, Kakali;Saha, BP;Mukherjee, Pulok K
    • Advances in Traditional Medicine
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    • v.5 no.1
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    • pp.21-28
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    • 2005
  • The leaf extracts of Araucaria bidwillii Hook. (Araucariaceae) were evaluated for their cytotoxic effect in various human cancer cell lines. Preliminary investigation by brine shrimp lethality assay indicated that $LC_{50}$ value of various successive extracts were found to be less than $1000\;{\mu}g/ml$, where the ethyl acetate extract showed maximum activity of less than $100\;{\mu}g/ml$. Further cytotoxic evaluation of various leaf extracts of Araucaria bidwilli Hook was carried out in four different human cancer cell lines-acute myeloblastic leukemia (HL-60), chronic myelogenic leukemia (K-562), breast adenocarcinoma (MCF-7) and cervical epithelial carcinoma (HeLa). Cytotoxicity was assessed by trypan blue dye exclusion method and 3-(4,5-dimethyl thiazole-2yl)-2,5-diphenyl tetrazolium bromide (MTT) reduction assay. From the present investigation it was found that the ethyl acetate and methanol extract of Araucaria bidwilli Hook was found to be more effective in leukemic cell lines and was less effective in MCF-7 and HeLa. The $IC_{50}$ value of the ethyl acetate extract in leukemic cell lines was found to be $28.18\;and\;34.64\;{\mu}g/ml$ and methanol extract was found to be $33.11\;&\;39.81\;{\mu}g/ml$. It can be concluded that various extract from the leaves of Araucaria bidwillii Hook. posses cytotoxic activity tested in brine shrimps and various human carcinoma cell lines.

Phenolic Compounds from the Twigs of Corylopsis coreana Uyeki and Their Cytotoxic Activity (히어리나무의 페놀성 화합물 및 세포독성활성)

  • Kwon, Oh Kil;Kim, Chung Sub;Suh, Won Se;Park, Kyoung Jin;Cha, Joon Min;Choi, Sang Un;Kwon, Hak Cheol;Lee, Kang Ro
    • Korean Journal of Pharmacognosy
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    • v.47 no.1
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    • pp.1-6
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    • 2016
  • Phytochemical investigation of the twigs of Corylopsis coreana afforded 10 phenolic compounds, bergenin (1), 6'-O-galloylbergenin (2), 3'-O-galloylbergenin (3), (-)-catechin (4), (-)-epicatechin (5), (-)-epicatechin-3-O-galloyl ester (6), 4-methoxy-3,-5-dihydroxybenzoic acid (7), gallic acid (8), 2,4,6-trimethoxyphenol-1-O-${\beta}-\small{D}$-glucopyranoside (9), and 2,4,6-trimethoxyphenol-1-O-${\beta}-\small{D}$-(6-O-galloyl)-glucopyranoside (10). Their structures were characterized by spectroscopic data and identified by comparing these data with those in the literatures. The compounds 3, 9 and 10 were isolated for the first time from this source. All the isolates (1-10) were tested for their cytotoxic activity against A549, SK-OV-3, SK-MEL-2, and HCT15 cell lines in vitro using the SRB bioassay. The compounds 5, 7 and 8 exhibited selective cytotoxic activity against SK-MEL-2 cell line.